LOCUS       XM_047416471           15988 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens ubiquitin protein ligase E3 component
            n-recognin 4 (UBR4), transcript variant X9, mRNA.
ACCESSION   XM_047416471
VERSION     XM_047416471.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000001.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..15988
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
     gene            1..15988
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /note="ubiquitin protein ligase E3 component n-recognin 4;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 12 mRNAs, 361 ESTs, 4672 long SRA reads, 8
                     Proteins, and 100% coverage of the annotated genomic
                     feature by RNAseq alignments, including 42 samples with
                     support for all annotated introns"
                     /db_xref="GeneID:23352"
                     /db_xref="HGNC:HGNC:30313"
                     /db_xref="MIM:609890"
     CDS             19..15666
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase UBR4 isoform X9"
                     /protein_id="XP_047272427.1"
                     /db_xref="GeneID:23352"
                     /db_xref="HGNC:HGNC:30313"
                     /db_xref="MIM:609890"
                     /translation="MATSGGEEAAAAAPAPGTPATGADTTPGWEVAVRPLLSASYSAF
                     EMKELPQLVASVIESESEILHHEKQYEPFYSSFVALSTHYITTVCSLIPRNQLQSVAA
                     ACKVLIEFSLLRLENPDEACAVSQKHLILLIKGLCTGCSRLDRTEIITFTAMMKSAKL
                     PQTVKTLSDVEDQKELASPVSPELRQKEVQMNFLNQLTSVFNPRTVASQPISTQTLVE
                     GENDEQSSTDQASAIKTKNVFIAQNVASLQELGGSEKLLRVCLNLPYFLRYINRFQDA
                     VLANSFFIMPATVADATAVRNGFHSLVIDVTMALDTLSLPVLEPLNPSRLQDVTVLSL
                     SCLYAGVSVATCMAILHVGSAQQVRTGSTSSKEDDYESDAATIVQKCLEIYDMIGQAI
                     SSSRRAGGEHYQNFQLLGAWCLLNSLFLILNLSPTALADKGKEKDPLAALRVRDILSR
                     TKEGVGSPKLGPGKGHQGFGVLSVILANHAIKLLTSLFQDLQVEALHKGWETDGPPAA
                     LSIMAQSTSIQRIQRLIDSVPLMNLLLTLLSTSYRKACVLQRQRKGSMSSDASASTDS
                     NTYYEDDFSSTEEDSSQDDDSEPILGQWFEETISPSKEKAAPPPPPPPPPLESSPRVK
                     SPSKQAPGEKGNILASRKDPELFLGLASNILNFITSSMLNSRNNFIRNYLSVSLSEHH
                     MATLASIIKEVDKDGLKGSSDEEFAAALYHFNHSLVTSDLQSPNLQNTLLQQLGVAPF
                     SEGPWPLYIHPQSLSVLSRLLLIWQHKASAQGDPDVPECLKVWDRFLSTMKQNALQGV
                     VPSETEDLNVEHLQMLLLIFHNFTETGRRAILSLFVQIIQELSVNMDAQMRFVPLILA
                     RLLLIFDYLLHQYSKAPVYLFEQVQHNLLSPPFGWASGSQDSNSRRATTPLYHGFKEV
                     EENWSKHFSSDAVPHPRFYCVLSPEASEDDLNRLDSVACDVLFSKLVKYDELYAALTA
                     LLAAGSQLDTVRRKENKNVTALEACALQYYFLILWRILGILPPSKTYINQLSMNSPEM
                     SECDILHTLRWSSRLRISSYVNWIKDHLIKQGMKAEHASSLLELASTTKCSSVKYDVE
                     IVEEYFARQISSFCSIDCTTILQLHEIPSLQSIYTLDAAISKVQVSLDEHFSKMAAET
                     DPHKSSEITKNLLPATLQLIDTYASFTRAYLLQNFNEEGTTEKPSKEKLQGFAAVLAI
                     GSSRCKANTLGPTLVQNLPSSVQTVCESWNNINTNEFPNIGSWRNAFANDTIPSESYI
                     SAVQAAHLGTLCSQSLPLAASLKHTLLSLVRLTGDLIVWSDEMNPPQVIRTLLPLLLE
                     SSTESVAEISSNSLERILGPAESDEFLARVYEKLITGCYNILANHADPNSGLDESILE
                     ECLQYLEKQLESSQARKAMEEFFSDSGELVQIMMATANENLSAKFCNRVLKFFTKLFQ
                     LTEKSPNPSLLHLCGSLAQLACVEPVRLQAWLTRMTTSPPKDSDQLDVIQENRQLLQL
                     LTTYIVRENSQVGEGVCAVLLGTLTPMATEMLANGDGTGFPELMVVMATLASAGQGAG
                     HLQLHNAAVDWLSRCKKYLSQKNVVEKLNANVMHGKHVMILECTCHIMSYLADVTNAL
                     SQSNGQGPSHLSVDGEERAIEVDSDWVEELAVEEEDSQAEDSDEDSLCNKLCTFTITQ
