LOCUS       XM_011541114           16027 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens ubiquitin protein ligase E3 component
            n-recognin 4 (UBR4), transcript variant X1, mRNA.
ACCESSION   XM_011541114
VERSION     XM_011541114.4
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000001.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_011541114.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..16027
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
     gene            1..16027
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /note="ubiquitin protein ligase E3 component n-recognin 4;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 12 mRNAs, 364 ESTs, 4865 long SRA reads, 8
                     Proteins, and 100% coverage of the annotated genomic
                     feature by RNAseq alignments, including 16 samples with
                     support for all annotated introns"
                     /db_xref="GeneID:23352"
                     /db_xref="HGNC:HGNC:30313"
                     /db_xref="MIM:609890"
     CDS             19..15705
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase UBR4 isoform X1"
                     /protein_id="XP_011539416.3"
                     /db_xref="GeneID:23352"
                     /db_xref="HGNC:HGNC:30313"
                     /db_xref="MIM:609890"
                     /translation="MATSGGEEAAAAAPAPGTPATGADTTPGWEVAVRPLLSASYSAF
                     EMKELPQLVASVIESESEILHHEKQYEPFYSSFVALSTHYITTVCSLIPRNQLQSVAA
                     ACKVLIEFSLLRLENPDEACAVSQKHLILLIKGLCTGCSRLDRTEIITFTAMMKSAKL
                     PQTVKTLSDVEDQKELASPVSPELRQKEVQMNFLNQLTSVFNPRTVASQPISTQTLVE
                     GENDEQSSTDQASAIKTKNVFIAQNVASLQELGGSEKLLRVCLNLPYFLRYINRFQDA
                     VLANSFFIMPATVADATAVRNGFHSLVIDVTMALDTLSLPVLEPLNPSRLQDVTVLSL
                     SCLYAGVSVATCMAILHVGSAQQVRTGSTSSKEDDYESDAATIVQKCLEIYDMIGQAI
                     SSSRRAGGEHYQNFQLLGAWCLLNSLFLILNLSPTALADKGKEKDPLAALRVRDILSR
                     TKEGVGSPKLGPGKGHQGFGVLSVILANHAIKLLTSLFQDLQVEALHKGWETDGPPAA
                     LSIMAQSTSIQRIQRLIDSVPLMNLLLTLLSTSYRKACVLQRQRKGSMSSDASASTDS
                     NTYYEDDFSSTEEDSSQDDDSEPILGQWFEETISPSKEKAAPPPPPPPPPLESSPRVK
                     SPSKQAPGEKGNILASRKDPELFLGLASNILNFITSSMLNSRNNFIRNYLSVSLSEHH
                     MATLASIIKEVDKDGLKGSSDEEFAAALYHFNHSLVTSDLQSPNLQNTLLQQLGVAPF
                     SEGPWPLYIHPQSLSVLSRLLLIWQHKASAQGDPDVPECLKVWDRFLSTMKQNALQGV
                     VPSETEDLNVEHLQMLLLIFHNFTETGRRAILSLFVQIIQELSVNMDAQMRFVPLILA
                     RLLLIFDYLLHQYSKAPVYLFEQVQHNLLSPPFGWASGSQDSNSRRATTPLYHGFKEV
                     EENWSKHFSSDAVPHPRFYCVLSPEASEDDLNRLDSVACDVLFSKLVKYDELYAALTA
                     LLAAGSQLDTVRRKENKNVTALEACALQYYFLILWRILGILPPSKTYINQLSMNSPEM
                     SECDILHTLRWSSRLRISSYVNWIKDHLIKQGMKAEHASSLLELASTTKCSSVKYDVE
                     IVEEYFARQISSFCSIDCTTILQLHEIPSLQSIYTLDAAISKVQVSLDEHFSKMAAET
