LOCUS       XM_017000822           16024 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens ubiquitin protein ligase E3 component
            n-recognin 4 (UBR4), transcript variant X3, mRNA.
ACCESSION   XM_017000822
VERSION     XM_017000822.3
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000001.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_017000822.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..16024
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
     gene            1..16024
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /note="ubiquitin protein ligase E3 component n-recognin 4;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 12 mRNAs, 359 ESTs, 4741 long SRA reads, 8
                     Proteins, and 100% coverage of the annotated genomic
                     feature by RNAseq alignments, including 10 samples with
                     support for all annotated introns"
                     /db_xref="GeneID:23352"
                     /db_xref="HGNC:HGNC:30313"
                     /db_xref="MIM:609890"
     CDS             19..15702
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase UBR4 isoform X3"
                     /protein_id="XP_016856311.3"
                     /db_xref="GeneID:23352"
                     /db_xref="HGNC:HGNC:30313"
                     /db_xref="MIM:609890"
                     /translation="MATSGGEEAAAAAPAPGTPATGADTTPGWEVAVRPLLSASYSAF
                     EMKELPQLVASVIESESEILHHEKQYEPFYSSFVALSTHYITTVCSLIPRNQLQSVAA
                     ACKVLIEFSLLRLENPDEACAVSQKHLILLIKGLCTGCSRLDRTEIITFTAMMKSAKL
                     PQTVKTLSDVEDQKELASPVSPELRQKEVQMNFLNQLTSVFNPRTVASQPISTQTLVE
                     GENDEQSSTDQASAIKTKNVFIAQNVASLQELGGSEKLLRVCLNLPYFLRYINRFQDA
                     VLANSFFIMPATVADATAVRNGFHSLVIDVTMALDTLSLPVLEPLNPSRLQDVTVLSL
                     SCLYAGVSVATCMAILHVGSAQQVRTGSTSSKEDDYESDAATIVQKCLEIYDMIGQAI
                     SSSRRAGGEHYQNFQLLGAWCLLNSLFLILNLSPTALADKGKEKDPLAALRVRDILSR
                     TKEGVGSPKLGPGKGHQGFGVLSVILANHAIKLLTSLFQDLQVEALHKGWETDGPPAA
                     LSIMAQSTSIQRIQRLIDSVPLMNLLLTLLSTSYRKACVLQRQRKGSMSSDASASTDS
                     NTYYEDDFSSTEEDSSQDDDSEPILGQWFEETISPSKEKAAPPPPPPPPPLESSPRVK
                     SPSKQAPGEKGNILASRKDPELFLGLASNILNFITSSMLNSRNNFIRNYLSVSLSEHH
                     MATLASIIKEVDKDGLKGSSDEEFAAALYHFNHSLVTSDLQSPNLQNTLLQQLGVAPF
                     SEGPWPLYIHPQSLSVLSRLLLIWQHKASAQGDPDVPECLKVWDRFLSTMKQNALQGV
                     VPSETEDLNVEHLQMLLLIFHNFTETGRRAILSLFVQIIQELSVNMDAQMRFVPLILA
                     RLLLIFDYLLHQYSKAPVYLFEQVQHNLLSPPFGWASGSQDSNSRRATTPLYHGFKEV
                     EENWSKHFSSDAVPHPRFYCVLSPEASEDDLNRLDSVACDVLFSKLVKYDELYAALTA
                     LLAAGSQLDTVRRKENKNVTALEACALQYYFLILWRILGILPPSKTYINQLSMNSPEM
                     SECDILHTLRWSSRLRISSYVNWIKDHLIKQGMKAEHASSLLELASTTKCSSVKYDVE
                     IVEEYFARQISSFCSIDCTTILQLHEIPSLQSIYTLDAAISKVQVSLDEHFSKMAAET
                     DPHKSSEITKNLLPATLQLIDTYASFTRAYLLQNFNEEGTTEKPSKEKLQGFAAVLAI
                     GSSRCKANTLGPTLVQNLPSSVQTVCESWNNINTNEFPNIGSWRNAFANDTIPSESYI
                     SAVQAAHLGTLCSQSLPLAASLKHTLLSLVRLTGDLIVWSDEMNPPQVIRTLLPLLLE
                     SSTESVAEISSNSLERILGPAESDEFLARVYEKLITGCYNILANHADPNSGLDESILE
                     ECLQYLEKQLESSQARKAMEEFFSDSGELVQIMMATANENLSAKFCNRVLKFFTKLFQ
                     LTEKSPNPSLLHLCGSLAQLACVEPVRLQAWLTRMTTSPPKDSDQLDVIQENRQLLQL
                     LTTYIVRENSQVGEGVCAVLLGTLTPMATEMLANGDGTGFPELMVVMATLASAGQGAG
                     HLQLHNAAVDWLSRCKKYLSQKNVVEKLNANVMHGKHVMILECTCHIMSYLADVTNAL