                     KEFMNQHWYHCHTCKMVDGVGVCTVCAKVCHKDHEISYAKYGSFFCDCGAKEDGSCLA
                     LVKRTPSSGMSSTMKESAFQSEPRISESLVRHASTSSPADKAKVTISDGKVADEEKPK
                     KSSLCRTVEGCREELQNQANFSFAPLVLDMLNFLMDAIQTNFQQASAVGSSSRAQQAL
                     SELHTVEKAVEMTDQLMVPTLGSQEGAFENVRMNYSGDQGQTIRQLISAHVLRRVAMC
                     VLSSPHGRRQHLAVSHEKGKITVLQLSALLKQADSSKRKLTLTRLASAPVPFTVLSLT
                     GNPCKEDYLAVCGLKDCHVLTFSSSGSVSDHLVLHPQLATGNFIIKAVWLPGSQTELA
                     IVTADFVKIYDLCVDALSPTFYFLLPSSKIRDVTFLFNEEGKNIIVIMSSAGYIYTQL
                     MEEASSAQQGPFYVTNVLEINHEDLKQDSNSQVAGGGVSVYYSHVLQMLFFSYCQGKS
                     FAATISRTTLEVLQLFPINIKSFVVCSSNGGSKTSPALCQWSEVMNHPGLVCCVQQTT
                     GVPLVVMVKPDTFLIQEIKTLPAKAKIQDMVAIRHTACNEQQRTTMILLCEDGSLRIY
                     MANVENTSYWLQPSLQPSSVISIMKPVRKRKTATITTRTSSQVTFPIDFFEHNQQLTD
                     VEFGGNDLLQVYNAQQIKHRLNSTGMYVANTKPGGFTIEISNNNSTMVMTGMRIQIGT
                     QAIERAPSYIEIFGRTMQLNLSRSRWFDFPFTREEALQADKKLNLFIGASVDPAGVTM
                     IDAVKIYGKTKEQFGWPDEPPEEFPSASVSNICPSNLNQSNGTGDSDSAAPTTTSGTV
                     LERLVVSSLEALESCFAVGPIIEKERNKNAAQELATLLLSLPAPASVQQQSKSLLASL
                     HTSRSAYHSHKDQALLSKAVQCLNTSSKEGKDLDPEVFQRLVITARSIAIMRPNNLVH
                     FTESKLPQMETDCFFPRCACWSLGIVGILIGAPLETPSPEGMDEGKEPQKQLEGDCCS
                     FITQLVNHFWKLHASKPKNAFLAPACLPGLTHIEATVNALVDIIHGYCTCELDCINTA
                     SKIYMQMLLCPDPAVSFSCKQALIRVLRPRNKRRHVTLPSSPRSNTPMGDKDDDDDDD
                     ADEKMQSSGIPNGGHIRQESQEQSEVDHGDFEMVSESMVLETAENVNNGNPSPLEALL
                     AGAEGFPPMLDIPPDADDETMVELAIALSLQQDQQGSSSSALGLQSLGLSGQAPSSSS
                     LDAGTLSDTTASASDDEGSTAATDGSTLRTSPADHGGSVGSESGGSAVDSVAGEHSVS
                     GRSSAYGDATAEGHPAGPGSVSSSTGAISTTTGHQEGDGSEGEGEGETEGDVHTSNRL
                     HMVRLMLLERLLQTLPQLRNVGGVRAIPYMQVILMLTTDLDGEDEKDKGALDNLLSQL
                     IAELGMDKKDVSKKNERSALNEVHLVVMRLLSVFMSRTKSGSKSSICESSSLISSATA
                     AALLSSGAVDYCLHVLKSLLEYWKSQQNDEEPVATSQLLKPHTTSSPPDMSPFFLRQY
                     VKGHAADVFEAYTQLLTEMVLRLPYQIKKITDTNSRIPPPVFDHSWFYFLSEYLMIQQ
                     TPFVRRQVRKLLLFICGSKEKYRQLRDLHTLDSHVRGIKKLLEEQGIFLRASVVTASS
                     GSALQYDTLISLMEHLKACAEIAAQRTINWQKFCIKDDSVLYFLLQVSFLVDEGVSPV
                     LLQLLSCALCGSKVLAALAASSGSSSASSSSAPVAASSGQATTQSKSSTKKSKKEEKE
                     KEKDGETSGSQEDQLCTALVNQLNKFADKETLIQFLRCFLLESNSSSVRWQAHCLTLH
                     IYRNSSKSQQELLLDLMWSIWPELPAYGRKAAQFVDLLGYFSLKTPQTEKKLKEYSQK
                     AVEILRTQNHILTNHPNSNIYNTLSGLVEFDGYYLESDPCLVCNNPEVPFCYIKLSSI
                     KVDTRYTTTQQVVKLIGSHTISKVTVKIGDLKRTKMVRTINLYYNNRTVQAIVELKNK
                     PARWHKAKKVQLTPGQTEVKIDLPLPIVASNLMIEFADFYENYQASTETLQCPRCSAS
                     VPANPGVCGNCGENVYQCHKCRSINYDEKDPFLCNACGFCKYARFDFMLYAKPCCAVD
                     PIENEEDRKKAVSNINTLLDKADRVYHQLMGHRPQLENLLCKVNEAAPEKPQDDSGTA
                     GGISSTSASVNRYILQLAQEYCGDCKNSFDELSKIIQKVFASRKELLEYDLQQREAAT
                     KSSRTSVQPTFTASQYRALSVLGCGHTSSTKCYGCASAVTEHCITLLRALATNPALRH
                     ILVSQGLIRELFDYNLRRGAAAMREEVRQLMCLLTRDNPEATQQMNDLIIGKVSTALK
                     GHWANPDLASSLQYEMLLLTDSISKEDSCWELRLRCALSLFLMAVNIKTPVVVENITL
                     MCLRILQKLIKPPAPTSKKNKDVPVEALTTVKPYCNEIHAQAQLWLKRDPKASYDAWK
                     KCLPIRGIDGNGKAPSKSELRHLYLTEKYVWRWKQFLSRRGKRTSPLDLKLGHNNWLR
                     QVLFTPATQAARQAACTIVEALATIPSRKQQVLDLLTSYLDELSIAGECAAEYLALYQ
                     KLITSAHWKVYLAARGVLPYVGNLITKEIARLLALEEATLSTDLQQGYALKSLTGLLS
