LOCUS       XM_047416497           15937 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens ubiquitin protein ligase E3 component
            n-recognin 4 (UBR4), transcript variant X19, mRNA.
ACCESSION   XM_047416497
VERSION     XM_047416497.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000001.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..15937
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
     gene            1..15937
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /note="ubiquitin protein ligase E3 component n-recognin 4;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 12 mRNAs, 360 ESTs, 4743 long SRA reads, 8
                     Proteins, and 100% coverage of the annotated genomic
                     feature by RNAseq alignments, including 10 samples with
                     support for all annotated introns"
                     /db_xref="GeneID:23352"
                     /db_xref="HGNC:HGNC:30313"
                     /db_xref="MIM:609890"
     CDS             19..15615
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase UBR4 isoform X19"
                     /protein_id="XP_047272453.1"
                     /db_xref="GeneID:23352"
                     /db_xref="HGNC:HGNC:30313"
                     /db_xref="MIM:609890"
                     /translation="MATSGGEEAAAAAPAPGTPATGADTTPGWEVAVRPLLSASYSAF
                     EMKELPQLVASVIESESEILHHEKQYEPFYSSFVALSTHYITTVCSLIPRNQLQSVAA
                     ACKVLIEFSLLRLENPDEACAVSQKHLILLIKGLCTGCSRLDRTEIITFTAMMKSAKL
                     PQTVKTLSDVEDQKELASPVSPELRQKEVQMNFLNQLTSVFNPRTVASQPISTQTLVE
                     GENDEQSSTDQASAIKTKNVFIAQNVASLQELGGSEKLLRVCLNLPYFLRYINRFQDA
                     VLANSFFIMPATVADATAVRNGFHSLVIDVTMALDTLSLPVLEPLNPSRLQDVTVLSL
                     SCLYAGVSVATCMAILHVGSAQQVRTGSTSSKEDDYESDAATIVQKCLEIYDMIGQAI
                     SSSRRAGGEHYQNFQLLGAWCLLNSLFLILNLSPTALADKGKEKDPLAALRVRDILSR
                     TKEGVGSPKLGPGKGHQGFGVLSVILANHAIKLLTSLFQDLQVEALHKGWETDGPPAA
                     LSIMAQSTSIQRIQRLIDSVPLMNLLLTLLSTSYRKACVLQRQRKGSMSSDASASTDS
                     NTYYEDDFSSTEEDSSQDDDSEPILGQWFEETISPSKEKAAPPPPPPPPPLESSPRVK
                     SPSKQAPGEKGNILASRKDPELFLGLASNILNFITSSMLNSRNNFIRNYLSVSLSEHH
                     MATLASIIKEVDKDGLKGSSDEEFAAALYHFNHSLVTSDLQSPNLQNTLLQQLGVAPF
                     SEGPWPLYIHPQSLSVLSRLLLIWQHKASAQGDPDVPECLKVWDRFLSTMKQNALQGV
                     VPSETEDLNVEHLQMLLLIFHNFTETGRRAILSLFVQIIQELSVNMDAQMRFVPLILA
                     RLLLIFDYLLHQYSKAPVYLFEQVQHNLLSPPFGWASGSQDSNSRRATTPLYHGFKEV
                     EENWSKHFSSDAVPHPRFYCVLSPEASEDDLNRLDSVACDVLFSKLVKYDELYAALTA
                     LLAAGSQLDTVRRKENKNVTALEACALQYYFLILWRILGILPPSKTYINQLSMNSPEM
                     SECDILHTLRWSSRLRISSYVNWIKDHLIKQGMKAEHASSLLELASTTKCSSVKYDVE
                     IVEEYFARQISSFCSIDCTTILQLHEIPSLQSIYTLDAAISKVQVSLDEHFSKMAAET
                     DPHKSSEITKNLLPATLQLIDTYASFTRAYLLQNFNEEGTTEKPSKEKLQGFAAVLAI
                     GSSRCKANTLGPTLVQNLPSSVQTVCESWNNINTNEFPNIGSWRNAFANDTIPSESYI
                     SAVQAAHLGTLCSQSLPLAASLKHTLLSLVRLTGDLIVWSDEMNPPQVIRTLLPLLLE
                     SSTESVAEISSNSLERILGPAESDEFLARVYEKLITGCYNILANHADPNSGLDESILE
                     ECLQYLEKQLESSQARKAMEEFFSDSGELVQIMMATANENLSAKFCNRVLKFFTKLFQ
                     LTEKSPNPSLLHLCGSLAQLACVEPVRLQAWLTRMTTSPPKDSDQLDVIQENRQLLQL
                     LTTYIVRENSQVGEGVCAVLLGTLTPMATEMLANGDGTGFPELMVVMATLASAGQGAG
                     HLQLHNAAVDWLSRCKKYLSQKNVVEKLNANVMHGKHVMILECTCHIMSYLADVTNAL
                     SQSNGQGPSHLSVDGEERAIEVDSDWVEELAVEEEDSQAEDSDEDSLCNKLCTFTITQ