                     SQSNGQGPSHLSVDGEERAIEVDSDWVEELAVEEEDSQAEDSDEDSLCNKLCTFTITQ
                     KEFMNQHWYHCHTCKMVDGVGVCTVCAKVCHKDHEISYAKYGSFFCDCGAKEDGSCLA
                     LVKRTPSSGMSSTMKESAFQSEPRISESLVRHASTSSPADKAKVTISDGKVADEEKPK
                     KSSLCRTVEGCREELQNQANFSFAPLVLDMLNFLMDAIQTNFQQASAVGSSSRAQQAL
                     SELHTVEKAVEMTDQLMVPTLGSQEGAFENVRMNYSGDQGQTIRQLISAHVLRRVAMC
                     VLSSPHGRRQHLAVSHEKGKITVLQLSALLKQADSSKRKLTLTRLASAPVPFTVLSLT
                     GNPCKEDYLAVCGLKDCHVLTFSSSGSVSDHLVLHPQLATGNFIIKAVWLPGSQTELA
                     IVTADFVKIYDLCVDALSPTFYFLLPSSKIRDVTFLFNEEGKNIIVIMSSAGYIYTQL
                     MEEASSAQQGPFYVTNVLEINHEDLKQDSNSQVAGGGVSVYYSHVLQMLFFSYCQGKS
                     FAATISRTTLEVLQLFPINIKSFVVCSSNGGSKTSPALCQWSEVMNHPGLVCCVQQTT
                     GVPLVVMVKPDTFLIQEIKTLPAKAKIQDMVAIRHTACNEQQRTTMILLCEDGSLRIY
                     MANVENTSYWLQPSLQPSSVISIMKPVRKRKTATITTRTSSQVTFPIDFFEHNQQLTD
                     VEFGGNDLLQVYNAQQIKHRLNSTGMYVANTKPGGFTIEISNNNSTMVMTGMRIQIGT
                     QAIERAPSYIEIFGRTMQLNLSRSRWFDFPFTREEALQADKKLNLFIGASVDPAGVTM
                     IDAVKIYGKTKEQFGWPDEPPEEFPSASVSNICPSNLNQSNGTGDSDSAAPTTTSGTV
                     LESSETESLTKLDRLVVSSLEALESCFAVGPIIEKERNKNAAQELATLLLSLPAPASV
                     QQQSKSLLASLHTSRSAYHSHKDQALLSKAVQCLNTSSKEGKDLDPEVFQRLVITARS
                     IAIMRPNNLVHFTESKLPQMETDCFFPRCACWSLGIVGILIGAPLETPSPEGMDEGKE
                     PQKQLEGDCCSFITQLVNHFWKLHASKPKNAFLAPACLPGLTHIEATVNALVDIIHGY
                     CTCELDCINTASKIYMQMLLCPDPAVSFSCKQALIRVLRPRNKRRHVTLPSSPRSNTP
                     MDKDDDDDDDADEKMQSSGIPNGGHIRQESQEQSEVDHGDFEMVSESMVLETAENVNN
                     GNPSPLEALLAGAEGFPPMLDIPPDADDETMVELAIALSLQQDQQGSSSSALGLQSLG
                     LSGQAPSSSSLDAGTLSDTTASAPASDDEGSTAATDGSTLRTSPADHGGSVGSESGGS
                     AVDSVAGEHSVSGRSSAYGDATAEGHPAGPGSVSSSTGAISTTTGHQEGDGSEGEGEG
                     ETEGDVHTSNRLHMVRLMLLERLLQTLPQLRNVGGVRAIPYMQVILMLTTDLDGEDEK
                     DKGALDNLLSQLIAELGMDKKDVSKKNERSALNEVHLVVMRLLSVFMSRTKSGSKSSI
                     CESSSLISSATAAALLSSGAVDYCLHVLKSLLEYWKSQQNDEEPVATSQLLKPHTTSS
                     PPDMSPFFLRQYVKGHAADVFEAYTQLLTEMVLRLPYQIKKITDTNSRIPPPVFDHSW
                     FYFLSEYLMIQQTPFVRRQVRKLLLFICGSKEKYRQLRDLHTLDSHVRGIKKLLEEQG
                     IFLRASVVTASSGSALQYDTLISLMEHLKACAEIAAQRTINWQKFCIKDDSVLYFLLQ
                     VSFLVDEGVSPVLLQLLSCALCGSKVLAALAASSGSSSASSSSAPVAASSGQATTQSK
                     SSTKKSKKEEKEKEKDGETSGSQEDQLCTALVNQLNKFADKETLIQFLRCFLLESNSS
                     SVRWQAHCLTLHIYRNSSKSQQELLLDLMWSIWPELPAYGRKAAQFVDLLGYFSLKTP
                     QTEKKLKEYSQKAVEILRTQNHILTNHPNSNIYNTLSGLVEFDGYYLESDPCLVCNNP
                     EVPFCYIKLSSIKVDTRYTTTQQVVKLIGSHTISKVTVKIGDLKRTKMVRTINLYYNN
                     RTVQAIVELKNKPARWHKAKKVQLTPGQTEVKIDLPLPIVASNLMIEFADFYENYQAS
                     TETLQCPRCSASVPANPGVCGNCGENVYQCHKCRSINYDEKDPFLCNACGFCKYARFD
                     FMLYAKPCCAVDPIENEEDRKKAVSNINTLLDKADRVYHQLMGHRPQLENLLCKVNEA
                     APEKPQDDSGTAGGISSTSASVNRYILQLAQEYCGDCKNSFDELSKIIQKVFASRKEL
                     LEYDLQQREAATKSSRTSVQPTFTASQYRALSVLGCGHTSSTKCYGCASAVTEHCITL
                     LRALATNPALRHILVSQGLIRELFDYNLRRGAAAMREEVRQLMCLLTRDNPEATQQMN
                     DLIIGKVSTALKGHWANPDLASSLQYEMLLLTDSISKEDSCWELRLRCALSLFLMAVN
                     IKTPVVVENITLMCLRILQKLIKPPAPTSKKNKDVPVEALTTVKPYCNEIHAQAQLWL
                     KRDPKASYDAWKKCLPIRGIDGNGKAPSKSELRHLYLTEKYVWRWKQFLSRRGKRTSP
                     LDLKLGHNNWLRQVLFTPATQAARQAACTIVEALATIPSRKQQVLDLLTSYLDELSIA