                     SFVEVESIKRHFKSRLVGTVLNGYLCLRKLVVQRTKLIDETQDMLLEMLEDMTTGTES
                     ETKAFMAVCIETAKRYNLDDYRTPVFIFERLCSIIYPEENEVTEFFVTLEKDPQQEDF
                     LQGRMPGNPYSSNEPGIGPLMRDIKNKICQDCDLVALLEDDSGMELLVNNKIISLDLP
                     VAEVYKKVWCTTNEGEPMRIVYRMRGLLGDATEEFIESLDSTTDEEEDEEEVYKMAGV
                     MAQCGGLECMLNRLAGIRDFKQGRHLLTVLLKLFSYCVKVKVNRQQLVKLEMNTLNVM
                     LGTLNLALVAEQESKDSGGAAVAEQVLSIMEIILDESNAEPLSEDKGNLLLTGDKDQL
                     VMLLDQINSTFVRSNPSVLQGLLRIIPYLSFGEVEKMQILVERFKPYCNFDKYDEDHS
                     GDDKVFLDCFCKIAAGIKNNSNGHQLKDLILQKGITQNALDYMKKHIPSAKNLDADIW
                     KKFLSRPALPFILRLLRGLAIQHPGTQVLIGTDSIPNLHKLEQVSSDEGIGTLAENLL
                     EALREHPDVNKKIDAARRETRAEKKRMAMAMRQKALGTLGMTTNEKGQVVTKTALLKQ
                     MEELIEEPGLTCCICREGYKFQPTKVLGIYTFTKRVALEEMENKPRKQQGYSTVSHFN
                     IVHYDCHLAAVRLARGREEWESAALQNANTKCNGLLPVWGPHVPESAFATCLARHNTY
                     LQECTGQREPTYQLNIHDIKLLFLRFAMEQSFSADTGGGGRESNIHLIPYIIHTVLYV
                     LNTTRATSREEKNLQGFLEQPKEKWVESAFEVDGPYYFTVLALHILPPEQWRATRVEI
                     LRRLLVTSQARAVAPGGATRLTDKAVKDYSAYRSSLLFWALVDLIYNMFKKVPTSNTE
                     GGWSCSLAEYIRHNDMPIYEAADKALKTFQEEFMPVETFSEFLDVAGLLSEITDPESF
                     LKDLLNSVP"
ORIGIN      
        1 gcagtagtac gacggaagat ggcgacgagc ggcggcgaag aggcggcggc agcggctccg
       61 gcgccgggga ccccggcaac gggggcggac acgaccccgg gctgggaggt ggctgtgcgg
      121 cccctgctgt ccgcgtccta ctccgccttc gagatgaagg agttgccgca gctggtggcc
      181 tcagtcatcg agagtgaatc agaaatcctg caccatgaga agcagtacga gccattctac
      241 tcatcttttg ttgcactttc cacacactat attacaacag tttgcagtct cattccccgg
      301 aaccaacttc agtcagtggc agcagcctgt aaagttctaa ttgagttttc tctcctgcgt
      361 ctggagaatc cagatgaggc ttgtgctgtg tcccagaaac acttgattct cctaatcaag
      421 ggcctgtgca ctggctgtag ccgactagat agaactgaaa ttatcacatt tacagcaatg
      481 atgaaatccg ccaagctgcc ccaaacagtg aagacacttt cagacgtgga agatcagaaa
      541 gagctggcct caccagtaag ccctgagttg aggcaaaagg aggtacagat gaattttttg
      601 aaccagctga cctcagtttt taaccctaga actgtagcat cacaacctat cagtacacag
      661 actctggtgg aaggagaaaa tgatgagcag tcatctacag atcaagcctc agctatcaaa
      721 accaagaatg tgttcatagc tcagaacgtg gctagtcttc aagagcttgg tggctcggag
      781 aagctactgc gtgtatgttt gaacctgcca tatttcctac gctatatcaa tcggttccaa
      841 gatgcagttt tagctaattc cttcttcata atgcctgcaa cagtagcaga tgccactgct
      901 gttcgtaatg gctttcattc attggtgatt gatgtaacta tggcattgga taccctttct
      961 ctacctgtgt tggaacctct caatccttct cgtctacaag atgtgacagt cctcagccta
     1021 agttgtctgt atgcaggtgt gagtgtggca acgtgcatgg ccatcctcca tgtgggtagt
     1081 gcccagcaag tgcggacagg gtccacgagc tccaaagaag atgactatga aagtgacgca
     1141 gctacaattg tccagaaatg tctcgaaatc tatgacatga ttggacaagc aatcagcagt
     1201 tctcgccggg ctggtggtga gcactatcag aatttccaat tgctgggtgc ttggtgcttg
     1261 ttaaacagcc ttttcctcat actgaacctc agtcctactg cgttggctga taaggggaaa
     1321 gagaaggacc cactggctgc cctccgagtc agagacatcc tttctcgtac taaagaggga
     1381 gtgggctccc ctaaactggg gcctggaaaa gggcatcagg gatttggggt actctcagta
     1441 atattggcaa accatgccat caaactgcta acgtctctct ttcaagacct acaagtggag
     1501 gcccttcaca agggttggga gacagatggc ccccctgcag ccttgagcat tatggcccag
     1561 agcacctcca tacagaggat tcaacggctg attgactctg tcccactgat gaacctgctc
     1621 ttgacgttac tttcaacttc ctacagaaag gcatgtgtcc tgcagcggca gaggaagggc
     1681 tccatgagca gcgatgccag cgcctccacc gactccaata cttactatga ggacgatttc
     1741 agtagcacgg aggaggacag cagccaagac gatgacagtg agcctatttt ggggcaatgg
