LOCUS       XM_047416475           15985 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens ubiquitin protein ligase E3 component
            n-recognin 4 (UBR4), transcript variant X10, mRNA.
ACCESSION   XM_047416475
VERSION     XM_047416475.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000001.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..15985
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
     gene            1..15985
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /note="ubiquitin protein ligase E3 component n-recognin 4;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 12 mRNAs, 363 ESTs, 4705 long SRA reads, 8
                     Proteins, and 100% coverage of the annotated genomic
                     feature by RNAseq alignments, including 42 samples with
                     support for all annotated introns"
                     /db_xref="GeneID:23352"
                     /db_xref="HGNC:HGNC:30313"
                     /db_xref="MIM:609890"
     CDS             19..15663
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase UBR4 isoform X10"
                     /protein_id="XP_047272431.1"
                     /db_xref="GeneID:23352"
                     /db_xref="HGNC:HGNC:30313"
                     /db_xref="MIM:609890"
                     /translation="MATSGGEEAAAAAPAPGTPATGADTTPGWEVAVRPLLSASYSAF
                     EMKELPQLVASVIESESEILHHEKQYEPFYSSFVALSTHYITTVCSLIPRNQLQSVAA
                     ACKVLIEFSLLRLENPDEACAVSQKHLILLIKGLCTGCSRLDRTEIITFTAMMKSAKL
                     PQTVKTLSDVEDQKELASPVSPELRQKEVQMNFLNQLTSVFNPRTVASQPISTQTLVE
                     GENDEQSSTDQASAIKTKNVFIAQNVASLQELGGSEKLLRVCLNLPYFLRYINRFQDA
                     VLANSFFIMPATVADATAVRNGFHSLVIDVTMALDTLSLPVLEPLNPSRLQDVTVLSL
                     SCLYAGVSVATCMAILHVGSAQQVRTGSTSSKEDDYESDAATIVQKCLEIYDMIGQAI
                     SSSRRAGGEHYQNFQLLGAWCLLNSLFLILNLSPTALADKGKEKDPLAALRVRDILSR
                     TKEGVGSPKLGPGKGHQGFGVLSVILANHAIKLLTSLFQDLQVEALHKGWETDGPPAA
                     LSIMAQSTSIQRIQRLIDSVPLMNLLLTLLSTSYRKACVLQRQRKGSMSSDASASTDS
                     NTYYEDDFSSTEEDSSQDDDSEPILGQWFEETISPSKEKAAPPPPPPPPPLESSPRVK
                     SPSKQAPGEKGNILASRKDPELFLGLASNILNFITSSMLNSRNNFIRNYLSVSLSEHH
                     MATLASIIKEVDKDGLKGSSDEEFAAALYHFNHSLVTSDLQSPNLQNTLLQQLGVAPF
                     SEGPWPLYIHPQSLSVLSRLLLIWQHKASAQGDPDVPECLKVWDRFLSTMKQNALQGV
                     VPSETEDLNVEHLQMLLLIFHNFTETGRRAILSLFVQIIQELSVNMDAQMRFVPLILA
                     RLLLIFDYLLHQYSKAPVYLFEQVQHNLLSPPFGWASGSQDSNSRRATTPLYHGFKEV
                     EENWSKHFSSDAVPHPRFYCVLSPEASEDDLNRLDSVACDVLFSKLVKYDELYAALTA
                     LLAAGSQLDTVRRKENKNVTALEACALQYYFLILWRILGILPPSKTYINQLSMNSPEM
                     SECDILHTLRWSSRLRISSYVNWIKDHLIKQGMKAEHASSLLELASTTKCSSVKYDVE
                     IVEEYFARQISSFCSIDCTTILQLHEIPSLQSIYTLDAAISKVQVSLDEHFSKMAAET
                     DPHKSSEITKNLLPATLQLIDTYASFTRAYLLQNFNEEGTTEKPSKEKLQGFAAVLAI
                     GSSRCKANTLGPTLVQNLPSSVQTVCESWNNINTNEFPNIGSWRNAFANDTIPSESYI
                     SAVQAAHLGTLCSQSLPLAASLKHTLLSLVRLTGDLIVWSDEMNPPQVIRTLLPLLLE
                     SSTESVAEISSNSLERILGPAESDEFLARVYEKLITGCYNILANHADPNSGLDESILE
                     ECLQYLEKQLESSQARKAMEEFFSDSGELVQIMMATANENLSAKFCNRVLKFFTKLFQ
                     LTEKSPNPSLLHLCGSLAQLACVEPVRLQAWLTRMTTSPPKDSDQLDVIQENRQLLQL
                     LTTYIVRENSQVGEGVCAVLLGTLTPMATEMLANGDGTGFPELMVVMATLASAGQGAG
                     HLQLHNAAVDWLSRCKKYLSQKNVVEKLNANVMHGKHVMILECTCHIMSYLADVTNAL
                     SQSNGQGPSHLSVDGEERAIEVDSDWVEELAVEEEDSQAEDSDEDSLCNKLCTFTITQ