                     GECAAEYLALYQKLITSAHWKVYLAARGVLPYVGNLITKEIARLLALEEATLSTDLQQ
                     GYALKSLTGLLSSFVEVESIKRHFKSRLVGTVLNGYLCLRKLVVQRTKLIDETQDMLL
                     EMLEDMTTGTESETKAFMAVCIETAKRYNLDDYRTPVFIFERLCSIIYPEENEVTEFF
                     VTLEKDPQQEDFLQGRMPGNPYSSNEPGIGPLMRDIKNKICQDCDLVALLEDDSGMEL
                     LVNNKIISLDLPVAEVYKKVWCTTNEGEPMRIVYRMRGLLGDATEEFIESLDSTTDEE
                     EDEEEVYKMAGVMAQCGGLECMLNRLAGIRDFKQGRHLLTVLLKLFSYCVKVKVNRQQ
                     LVKLEMNTLNVMLGTLNLALVAEQESKDSGGAAVAEQVLSIMEIILDESNAEPLSEDK
                     GNLLLTGDKDQLVMLLDQINSTFVRSNPSVLQGLLRIIPYLSFGEVEKMQILVERFKP
                     YCNFDKYDEDHSGDDKVFLDCFCKIAAGIKNNSNGHQLKDLILQKGITQNALDYMKKH
                     IPSAKNLDADIWKKFLSRPALPFILRLLRGLAIQHPGTQVLIGTDSIPNLHKLEQVSS
                     DEGIGTLAENLLEALREHPDVNKKIDAARRETRAEKKRMAMAMRQKALGTLGMTTNEK
                     GQVVTKTALLKQMEELIEEPGLTCCICREGYKFQPTKVLGIYTFTKRVALEEMENKPR
                     KQQGYSTVSHFNIVHYDCHLAAVRLARGREEWESAALQNANTKCNGLLPVWGPHVPES
                     AFATCLARHNTYLQECTGQREPTYQLNIHDIKLLFLRFAMEQSFSADTGGGGRESNIH
                     LIPYIIHTVLYVLNTTRATSREEKNLQGFLEQPKEKWVESAFEVDGPYYFTVLALHIL
                     PPEQWRATRVEILRRLLVTSQARAVAPGGATRLTDKAVKDYSAYRSSLLFWALVDLIY
                     NMFKKVPTSNTEGGWSCSLAEYIRHNDMPIYEAADKALKTFQEEFMPVETFSEFLDVA
                     GLLSEITDPESFLKDLLNSVP"
ORIGIN      
        1 gcagtagtac gacggaagat ggcgacgagc ggcggcgaag aggcggcggc agcggctccg
       61 gcgccgggga ccccggcaac gggggcggac acgaccccgg gctgggaggt ggctgtgcgg
      121 cccctgctgt ccgcgtccta ctccgccttc gagatgaagg agttgccgca gctggtggcc
      181 tcagtcatcg agagtgaatc agaaatcctg caccatgaga agcagtacga gccattctac
      241 tcatcttttg ttgcactttc cacacactat attacaacag tttgcagtct cattccccgg
      301 aaccaacttc agtcagtggc agcagcctgt aaagttctaa ttgagttttc tctcctgcgt
      361 ctggagaatc cagatgaggc ttgtgctgtg tcccagaaac acttgattct cctaatcaag
      421 ggcctgtgca ctggctgtag ccgactagat agaactgaaa ttatcacatt tacagcaatg
      481 atgaaatccg ccaagctgcc ccaaacagtg aagacacttt cagacgtgga agatcagaaa
      541 gagctggcct caccagtaag ccctgagttg aggcaaaagg aggtacagat gaattttttg
      601 aaccagctga cctcagtttt taaccctaga actgtagcat cacaacctat cagtacacag
      661 actctggtgg aaggagaaaa tgatgagcag tcatctacag atcaagcctc agctatcaaa
      721 accaagaatg tgttcatagc tcagaacgtg gctagtcttc aagagcttgg tggctcggag
      781 aagctactgc gtgtatgttt gaacctgcca tatttcctac gctatatcaa tcggttccaa
      841 gatgcagttt tagctaattc cttcttcata atgcctgcaa cagtagcaga tgccactgct
      901 gttcgtaatg gctttcattc attggtgatt gatgtaacta tggcattgga taccctttct
      961 ctacctgtgt tggaacctct caatccttct cgtctacaag atgtgacagt cctcagccta
     1021 agttgtctgt atgcaggtgt gagtgtggca acgtgcatgg ccatcctcca tgtgggtagt
     1081 gcccagcaag tgcggacagg gtccacgagc tccaaagaag atgactatga aagtgacgca
     1141 gctacaattg tccagaaatg tctcgaaatc tatgacatga ttggacaagc aatcagcagt
     1201 tctcgccggg ctggtggtga gcactatcag aatttccaat tgctgggtgc ttggtgcttg
     1261 ttaaacagcc ttttcctcat actgaacctc agtcctactg cgttggctga taaggggaaa
     1321 gagaaggacc cactggctgc cctccgagtc agagacatcc tttctcgtac taaagaggga
     1381 gtgggctccc ctaaactggg gcctggaaaa gggcatcagg gatttggggt actctcagta
     1441 atattggcaa accatgccat caaactgcta acgtctctct ttcaagacct acaagtggag
     1501 gcccttcaca agggttggga gacagatggc ccccctgcag ccttgagcat tatggcccag
     1561 agcacctcca tacagaggat tcaacggctg attgactctg tcccactgat gaacctgctc
     1621 ttgacgttac tttcaacttc ctacagaaag gcatgtgtcc tgcagcggca gaggaagggc
     1681 tccatgagca gcgatgccag cgcctccacc gactccaata cttactatga ggacgatttc