                     KEFMNQHWYHCHTCKMVDGVGVCTVCAKVCHKDHEISYAKYGSFFCDCGAKEDGSCLA
                     LVKRTPSSGMSSTMKESAFQSEPRISESLVRHASTSSPADKAKVTISDGKVADEEKPK
                     KSSLCRTVEGCREELQNQANFSFAPLVLDMLNFLMDAIQTNFQQASAVGSSSRAQQAL
                     SELHTVEKAVEMTDQLMVPTLGSQEGAFENVRMNYSGDQGQTIRQLISAHVLRRVAMC
                     VLSSPHGRRQHLAVSHEKGKITVLQLSALLKQADSSKRKLTLTRLASAPVPFTVLSLT
                     GNPCKEDYLAVCGLKDCHVLTFSSSGSVSDHLVLHPQLATGNFIIKAVWLPGSQTELA
                     IVTADFVKIYDLCVDALSPTFYFLLPSSKIRDVTFLFNEEGKNIIVIMSSAGYIYTQL
                     MEEASSAQQGPFYVTNVLEINHEDLKQDSNSQVAGGGVSVYYSHVLQMLFFSYCQGKS
                     FAATISRTTLEVLQLFPINIKSFVVCSSNGGSKTSPALCQWSEVMNHPGLVCCVQQTT
                     GVPLVVMVKPDTFLIQEIKTLPAKAKIQDMVAIRHTACNEQQRTTMILLCEDGSLRIY
                     MANVENTSYWLQPSLQPSSVISIMKPVRKRKTATITTRTSSQVTFPIDFFEHNQQLTD
                     VEFGGNDLLQVYNAQQIKHRLNSTGMYVANTKPGGFTIEISNNNSTMVMTGMRIQIGT
                     QAIERAPSYIEIFGRTMQLNLSRSRWFDFPFTREEALQADKKLNLFIGASVDPAGVTM
                     IDAVKIYGKTKEQFGWPDEPPEEFPSASVSNICPSNLNQSNGTGDSDSAAPTTTSGTV
                     LESSETESLTKLDRLVVSSLEALESCFAVGPIIEKERNKNAAQELATLLLSLPAPASV
                     QQQSKSLLASLHTSRSAYHSHKDQALLSKAVQCLNTSSKEGKDLDPEVFQRLVITARS
                     IAIMRPNNLVHFTESKLPQMETGMDEGKEPQKQLEGDCCSFITQLVNHFWKLHASKPK
                     NAFLAPACLPGLTHIEATVNALVDIIHGYCTCELDCINTASKIYMQMLLCPDPAVSFS
                     CKQALIRVLRPRNKRRHVTLPSSPRSNTPMDKDDDDDDDADEKMQSSGIPNGGHIRQE
                     SQEQSEVDHGDFEMVSESMVLETAENVNNGNPSPLEALLAGAEGFPPMLDIPPDADDE
                     TMVELAIALSLQQDQQGSSSSALGLQSLGLSGQAPSSSSLDAGTLSDTTASAPASDDE
                     GSTAATDGSTLRTSPADHGGSVGSESGGSAVDSVAGEHSVSGRSSAYGDATAEGHPAG
                     PGSVSSSTGAISTTTGHQEGDGSEGEGEGETEGDVHTSNRLHMVRLMLLERLLQTLPQ
                     LRNVGGVRAIPYMQVILMLTTDLDGEDEKDKGALDNLLSQLIAELGMDKKDVSKKNER
                     SALNEVHLVVMRLLSVFMSRTKSGSKSSICESSSLISSATAAALLSSGAVDYCLHVLK
                     SLLEYWKSQQNDEEPVATSQLLKPHTTSSPPDMSPFFLRQYVKGHAADVFEAYTQLLT
                     EMVLRLPYQIKKITDTNSRIPPPVFDHSWFYFLSEYLMIQQTPFVRRQVRKLLLFICG
                     SKEKYRQLRDLHTLDSHVRGIKKLLEEQGIFLRASVVTASSGSALQYDTLISLMEHLK
                     ACAEIAAQRTINWQKFCIKDDSVLYFLLQVSFLVDEGVSPVLLQLLSCALCGSKVLAA
                     LAASSGSSSASSSSAPVAASSGQATTQSKSSTKKSKKEEKEKEKDGETSGSQEDQLCT
                     ALVNQLNKFADKETLIQFLRCFLLESNSSSVRWQAHCLTLHIYRNSSKSQQELLLDLM
                     WSIWPELPAYGRKAAQFVDLLGYFSLKTPQTEKKLKEYSQKAVEILRTQNHILTNHPN
                     SNIYNTLSGLVEFDGYYLESDPCLVCNNPEVPFCYIKLSSIKVDTRYTTTQQVVKLIG
                     SHTISKVTVKIGDLKRTKMVRTINLYYNNRTVQAIVELKNKPARWHKAKKVQLTPGQT
                     EVKIDLPLPIVASNLMIEFADFYENYQASTETLQCPRCSASVPANPGVCGNCGENVYQ
                     CHKCRSINYDEKDPFLCNACGFCKYARFDFMLYAKPCCAVDPIENEEDRKKAVSNINT
                     LLDKADRVYHQLMGHRPQLENLLCKVNEAAPEKPQDDSGTAGGISSTSASVNRYILQL
                     AQEYCGDCKNSFDELSKIIQKVFASRKELLEYDLQQREAATKSSRTSVQPTFTASQYR
                     ALSVLGCGHTSSTKCYGCASAVTEHCITLLRALATNPALRHILVSQGLIRELFDYNLR
                     RGAAAMREEVRQLMCLLTRDNPEATQQMNDLIIGKVSTALKGHWANPDLASSLQYEML
                     LLTDSISKEDSCWELRLRCALSLFLMAVNIKTPVVVENITLMCLRILQKLIKPPAPTS
                     KKNKDVPVEALTTVKPYCNEIHAQAQLWLKRDPKASYDAWKKCLPIRGIDGNGKAPSK
                     SELRHLYLTEKYVWRWKQFLSRRGKRTSPLDLKLGHNNWLRQVLFTPATQAARQAACT
                     IVEALATIPSRKQQVLDLLTSYLDELSIAGECAAEYLALYQKLITSAHWKVYLAARGV