                     KEFMNQHWYHCHTCKMVDGVGVCTVCAKVCHKDHEISYAKYGSFFCDCGAKEDGSCLA
                     LVKRTPSSGMSSTMKESAFQSEPRISESLVRHASTSSPADKAKVTISDGKVADEEKPK
                     KSSLCRTVEGCREELQNQANFSFAPLVLDMLNFLMDAIQTNFQQASAVGSSSRAQQAL
                     SELHTVEKAVEMTDQLMVPTLGSQEGAFENVRMNYSGDQGQTIRQLISAHVLRRVAMC
                     VLSSPHGRRQHLAVSHEKGKITVLQLSALLKQADSSKRKLTLTRLASAPVPFTVLSLT
                     GNPCKEDYLAVCGLKDCHVLTFSSSGSVSDHLVLHPQLATGNFIIKAVWLPGSQTELA
                     IVTADFVKIYDLCVDALSPTFYFLLPSSKIRDVTFLFNEEGKNIIVIMSSAGYIYTQL
                     MEEASSAQQGPFYVTNVLEINHEDLKDSNSQVAGGGVSVYYSHVLQMLFFSYCQGKSF
                     AATISRTTLEVLQLFPINIKSFVVCSSNGGSKTSPALCQWSEVMNHPGLVCCVQQTTG
                     VPLVVMVKPDTFLIQEIKTLPAKAKIQDMVAIRHTACNEQQRTTMILLCEDGSLRIYM
                     ANVENTSYWLQPSLQPSSVISIMKPVRKRKTATITTRTSSQVTFPIDFFEHNQQLTDV
                     EFGGNDLLQVYNAQQIKHRLNSTGMYVANTKPGGFTIEISNNNSTMVMTGMRIQIGTQ
                     AIERAPSYIEIFGRTMQLNLSRSRWFDFPFTREEALQADKKLNLFIGASVDPAGVTMI
                     DAVKIYGKTKEQFGWPDEPPEEFPSASVSNICPSNLNQSNGTGDSDSAAPTTTSGTVL
                     ERLVVSSLEALESCFAVGPIIEKERNKNAAQELATLLLSLPAPASVQQQSKSLLASLH
                     TSRSAYHSHKDQALLSKAVQCLNTSSKEGKDLDPEVFQRLVITARSIAIMRPNNLVHF
                     TESKLPQMETDCFFPRCACWSLGIVGILIGAPLETPSPEGMDEGKEPQKQLEGDCCSF
                     ITQLVNHFWKLHASKPKNAFLAPACLPGLTHIEATVNALVDIIHGYCTCELDCINTAS
                     KIYMQMLLCPDPAVSFSCKQALIRVLRPRNKRRHVTLPSSPRSNTPMGDKDDDDDDDA
                     DEKMQSSGIPNGGHIRQESQEQSEVDHGDFEMVSESMVLETAENVNNGNPSPLEALLA
                     GAEGFPPMLDIPPDADDETMVELAIALSLQQDQQGSSSSALGLQSLGLSGQAPSSSSL
                     DAGTLSDTTASASDDEGSTAATDGSTLRTSPADHGGSVGSESGGSAVDSVAGEHSVSG
                     RSSAYGDATAEGHPAGPGSVSSSTGAISTTTGHQEGDGSEGEGEGETEGDVHTSNRLH
                     MVRLMLLERLLQTLPQLRNVGGVRAIPYMQVILMLTTDLDGEDEKDKGALDNLLSQLI
                     AELGMDKKDVSKKNERSALNEVHLVVMRLLSVFMSRTKSGSKSSICESSSLISSATAA
                     ALLSSGAVDYCLHVLKSLLEYWKSQQNDEEPVATSQLLKPHTTSSPPDMSPFFLRQYV
                     KGHAADVFEAYTQLLTEMVLRLPYQIKKITDTNSRIPPPVFDHSWFYFLSEYLMIQQT
                     PFVRRQVRKLLLFICGSKEKYRQLRDLHTLDSHVRGIKKLLEEQGIFLRASVVTASSG
                     SALQYDTLISLMEHLKACAEIAAQRTINWQKFCIKDDSVLYFLLQVSFLVDEGVSPVL
                     LQLLSCALCGSKVLAALAASSGSSSASSSSAPVAASSGQATTQSKSSTKKSKKEEKEK
                     EKDGETSGSQEDQLCTALVNQLNKFADKETLIQFLRCFLLESNSSSVRWQAHCLTLHI
                     YRNSSKSQQELLLDLMWSIWPELPAYGRKAAQFVDLLGYFSLKTPQTEKKLKEYSQKA
                     VEILRTQNHILTNHPNSNIYNTLSGLVEFDGYYLESDPCLVCNNPEVPFCYIKLSSIK
                     VDTRYTTTQQVVKLIGSHTISKVTVKIGDLKRTKMVRTINLYYNNRTVQAIVELKNKP
                     ARWHKAKKVQLTPGQTEVKIDLPLPIVASNLMIEFADFYENYQASTETLQCPRCSASV
                     PANPGVCGNCGENVYQCHKCRSINYDEKDPFLCNACGFCKYARFDFMLYAKPCCAVDP
                     IENEEDRKKAVSNINTLLDKADRVYHQLMGHRPQLENLLCKVNEAAPEKPQDDSGTAG
                     GISSTSASVNRYILQLAQEYCGDCKNSFDELSKIIQKVFASRKELLEYDLQQREAATK
                     SSRTSVQPTFTASQYRALSVLGCGHTSSTKCYGCASAVTEHCITLLRALATNPALRHI
                     LVSQGLIRELFDYNLRRGAAAMREEVRQLMCLLTRDNPEATQQMNDLIIGKVSTALKG
                     HWANPDLASSLQYEMLLLTDSISKEDSCWELRLRCALSLFLMAVNIKTPVVVENITLM
                     CLRILQKLIKPPAPTSKKNKDVPVEALTTVKPYCNEIHAQAQLWLKRDPKASYDAWKK
                     CLPIRGIDGNGKAPSKSELRHLYLTEKYVWRWKQFLSRRGKRTSPLDLKLGHNNWLRQ
                     VLFTPATQAARQAACTIVEALATIPSRKQQVLDLLTSYLDELSIAGECAAEYLALYQK
                     LITSAHWKVYLAARGVLPYVGNLITKEIARLLALEEATLSTDLQQGYALKSLTGLLSS