     1801 tttgaggaga ctatttctcc cagtaaagag aaagcagcac ctccgcctcc tcccccacct
     1861 cctccactgg aaagctctcc tcgggttaaa agccccagta agcaggcccc tggtgagaag
     1921 ggcaacattc tggcgagtcg caaagatcct gagttgttct taggtctggc ttccaacatt
     1981 ttgaacttca tcacctcttc catgctgaac tctcggaaca attttatccg aaactatctg
     2041 agtgtatctc tttcagaaca ccatatggcc accctagcca gtatcatcaa ggaggtggac
     2101 aaagatggac tcaagggttc atcagatgaa gagtttgctg cagctctcta tcacttcaac
     2161 cactcactgg taacctctga ccttcagtca cctaacctgc agaacacact gttgcagcag
     2221 ctaggagtgg ctcctttttc tgagggccct tggcccttgt acattcaccc tcaaagcctc
     2281 tctgtgcttt cacgcctcct gctcatctgg caacataaag ccagtgctca aggtgaccct
     2341 gacgtcccag aatgccttaa agtttgggac aggtttttgt ctacaatgaa gcagaatgcc
     2401 ctgcaaggtg tggtgcccag tgagacagag gatctgaatg tagaacacct gcagatgctc
     2461 ctcctcattt tccacaattt caccgagaca ggccggcggg ccatattgtc gctttttgtc
     2521 cagatcatcc aggagttgag cgtcaacatg gatgctcaga tgcgcttcgt gccgcttatc
     2581 ttggctcgcc tccttctcat ctttgattat ctgcttcatc agtactccaa agcccctgtg
     2641 tatctatttg agcaggtaca gcataacctg ctaagtcctc cctttgggtg ggcaagtgga
     2701 tcccaggaca gcaacagccg ccgggcaacc actcctctct atcatggatt caaagaagta
     2761 gaagaaaact ggtctaagca tttctcatca gatgctgtcc cacaccccag attctactgt
     2821 gtcctgtccc cagaagcctc agaggatgat ttgaaccgac ttgattctgt ggcatgtgac
     2881 gtccttttct ccaagcttgt caagtatgat gagctttatg ctgcactgac agccctgctt
     2941 gcagctgggt cccagcttga tacagttagg agaaaggaaa acaagaatgt aacagccttg
     3001 gaggcctgtg cccttcaata ttacttcttg atactgtgga ggatcctagg aattttacca
     3061 ccatcaaaga cttacattaa ccagctatcc atgaactcac ctgagatgag cgaatgtgac
     3121 atcttgcaca ctctgcgatg gtcttctcgg ctccggatca gctcctatgt caactggata
     3181 aaggatcacc ttatcaaaca gggaatgaag gctgagcatg ctagctcgct tctagaactg
     3241 gcatccacca ctaagtgtag ctcagtgaaa tatgatgttg aaatagtaga ggaatacttc
     3301 gctcgacaga tctcatcctt ctgtagtatc gactgtacca ccatcttgca gctgcatgaa
     3361 attcccagtc tgcagtccat ctacaccctt gatgccgcga tctcaaaggt ccaggtctct
     3421 ttggatgagc atttttctaa gatggctgct gagactgatc ctcataagtc gtctgagatt
     3481 accaagaacc tacttccagc cacgctgcaa ctcattgaca cctatgcatc gttcaccaga
     3541 gcctatttgc tgcaaaactt taatgaagag ggaacaactg agaaaccttc caaggagaaa
     3601 ctgcaaggct ttgctgctgt tttggctatt ggctctagca ggtgcaaggc aaatactctg
     3661 ggtccgacac tggttcagaa tttgccatcg tcagtgcaga ctgtgtgtga gtcctggaac
     3721 aacatcaata ccaatgaatt tcccaatatt ggatcctggc gcaatgcctt tgccaatgac
     3781 accatccctt cagagagtta tattagtgca gtgcaggctg cacacctggg gactctctgt
     3841 agccaaagtc tgcccctggc tgcttccctg aagcataccc tcctctcact ggtcaggttg
     3901 actggagatc ttattgtttg gtcagatgag atgaacccac cacaggtaat tcggacactg
     3961 ctacctcttc ttttggaatc aagcactgag agtgttgccg agatcagtag caactccctg
     4021 gaacgcatct tgggccctgc tgagtctgat gagttcttgg ctcgtgttta tgagaagctg
     4081 atcactggtt gttacaacat tctggccaat catgcagatc ctaacagtgg actggatgaa
     4141 tccatcctgg aggaatgtct ccagtacttg gaaaagcagc tggaaagtag ccaggctcgt
     4201 aaagctatgg aggagttttt ctctgacagt ggagaacttg tacagatcat gatggcaaca
     4261 gccaatgaga acctctctgc taaattctgt aaccgagttt tgaaattctt caccaaactc
     4321 ttccagctga ctgagaagag ccctaacccg agcctgttgc atctctgtgg ctccctggca
     4381 caactggcct gtgtggaacc tgtgcgcctg caggcctggc tcacccgcat gactacatcg
     4441 cccccaaaag attctgatca gctggatgta attcaggaga accggcagct gctgcagtta
     4501 ctgaccacat acattgttcg ggaaaacagc caagttgggg aaggtgtgtg tgctgttctt
     4561 ctgggcaccc tgactcccat ggcaacagag atgctggcca acggtgatgg gactggcttc