     1741 agtagcacgg aggaggacag cagccaagac gatgacagtg agcctatttt ggggcaatgg
     1801 tttgaggaga ctatttctcc cagtaaagag aaagcagcac ctccgcctcc tcccccacct
     1861 cctccactgg aaagctctcc tcgggttaaa agccccagta agcaggcccc tggtgagaag
     1921 ggcaacattc tggcgagtcg caaagatcct gagttgttct taggtctggc ttccaacatt
     1981 ttgaacttca tcacctcttc catgctgaac tctcggaaca attttatccg aaactatctg
     2041 agtgtatctc tttcagaaca ccatatggcc accctagcca gtatcatcaa ggaggtggac
     2101 aaagatggac tcaagggttc atcagatgaa gagtttgctg cagctctcta tcacttcaac
     2161 cactcactgg taacctctga ccttcagtca cctaacctgc agaacacact gttgcagcag
     2221 ctaggagtgg ctcctttttc tgagggccct tggcccttgt acattcaccc tcaaagcctc
     2281 tctgtgcttt cacgcctcct gctcatctgg caacataaag ccagtgctca aggtgaccct
     2341 gacgtcccag aatgccttaa agtttgggac aggtttttgt ctacaatgaa gcagaatgcc
     2401 ctgcaaggtg tggtgcccag tgagacagag gatctgaatg tagaacacct gcagatgctc
     2461 ctcctcattt tccacaattt caccgagaca ggccggcggg ccatattgtc gctttttgtc
     2521 cagatcatcc aggagttgag cgtcaacatg gatgctcaga tgcgcttcgt gccgcttatc
     2581 ttggctcgcc tccttctcat ctttgattat ctgcttcatc agtactccaa agcccctgtg
     2641 tatctatttg agcaggtaca gcataacctg ctaagtcctc cctttgggtg ggcaagtgga
     2701 tcccaggaca gcaacagccg ccgggcaacc actcctctct atcatggatt caaagaagta
     2761 gaagaaaact ggtctaagca tttctcatca gatgctgtcc cacaccccag attctactgt
     2821 gtcctgtccc cagaagcctc agaggatgat ttgaaccgac ttgattctgt ggcatgtgac
     2881 gtccttttct ccaagcttgt caagtatgat gagctttatg ctgcactgac agccctgctt
     2941 gcagctgggt cccagcttga tacagttagg agaaaggaaa acaagaatgt aacagccttg
     3001 gaggcctgtg cccttcaata ttacttcttg atactgtgga ggatcctagg aattttacca
     3061 ccatcaaaga cttacattaa ccagctatcc atgaactcac ctgagatgag cgaatgtgac
     3121 atcttgcaca ctctgcgatg gtcttctcgg ctccggatca gctcctatgt caactggata
     3181 aaggatcacc ttatcaaaca gggaatgaag gctgagcatg ctagctcgct tctagaactg
     3241 gcatccacca ctaagtgtag ctcagtgaaa tatgatgttg aaatagtaga ggaatacttc
     3301 gctcgacaga tctcatcctt ctgtagtatc gactgtacca ccatcttgca gctgcatgaa
     3361 attcccagtc tgcagtccat ctacaccctt gatgccgcga tctcaaaggt ccaggtctct
     3421 ttggatgagc atttttctaa gatggctgct gagactgatc ctcataagtc gtctgagatt
     3481 accaagaacc tacttccagc cacgctgcaa ctcattgaca cctatgcatc gttcaccaga
     3541 gcctatttgc tgcaaaactt taatgaagag ggaacaactg agaaaccttc caaggagaaa
     3601 ctgcaaggct ttgctgctgt tttggctatt ggctctagca ggtgcaaggc aaatactctg
     3661 ggtccgacac tggttcagaa tttgccatcg tcagtgcaga ctgtgtgtga gtcctggaac
     3721 aacatcaata ccaatgaatt tcccaatatt ggatcctggc gcaatgcctt tgccaatgac
     3781 accatccctt cagagagtta tattagtgca gtgcaggctg cacacctggg gactctctgt
     3841 agccaaagtc tgcccctggc tgcttccctg aagcataccc tcctctcact ggtcaggttg
     3901 actggagatc ttattgtttg gtcagatgag atgaacccac cacaggtaat tcggacactg
     3961 ctacctcttc ttttggaatc aagcactgag agtgttgccg agatcagtag caactccctg
     4021 gaacgcatct tgggccctgc tgagtctgat gagttcttgg ctcgtgttta tgagaagctg
     4081 atcactggtt gttacaacat tctggccaat catgcagatc ctaacagtgg actggatgaa
     4141 tccatcctgg aggaatgtct ccagtacttg gaaaagcagc tggaaagtag ccaggctcgt
     4201 aaagctatgg aggagttttt ctctgacagt ggagaacttg tacagatcat gatggcaaca
     4261 gccaatgaga acctctctgc taaattctgt aaccgagttt tgaaattctt caccaaactc
     4321 ttccagctga ctgagaagag ccctaacccg agcctgttgc atctctgtgg ctccctggca
     4381 caactggcct gtgtggaacc tgtgcgcctg caggcctggc tcacccgcat gactacatcg
     4441 cccccaaaag attctgatca gctggatgta attcaggaga accggcagct gctgcagtta
     4501 ctgaccacat acattgttcg ggaaaacagc caagttgggg aaggtgtgtg tgctgttctt
     4561 ctgggcaccc tgactcccat ggcaacagag atgctggcca acggtgatgg gactggcttc