                     FVEVESIKRHFKSRLVGTVLNGYLCLRKLVVQRTKLIDETQDMLLEMLEDMTTGTESE
                     TKAFMAVCIETAKRYNLDDYRTPVFIFERLCSIIYPEENEVTEFFVTLEKDPQQEDFL
                     QGRMPGNPYSSNEPGIGPLMRDIKNKICQDCDLVALLEDDSGMELLVNNKIISLDLPV
                     AEVYKKVWCTTNEGEPMRIVYRMRGLLGDATEEFIESLDSTTDEEEDEEEVYKMAGVM
                     AQCGGLECMLNRLAGIRDFKQGRHLLTVLLKLFSYCVKVKVNRQQLVKLEMNTLNVML
                     GTLNLALVAEQESKDSGGAAVAEQVLSIMEIILDESNAEPLSEDKGNLLLTGDKDQLV
                     MLLDQINSTFVRSNPSVLQGLLRIIPYLSFGEVEKMQILVERFKPYCNFDKYDEDHSG
                     DDKVFLDCFCKIAAGIKNNSNGHQLKDLILQKGITQNALDYMKKHIPSAKNLDADIWK
                     KFLSRPALPFILRLLRGLAIQHPGTQVLIGTDSIPNLHKLEQVSSDEGIGTLAENLLE
                     ALREHPDVNKKIDAARRETRAEKKRMAMAMRQKALGTLGMTTNEKGQVVTKTALLKQM
                     EELIEEPGLTCCICREGYKFQPTKVLGIYTFTKRVALEEMENKPRKQQGYSTVSHFNI
                     VHYDCHLAAVRLARGREEWESAALQNANTKCNGLLPVWGPHVPESAFATCLARHNTYL
                     QECTGQREPTYQLNIHDIKLLFLRFAMEQSFSADTGGGGRESNIHLIPYIIHTVLYVL
                     NTTRATSREEKNLQGFLEQPKEKWVESAFEVDGPYYFTVLALHILPPEQWRATRVEIL
                     RRLLVTSQARAVAPGGATRLTDKAVKDYSAYRSSLLFWALVDLIYNMFKKVPTSNTEG
                     GWSCSLAEYIRHNDMPIYEAADKALKTFQEEFMPVETFSEFLDVAGLLSEITDPESFL
                     KDLLNSVP"
ORIGIN      
        1 gcagtagtac gacggaagat ggcgacgagc ggcggcgaag aggcggcggc agcggctccg
       61 gcgccgggga ccccggcaac gggggcggac acgaccccgg gctgggaggt ggctgtgcgg
      121 cccctgctgt ccgcgtccta ctccgccttc gagatgaagg agttgccgca gctggtggcc
      181 tcagtcatcg agagtgaatc agaaatcctg caccatgaga agcagtacga gccattctac
      241 tcatcttttg ttgcactttc cacacactat attacaacag tttgcagtct cattccccgg
      301 aaccaacttc agtcagtggc agcagcctgt aaagttctaa ttgagttttc tctcctgcgt
      361 ctggagaatc cagatgaggc ttgtgctgtg tcccagaaac acttgattct cctaatcaag
      421 ggcctgtgca ctggctgtag ccgactagat agaactgaaa ttatcacatt tacagcaatg
      481 atgaaatccg ccaagctgcc ccaaacagtg aagacacttt cagacgtgga agatcagaaa
      541 gagctggcct caccagtaag ccctgagttg aggcaaaagg aggtacagat gaattttttg
      601 aaccagctga cctcagtttt taaccctaga actgtagcat cacaacctat cagtacacag
      661 actctggtgg aaggagaaaa tgatgagcag tcatctacag atcaagcctc agctatcaaa
      721 accaagaatg tgttcatagc tcagaacgtg gctagtcttc aagagcttgg tggctcggag
      781 aagctactgc gtgtatgttt gaacctgcca tatttcctac gctatatcaa tcggttccaa
      841 gatgcagttt tagctaattc cttcttcata atgcctgcaa cagtagcaga tgccactgct
      901 gttcgtaatg gctttcattc attggtgatt gatgtaacta tggcattgga taccctttct
      961 ctacctgtgt tggaacctct caatccttct cgtctacaag atgtgacagt cctcagccta
     1021 agttgtctgt atgcaggtgt gagtgtggca acgtgcatgg ccatcctcca tgtgggtagt
     1081 gcccagcaag tgcggacagg gtccacgagc tccaaagaag atgactatga aagtgacgca
     1141 gctacaattg tccagaaatg tctcgaaatc tatgacatga ttggacaagc aatcagcagt
     1201 tctcgccggg ctggtggtga gcactatcag aatttccaat tgctgggtgc ttggtgcttg
     1261 ttaaacagcc ttttcctcat actgaacctc agtcctactg cgttggctga taaggggaaa
     1321 gagaaggacc cactggctgc cctccgagtc agagacatcc tttctcgtac taaagaggga
     1381 gtgggctccc ctaaactggg gcctggaaaa gggcatcagg gatttggggt actctcagta
     1441 atattggcaa accatgccat caaactgcta acgtctctct ttcaagacct acaagtggag
     1501 gcccttcaca agggttggga gacagatggc ccccctgcag ccttgagcat tatggcccag
     1561 agcacctcca tacagaggat tcaacggctg attgactctg tcccactgat gaacctgctc
     1621 ttgacgttac tttcaacttc ctacagaaag gcatgtgtcc tgcagcggca gaggaagggc
     1681 tccatgagca gcgatgccag cgcctccacc gactccaata cttactatga ggacgatttc
     1741 agtagcacgg aggaggacag cagccaagac gatgacagtg agcctatttt ggggcaatgg