     4621 cctgaactta tggttgtgat ggccactctg gccagtgcag gtcaaggtgc tggtcacctt
     4681 cagcttcata atgctgctgt ggattggctg agcagatgca agaaatacct gtcacagaag
     4741 aatgtagttg aaaaactgaa tgccaatgta atgcatggaa agcatgtgat gatcttggag
     4801 tgcacatgcc atatcatgtc ttacttggct gatgtcacga atgccctgag ccagagtaat
     4861 ggtcaaggcc caagtcatct ctcagtggat ggggaagagc gggccattga agtagactca
     4921 gactgggtgg aggagttggc ggtggaagag gaagattccc aggctgagga ttcagatgaa
     4981 gattctcttt gcaataaact ctgcactttt acgatcacac agaaagaatt catgaaccag
     5041 cattggtacc actgtcacac ctgtaaaatg gtggatggcg tgggtgtctg cacagtgtgt
     5101 gctaaggtgt gccacaagga tcatgagatt tcctatgcca agtatggatc cttcttctgt
     5161 gactgtggag ccaaggaaga tggcagctgt ttggctctgg tgaagagaac tcctagcagt
     5221 ggcatgagct ctaccatgaa ggagtcggca tttcagagtg aacccaggat ttcagagagt
     5281 ctagtgcgtc atgccagcac ctcctcgcca gctgacaaag ccaaggttac catcagtgat
     5341 ggaaaggttg ctgacgaaga gaagcccaag aagagcagcc tctgccgcac agtagagggc
     5401 tgccgggagg aattacagaa ccaggccaat ttctccttcg ctcctctcgt gttagacatg
     5461 cttaatttcc ttatggatgc cattcagacc aacttccagc aagcttcagc cgtcgggagc
     5521 agcagccgtg ctcagcaagc cctcagtgag ctacacactg tggagaaggc agtggagatg
     5581 acagaccagc tgatggttcc caccttaggg tcccaggaag gtgcctttga gaatgtgcgg
     5641 atgaattaca gtggagacca gggccagacc atccggcagc tgatcagtgc tcatgtgctc
     5701 aggcgggtgg ctatgtgtgt gctctcctct ccccatgggc gccgccaaca tttggctgtc
     5761 agccatgaga agggcaagat caccgttctg cagctctctg cactcctgaa gcaagcagat
     5821 tccagcaaaa ggaagttaac tctgacccgc ttggcttctg ccccagttcc ttttactgtg
     5881 ttgagcctca caggaaatcc ctgcaaggaa gactacttgg cggtttgtgg gctaaaggac
     5941 tgtcatgtgc tcacctttag tagctcaggc tctgtttcgg atcacttggt tttgcaccct
     6001 cagttggcaa cggggaactt catcatcaaa gccgtgtggt tacctggttc acagaccgag
     6061 ttagcaattg tcaccgcaga ctttgttaag atttatgacc tgtgtgttga tgccttgagt
     6121 ccaaccttct attttctcct gccaagctca aagataagag atgttacctt ccttttcaat
     6181 gaggagggaa agaacatcat tgttataatg tcttcggctg ggtacatcta tactcagctt
     6241 atggaagagg ccagcagtgc ccagcaggga cccttctatg tcactaatgt gttggaaatc
     6301 aatcatgagg acctgaagca ggacagtaac agccaggtgg cgggcggtgg tgtgtccgtg
     6361 tactactccc acgtgttgca gatgttgttc ttcagctatt gtcaaggcaa atcattcgca
     6421 gccaccatca gcaggacaac cctggaggtg ttgcaactct tccccatcaa catcaaaagt
     6481 tttgttgtct gcagttccaa tggtggcagt aagacttctc ctgctctttg ccagtggtct
     6541 gaggtgatga accaccctgg cttggtgtgc tgtgtccagc aaactacagg ggtgccgctg
     6601 gtagttatgg tgaaaccaga cacttttctt atccaggaga ttaagactct tcctgctaaa
     6661 gcgaagatcc aagacatggt tgctattagg cacacggcct gcaatgagca gcagcggaca
     6721 acaatgattc tgctgtgtga ggatggcagc ctgcgcattt acatggccaa cgtggagaac
     6781 acctcctact ggctgcagcc atccctgcag cccagcagtg tcatcagcat catgaagcct
     6841 gttcgaaagc gcaaaacagc tacaatcaca acccgcacgt ctagccaggt gactttcccc
     6901 attgactttt ttgaacacaa ccagcagctg acagatgtgg agtttggtgg taacgacctc
     6961 ctacaggtct ataatgcaca acagataaaa caccggctga attccactgg catgtatgtg
     7021 gccaacacca agcccggagg cttcaccatt gagattagta acaacaatag cactatggtg
     7081 atgacaggca tgcggatcca gattgggact caagcaatag aacgggcccc gtcatatatc
     7141 gagatcttcg gcagaactat gcagctcaac ctgagtcgct cacgctggtt tgacttcccc
     7201 ttcaccagag aagaagccct gcaggctgat aagaagctga acctcttcat tggggcctcg
     7261 gtggatccag caggtgtcac catgatagat gctgtaaaaa tttatggcaa gactaaggag
     7321 cagtttggct ggcctgatga gcccccagaa gaattccctt ctgcctctgt cagcaacatc
     7381 tgcccttcaa atctgaacca gagcaacggc actggagata gcgactcagc tgcccccact