     4621 cctgaactta tggttgtgat ggccactctg gccagtgcag gtcaaggtgc tggtcacctt
     4681 cagcttcata atgctgctgt ggattggctg agcagatgca agaaatacct gtcacagaag
     4741 aatgtagttg aaaaactgaa tgccaatgta atgcatggaa agcatgtgat gatcttggag
     4801 tgcacatgcc atatcatgtc ttacttggct gatgtcacga atgccctgag ccagagtaat
     4861 ggtcaaggcc caagtcatct ctcagtggat ggggaagagc gggccattga agtagactca
     4921 gactgggtgg aggagttggc ggtggaagag gaagattccc aggctgagga ttcagatgaa
     4981 gattctcttt gcaataaact ctgcactttt acgatcacac agaaagaatt catgaaccag
     5041 cattggtacc actgtcacac ctgtaaaatg gtggatggcg tgggtgtctg cacagtgtgt
     5101 gctaaggtgt gccacaagga tcatgagatt tcctatgcca agtatggatc cttcttctgt
     5161 gactgtggag ccaaggaaga tggcagctgt ttggctctgg tgaagagaac tcctagcagt
     5221 ggcatgagct ctaccatgaa ggagtcggca tttcagagtg aacccaggat ttcagagagt
     5281 ctagtgcgtc atgccagcac ctcctcgcca gctgacaaag ccaaggttac catcagtgat
     5341 ggaaaggttg ctgacgaaga gaagcccaag aagagcagcc tctgccgcac agtagagggc
     5401 tgccgggagg aattacagaa ccaggccaat ttctccttcg ctcctctcgt gttagacatg
     5461 cttaatttcc ttatggatgc cattcagacc aacttccagc aagcttcagc cgtcgggagc
     5521 agcagccgtg ctcagcaagc cctcagtgag ctacacactg tggagaaggc agtggagatg
     5581 acagaccagc tgatggttcc caccttaggg tcccaggaag gtgcctttga gaatgtgcgg
     5641 atgaattaca gtggagacca gggccagacc atccggcagc tgatcagtgc tcatgtgctc
     5701 aggcgggtgg ctatgtgtgt gctctcctct ccccatgggc gccgccaaca tttggctgtc
     5761 agccatgaga agggcaagat caccgttctg cagctctctg cactcctgaa gcaagcagat
     5821 tccagcaaaa ggaagttaac tctgacccgc ttggcttctg ccccagttcc ttttactgtg
     5881 ttgagcctca caggaaatcc ctgcaaggaa gactacttgg cggtttgtgg gctaaaggac
     5941 tgtcatgtgc tcacctttag tagctcaggc tctgtttcgg atcacttggt tttgcaccct
     6001 cagttggcaa cggggaactt catcatcaaa gccgtgtggt tacctggttc acagaccgag
     6061 ttagcaattg tcaccgcaga ctttgttaag atttatgacc tgtgtgttga tgccttgagt
     6121 ccaaccttct attttctcct gccaagctca aagataagag atgttacctt ccttttcaat
     6181 gaggagggaa agaacatcat tgttataatg tcttcggctg ggtacatcta tactcagctt
     6241 atggaagagg ccagcagtgc ccagcaggga cccttctatg tcactaatgt gttggaaatc
     6301 aatcatgagg acctgaagca ggacagtaac agccaggtgg cgggcggtgg tgtgtccgtg
     6361 tactactccc acgtgttgca gatgttgttc ttcagctatt gtcaaggcaa atcattcgca
     6421 gccaccatca gcaggacaac cctggaggtg ttgcaactct tccccatcaa catcaaaagt
     6481 tttgttgtct gcagttccaa tggtggcagt aagacttctc ctgctctttg ccagtggtct
     6541 gaggtgatga accaccctgg cttggtgtgc tgtgtccagc aaactacagg ggtgccgctg
     6601 gtagttatgg tgaaaccaga cacttttctt atccaggaga ttaagactct tcctgctaaa
     6661 gcgaagatcc aagacatggt tgctattagg cacacggcct gcaatgagca gcagcggaca
     6721 acaatgattc tgctgtgtga ggatggcagc ctgcgcattt acatggccaa cgtggagaac
     6781 acctcctact ggctgcagcc atccctgcag cccagcagtg tcatcagcat catgaagcct
     6841 gttcgaaagc gcaaaacagc tacaatcaca acccgcacgt ctagccaggt gactttcccc
     6901 attgactttt ttgaacacaa ccagcagctg acagatgtgg agtttggtgg taacgacctc
     6961 ctacaggtct ataatgcaca acagataaaa caccggctga attccactgg catgtatgtg
     7021 gccaacacca agcccggagg cttcaccatt gagattagta acaacaatag cactatggtg
     7081 atgacaggca tgcggatcca gattgggact caagcaatag aacgggcccc gtcatatatc
     7141 gagatcttcg gcagaactat gcagctcaac ctgagtcgct cacgctggtt tgacttcccc
     7201 ttcaccagag aagaagccct gcaggctgat aagaagctga acctcttcat tggggcctcg
     7261 gtggatccag caggtgtcac catgatagat gctgtaaaaa tttatggcaa gactaaggag
     7321 cagtttggct ggcctgatga gcccccagaa gaattccctt ctgcctctgt cagcaacatc
     7381 tgcccttcaa atctgaacca gagcaacggc actggagata gcgactcagc tgcccccact