     1801 tttgaggaga ctatttctcc cagtaaagag aaagcagcac ctccgcctcc tcccccacct
     1861 cctccactgg aaagctctcc tcgggttaaa agccccagta agcaggcccc tggtgagaag
     1921 ggcaacattc tggcgagtcg caaagatcct gagttgttct taggtctggc ttccaacatt
     1981 ttgaacttca tcacctcttc catgctgaac tctcggaaca attttatccg aaactatctg
     2041 agtgtatctc tttcagaaca ccatatggcc accctagcca gtatcatcaa ggaggtggac
     2101 aaagatggac tcaagggttc atcagatgaa gagtttgctg cagctctcta tcacttcaac
     2161 cactcactgg taacctctga ccttcagtca cctaacctgc agaacacact gttgcagcag
     2221 ctaggagtgg ctcctttttc tgagggccct tggcccttgt acattcaccc tcaaagcctc
     2281 tctgtgcttt cacgcctcct gctcatctgg caacataaag ccagtgctca aggtgaccct
     2341 gacgtcccag aatgccttaa agtttgggac aggtttttgt ctacaatgaa gcagaatgcc
     2401 ctgcaaggtg tggtgcccag tgagacagag gatctgaatg tagaacacct gcagatgctc
     2461 ctcctcattt tccacaattt caccgagaca ggccggcggg ccatattgtc gctttttgtc
     2521 cagatcatcc aggagttgag cgtcaacatg gatgctcaga tgcgcttcgt gccgcttatc
     2581 ttggctcgcc tccttctcat ctttgattat ctgcttcatc agtactccaa agcccctgtg
     2641 tatctatttg agcaggtaca gcataacctg ctaagtcctc cctttgggtg ggcaagtgga
     2701 tcccaggaca gcaacagccg ccgggcaacc actcctctct atcatggatt caaagaagta
     2761 gaagaaaact ggtctaagca tttctcatca gatgctgtcc cacaccccag attctactgt
     2821 gtcctgtccc cagaagcctc agaggatgat ttgaaccgac ttgattctgt ggcatgtgac
     2881 gtccttttct ccaagcttgt caagtatgat gagctttatg ctgcactgac agccctgctt
     2941 gcagctgggt cccagcttga tacagttagg agaaaggaaa acaagaatgt aacagccttg
     3001 gaggcctgtg cccttcaata ttacttcttg atactgtgga ggatcctagg aattttacca
     3061 ccatcaaaga cttacattaa ccagctatcc atgaactcac ctgagatgag cgaatgtgac
     3121 atcttgcaca ctctgcgatg gtcttctcgg ctccggatca gctcctatgt caactggata
     3181 aaggatcacc ttatcaaaca gggaatgaag gctgagcatg ctagctcgct tctagaactg
     3241 gcatccacca ctaagtgtag ctcagtgaaa tatgatgttg aaatagtaga ggaatacttc
     3301 gctcgacaga tctcatcctt ctgtagtatc gactgtacca ccatcttgca gctgcatgaa
     3361 attcccagtc tgcagtccat ctacaccctt gatgccgcga tctcaaaggt ccaggtctct
     3421 ttggatgagc atttttctaa gatggctgct gagactgatc ctcataagtc gtctgagatt
     3481 accaagaacc tacttccagc cacgctgcaa ctcattgaca cctatgcatc gttcaccaga
     3541 gcctatttgc tgcaaaactt taatgaagag ggaacaactg agaaaccttc caaggagaaa
     3601 ctgcaaggct ttgctgctgt tttggctatt ggctctagca ggtgcaaggc aaatactctg
     3661 ggtccgacac tggttcagaa tttgccatcg tcagtgcaga ctgtgtgtga gtcctggaac
     3721 aacatcaata ccaatgaatt tcccaatatt ggatcctggc gcaatgcctt tgccaatgac
     3781 accatccctt cagagagtta tattagtgca gtgcaggctg cacacctggg gactctctgt
     3841 agccaaagtc tgcccctggc tgcttccctg aagcataccc tcctctcact ggtcaggttg
     3901 actggagatc ttattgtttg gtcagatgag atgaacccac cacaggtaat tcggacactg
     3961 ctacctcttc ttttggaatc aagcactgag agtgttgccg agatcagtag caactccctg
     4021 gaacgcatct tgggccctgc tgagtctgat gagttcttgg ctcgtgttta tgagaagctg
     4081 atcactggtt gttacaacat tctggccaat catgcagatc ctaacagtgg actggatgaa
     4141 tccatcctgg aggaatgtct ccagtacttg gaaaagcagc tggaaagtag ccaggctcgt
     4201 aaagctatgg aggagttttt ctctgacagt ggagaacttg tacagatcat gatggcaaca
     4261 gccaatgaga acctctctgc taaattctgt aaccgagttt tgaaattctt caccaaactc
     4321 ttccagctga ctgagaagag ccctaacccg agcctgttgc atctctgtgg ctccctggca
     4381 caactggcct gtgtggaacc tgtgcgcctg caggcctggc tcacccgcat gactacatcg
     4441 cccccaaaag attctgatca gctggatgta attcaggaga accggcagct gctgcagtta
     4501 ctgaccacat acattgttcg ggaaaacagc caagttgggg aaggtgtgtg tgctgttctt
     4561 ctgggcaccc tgactcccat ggcaacagag atgctggcca acggtgatgg gactggcttc