     7441 acgaccagtg gaactgtcct ggagaggctg gttgtgagtt ctttagaagc cctggaaagc
     7501 tgctttgccg ttggcccaat catcgagaag gagagaaaca agaatgctgc tcaggagctg
     7561 gccactttgc tgttgtccct gccagcacct gccagtgtcc agcagcagtc caagagcctt
     7621 ctggccagcc tgcacaccag ccgctcggcc taccacagcc acaaggatca ggccttgctg
     7681 agcaaagctg tgcagtgtct caacacatct agcaaagagg gcaaggattt ggaccctgag
     7741 gtgttccaga ggctagtgat cacagctcgc tccattgcca tcatgcgccc caacaacctt
     7801 gtccacttta cggagtcaaa gctgccccag atggaaacag actgtttttt tcctagatgt
     7861 gcctgctgga gtctagggat agttggcata ttgattgggg ccccacttga aactccctcc
     7921 ccagaaggaa tggatgaagg gaaggaaccg cagaagcagt tggaaggaga ttgctgtagt
     7981 ttcatcaccc agcttgtgaa ccacttctgg aaactccatg catccaaacc caagaatgcc
     8041 ttcttggcac ctgcctgcct tccaggacta actcatattg aagctactgt caatgctctg
     8101 gtggacatca tccatggcta ctgtacctgt gagctggatt gtattaacac agcatccaag
     8161 atctacatgc agatgctctt gtgtcctgat cctgctgtga gcttctcttg taaacaagct
     8221 ctaattcgag tcctaaggcc caggaacaaa cggagacatg tgactttacc ctcttcccct
     8281 cgaagcaaca ctccaatggg agacaaggat gatgatgacg atgatgatgc agatgagaaa
     8341 atgcagtcat cagggatccc gaatggtggt cacatccgtc aggaaagcca ggaacagagt
     8401 gaggtggacc atggagattt tgagatggtg tctgagtcga tggtcctgga gacagctgaa
     8461 aatgtcaaca atggcaaccc ctctcccctg gaggccctgc tggcaggcgc agagggcttc
     8521 ccccccatgc tggacatccc acctgatgca gatgacgaga ccatggttga actagccatt
     8581 gccctgagcc tgcagcagga ccaacaaggc agcagcagca gtgccctggg cctgcagagc
     8641 ctgggactgt ccggccaggc acccagctct tcctctctgg acgcaggaac cctctctgac
     8701 accacagcat cagcctcaga cgacgagggc agtacagcag cgacagatgg ttctaccctt
     8761 cggacctctc ctgctgacca cggtggtagt gtgggctcgg agagcggggg cagtgcagtg
     8821 gactcagtgg ctggcgagca cagtgtatct ggccggagca gtgcttatgg cgatgctaca
     8881 gctgaggggc atccggctgg accaggaagt gtcagctcaa gcactggagc catcagcacc
     8941 accactgggc accaggaggg agatggctcc gagggagaag gagaaggaga aactgaagga
     9001 gatgtccaca ctagcaacag gctgcacatg gtccgtctaa tgctgttgga gagattactg
     9061 cagaccctgc ctcaattacg aaacgttggc ggtgtccggg ccatcccata catgcaggtc
     9121 attctaatgc tcactacaga tctggatgga gaagatgaga aagacaaggg ggccctagac
     9181 aacctgctct cccagcttat tgctgagttg ggtatggata aaaaggatgt ctccaagaag
     9241 aatgagcgca gcgccctgaa tgaagtccat ctggtagtaa tgagactcct gagtgtcttc
     9301 atgtcccgca ccaaatctgg atccaagtct tccatatgtg agtcatcttc cctcatctcc
     9361 agtgccacag cagcagctct actgagctct ggggctgtgg actactgcct gcacgtgctc
     9421 aaatcactgc tggaatattg gaagagccaa cagaatgacg aggagcctgt ggctaccagc
     9481 cagttgctga aaccacatac tacctcctcc ccacctgaca tgagcccatt ctttctccgc
     9541 cagtatgtga agggtcatgc tgctgatgtg tttgaggcct atactcagct tctaacagaa
     9601 atggtactga ggcttcctta ccaaatcaaa aagattactg acaccaattc tcgaatccca
     9661 cctcctgtct ttgaccactc gtggttttac tttctctccg agtacctcat gatccagcag
     9721 actccatttg tgcgccgtca agtccgcaaa cttctgctct tcatctgtgg atccaaagag
     9781 aagtaccgcc agctccggga tttgcacacc ctggactctc acgtgcgtgg gatcaagaag
     9841 ctgctagaag agcaggggat attcctccgg gcaagtgtgg ttacagccag ctcaggctcc
     9901 gccttgcaat atgacacact catcagcctg atggagcacc tgaaagcctg tgcagagatt
     9961 gccgcccagc gaaccatcaa ctggcagaaa ttctgcatca aagatgactc cgtcctgtac
    10021 ttcctcctcc aagtcagttt ccttgtggat gagggcgtgt ccccagtgct gctgcaactg
    10081 ctctcctgtg ctctgtgcgg cagcaaggtg ctcgctgcac tggcagcctc ttcgggatcc
    10141 tccagtgctt cttcctcctc agcccctgtg gctgccagtt ctggacaagc cacaacacag
    10201 tccaagtctt ccactaaaaa gagcaagaaa gaagaaaaag aaaaggagaa agatggtgag
    10261 acctctggca gccaggagga ccagctgtgc acagctctgg tgaaccagct gaacaaattt