     7441 acgaccagtg gaactgtcct ggagagttct gaaactgagt ccctaaccaa gctggaccgg
     7501 ctggttgtga gttctttaga agccctggaa agctgctttg ccgttggccc aatcatcgag
     7561 aaggagagaa acaagaatgc tgctcaggag ctggccactt tgctgttgtc cctgccagca
     7621 cctgccagtg tccagcagca gtccaagagc cttctggcca gcctgcacac cagccgctcg
     7681 gcctaccaca gccacaagga tcaggccttg ctgagcaaag ctgtgcagtg tctcaacaca
     7741 tctagcaaag agggcaagga tttggaccct gaggtgttcc agaggctagt gatcacagct
     7801 cgctccattg ccatcatgcg ccccaacaac cttgtccact ttacggagtc aaagctgccc
     7861 cagatggaaa cagactgttt ttttcctaga tgtgcctgct ggagtctagg gatagttggc
     7921 atattgattg gggccccact tgaaactccc tccccagaag gaatggatga agggaaggaa
     7981 ccgcagaagc agttggaagg agattgctgt agtttcatca cccagcttgt gaaccacttc
     8041 tggaaactcc atgcatccaa acccaagaat gccttcttgg cacctgcctg ccttccagga
     8101 ctaactcata ttgaagctac tgtcaatgct ctggtggaca tcatccatgg ctactgtacc
     8161 tgtgagctgg attgtattaa cacagcatcc aagatctaca tgcagatgct cttgtgtcct
     8221 gatcctgctg tgagcttctc ttgtaaacaa gctctaattc gagtcctaag gcccaggaac
     8281 aaacggagac atgtgacttt accctcttcc cctcgaagca acactccaat ggacaaggat
     8341 gatgatgacg atgatgatgc agatgagaaa atgcagtcat cagggatccc gaatggtggt
     8401 cacatccgtc aggaaagcca ggaacagagt gaggtggacc atggagattt tgagatggtg
     8461 tctgagtcga tggtcctgga gacagctgaa aatgtcaaca atggcaaccc ctctcccctg
     8521 gaggccctgc tggcaggcgc agagggcttc ccccccatgc tggacatccc acctgatgca
     8581 gatgacgaga ccatggttga actagccatt gccctgagcc tgcagcagga ccaacaaggc
     8641 agcagcagca gtgccctggg cctgcagagc ctgggactgt ccggccaggc acccagctct
     8701 tcctctctgg acgcaggaac cctctctgac accacagcat cagctccagc ctcagacgac
     8761 gagggcagta cagcagcgac agatggttct acccttcgga cctctcctgc tgaccacggt
     8821 ggtagtgtgg gctcggagag cgggggcagt gcagtggact cagtggctgg cgagcacagt
     8881 gtatctggcc ggagcagtgc ttatggcgat gctacagctg aggggcatcc ggctggacca
     8941 ggaagtgtca gctcaagcac tggagccatc agcaccacca ctgggcacca ggagggagat
     9001 ggctccgagg gagaaggaga aggagaaact gaaggagatg tccacactag caacaggctg
     9061 cacatggtcc gtctaatgct gttggagaga ttactgcaga ccctgcctca attacgaaac
     9121 gttggcggtg tccgggccat cccatacatg caggtcattc taatgctcac tacagatctg
     9181 gatggagaag atgagaaaga caagggggcc ctagacaacc tgctctccca gcttattgct
     9241 gagttgggta tggataaaaa ggatgtctcc aagaagaatg agcgcagcgc cctgaatgaa
     9301 gtccatctgg tagtaatgag actcctgagt gtcttcatgt cccgcaccaa atctggatcc
     9361 aagtcttcca tatgtgagtc atcttccctc atctccagtg ccacagcagc agctctactg
     9421 agctctgggg ctgtggacta ctgcctgcac gtgctcaaat cactgctgga atattggaag
     9481 agccaacaga atgacgagga gcctgtggct accagccagt tgctgaaacc acatactacc
     9541 tcctccccac ctgacatgag cccattcttt ctccgccagt atgtgaaggg tcatgctgct
     9601 gatgtgtttg aggcctatac tcagcttcta acagaaatgg tactgaggct tccttaccaa
     9661 atcaaaaaga ttactgacac caattctcga atcccacctc ctgtctttga ccactcgtgg
     9721 ttttactttc tctccgagta cctcatgatc cagcagactc catttgtgcg ccgtcaagtc
     9781 cgcaaacttc tgctcttcat ctgtggatcc aaagagaagt accgccagct ccgggatttg
     9841 cacaccctgg actctcacgt gcgtgggatc aagaagctgc tagaagagca ggggatattc
     9901 ctccgggcaa gtgtggttac agccagctca ggctccgcct tgcaatatga cacactcatc
     9961 agcctgatgg agcacctgaa agcctgtgca gagattgccg cccagcgaac catcaactgg
    10021 cagaaattct gcatcaaaga tgactccgtc ctgtacttcc tcctccaagt cagtttcctt
    10081 gtggatgagg gcgtgtcccc agtgctgctg caactgctct cctgtgctct gtgcggcagc
    10141 aaggtgctcg ctgcactggc agcctcttcg ggatcctcca gtgcttcttc ctcctcagcc
    10201 cctgtggctg ccagttctgg acaagccaca acacagtcca agtcttccac taaaaagagc
    10261 aagaaagaag aaaaagaaaa ggagaaagat ggtgagacct ctggcagcca ggaggaccag