                     DPHKSSEITKNLLPATLQLIDTYASFTRAYLLQNFNEEGTTEKPSKEKLQGFAAVLAI
                     GSSRCKANTLGPTLVQNLPSSVQTVCESWNNINTNEFPNIGSWRNAFANDTIPSESYI
                     SAVQAAHLGTLCSQSLPLAASLKHTLLSLVRLTGDLIVWSDEMNPPQVIRTLLPLLLE
                     SSTESVAEISSNSLERILGPAESDEFLARVYEKLITGCYNILANHADPNSGLDESILE
                     ECLQYLEKQLESSQARKAMEEFFSDSGELVQIMMATANENLSAKFCNRVLKFFTKLFQ
                     LTEKSPNPSLLHLCGSLAQLACVEPVRLQAWLTRMTTSPPKDSDQLDVIQENRQLLQL
                     LTTYIVRENSQVGEGVCAVLLGTLTPMATEMLANGDGTGFPELMVVMATLASAGQGAG
                     HLQLHNAAVDWLSRCKKYLSQKNVVEKLNANVMHGKHVMILECTCHIMSYLADVTNAL
                     SQSNGQGPSHLSVDGEERAIEVDSDWVEELAVEEEDSQAEDSDEDSLCNKLCTFTITQ
                     KEFMNQHWYHCHTCKMVDGVGVCTVCAKVCHKDHEISYAKYGSFFCDCGAKEDGSCLA
                     LVKRTPSSGMSSTMKESAFQSEPRISESLVRHASTSSPADKAKVTISDGKVADEEKPK
                     KSSLCRTVEGCREELQNQANFSFAPLVLDMLNFLMDAIQTNFQQASAVGSSSRAQQAL
                     SELHTVEKAVEMTDQLMVPTLGSQEGAFENVRMNYSGDQGQTIRQLISAHVLRRVAMC
                     VLSSPHGRRQHLAVSHEKGKITVLQLSALLKQADSSKRKLTLTRLASAPVPFTVLSLT
                     GNPCKEDYLAVCGLKDCHVLTFSSSGSVSDHLVLHPQLATGNFIIKAVWLPGSQTELA
                     IVTADFVKIYDLCVDALSPTFYFLLPSSKIRDVTFLFNEEGKNIIVIMSSAGYIYTQL
                     MEEASSAQQGPFYVTNVLEINHEDLKQDSNSQVAGGGVSVYYSHVLQMLFFSYCQGKS
                     FAATISRTTLEVLQLFPINIKSFVVCSSNGGSKTSPALCQWSEVMNHPGLVCCVQQTT
                     GVPLVVMVKPDTFLIQEIKTLPAKAKIQDMVAIRHTACNEQQRTTMILLCEDGSLRIY
                     MANVENTSYWLQPSLQPSSVISIMKPVRKRKTATITTRTSSQVTFPIDFFEHNQQLTD
                     VEFGGNDLLQVYNAQQIKHRLNSTGMYVANTKPGGFTIEISNNNSTMVMTGMRIQIGT
                     QAIERAPSYIEIFGRTMQLNLSRSRWFDFPFTREEALQADKKLNLFIGASVDPAGVTM
                     IDAVKIYGKTKEQFGWPDEPPEEFPSASVSNICPSNLNQSNGTGDSDSAAPTTTSGTV
                     LESSETESLTKLDRLVVSSLEALESCFAVGPIIEKERNKNAAQELATLLLSLPAPASV
                     QQQSKSLLASLHTSRSAYHSHKDQALLSKAVQCLNTSSKEGKDLDPEVFQRLVITARS
                     IAIMRPNNLVHFTESKLPQMETDCFFPRCACWSLGIVGILIGAPLETPSPEGMDEGKE
                     PQKQLEGDCCSFITQLVNHFWKLHASKPKNAFLAPACLPGLTHIEATVNALVDIIHGY
                     CTCELDCINTASKIYMQMLLCPDPAVSFSCKQALIRVLRPRNKRRHVTLPSSPRSNTP
                     MGDKDDDDDDDADEKMQSSGIPNGGHIRQESQEQSEVDHGDFEMVSESMVLETAENVN
                     NGNPSPLEALLAGAEGFPPMLDIPPDADDETMVELAIALSLQQDQQGSSSSALGLQSL
                     GLSGQAPSSSSLDAGTLSDTTASAPASDDEGSTAATDGSTLRTSPADHGGSVGSESGG
                     SAVDSVAGEHSVSGRSSAYGDATAEGHPAGPGSVSSSTGAISTTTGHQEGDGSEGEGE
                     GETEGDVHTSNRLHMVRLMLLERLLQTLPQLRNVGGVRAIPYMQVILMLTTDLDGEDE
                     KDKGALDNLLSQLIAELGMDKKDVSKKNERSALNEVHLVVMRLLSVFMSRTKSGSKSS
                     ICESSSLISSATAAALLSSGAVDYCLHVLKSLLEYWKSQQNDEEPVATSQLLKPHTTS
                     SPPDMSPFFLRQYVKGHAADVFEAYTQLLTEMVLRLPYQIKKITDTNSRIPPPVFDHS
                     WFYFLSEYLMIQQTPFVRRQVRKLLLFICGSKEKYRQLRDLHTLDSHVRGIKKLLEEQ
                     GIFLRASVVTASSGSALQYDTLISLMEHLKACAEIAAQRTINWQKFCIKDDSVLYFLL