    10321 gccgataagg aaaccctgat ccagttcctg cgttgtttcc tgttagagtc caattcttcc
    10381 tcggtgcgct ggcaggccca ctgtctgaca ctgcacatct acagaaattc cagcaaatct
    10441 caacaggagc tcctgctaga tctgatgtgg tccatctggc cagaactccc agcctatggt
    10501 cgtaaggctg cccagtttgt ggacctacta ggatatttct ccctgaaaac tccacaaaca
    10561 gagaagaagt tgaaggagta ttcacagaag gctgtggaga ttctgcggac tcaaaaccat
    10621 attcttacca accaccccaa ctcgaacatt tataacactt tgtctggctt agtggagttt
    10681 gatggctatt acctggagag cgatccctgc ctggtgtgta ataacccgga agtaccgttc
    10741 tgttatatca agctgtcttc cattaaagtg gacacgcggt acaccaccac ccagcaggtt
    10801 gtgaagctca ttggcagtca caccatcagc aaagtgacag tgaaaatcgg ggatctgaaa
    10861 cggaccaaga tggtgcggac catcaacctg tattataaca accgaaccgt gcaggccatc
    10921 gtggagttga aaaacaagcc agctcgctgg cacaaagcca agaaggttca gctgacccct
    10981 ggacagacag aggtgaagat tgacctgccg ttgcccattg tggcctccaa tctgatgatt
    11041 gagtttgcag acttctatga aaactaccag gcctccacag agaccctgca gtgccctcgc
    11101 tgtagtgcct cggtccctgc caacccagga gtctgtggca actgtggaga gaatgtgtac
    11161 cagtgtcaca aatgcagatc catcaactac gatgaaaagg atcccttcct ctgcaatgcc
    11221 tgtggcttct gtaaatatgc ccgcttcgac ttcatgctct atgccaagcc ttgctgtgca
    11281 gtggatccca ttgagaatga agaagaccgg aagaaggctg tatccaacat caatacactt
    11341 ttggacaaag ctgatcgagt gtatcatcag ctgatgggac accggccaca gctggagaac
    11401 ctgctctgca aagtgaatga ggcagctcca gaaaagccac aggatgactc aggaacagca
    11461 gggggcatca gctccacttc tgccagtgtg aatcgttaca tcctgcagtt ggctcaggag
    11521 tattgtggag actgcaagaa ctcttttgat gaactctcca aaatcatcca gaaagtcttt
    11581 gcttcgcgca aagagttgtt ggaatatgac ctacagcaga gggaagcagc cactaaatca
    11641 tcccggacct ccgtgcagcc cacattcact gccagccagt accgtgcctt atccgtcctg
    11701 ggctgtggcc acacatcctc caccaagtgc tatggctgcg cctcggctgt cacagaacat
    11761 tgtatcacac tacttcgggc cctggccacc aacccagcct tgaggcacat ccttgtctcc
    11821 cagggcctta tccgggagct ctttgattat aatcttcgcc gaggggctgc ggccatgcgg
    11881 gaggaggtcc gccagctcat gtgcctccta actcgagaca acccagaagc cacccaacag
    11941 atgaatgacc tgattattgg caaggtctcc acagccctga agggccactg ggccaacccc
    12001 gatctggcaa gtagcctgca gtatgaaatg ctgctgctga cggattctat ctccaaggag
    12061 gacagctgct gggagctccg gttacgctgt gctctcagcc ttttcctcat ggctgtgaac
    12121 attaagactc ctgtggtggt tgaaaacatt accctcatgt gcctgaggat cttgcagaag
    12181 ctgataaaac cacctgctcc cactagcaag aagaacaagg atgtccccgt tgaggccctc
    12241 accacggtga agccatactg caatgagatc catgcccagg ctcaactgtg gctcaagaga
    12301 gaccccaagg catcctatga tgcctggaag aagtgtcttc ctatcagagg gatagatggc
    12361 aatgggaaag cccccagcaa atcagagctc cgccatctct atttgactga gaagtatgtg
    12421 tggaggtgga aacagttcct gagtcgtcgg gggaagagga cctccccctt ggatctcaaa
    12481 ctggggcata acaactggct gcgacaagtg cttttcactc cagcaacgca ggccgcacgg
    12541 caggcagcct gtaccattgt ggaagctcta gccaccattc ccagccgcaa gcagcaggtc
    12601 ctggacctgc ttaccagtta cctggatgag ctgagcatag ctggggagtg tgcagctgag
    12661 tacctggctc tctaccagaa gctcatcact tctgcgcact ggaaagtcta cttggcagct
    12721 cggggagtcc taccctatgt gggcaacctc atcaccaagg aaatagctcg tctgctggcc
    12781 ctggaggagg ctaccctgag taccgatctg cagcagggtt atgcccttaa aagtctcaca
    12841 ggccttctct cctcctttgt tgaggtggaa tccatcaaaa gacattttaa aagtcgcttg
    12901 gtgggtactg tgctgaatgg atacctgtgc ttgcggaagc tggtggtgca gaggaccaag
    12961 ctgatcgatg agacgcagga catgctgctg gagatgctgg aggacatgac cacaggtaca
    13021 gaatcagaaa ccaaggcctt catggctgtg tgcattgaga cagccaagcg ctacaatctg
    13081 gatgactacc ggaccccggt gttcatcttc gagaggctct gcagcatcat ttatcctgag