                     LPYVGNLITKEIARLLALEEATLSTDLQQGYALKSLTGLLSSFVEVESIKRHFKSRLV
                     GTVLNGYLCLRKLVVQRTKLIDETQDMLLEMLEDMTTGTESETKAFMAVCIETAKRYN
                     LDDYRTPVFIFERLCSIIYPEENEVTEFFVTLEKDPQQEDFLQGRMPGNPYSSNEPGI
                     GPLMRDIKNKICQDCDLVALLEDDSGMELLVNNKIISLDLPVAEVYKKVWCTTNEGEP
                     MRIVYRMRGLLGDATEEFIESLDSTTDEEEDEEEVYKMAGVMAQCGGLECMLNRLAGI
                     RDFKQGRHLLTVLLKLFSYCVKVKVNRQQLVKLEMNTLNVMLGTLNLALVAEQESKDS
                     GGAAVAEQVLSIMEIILDESNAEPLSEDKGNLLLTGDKDQLVMLLDQINSTFVRSNPS
                     VLQGLLRIIPYLSFGEVEKMQILVERFKPYCNFDKYDEDHSGDDKVFLDCFCKIAAGI
                     KNNSNGHQLKDLILQKGITQNALDYMKKHIPSAKNLDADIWKKFLSRPALPFILRLLR
                     GLAIQHPGTQVLIGTDSIPNLHKLEQVSSDEGIGTLAENLLEALREHPDVNKKIDAAR
                     RETRAEKKRMAMAMRQKALGTLGMTTNEKGQVVTKTALLKQMEELIEEPGLTCCICRE
                     GYKFQPTKVLGIYTFTKRVALEEMENKPRKQQGYSTVSHFNIVHYDCHLAAVRLARGR
                     EEWESAALQNANTKCNGLLPVWGPHVPESAFATCLARHNTYLQECTGQREPTYQLNIH
                     DIKLLFLRFAMEQSFSADTGGGGRESNIHLIPYIIHTVLYVLNTTRATSREEKNLQGF
                     LEQPKEKWVESAFEVDGPYYFTVLALHILPPEQWRATRVEILRRLLVTSQARAVAPGG
                     ATRLTDKAVKDYSAYRSSLLFWALVDLIYNMFKKVPTSNTEGGWSCSLAEYIRHNDMP
                     IYEAADKALKTFQEEFMPVETFSEFLDVAGLLSEITDPESFLKDLLNSVP"
ORIGIN      
        1 gcagtagtac gacggaagat ggcgacgagc ggcggcgaag aggcggcggc agcggctccg
       61 gcgccgggga ccccggcaac gggggcggac acgaccccgg gctgggaggt ggctgtgcgg
      121 cccctgctgt ccgcgtccta ctccgccttc gagatgaagg agttgccgca gctggtggcc
      181 tcagtcatcg agagtgaatc agaaatcctg caccatgaga agcagtacga gccattctac
      241 tcatcttttg ttgcactttc cacacactat attacaacag tttgcagtct cattccccgg
      301 aaccaacttc agtcagtggc agcagcctgt aaagttctaa ttgagttttc tctcctgcgt
      361 ctggagaatc cagatgaggc ttgtgctgtg tcccagaaac acttgattct cctaatcaag
      421 ggcctgtgca ctggctgtag ccgactagat agaactgaaa ttatcacatt tacagcaatg
      481 atgaaatccg ccaagctgcc ccaaacagtg aagacacttt cagacgtgga agatcagaaa
      541 gagctggcct caccagtaag ccctgagttg aggcaaaagg aggtacagat gaattttttg
      601 aaccagctga cctcagtttt taaccctaga actgtagcat cacaacctat cagtacacag
      661 actctggtgg aaggagaaaa tgatgagcag tcatctacag atcaagcctc agctatcaaa
      721 accaagaatg tgttcatagc tcagaacgtg gctagtcttc aagagcttgg tggctcggag
      781 aagctactgc gtgtatgttt gaacctgcca tatttcctac gctatatcaa tcggttccaa
      841 gatgcagttt tagctaattc cttcttcata atgcctgcaa cagtagcaga tgccactgct
      901 gttcgtaatg gctttcattc attggtgatt gatgtaacta tggcattgga taccctttct
      961 ctacctgtgt tggaacctct caatccttct cgtctacaag atgtgacagt cctcagccta
     1021 agttgtctgt atgcaggtgt gagtgtggca acgtgcatgg ccatcctcca tgtgggtagt
     1081 gcccagcaag tgcggacagg gtccacgagc tccaaagaag atgactatga aagtgacgca
     1141 gctacaattg tccagaaatg tctcgaaatc tatgacatga ttggacaagc aatcagcagt
     1201 tctcgccggg ctggtggtga gcactatcag aatttccaat tgctgggtgc ttggtgcttg
     1261 ttaaacagcc ttttcctcat actgaacctc agtcctactg cgttggctga taaggggaaa
     1321 gagaaggacc cactggctgc cctccgagtc agagacatcc tttctcgtac taaagaggga
     1381 gtgggctccc ctaaactggg gcctggaaaa gggcatcagg gatttggggt actctcagta
     1441 atattggcaa accatgccat caaactgcta acgtctctct ttcaagacct acaagtggag
     1501 gcccttcaca agggttggga gacagatggc ccccctgcag ccttgagcat tatggcccag
     1561 agcacctcca tacagaggat tcaacggctg attgactctg tcccactgat gaacctgctc
     1621 ttgacgttac tttcaacttc ctacagaaag gcatgtgtcc tgcagcggca gaggaagggc
     1681 tccatgagca gcgatgccag cgcctccacc gactccaata cttactatga ggacgatttc
     1741 agtagcacgg aggaggacag cagccaagac gatgacagtg agcctatttt ggggcaatgg