    10321 ctgtgcacag ctctggtgaa ccagctgaac aaatttgccg ataaggaaac cctgatccag
    10381 ttcctgcgtt gtttcctgtt agagtccaat tcttcctcgg tgcgctggca ggcccactgt
    10441 ctgacactgc acatctacag aaattccagc aaatctcaac aggagctcct gctagatctg
    10501 atgtggtcca tctggccaga actcccagcc tatggtcgta aggctgccca gtttgtggac
    10561 ctactaggat atttctccct gaaaactcca caaacagaga agaagttgaa ggagtattca
    10621 cagaaggctg tggagattct gcggactcaa aaccatattc ttaccaacca ccccaactcg
    10681 aacatttata acactttgtc tggcttagtg gagtttgatg gctattacct ggagagcgat
    10741 ccctgcctgg tgtgtaataa cccggaagta ccgttctgtt atatcaagct gtcttccatt
    10801 aaagtggaca cgcggtacac caccacccag caggttgtga agctcattgg cagtcacacc
    10861 atcagcaaag tgacagtgaa aatcggggat ctgaaacgga ccaagatggt gcggaccatc
    10921 aacctgtatt ataacaaccg aaccgtgcag gccatcgtgg agttgaaaaa caagccagct
    10981 cgctggcaca aagccaagaa ggttcagctg acccctggac agacagaggt gaagattgac
    11041 ctgccgttgc ccattgtggc ctccaatctg atgattgagt ttgcagactt ctatgaaaac
    11101 taccaggcct ccacagagac cctgcagtgc cctcgctgta gtgcctcggt ccctgccaac
    11161 ccaggagtct gtggcaactg tggagagaat gtgtaccagt gtcacaaatg cagatccatc
    11221 aactacgatg aaaaggatcc cttcctctgc aatgcctgtg gcttctgtaa atatgcccgc
    11281 ttcgacttca tgctctatgc caagccttgc tgtgcagtgg atcccattga gaatgaagaa
    11341 gaccggaaga aggctgtatc caacatcaat acacttttgg acaaagctga tcgagtgtat
    11401 catcagctga tgggacaccg gccacagctg gagaacctgc tctgcaaagt gaatgaggca
    11461 gctccagaaa agccacagga tgactcagga acagcagggg gcatcagctc cacttctgcc
    11521 agtgtgaatc gttacatcct gcagttggct caggagtatt gtggagactg caagaactct
    11581 tttgatgaac tctccaaaat catccagaaa gtctttgctt cgcgcaaaga gttgttggaa
    11641 tatgacctac agcagaggga agcagccact aaatcatccc ggacctccgt gcagcccaca
    11701 ttcactgcca gccagtaccg tgccttatcc gtcctgggct gtggccacac atcctccacc
    11761 aagtgctatg gctgcgcctc ggctgtcaca gaacattgta tcacactact tcgggccctg
    11821 gccaccaacc cagccttgag gcacatcctt gtctcccagg gccttatccg ggagctcttt
    11881 gattataatc ttcgccgagg ggctgcggcc atgcgggagg aggtccgcca gctcatgtgc
    11941 ctcctaactc gagacaaccc agaagccacc caacagatga atgacctgat tattggcaag
    12001 gtctccacag ccctgaaggg ccactgggcc aaccccgatc tggcaagtag cctgcagtat
    12061 gaaatgctgc tgctgacgga ttctatctcc aaggaggaca gctgctggga gctccggtta
    12121 cgctgtgctc tcagcctttt cctcatggct gtgaacatta agactcctgt ggtggttgaa
    12181 aacattaccc tcatgtgcct gaggatcttg cagaagctga taaaaccacc tgctcccact
    12241 agcaagaaga acaaggatgt ccccgttgag gccctcacca cggtgaagcc atactgcaat
    12301 gagatccatg cccaggctca actgtggctc aagagagacc ccaaggcatc ctatgatgcc
    12361 tggaagaagt gtcttcctat cagagggata gatggcaatg ggaaagcccc cagcaaatca
    12421 gagctccgcc atctctattt gactgagaag tatgtgtgga ggtggaaaca gttcctgagt
    12481 cgtcggggga agaggacctc ccccttggat ctcaaactgg ggcataacaa ctggctgcga
    12541 caagtgcttt tcactccagc aacgcaggcc gcacggcagg cagcctgtac cattgtggaa
    12601 gctctagcca ccattcccag ccgcaagcag caggtcctgg acctgcttac cagttacctg
    12661 gatgagctga gcatagctgg ggagtgtgca gctgagtacc tggctctcta ccagaagctc
    12721 atcacttctg cgcactggaa agtctacttg gcagctcggg gagtcctacc ctatgtgggc
    12781 aacctcatca ccaaggaaat agctcgtctg ctggccctgg aggaggctac cctgagtacc
    12841 gatctgcagc agggttatgc ccttaaaagt ctcacaggcc ttctctcctc ctttgttgag
    12901 gtggaatcca tcaaaagaca ttttaaaagt cgcttggtgg gtactgtgct gaatggatac
    12961 ctgtgcttgc ggaagctggt ggtgcagagg accaagctga tcgatgagac gcaggacatg
    13021 ctgctggaga tgctggagga catgaccaca ggtacagaat cagaaaccaa ggccttcatg
    13081 gctgtgtgca ttgagacagc caagcgctac aatctggatg actaccggac cccggtgttc
    13141 atcttcgaga ggctctgcag catcatttat cctgaggaga atgaagtcac tgagttcttt