    13141 gagaatgaag tcactgagtt ctttgtgacc ctggagaagg atccccaaca agaagacttc
    13201 ttacagggca ggatgcctgg gaacccgtat agcagcaatg agccaggcat cgggccgctg
    13261 atgagggata taaagaacaa gatttgccag gactgtgact tagtggccct cctggaagat
    13321 gacagtggca tggagcttct agtgaacaat aaaatcatta gtttggacct tcctgtggct
    13381 gaagtttaca agaaagtctg gtgtaccacg aatgagggag agcccatgag gattgtttat
    13441 cgtatgcggg ggctgctggg cgatgccaca gaggagttca ttgagtccct ggactctact
    13501 acagatgaag aagaagatga agaagaagtg tataaaatgg ctggtgtgat ggcccagtgt
    13561 gggggcctgg aatgcatgct taacagactc gcagggatca gagatttcaa gcagggacgc
    13621 caccttctaa cagtgctact gaaattgttc agttactgcg tgaaggtgaa agtcaaccgg
    13681 cagcaactgg tcaaactgga aatgaacacc ttgaacgtca tgctggggac cctaaacctg
    13741 gcccttgtag ctgaacaaga aagcaaggac agtgggggtg cagctgtggc tgagcaggtg
    13801 cttagcatca tggagatcat tctagatgag tccaatgctg agcccctgag tgaggacaag
    13861 ggcaacctcc tcctgacagg tgacaaggat caactggtga tgctcttgga ccagatcaac
    13921 agcacctttg ttcgctccaa ccccagtgtg ctccagggcc tgcttcgcat catcccgtac
    13981 ctttcctttg gagaggtgga gaaaatgcag atcttggtgg agcgattcaa accatactgc
    14041 aactttgata aatatgatga agatcacagt ggtgatgata aagtcttcct ggactgcttc
    14101 tgtaaaatag ctgctggcat caagaacaac agcaatgggc accagctgaa ggatctgatt
    14161 ctccagaagg ggatcaccca gaatgcactt gactacatga aaaagcacat ccctagcgcc
    14221 aagaatttgg atgccgacat ctggaaaaag tttttgtctc gcccagcctt gccatttatc
    14281 ctaaggctgc ttcggggcct ggccatccag caccctggca cccaggttct gattggaact
    14341 gattccatcc cgaacctgca taagctggag caggtgtcca gtgatgaggg cattgggacc
    14401 ttggcagaga acctgctgga agccctgcgg gaacaccctg acgtaaacaa gaagattgac
    14461 gcagcccgca gggagacccg ggcagagaag aagcgcatgg ccatggcaat gaggcagaag
    14521 gccctgggca ccctgggcat gacgacaaat gaaaagggcc aggtcgtgac caagacagca
    14581 ctcctgaagc agatggaaga gctgatcgag gagcctggcc tcacgtgctg catctgcagg
    14641 gagggataca agttccagcc cacaaaggtc ctgggcattt ataccttcac gaagcgggta
    14701 gccttggagg agatggagaa taagccccgg aaacagcagg gctacagcac cgtgtcccac
    14761 ttcaacattg tgcactacga ctgccatctg gctgccgtca ggttggctcg aggccgggaa
    14821 gagtgggaga gtgccgccct gcagaatgcc aacaccaagt gcaacgggct ccttccggtc
    14881 tggggacctc atgtccctga atcagctttt gccacttgct tggcaagaca caacacttac
    14941 ctccaggaat gtacaggcca gcgggagccc acgtatcagc tcaacatcca tgacatcaaa
    15001 ctgctcttcc tgcgcttcgc catggagcag tcgttcagcg cagacactgg cgggggcggc
    15061 cgggagagca acatccacct gatcccgtac atcattcaca ctgtgcttta cgtcctgaac
    15121 acaacccgag caacttcccg agaagagaag aacctccaag gctttctgga acagcccaag
    15181 gagaagtggg tggagagtgc ctttgaagtg gacgggccct actatttcac agtcttggcc
    15241 cttcacatcc tgccccctga gcagtggaga gccacacgtg tggaaatctt gcggaggctg
    15301 ttggtgacct cgcaggctcg ggcagtggct ccaggtggag ccaccaggct gacagataag
    15361 gcagtgaagg actattccgc ttaccgttct tcccttctct tttgggccct cgtcgatctc
    15421 atttacaaca tgtttaagaa ggtgcctacc agtaacacag agggaggctg gtcctgctct
    15481 ctcgctgagt acatccgcca caacgacatg cccatctacg aagctgccga caaagccctg
    15541 aaaaccttcc aggaggagtt catgccagtg gagaccttct cagagttcct cgatgtggcc
    15601 ggtcttttat cagaaatcac cgatccagag agcttcctga aggacctgtt gaactcagtc
    15661 ccctgaccac cacacagcag ctgcggcggc gaagacgaag ctggcttgcc ttccaccctc
    15721 tgttctccct ccttgtgcat taagttccct ccgcgggatg ctgcattgtt accccgccct
    15781 cccctctctc atttttcttg gtgtggcttg gggtttttag gcttcctgtt ttatctcgtg
    15841 tgtgtggtgc accagctatg aggttgtctg taacccaagc catcaaaggg cctgtacata
    15901 cctaggagcc atgagttgtc ccggccagct tcatacttga gtgtgcacat cttgagaaat
    15961 aaacaagtga cttaacacac attgaaaa
//