                     QVSFLVDEGVSPVLLQLLSCALCGSKVLAALAASSGSSSASSSSAPVAASSGQATTQS
                     KSSTKKSKKEEKEKEKDGETSGSQEDQLCTALVNQLNKFADKETLIQFLRCFLLESNS
                     SSVRWQAHCLTLHIYRNSSKSQQELLLDLMWSIWPELPAYGRKAAQFVDLLGYFSLKT
                     PQTEKKLKEYSQKAVEILRTQNHILTNHPNSNIYNTLSGLVEFDGYYLESDPCLVCNN
                     PEVPFCYIKLSSIKVDTRYTTTQQVVKLIGSHTISKVTVKIGDLKRTKMVRTINLYYN
                     NRTVQAIVELKNKPARWHKAKKVQLTPGQTEVKIDLPLPIVASNLMIEFADFYENYQA
                     STETLQCPRCSASVPANPGVCGNCGENVYQCHKCRSINYDEKDPFLCNACGFCKYARF
                     DFMLYAKPCCAVDPIENEEDRKKAVSNINTLLDKADRVYHQLMGHRPQLENLLCKVNE
                     AAPEKPQDDSGTAGGISSTSASVNRYILQLAQEYCGDCKNSFDELSKIIQKVFASRKE
                     LLEYDLQQREAATKSSRTSVQPTFTASQYRALSVLGCGHTSSTKCYGCASAVTEHCIT
                     LLRALATNPALRHILVSQGLIRELFDYNLRRGAAAMREEVRQLMCLLTRDNPEATQQM
                     NDLIIGKVSTALKGHWANPDLASSLQYEMLLLTDSISKEDSCWELRLRCALSLFLMAV
                     NIKTPVVVENITLMCLRILQKLIKPPAPTSKKNKDVPVEALTTVKPYCNEIHAQAQLW
                     LKRDPKASYDAWKKCLPIRGIDGNGKAPSKSELRHLYLTEKYVWRWKQFLSRRGKRTS
                     PLDLKLGHNNWLRQVLFTPATQAARQAACTIVEALATIPSRKQQVLDLLTSYLDELSI
                     AGECAAEYLALYQKLITSAHWKVYLAARGVLPYVGNLITKEIARLLALEEATLSTDLQ
                     QGYALKSLTGLLSSFVEVESIKRHFKSRLVGTVLNGYLCLRKLVVQRTKLIDETQDML
                     LEMLEDMTTGTESETKAFMAVCIETAKRYNLDDYRTPVFIFERLCSIIYPEENEVTEF
                     FVTLEKDPQQEDFLQGRMPGNPYSSNEPGIGPLMRDIKNKICQDCDLVALLEDDSGME
                     LLVNNKIISLDLPVAEVYKKVWCTTNEGEPMRIVYRMRGLLGDATEEFIESLDSTTDE
                     EEDEEEVYKMAGVMAQCGGLECMLNRLAGIRDFKQGRHLLTVLLKLFSYCVKVKVNRQ
                     QLVKLEMNTLNVMLGTLNLALVAEQESKDSGGAAVAEQVLSIMEIILDESNAEPLSED
                     KGNLLLTGDKDQLVMLLDQINSTFVRSNPSVLQGLLRIIPYLSFGEVEKMQILVERFK
                     PYCNFDKYDEDHSGDDKVFLDCFCKIAAGIKNNSNGHQLKDLILQKGITQNALDYMKK
                     HIPSAKNLDADIWKKFLSRPALPFILRLLRGLAIQHPGTQVLIGTDSIPNLHKLEQVS
                     SDEGIGTLAENLLEALREHPDVNKKIDAARRETRAEKKRMAMAMRQKALGTLGMTTNE
                     KGQVVTKTALLKQMEELIEEPGLTCCICREGYKFQPTKVLGIYTFTKRVALEEMENKP
                     RKQQGYSTVSHFNIVHYDCHLAAVRLARGREEWESAALQNANTKCNGLLPVWGPHVPE
                     SAFATCLARHNTYLQECTGQREPTYQLNIHDIKLLFLRFAMEQSFSADTGGGGRESNI
                     HLIPYIIHTVLYVLNTTRATSREEKNLQGFLEQPKEKWVESAFEVDGPYYFTVLALHI
                     LPPEQWRATRVEILRRLLVTSQARAVAPGGATRLTDKAVKDYSAYRSSLLFWALVDLI
                     YNMFKKVPTSNTEGGWSCSLAEYIRHNDMPIYEAADKALKTFQEEFMPVETFSEFLDV
                     AGLLSEITDPESFLKDLLNSVP"
ORIGIN      
        1 gcagtagtac gacggaagat ggcgacgagc ggcggcgaag aggcggcggc agcggctccg
       61 gcgccgggga ccccggcaac gggggcggac acgaccccgg gctgggaggt ggctgtgcgg
      121 cccctgctgt ccgcgtccta ctccgccttc gagatgaagg agttgccgca gctggtggcc
      181 tcagtcatcg agagtgaatc agaaatcctg caccatgaga agcagtacga gccattctac
      241 tcatcttttg ttgcactttc cacacactat attacaacag tttgcagtct cattccccgg