     1801 tttgaggaga ctatttctcc cagtaaagag aaagcagcac ctccgcctcc tcccccacct
     1861 cctccactgg aaagctctcc tcgggttaaa agccccagta agcaggcccc tggtgagaag
     1921 ggcaacattc tggcgagtcg caaagatcct gagttgttct taggtctggc ttccaacatt
     1981 ttgaacttca tcacctcttc catgctgaac tctcggaaca attttatccg aaactatctg
     2041 agtgtatctc tttcagaaca ccatatggcc accctagcca gtatcatcaa ggaggtggac
     2101 aaagatggac tcaagggttc atcagatgaa gagtttgctg cagctctcta tcacttcaac
     2161 cactcactgg taacctctga ccttcagtca cctaacctgc agaacacact gttgcagcag
     2221 ctaggagtgg ctcctttttc tgagggccct tggcccttgt acattcaccc tcaaagcctc
     2281 tctgtgcttt cacgcctcct gctcatctgg caacataaag ccagtgctca aggtgaccct
     2341 gacgtcccag aatgccttaa agtttgggac aggtttttgt ctacaatgaa gcagaatgcc
     2401 ctgcaaggtg tggtgcccag tgagacagag gatctgaatg tagaacacct gcagatgctc
     2461 ctcctcattt tccacaattt caccgagaca ggccggcggg ccatattgtc gctttttgtc
     2521 cagatcatcc aggagttgag cgtcaacatg gatgctcaga tgcgcttcgt gccgcttatc
     2581 ttggctcgcc tccttctcat ctttgattat ctgcttcatc agtactccaa agcccctgtg
     2641 tatctatttg agcaggtaca gcataacctg ctaagtcctc cctttgggtg ggcaagtgga
     2701 tcccaggaca gcaacagccg ccgggcaacc actcctctct atcatggatt caaagaagta
     2761 gaagaaaact ggtctaagca tttctcatca gatgctgtcc cacaccccag attctactgt
     2821 gtcctgtccc cagaagcctc agaggatgat ttgaaccgac ttgattctgt ggcatgtgac
     2881 gtccttttct ccaagcttgt caagtatgat gagctttatg ctgcactgac agccctgctt
     2941 gcagctgggt cccagcttga tacagttagg agaaaggaaa acaagaatgt aacagccttg
     3001 gaggcctgtg cccttcaata ttacttcttg atactgtgga ggatcctagg aattttacca
     3061 ccatcaaaga cttacattaa ccagctatcc atgaactcac ctgagatgag cgaatgtgac
     3121 atcttgcaca ctctgcgatg gtcttctcgg ctccggatca gctcctatgt caactggata
     3181 aaggatcacc ttatcaaaca gggaatgaag gctgagcatg ctagctcgct tctagaactg
     3241 gcatccacca ctaagtgtag ctcagtgaaa tatgatgttg aaatagtaga ggaatacttc
     3301 gctcgacaga tctcatcctt ctgtagtatc gactgtacca ccatcttgca gctgcatgaa
     3361 attcccagtc tgcagtccat ctacaccctt gatgccgcga tctcaaaggt ccaggtctct
     3421 ttggatgagc atttttctaa gatggctgct gagactgatc ctcataagtc gtctgagatt
     3481 accaagaacc tacttccagc cacgctgcaa ctcattgaca cctatgcatc gttcaccaga
     3541 gcctatttgc tgcaaaactt taatgaagag ggaacaactg agaaaccttc caaggagaaa
     3601 ctgcaaggct ttgctgctgt tttggctatt ggctctagca ggtgcaaggc aaatactctg
     3661 ggtccgacac tggttcagaa tttgccatcg tcagtgcaga ctgtgtgtga gtcctggaac
     3721 aacatcaata ccaatgaatt tcccaatatt ggatcctggc gcaatgcctt tgccaatgac
     3781 accatccctt cagagagtta tattagtgca gtgcaggctg cacacctggg gactctctgt
     3841 agccaaagtc tgcccctggc tgcttccctg aagcataccc tcctctcact ggtcaggttg
     3901 actggagatc ttattgtttg gtcagatgag atgaacccac cacaggtaat tcggacactg
     3961 ctacctcttc ttttggaatc aagcactgag agtgttgccg agatcagtag caactccctg
     4021 gaacgcatct tgggccctgc tgagtctgat gagttcttgg ctcgtgttta tgagaagctg
     4081 atcactggtt gttacaacat tctggccaat catgcagatc ctaacagtgg actggatgaa
     4141 tccatcctgg aggaatgtct ccagtacttg gaaaagcagc tggaaagtag ccaggctcgt
     4201 aaagctatgg aggagttttt ctctgacagt ggagaacttg tacagatcat gatggcaaca
     4261 gccaatgaga acctctctgc taaattctgt aaccgagttt tgaaattctt caccaaactc
     4321 ttccagctga ctgagaagag ccctaacccg agcctgttgc atctctgtgg ctccctggca
     4381 caactggcct gtgtggaacc tgtgcgcctg caggcctggc tcacccgcat gactacatcg
     4441 cccccaaaag attctgatca gctggatgta attcaggaga accggcagct gctgcagtta
     4501 ctgaccacat acattgttcg ggaaaacagc caagttgggg aaggtgtgtg tgctgttctt
     4561 ctgggcaccc tgactcccat ggcaacagag atgctggcca acggtgatgg gactggcttc