    13201 gtgaccctgg agaaggatcc ccaacaagaa gacttcttac agggcaggat gcctgggaac
    13261 ccgtatagca gcaatgagcc aggcatcggg ccgctgatga gggatataaa gaacaagatt
    13321 tgccaggact gtgacttagt ggccctcctg gaagatgaca gtggcatgga gcttctagtg
    13381 aacaataaaa tcattagttt ggaccttcct gtggctgaag tttacaagaa agtctggtgt
    13441 accacgaatg agggagagcc catgaggatt gtttatcgta tgcgggggct gctgggcgat
    13501 gccacagagg agttcattga gtccctggac tctactacag atgaagaaga agatgaagaa
    13561 gaagtgtata aaatggctgg tgtgatggcc cagtgtgggg gcctggaatg catgcttaac
    13621 agactcgcag ggatcagaga tttcaagcag ggacgccacc ttctaacagt gctactgaaa
    13681 ttgttcagtt actgcgtgaa ggtgaaagtc aaccggcagc aactggtcaa actggaaatg
    13741 aacaccttga acgtcatgct ggggacccta aacctggccc ttgtagctga acaagaaagc
    13801 aaggacagtg ggggtgcagc tgtggctgag caggtgctta gcatcatgga gatcattcta
    13861 gatgagtcca atgctgagcc cctgagtgag gacaagggca acctcctcct gacaggtgac
    13921 aaggatcaac tggtgatgct cttggaccag atcaacagca cctttgttcg ctccaacccc
    13981 agtgtgctcc agggcctgct tcgcatcatc ccgtaccttt cctttggaga ggtggagaaa
    14041 atgcagatct tggtggagcg attcaaacca tactgcaact ttgataaata tgatgaagat
    14101 cacagtggtg atgataaagt cttcctggac tgcttctgta aaatagctgc tggcatcaag
    14161 aacaacagca atgggcacca gctgaaggat ctgattctcc agaaggggat cacccagaat
    14221 gcacttgact acatgaaaaa gcacatccct agcgccaaga atttggatgc cgacatctgg
    14281 aaaaagtttt tgtctcgccc agccttgcca tttatcctaa ggctgcttcg gggcctggcc
    14341 atccagcacc ctggcaccca ggttctgatt ggaactgatt ccatcccgaa cctgcataag
    14401 ctggagcagg tgtccagtga tgagggcatt gggaccttgg cagagaacct gctggaagcc
    14461 ctgcgggaac accctgacgt aaacaagaag attgacgcag cccgcaggga gacccgggca
    14521 gagaagaagc gcatggccat ggcaatgagg cagaaggccc tgggcaccct gggcatgacg
    14581 acaaatgaaa agggccaggt cgtgaccaag acagcactcc tgaagcagat ggaagagctg
    14641 atcgaggagc ctggcctcac gtgctgcatc tgcagggagg gatacaagtt ccagcccaca
    14701 aaggtcctgg gcatttatac cttcacgaag cgggtagcct tggaggagat ggagaataag
    14761 ccccggaaac agcagggcta cagcaccgtg tcccacttca acattgtgca ctacgactgc
    14821 catctggctg ccgtcaggtt ggctcgaggc cgggaagagt gggagagtgc cgccctgcag
    14881 aatgccaaca ccaagtgcaa cgggctcctt ccggtctggg gacctcatgt ccctgaatca
    14941 gcttttgcca cttgcttggc aagacacaac acttacctcc aggaatgtac aggccagcgg
    15001 gagcccacgt atcagctcaa catccatgac atcaaactgc tcttcctgcg cttcgccatg
    15061 gagcagtcgt tcagcgcaga cactggcggg ggcggccggg agagcaacat ccacctgatc
    15121 ccgtacatca ttcacactgt gctttacgtc ctgaacacaa cccgagcaac ttcccgagaa
    15181 gagaagaacc tccaaggctt tctggaacag cccaaggaga agtgggtgga gagtgccttt
    15241 gaagtggacg ggccctacta tttcacagtc ttggcccttc acatcctgcc ccctgagcag
    15301 tggagagcca cacgtgtgga aatcttgcgg aggctgttgg tgacctcgca ggctcgggca
    15361 gtggctccag gtggagccac caggctgaca gataaggcag tgaaggacta ttccgcttac
    15421 cgttcttccc ttctcttttg ggccctcgtc gatctcattt acaacatgtt taagaaggtg
    15481 cctaccagta acacagaggg aggctggtcc tgctctctcg ctgagtacat ccgccacaac
    15541 gacatgccca tctacgaagc tgccgacaaa gccctgaaaa ccttccagga ggagttcatg
    15601 ccagtggaga ccttctcaga gttcctcgat gtggccggtc ttttatcaga aatcaccgat
    15661 ccagagagct tcctgaagga cctgttgaac tcagtcccct gaccaccaca cagcagctgc
    15721 ggcggcgaag acgaagctgg cttgccttcc accctctgtt ctccctcctt gtgcattaag
    15781 ttccctccgc gggatgctgc attgttaccc cgccctcccc tctctcattt ttcttggtgt
    15841 ggcttggggt ttttaggctt cctgttttat ctcgtgtgtg tggtgcacca gctatgaggt
    15901 tgtctgtaac ccaagccatc aaagggcctg tacataccta ggagccatga gttgtcccgg
    15961 ccagcttcat acttgagtgt gcacatcttg agaaataaac aagtgactta acacacattg
    16021 aaaa
//