     4621 cctgaactta tggttgtgat ggccactctg gccagtgcag gtcaaggtgc tggtcacctt
     4681 cagcttcata atgctgctgt ggattggctg agcagatgca agaaatacct gtcacagaag
     4741 aatgtagttg aaaaactgaa tgccaatgta atgcatggaa agcatgtgat gatcttggag
     4801 tgcacatgcc atatcatgtc ttacttggct gatgtcacga atgccctgag ccagagtaat
     4861 ggtcaaggcc caagtcatct ctcagtggat ggggaagagc gggccattga agtagactca
     4921 gactgggtgg aggagttggc ggtggaagag gaagattccc aggctgagga ttcagatgaa
     4981 gattctcttt gcaataaact ctgcactttt acgatcacac agaaagaatt catgaaccag
     5041 cattggtacc actgtcacac ctgtaaaatg gtggatggcg tgggtgtctg cacagtgtgt
     5101 gctaaggtgt gccacaagga tcatgagatt tcctatgcca agtatggatc cttcttctgt
     5161 gactgtggag ccaaggaaga tggcagctgt ttggctctgg tgaagagaac tcctagcagt
     5221 ggcatgagct ctaccatgaa ggagtcggca tttcagagtg aacccaggat ttcagagagt
     5281 ctagtgcgtc atgccagcac ctcctcgcca gctgacaaag ccaaggttac catcagtgat
     5341 ggaaaggttg ctgacgaaga gaagcccaag aagagcagcc tctgccgcac agtagagggc
     5401 tgccgggagg aattacagaa ccaggccaat ttctccttcg ctcctctcgt gttagacatg
     5461 cttaatttcc ttatggatgc cattcagacc aacttccagc aagcttcagc cgtcgggagc
     5521 agcagccgtg ctcagcaagc cctcagtgag ctacacactg tggagaaggc agtggagatg
     5581 acagaccagc tgatggttcc caccttaggg tcccaggaag gtgcctttga gaatgtgcgg
     5641 atgaattaca gtggagacca gggccagacc atccggcagc tgatcagtgc tcatgtgctc
     5701 aggcgggtgg ctatgtgtgt gctctcctct ccccatgggc gccgccaaca tttggctgtc
     5761 agccatgaga agggcaagat caccgttctg cagctctctg cactcctgaa gcaagcagat
     5821 tccagcaaaa ggaagttaac tctgacccgc ttggcttctg ccccagttcc ttttactgtg
     5881 ttgagcctca caggaaatcc ctgcaaggaa gactacttgg cggtttgtgg gctaaaggac
     5941 tgtcatgtgc tcacctttag tagctcaggc tctgtttcgg atcacttggt tttgcaccct
     6001 cagttggcaa cggggaactt catcatcaaa gccgtgtggt tacctggttc acagaccgag
     6061 ttagcaattg tcaccgcaga ctttgttaag atttatgacc tgtgtgttga tgccttgagt
     6121 ccaaccttct attttctcct gccaagctca aagataagag atgttacctt ccttttcaat
     6181 gaggagggaa agaacatcat tgttataatg tcttcggctg ggtacatcta tactcagctt
     6241 atggaagagg ccagcagtgc ccagcaggga cccttctatg tcactaatgt gttggaaatc
     6301 aatcatgagg acctgaagga cagtaacagc caggtggcgg gcggtggtgt gtccgtgtac
     6361 tactcccacg tgttgcagat gttgttcttc agctattgtc aaggcaaatc attcgcagcc
     6421 accatcagca ggacaaccct ggaggtgttg caactcttcc ccatcaacat caaaagtttt
     6481 gttgtctgca gttccaatgg tggcagtaag acttctcctg ctctttgcca gtggtctgag
     6541 gtgatgaacc accctggctt ggtgtgctgt gtccagcaaa ctacaggggt gccgctggta
     6601 gttatggtga aaccagacac ttttcttatc caggagatta agactcttcc tgctaaagcg
     6661 aagatccaag acatggttgc tattaggcac acggcctgca atgagcagca gcggacaaca
     6721 atgattctgc tgtgtgagga tggcagcctg cgcatttaca tggccaacgt ggagaacacc
     6781 tcctactggc tgcagccatc cctgcagccc agcagtgtca tcagcatcat gaagcctgtt
     6841 cgaaagcgca aaacagctac aatcacaacc cgcacgtcta gccaggtgac tttccccatt
     6901 gacttttttg aacacaacca gcagctgaca gatgtggagt ttggtggtaa cgacctccta
     6961 caggtctata atgcacaaca gataaaacac cggctgaatt ccactggcat gtatgtggcc
     7021 aacaccaagc ccggaggctt caccattgag attagtaaca acaatagcac tatggtgatg
     7081 acaggcatgc ggatccagat tgggactcaa gcaatagaac gggccccgtc atatatcgag
     7141 atcttcggca gaactatgca gctcaacctg agtcgctcac gctggtttga cttccccttc
     7201 accagagaag aagccctgca ggctgataag aagctgaacc tcttcattgg ggcctcggtg
     7261 gatccagcag gtgtcaccat gatagatgct gtaaaaattt atggcaagac taaggagcag
     7321 tttggctggc ctgatgagcc cccagaagaa ttcccttctg cctctgtcag caacatctgc
     7381 ccttcaaatc tgaaccagag caacggcact ggagatagcg actcagctgc ccccactacg