     4621 cctgaactta tggttgtgat ggccactctg gccagtgcag gtcaaggtgc tggtcacctt
     4681 cagcttcata atgctgctgt ggattggctg agcagatgca agaaatacct gtcacagaag
     4741 aatgtagttg aaaaactgaa tgccaatgta atgcatggaa agcatgtgat gatcttggag
     4801 tgcacatgcc atatcatgtc ttacttggct gatgtcacga atgccctgag ccagagtaat
     4861 ggtcaaggcc caagtcatct ctcagtggat ggggaagagc gggccattga agtagactca
     4921 gactgggtgg aggagttggc ggtggaagag gaagattccc aggctgagga ttcagatgaa
     4981 gattctcttt gcaataaact ctgcactttt acgatcacac agaaagaatt catgaaccag
     5041 cattggtacc actgtcacac ctgtaaaatg gtggatggcg tgggtgtctg cacagtgtgt
     5101 gctaaggtgt gccacaagga tcatgagatt tcctatgcca agtatggatc cttcttctgt
     5161 gactgtggag ccaaggaaga tggcagctgt ttggctctgg tgaagagaac tcctagcagt
     5221 ggcatgagct ctaccatgaa ggagtcggca tttcagagtg aacccaggat ttcagagagt
     5281 ctagtgcgtc atgccagcac ctcctcgcca gctgacaaag ccaaggttac catcagtgat
     5341 ggaaaggttg ctgacgaaga gaagcccaag aagagcagcc tctgccgcac agtagagggc
     5401 tgccgggagg aattacagaa ccaggccaat ttctccttcg ctcctctcgt gttagacatg
     5461 cttaatttcc ttatggatgc cattcagacc aacttccagc aagcttcagc cgtcgggagc
     5521 agcagccgtg ctcagcaagc cctcagtgag ctacacactg tggagaaggc agtggagatg
     5581 acagaccagc tgatggttcc caccttaggg tcccaggaag gtgcctttga gaatgtgcgg
     5641 atgaattaca gtggagacca gggccagacc atccggcagc tgatcagtgc tcatgtgctc
     5701 aggcgggtgg ctatgtgtgt gctctcctct ccccatgggc gccgccaaca tttggctgtc
     5761 agccatgaga agggcaagat caccgttctg cagctctctg cactcctgaa gcaagcagat
     5821 tccagcaaaa ggaagttaac tctgacccgc ttggcttctg ccccagttcc ttttactgtg
     5881 ttgagcctca caggaaatcc ctgcaaggaa gactacttgg cggtttgtgg gctaaaggac
     5941 tgtcatgtgc tcacctttag tagctcaggc tctgtttcgg atcacttggt tttgcaccct
     6001 cagttggcaa cggggaactt catcatcaaa gccgtgtggt tacctggttc acagaccgag
     6061 ttagcaattg tcaccgcaga ctttgttaag atttatgacc tgtgtgttga tgccttgagt
     6121 ccaaccttct attttctcct gccaagctca aagataagag atgttacctt ccttttcaat
     6181 gaggagggaa agaacatcat tgttataatg tcttcggctg ggtacatcta tactcagctt
     6241 atggaagagg ccagcagtgc ccagcaggga cccttctatg tcactaatgt gttggaaatc
     6301 aatcatgagg acctgaagca ggacagtaac agccaggtgg cgggcggtgg tgtgtccgtg
     6361 tactactccc acgtgttgca gatgttgttc ttcagctatt gtcaaggcaa atcattcgca
     6421 gccaccatca gcaggacaac cctggaggtg ttgcaactct tccccatcaa catcaaaagt
     6481 tttgttgtct gcagttccaa tggtggcagt aagacttctc ctgctctttg ccagtggtct
     6541 gaggtgatga accaccctgg cttggtgtgc tgtgtccagc aaactacagg ggtgccgctg
     6601 gtagttatgg tgaaaccaga cacttttctt atccaggaga ttaagactct tcctgctaaa
     6661 gcgaagatcc aagacatggt tgctattagg cacacggcct gcaatgagca gcagcggaca
     6721 acaatgattc tgctgtgtga ggatggcagc ctgcgcattt acatggccaa cgtggagaac
     6781 acctcctact ggctgcagcc atccctgcag cccagcagtg tcatcagcat catgaagcct
     6841 gttcgaaagc gcaaaacagc tacaatcaca acccgcacgt ctagccaggt gactttcccc
     6901 attgactttt ttgaacacaa ccagcagctg acagatgtgg agtttggtgg taacgacctc
     6961 ctacaggtct ataatgcaca acagataaaa caccggctga attccactgg catgtatgtg
     7021 gccaacacca agcccggagg cttcaccatt gagattagta acaacaatag cactatggtg
     7081 atgacaggca tgcggatcca gattgggact caagcaatag aacgggcccc gtcatatatc
     7141 gagatcttcg gcagaactat gcagctcaac ctgagtcgct cacgctggtt tgacttcccc
     7201 ttcaccagag aagaagccct gcaggctgat aagaagctga acctcttcat tggggcctcg
     7261 gtggatccag caggtgtcac catgatagat gctgtaaaaa tttatggcaa gactaaggag
     7321 cagtttggct ggcctgatga gcccccagaa gaattccctt ctgcctctgt cagcaacatc
     7381 tgcccttcaa atctgaacca gagcaacggc actggagata gcgactcagc tgcccccact
     7441 acgaccagtg gaactgtcct ggagagttct gaaactgagt ccctaaccaa gctggaccgg
     7501 ctggttgtga gttctttaga agccctggaa agctgctttg ccgttggccc aatcatcgag
     7561 aaggagagaa acaagaatgc tgctcaggag ctggccactt tgctgttgtc cctgccagca
     7621 cctgccagtg tccagcagca gtccaagagc cttctggcca gcctgcacac cagccgctcg
     7681 gcctaccaca gccacaagga tcaggccttg ctgagcaaag ctgtgcagtg tctcaacaca
     7741 tctagcaaag agggcaagga tttggaccct gaggtgttcc agaggctagt gatcacagct
     7801 cgctccattg ccatcatgcg ccccaacaac cttgtccact ttacggagtc aaagctgccc
     7861 cagatggaaa caggaatgga tgaagggaag gaaccgcaga agcagttgga aggagattgc
     7921 tgtagtttca tcacccagct tgtgaaccac ttctggaaac tccatgcatc caaacccaag
     7981 aatgccttct tggcacctgc ctgccttcca ggactaactc atattgaagc tactgtcaat
     8041 gctctggtgg acatcatcca tggctactgt acctgtgagc tggattgtat taacacagca
     8101 tccaagatct acatgcagat gctcttgtgt cctgatcctg ctgtgagctt ctcttgtaaa
     8161 caagctctaa ttcgagtcct aaggcccagg aacaaacgga gacatgtgac tttaccctct
     8221 tcccctcgaa gcaacactcc aatggacaag gatgatgatg acgatgatga tgcagatgag
     8281 aaaatgcagt catcagggat cccgaatggt ggtcacatcc gtcaggaaag ccaggaacag
     8341 agtgaggtgg accatggaga ttttgagatg gtgtctgagt cgatggtcct ggagacagct
     8401 gaaaatgtca acaatggcaa cccctctccc ctggaggccc tgctggcagg cgcagagggc
     8461 ttccccccca tgctggacat cccacctgat gcagatgacg agaccatggt tgaactagcc
     8521 attgccctga gcctgcagca ggaccaacaa ggcagcagca gcagtgccct gggcctgcag
     8581 agcctgggac tgtccggcca ggcacccagc tcttcctctc tggacgcagg aaccctctct
     8641 gacaccacag catcagctcc agcctcagac gacgagggca gtacagcagc gacagatggt
     8701 tctacccttc ggacctctcc tgctgaccac ggtggtagtg tgggctcgga gagcgggggc
     8761 agtgcagtgg actcagtggc tggcgagcac agtgtatctg gccggagcag tgcttatggc
     8821 gatgctacag ctgaggggca tccggctgga ccaggaagtg tcagctcaag cactggagcc
     8881 atcagcacca ccactgggca ccaggaggga gatggctccg agggagaagg agaaggagaa
     8941 actgaaggag atgtccacac tagcaacagg ctgcacatgg tccgtctaat gctgttggag
     9001 agattactgc agaccctgcc tcaattacga aacgttggcg gtgtccgggc catcccatac
     9061 atgcaggtca ttctaatgct cactacagat ctggatggag aagatgagaa agacaagggg
     9121 gccctagaca acctgctctc ccagcttatt gctgagttgg gtatggataa aaaggatgtc
     9181 tccaagaaga atgagcgcag cgccctgaat gaagtccatc tggtagtaat gagactcctg
     9241 agtgtcttca tgtcccgcac caaatctgga tccaagtctt ccatatgtga gtcatcttcc
     9301 ctcatctcca gtgccacagc agcagctcta ctgagctctg gggctgtgga ctactgcctg
     9361 cacgtgctca aatcactgct ggaatattgg aagagccaac agaatgacga ggagcctgtg
     9421 gctaccagcc agttgctgaa accacatact acctcctccc cacctgacat gagcccattc
     9481 tttctccgcc agtatgtgaa gggtcatgct gctgatgtgt ttgaggccta tactcagctt
     9541 ctaacagaaa tggtactgag gcttccttac caaatcaaaa agattactga caccaattct
     9601 cgaatcccac ctcctgtctt tgaccactcg tggttttact ttctctccga gtacctcatg
     9661 atccagcaga ctccatttgt gcgccgtcaa gtccgcaaac ttctgctctt catctgtgga
     9721 tccaaagaga agtaccgcca gctccgggat ttgcacaccc tggactctca cgtgcgtggg
     9781 atcaagaagc tgctagaaga gcaggggata ttcctccggg caagtgtggt tacagccagc
     9841 tcaggctccg ccttgcaata tgacacactc atcagcctga tggagcacct gaaagcctgt
     9901 gcagagattg ccgcccagcg aaccatcaac tggcagaaat tctgcatcaa agatgactcc
     9961 gtcctgtact tcctcctcca agtcagtttc cttgtggatg agggcgtgtc cccagtgctg
    10021 ctgcaactgc tctcctgtgc tctgtgcggc agcaaggtgc tcgctgcact ggcagcctct
    10081 tcgggatcct ccagtgcttc ttcctcctca gcccctgtgg ctgccagttc tggacaagcc
    10141 acaacacagt ccaagtcttc cactaaaaag agcaagaaag aagaaaaaga aaaggagaaa
    10201 gatggtgaga cctctggcag ccaggaggac cagctgtgca cagctctggt gaaccagctg