     7441 accagtggaa ctgtcctgga gaggctggtt gtgagttctt tagaagccct ggaaagctgc
     7501 tttgccgttg gcccaatcat cgagaaggag agaaacaaga atgctgctca ggagctggcc
     7561 actttgctgt tgtccctgcc agcacctgcc agtgtccagc agcagtccaa gagccttctg
     7621 gccagcctgc acaccagccg ctcggcctac cacagccaca aggatcaggc cttgctgagc
     7681 aaagctgtgc agtgtctcaa cacatctagc aaagagggca aggatttgga ccctgaggtg
     7741 ttccagaggc tagtgatcac agctcgctcc attgccatca tgcgccccaa caaccttgtc
     7801 cactttacgg agtcaaagct gccccagatg gaaacagact gtttttttcc tagatgtgcc
     7861 tgctggagtc tagggatagt tggcatattg attggggccc cacttgaaac tccctcccca
     7921 gaaggaatgg atgaagggaa ggaaccgcag aagcagttgg aaggagattg ctgtagtttc
     7981 atcacccagc ttgtgaacca cttctggaaa ctccatgcat ccaaacccaa gaatgccttc
     8041 ttggcacctg cctgccttcc aggactaact catattgaag ctactgtcaa tgctctggtg
     8101 gacatcatcc atggctactg tacctgtgag ctggattgta ttaacacagc atccaagatc
     8161 tacatgcaga tgctcttgtg tcctgatcct gctgtgagct tctcttgtaa acaagctcta
     8221 attcgagtcc taaggcccag gaacaaacgg agacatgtga ctttaccctc ttcccctcga
     8281 agcaacactc caatgggaga caaggatgat gatgacgatg atgatgcaga tgagaaaatg
     8341 cagtcatcag ggatcccgaa tggtggtcac atccgtcagg aaagccagga acagagtgag
     8401 gtggaccatg gagattttga gatggtgtct gagtcgatgg tcctggagac agctgaaaat
     8461 gtcaacaatg gcaacccctc tcccctggag gccctgctgg caggcgcaga gggcttcccc
     8521 cccatgctgg acatcccacc tgatgcagat gacgagacca tggttgaact agccattgcc
     8581 ctgagcctgc agcaggacca acaaggcagc agcagcagtg ccctgggcct gcagagcctg
     8641 ggactgtccg gccaggcacc cagctcttcc tctctggacg caggaaccct ctctgacacc
     8701 acagcatcag cctcagacga cgagggcagt acagcagcga cagatggttc tacccttcgg
     8761 acctctcctg ctgaccacgg tggtagtgtg ggctcggaga gcgggggcag tgcagtggac
     8821 tcagtggctg gcgagcacag tgtatctggc cggagcagtg cttatggcga tgctacagct
     8881 gaggggcatc cggctggacc aggaagtgtc agctcaagca ctggagccat cagcaccacc
     8941 actgggcacc aggagggaga tggctccgag ggagaaggag aaggagaaac tgaaggagat
     9001 gtccacacta gcaacaggct gcacatggtc cgtctaatgc tgttggagag attactgcag
     9061 accctgcctc aattacgaaa cgttggcggt gtccgggcca tcccatacat gcaggtcatt
     9121 ctaatgctca ctacagatct ggatggagaa gatgagaaag acaagggggc cctagacaac
     9181 ctgctctccc agcttattgc tgagttgggt atggataaaa aggatgtctc caagaagaat
     9241 gagcgcagcg ccctgaatga agtccatctg gtagtaatga gactcctgag tgtcttcatg
     9301 tcccgcacca aatctggatc caagtcttcc atatgtgagt catcttccct catctccagt
     9361 gccacagcag cagctctact gagctctggg gctgtggact actgcctgca cgtgctcaaa
     9421 tcactgctgg aatattggaa gagccaacag aatgacgagg agcctgtggc taccagccag
     9481 ttgctgaaac cacatactac ctcctcccca cctgacatga gcccattctt tctccgccag
     9541 tatgtgaagg gtcatgctgc tgatgtgttt gaggcctata ctcagcttct aacagaaatg
     9601 gtactgaggc ttccttacca aatcaaaaag attactgaca ccaattctcg aatcccacct
     9661 cctgtctttg accactcgtg gttttacttt ctctccgagt acctcatgat ccagcagact
     9721 ccatttgtgc gccgtcaagt ccgcaaactt ctgctcttca tctgtggatc caaagagaag
     9781 taccgccagc tccgggattt gcacaccctg gactctcacg tgcgtgggat caagaagctg
     9841 ctagaagagc aggggatatt cctccgggca agtgtggtta cagccagctc aggctccgcc
     9901 ttgcaatatg acacactcat cagcctgatg gagcacctga aagcctgtgc agagattgcc
     9961 gcccagcgaa ccatcaactg gcagaaattc tgcatcaaag atgactccgt cctgtacttc
    10021 ctcctccaag tcagtttcct tgtggatgag ggcgtgtccc cagtgctgct gcaactgctc
    10081 tcctgtgctc tgtgcggcag caaggtgctc gctgcactgg cagcctcttc gggatcctcc
    10141 agtgcttctt cctcctcagc ccctgtggct gccagttctg gacaagccac aacacagtcc
    10201 aagtcttcca ctaaaaagag caagaaagaa gaaaaagaaa aggagaaaga tggtgagacc
    10261 tctggcagcc aggaggacca gctgtgcaca gctctggtga accagctgaa caaatttgcc