    10261 aacaaatttg ccgataagga aaccctgatc cagttcctgc gttgtttcct gttagagtcc
    10321 aattcttcct cggtgcgctg gcaggcccac tgtctgacac tgcacatcta cagaaattcc
    10381 agcaaatctc aacaggagct cctgctagat ctgatgtggt ccatctggcc agaactccca
    10441 gcctatggtc gtaaggctgc ccagtttgtg gacctactag gatatttctc cctgaaaact
    10501 ccacaaacag agaagaagtt gaaggagtat tcacagaagg ctgtggagat tctgcggact
    10561 caaaaccata ttcttaccaa ccaccccaac tcgaacattt ataacacttt gtctggctta
    10621 gtggagtttg atggctatta cctggagagc gatccctgcc tggtgtgtaa taacccggaa
    10681 gtaccgttct gttatatcaa gctgtcttcc attaaagtgg acacgcggta caccaccacc
    10741 cagcaggttg tgaagctcat tggcagtcac accatcagca aagtgacagt gaaaatcggg
    10801 gatctgaaac ggaccaagat ggtgcggacc atcaacctgt attataacaa ccgaaccgtg
    10861 caggccatcg tggagttgaa aaacaagcca gctcgctggc acaaagccaa gaaggttcag
    10921 ctgacccctg gacagacaga ggtgaagatt gacctgccgt tgcccattgt ggcctccaat
    10981 ctgatgattg agtttgcaga cttctatgaa aactaccagg cctccacaga gaccctgcag
    11041 tgccctcgct gtagtgcctc ggtccctgcc aacccaggag tctgtggcaa ctgtggagag
    11101 aatgtgtacc agtgtcacaa atgcagatcc atcaactacg atgaaaagga tcccttcctc
    11161 tgcaatgcct gtggcttctg taaatatgcc cgcttcgact tcatgctcta tgccaagcct
    11221 tgctgtgcag tggatcccat tgagaatgaa gaagaccgga agaaggctgt atccaacatc
    11281 aatacacttt tggacaaagc tgatcgagtg tatcatcagc tgatgggaca ccggccacag
    11341 ctggagaacc tgctctgcaa agtgaatgag gcagctccag aaaagccaca ggatgactca
    11401 ggaacagcag ggggcatcag ctccacttct gccagtgtga atcgttacat cctgcagttg
    11461 gctcaggagt attgtggaga ctgcaagaac tcttttgatg aactctccaa aatcatccag
    11521 aaagtctttg cttcgcgcaa agagttgttg gaatatgacc tacagcagag ggaagcagcc
    11581 actaaatcat cccggacctc cgtgcagccc acattcactg ccagccagta ccgtgcctta
    11641 tccgtcctgg gctgtggcca cacatcctcc accaagtgct atggctgcgc ctcggctgtc
    11701 acagaacatt gtatcacact acttcgggcc ctggccacca acccagcctt gaggcacatc
    11761 cttgtctccc agggccttat ccgggagctc tttgattata atcttcgccg aggggctgcg
    11821 gccatgcggg aggaggtccg ccagctcatg tgcctcctaa ctcgagacaa cccagaagcc
    11881 acccaacaga tgaatgacct gattattggc aaggtctcca cagccctgaa gggccactgg
    11941 gccaaccccg atctggcaag tagcctgcag tatgaaatgc tgctgctgac ggattctatc
    12001 tccaaggagg acagctgctg ggagctccgg ttacgctgtg ctctcagcct tttcctcatg
    12061 gctgtgaaca ttaagactcc tgtggtggtt gaaaacatta ccctcatgtg cctgaggatc
    12121 ttgcagaagc tgataaaacc acctgctccc actagcaaga agaacaagga tgtccccgtt
    12181 gaggccctca ccacggtgaa gccatactgc aatgagatcc atgcccaggc tcaactgtgg
    12241 ctcaagagag accccaaggc atcctatgat gcctggaaga agtgtcttcc tatcagaggg
    12301 atagatggca atgggaaagc ccccagcaaa tcagagctcc gccatctcta tttgactgag
    12361 aagtatgtgt ggaggtggaa acagttcctg agtcgtcggg ggaagaggac ctcccccttg
    12421 gatctcaaac tggggcataa caactggctg cgacaagtgc ttttcactcc agcaacgcag
    12481 gccgcacggc aggcagcctg taccattgtg gaagctctag ccaccattcc cagccgcaag
    12541 cagcaggtcc tggacctgct taccagttac ctggatgagc tgagcatagc tggggagtgt
    12601 gcagctgagt acctggctct ctaccagaag ctcatcactt ctgcgcactg gaaagtctac
    12661 ttggcagctc ggggagtcct accctatgtg ggcaacctca tcaccaagga aatagctcgt
    12721 ctgctggccc tggaggaggc taccctgagt accgatctgc agcagggtta tgcccttaaa
    12781 agtctcacag gccttctctc ctcctttgtt gaggtggaat ccatcaaaag acattttaaa
    12841 agtcgcttgg tgggtactgt gctgaatgga tacctgtgct tgcggaagct ggtggtgcag
    12901 aggaccaagc tgatcgatga gacgcaggac atgctgctgg agatgctgga ggacatgacc
    12961 acaggtacag aatcagaaac caaggccttc atggctgtgt gcattgagac agccaagcgc
    13021 tacaatctgg atgactaccg gaccccggtg ttcatcttcg agaggctctg cagcatcatt
    13081 tatcctgagg agaatgaagt cactgagttc tttgtgaccc tggagaagga tccccaacaa