    10321 gataaggaaa ccctgatcca gttcctgcgt tgtttcctgt tagagtccaa ttcttcctcg
    10381 gtgcgctggc aggcccactg tctgacactg cacatctaca gaaattccag caaatctcaa
    10441 caggagctcc tgctagatct gatgtggtcc atctggccag aactcccagc ctatggtcgt
    10501 aaggctgccc agtttgtgga cctactagga tatttctccc tgaaaactcc acaaacagag
    10561 aagaagttga aggagtattc acagaaggct gtggagattc tgcggactca aaaccatatt
    10621 cttaccaacc accccaactc gaacatttat aacactttgt ctggcttagt ggagtttgat
    10681 ggctattacc tggagagcga tccctgcctg gtgtgtaata acccggaagt accgttctgt
    10741 tatatcaagc tgtcttccat taaagtggac acgcggtaca ccaccaccca gcaggttgtg
    10801 aagctcattg gcagtcacac catcagcaaa gtgacagtga aaatcgggga tctgaaacgg
    10861 accaagatgg tgcggaccat caacctgtat tataacaacc gaaccgtgca ggccatcgtg
    10921 gagttgaaaa acaagccagc tcgctggcac aaagccaaga aggttcagct gacccctgga
    10981 cagacagagg tgaagattga cctgccgttg cccattgtgg cctccaatct gatgattgag
    11041 tttgcagact tctatgaaaa ctaccaggcc tccacagaga ccctgcagtg ccctcgctgt
    11101 agtgcctcgg tccctgccaa cccaggagtc tgtggcaact gtggagagaa tgtgtaccag
    11161 tgtcacaaat gcagatccat caactacgat gaaaaggatc ccttcctctg caatgcctgt
    11221 ggcttctgta aatatgcccg cttcgacttc atgctctatg ccaagccttg ctgtgcagtg
    11281 gatcccattg agaatgaaga agaccggaag aaggctgtat ccaacatcaa tacacttttg
    11341 gacaaagctg atcgagtgta tcatcagctg atgggacacc ggccacagct ggagaacctg
    11401 ctctgcaaag tgaatgaggc agctccagaa aagccacagg atgactcagg aacagcaggg
    11461 ggcatcagct ccacttctgc cagtgtgaat cgttacatcc tgcagttggc tcaggagtat
    11521 tgtggagact gcaagaactc ttttgatgaa ctctccaaaa tcatccagaa agtctttgct
    11581 tcgcgcaaag agttgttgga atatgaccta cagcagaggg aagcagccac taaatcatcc
    11641 cggacctccg tgcagcccac attcactgcc agccagtacc gtgccttatc cgtcctgggc
    11701 tgtggccaca catcctccac caagtgctat ggctgcgcct cggctgtcac agaacattgt
    11761 atcacactac ttcgggccct ggccaccaac ccagccttga ggcacatcct tgtctcccag
    11821 ggccttatcc gggagctctt tgattataat cttcgccgag gggctgcggc catgcgggag
    11881 gaggtccgcc agctcatgtg cctcctaact cgagacaacc cagaagccac ccaacagatg
    11941 aatgacctga ttattggcaa ggtctccaca gccctgaagg gccactgggc caaccccgat
    12001 ctggcaagta gcctgcagta tgaaatgctg ctgctgacgg attctatctc caaggaggac
    12061 agctgctggg agctccggtt acgctgtgct ctcagccttt tcctcatggc tgtgaacatt
    12121 aagactcctg tggtggttga aaacattacc ctcatgtgcc tgaggatctt gcagaagctg
    12181 ataaaaccac ctgctcccac tagcaagaag aacaaggatg tccccgttga ggccctcacc
    12241 acggtgaagc catactgcaa tgagatccat gcccaggctc aactgtggct caagagagac
    12301 cccaaggcat cctatgatgc ctggaagaag tgtcttccta tcagagggat agatggcaat
    12361 gggaaagccc ccagcaaatc agagctccgc catctctatt tgactgagaa gtatgtgtgg
    12421 aggtggaaac agttcctgag tcgtcggggg aagaggacct cccccttgga tctcaaactg
    12481 gggcataaca actggctgcg acaagtgctt ttcactccag caacgcaggc cgcacggcag
    12541 gcagcctgta ccattgtgga agctctagcc accattccca gccgcaagca gcaggtcctg
    12601 gacctgctta ccagttacct ggatgagctg agcatagctg gggagtgtgc agctgagtac
    12661 ctggctctct accagaagct catcacttct gcgcactgga aagtctactt ggcagctcgg
    12721 ggagtcctac cctatgtggg caacctcatc accaaggaaa tagctcgtct gctggccctg
    12781 gaggaggcta ccctgagtac cgatctgcag cagggttatg cccttaaaag tctcacaggc
    12841 cttctctcct cctttgttga ggtggaatcc atcaaaagac attttaaaag tcgcttggtg
    12901 ggtactgtgc tgaatggata cctgtgcttg cggaagctgg tggtgcagag gaccaagctg
    12961 atcgatgaga cgcaggacat gctgctggag atgctggagg acatgaccac aggtacagaa
    13021 tcagaaacca aggccttcat ggctgtgtgc attgagacag ccaagcgcta caatctggat
    13081 gactaccgga ccccggtgtt catcttcgag aggctctgca gcatcattta tcctgaggag
    13141 aatgaagtca ctgagttctt tgtgaccctg gagaaggatc cccaacaaga agacttctta
    13201 cagggcagga tgcctgggaa cccgtatagc agcaatgagc caggcatcgg gccgctgatg
    13261 agggatataa agaacaagat ttgccaggac tgtgacttag tggccctcct ggaagatgac
    13321 agtggcatgg agcttctagt gaacaataaa atcattagtt tggaccttcc tgtggctgaa
    13381 gtttacaaga aagtctggtg taccacgaat gagggagagc ccatgaggat tgtttatcgt
    13441 atgcgggggc tgctgggcga tgccacagag gagttcattg agtccctgga ctctactaca
    13501 gatgaagaag aagatgaaga agaagtgtat aaaatggctg gtgtgatggc ccagtgtggg
    13561 ggcctggaat gcatgcttaa cagactcgca gggatcagag atttcaagca gggacgccac
    13621 cttctaacag tgctactgaa attgttcagt tactgcgtga aggtgaaagt caaccggcag
    13681 caactggtca aactggaaat gaacaccttg aacgtcatgc tggggaccct aaacctggcc
    13741 cttgtagctg aacaagaaag caaggacagt gggggtgcag ctgtggctga gcaggtgctt
    13801 agcatcatgg agatcattct agatgagtcc aatgctgagc ccctgagtga ggacaagggc
    13861 aacctcctcc tgacaggtga caaggatcaa ctggtgatgc tcttggacca gatcaacagc
    13921 acctttgttc gctccaaccc cagtgtgctc cagggcctgc ttcgcatcat cccgtacctt
    13981 tcctttggag aggtggagaa aatgcagatc ttggtggagc gattcaaacc atactgcaac
    14041 tttgataaat atgatgaaga tcacagtggt gatgataaag tcttcctgga ctgcttctgt
    14101 aaaatagctg ctggcatcaa gaacaacagc aatgggcacc agctgaagga tctgattctc
    14161 cagaagggga tcacccagaa tgcacttgac tacatgaaaa agcacatccc tagcgccaag
    14221 aatttggatg ccgacatctg gaaaaagttt ttgtctcgcc cagccttgcc atttatccta
    14281 aggctgcttc ggggcctggc catccagcac cctggcaccc aggttctgat tggaactgat
    14341 tccatcccga acctgcataa gctggagcag gtgtccagtg atgagggcat tgggaccttg
    14401 gcagagaacc tgctggaagc cctgcgggaa caccctgacg taaacaagaa gattgacgca
    14461 gcccgcaggg agacccgggc agagaagaag cgcatggcca tggcaatgag gcagaaggcc
    14521 ctgggcaccc tgggcatgac gacaaatgaa aagggccagg tcgtgaccaa gacagcactc
    14581 ctgaagcaga tggaagagct gatcgaggag cctggcctca cgtgctgcat ctgcagggag
    14641 ggatacaagt tccagcccac aaaggtcctg ggcatttata ccttcacgaa gcgggtagcc
    14701 ttggaggaga tggagaataa gccccggaaa cagcagggct acagcaccgt gtcccacttc
    14761 aacattgtgc actacgactg ccatctggct gccgtcaggt tggctcgagg ccgggaagag
    14821 tgggagagtg ccgccctgca gaatgccaac accaagtgca acgggctcct tccggtctgg
    14881 ggacctcatg tccctgaatc agcttttgcc acttgcttgg caagacacaa cacttacctc
    14941 caggaatgta caggccagcg ggagcccacg tatcagctca acatccatga catcaaactg
    15001 ctcttcctgc gcttcgccat ggagcagtcg ttcagcgcag acactggcgg gggcggccgg
    15061 gagagcaaca tccacctgat cccgtacatc attcacactg tgctttacgt cctgaacaca
    15121 acccgagcaa cttcccgaga agagaagaac ctccaaggct ttctggaaca gcccaaggag
    15181 aagtgggtgg agagtgcctt tgaagtggac gggccctact atttcacagt cttggccctt
    15241 cacatcctgc cccctgagca gtggagagcc acacgtgtgg aaatcttgcg gaggctgttg
    15301 gtgacctcgc aggctcgggc agtggctcca ggtggagcca ccaggctgac agataaggca
    15361 gtgaaggact attccgctta ccgttcttcc cttctctttt gggccctcgt cgatctcatt
    15421 tacaacatgt ttaagaaggt gcctaccagt aacacagagg gaggctggtc ctgctctctc
    15481 gctgagtaca tccgccacaa cgacatgccc atctacgaag ctgccgacaa agccctgaaa
    15541 accttccagg aggagttcat gccagtggag accttctcag agttcctcga tgtggccggt
    15601 cttttatcag aaatcaccga tccagagagc ttcctgaagg acctgttgaa ctcagtcccc
    15661 tgaccaccac acagcagctg cggcggcgaa gacgaagctg gcttgccttc caccctctgt
    15721 tctccctcct tgtgcattaa gttccctccg cgggatgctg cattgttacc ccgccctccc
    15781 ctctctcatt tttcttggtg tggcttgggg tttttaggct tcctgtttta tctcgtgtgt
    15841 gtggtgcacc agctatgagg ttgtctgtaa cccaagccat caaagggcct gtacatacct
    15901 aggagccatg agttgtcccg gccagcttca tacttgagtg tgcacatctt gagaaataaa
    15961 caagtgactt aacacacatt gaaaa
//