    13141 gaagacttct tacagggcag gatgcctggg aacccgtata gcagcaatga gccaggcatc
    13201 gggccgctga tgagggatat aaagaacaag atttgccagg actgtgactt agtggccctc
    13261 ctggaagatg acagtggcat ggagcttcta gtgaacaata aaatcattag tttggacctt
    13321 cctgtggctg aagtttacaa gaaagtctgg tgtaccacga atgagggaga gcccatgagg
    13381 attgtttatc gtatgcgggg gctgctgggc gatgccacag aggagttcat tgagtccctg
    13441 gactctacta cagatgaaga agaagatgaa gaagaagtgt ataaaatggc tggtgtgatg
    13501 gcccagtgtg ggggcctgga atgcatgctt aacagactcg cagggatcag agatttcaag
    13561 cagggacgcc accttctaac agtgctactg aaattgttca gttactgcgt gaaggtgaaa
    13621 gtcaaccggc agcaactggt caaactggaa atgaacacct tgaacgtcat gctggggacc
    13681 ctaaacctgg cccttgtagc tgaacaagaa agcaaggaca gtgggggtgc agctgtggct
    13741 gagcaggtgc ttagcatcat ggagatcatt ctagatgagt ccaatgctga gcccctgagt
    13801 gaggacaagg gcaacctcct cctgacaggt gacaaggatc aactggtgat gctcttggac
    13861 cagatcaaca gcacctttgt tcgctccaac cccagtgtgc tccagggcct gcttcgcatc
    13921 atcccgtacc tttcctttgg agaggtggag aaaatgcaga tcttggtgga gcgattcaaa
    13981 ccatactgca actttgataa atatgatgaa gatcacagtg gtgatgataa agtcttcctg
    14041 gactgcttct gtaaaatagc tgctggcatc aagaacaaca gcaatgggca ccagctgaag
    14101 gatctgattc tccagaaggg gatcacccag aatgcacttg actacatgaa aaagcacatc
    14161 cctagcgcca agaatttgga tgccgacatc tggaaaaagt ttttgtctcg cccagccttg
    14221 ccatttatcc taaggctgct tcggggcctg gccatccagc accctggcac ccaggttctg
    14281 attggaactg attccatccc gaacctgcat aagctggagc aggtgtccag tgatgagggc
    14341 attgggacct tggcagagaa cctgctggaa gccctgcggg aacaccctga cgtaaacaag
    14401 aagattgacg cagcccgcag ggagacccgg gcagagaaga agcgcatggc catggcaatg
    14461 aggcagaagg ccctgggcac cctgggcatg acgacaaatg aaaagggcca ggtcgtgacc
    14521 aagacagcac tcctgaagca gatggaagag ctgatcgagg agcctggcct cacgtgctgc
    14581 atctgcaggg agggatacaa gttccagccc acaaaggtcc tgggcattta taccttcacg
    14641 aagcgggtag ccttggagga gatggagaat aagccccgga aacagcaggg ctacagcacc
    14701 gtgtcccact tcaacattgt gcactacgac tgccatctgg ctgccgtcag gttggctcga
    14761 ggccgggaag agtgggagag tgccgccctg cagaatgcca acaccaagtg caacgggctc
    14821 cttccggtct ggggacctca tgtccctgaa tcagcttttg ccacttgctt ggcaagacac
    14881 aacacttacc tccaggaatg tacaggccag cgggagccca cgtatcagct caacatccat
    14941 gacatcaaac tgctcttcct gcgcttcgcc atggagcagt cgttcagcgc agacactggc
    15001 gggggcggcc gggagagcaa catccacctg atcccgtaca tcattcacac tgtgctttac
    15061 gtcctgaaca caacccgagc aacttcccga gaagagaaga acctccaagg ctttctggaa
    15121 cagcccaagg agaagtgggt ggagagtgcc tttgaagtgg acgggcccta ctatttcaca
    15181 gtcttggccc ttcacatcct gccccctgag cagtggagag ccacacgtgt ggaaatcttg
    15241 cggaggctgt tggtgacctc gcaggctcgg gcagtggctc caggtggagc caccaggctg
    15301 acagataagg cagtgaagga ctattccgct taccgttctt cccttctctt ttgggccctc
    15361 gtcgatctca tttacaacat gtttaagaag gtgcctacca gtaacacaga gggaggctgg
    15421 tcctgctctc tcgctgagta catccgccac aacgacatgc ccatctacga agctgccgac
    15481 aaagccctga aaaccttcca ggaggagttc atgccagtgg agaccttctc agagttcctc
    15541 gatgtggccg gtcttttatc agaaatcacc gatccagaga gcttcctgaa ggacctgttg
    15601 aactcagtcc cctgaccacc acacagcagc tgcggcggcg aagacgaagc tggcttgcct
    15661 tccaccctct gttctccctc cttgtgcatt aagttccctc cgcgggatgc tgcattgtta
    15721 ccccgccctc ccctctctca tttttcttgg tgtggcttgg ggtttttagg cttcctgttt
    15781 tatctcgtgt gtgtggtgca ccagctatga ggttgtctgt aacccaagcc atcaaagggc
    15841 ctgtacatac ctaggagcca tgagttgtcc cggccagctt catacttgag tgtgcacatc
    15901 ttgagaaata aacaagtgac ttaacacaca ttgaaaa
//