      301 aaccaacttc agtcagtggc agcagcctgt aaagttctaa ttgagttttc tctcctgcgt
      361 ctggagaatc cagatgaggc ttgtgctgtg tcccagaaac acttgattct cctaatcaag
      421 ggcctgtgca ctggctgtag ccgactagat agaactgaaa ttatcacatt tacagcaatg
      481 atgaaatccg ccaagctgcc ccaaacagtg aagacacttt cagacgtgga agatcagaaa
      541 gagctggcct caccagtaag ccctgagttg aggcaaaagg aggtacagat gaattttttg
      601 aaccagctga cctcagtttt taaccctaga actgtagcat cacaacctat cagtacacag
      661 actctggtgg aaggagaaaa tgatgagcag tcatctacag atcaagcctc agctatcaaa
      721 accaagaatg tgttcatagc tcagaacgtg gctagtcttc aagagcttgg tggctcggag
      781 aagctactgc gtgtatgttt gaacctgcca tatttcctac gctatatcaa tcggttccaa
      841 gatgcagttt tagctaattc cttcttcata atgcctgcaa cagtagcaga tgccactgct
      901 gttcgtaatg gctttcattc attggtgatt gatgtaacta tggcattgga taccctttct
      961 ctacctgtgt tggaacctct caatccttct cgtctacaag atgtgacagt cctcagccta
     1021 agttgtctgt atgcaggtgt gagtgtggca acgtgcatgg ccatcctcca tgtgggtagt
     1081 gcccagcaag tgcggacagg gtccacgagc tccaaagaag atgactatga aagtgacgca
     1141 gctacaattg tccagaaatg tctcgaaatc tatgacatga ttggacaagc aatcagcagt
     1201 tctcgccggg ctggtggtga gcactatcag aatttccaat tgctgggtgc ttggtgcttg
     1261 ttaaacagcc ttttcctcat actgaacctc agtcctactg cgttggctga taaggggaaa
     1321 gagaaggacc cactggctgc cctccgagtc agagacatcc tttctcgtac taaagaggga
     1381 gtgggctccc ctaaactggg gcctggaaaa gggcatcagg gatttggggt actctcagta
     1441 atattggcaa accatgccat caaactgcta acgtctctct ttcaagacct acaagtggag
     1501 gcccttcaca agggttggga gacagatggc ccccctgcag ccttgagcat tatggcccag
     1561 agcacctcca tacagaggat tcaacggctg attgactctg tcccactgat gaacctgctc
     1621 ttgacgttac tttcaacttc ctacagaaag gcatgtgtcc tgcagcggca gaggaagggc
     1681 tccatgagca gcgatgccag cgcctccacc gactccaata cttactatga ggacgatttc
     1741 agtagcacgg aggaggacag cagccaagac gatgacagtg agcctatttt ggggcaatgg
     1801 tttgaggaga ctatttctcc cagtaaagag aaagcagcac ctccgcctcc tcccccacct
     1861 cctccactgg aaagctctcc tcgggttaaa agccccagta agcaggcccc tggtgagaag
     1921 ggcaacattc tggcgagtcg caaagatcct gagttgttct taggtctggc ttccaacatt
     1981 ttgaacttca tcacctcttc catgctgaac tctcggaaca attttatccg aaactatctg
     2041 agtgtatctc tttcagaaca ccatatggcc accctagcca gtatcatcaa ggaggtggac
     2101 aaagatggac tcaagggttc atcagatgaa gagtttgctg cagctctcta tcacttcaac
     2161 cactcactgg taacctctga ccttcagtca cctaacctgc agaacacact gttgcagcag
     2221 ctaggagtgg ctcctttttc tgagggccct tggcccttgt acattcaccc tcaaagcctc
     2281 tctgtgcttt cacgcctcct gctcatctgg caacataaag ccagtgctca aggtgaccct
     2341 gacgtcccag aatgccttaa agtttgggac aggtttttgt ctacaatgaa gcagaatgcc
     2401 ctgcaaggtg tggtgcccag tgagacagag gatctgaatg tagaacacct gcagatgctc
     2461 ctcctcattt tccacaattt caccgagaca ggccggcggg ccatattgtc gctttttgtc
     2521 cagatcatcc aggagttgag cgtcaacatg gatgctcaga tgcgcttcgt gccgcttatc
     2581 ttggctcgcc tccttctcat ctttgattat ctgcttcatc agtactccaa agcccctgtg
     2641 tatctatttg agcaggtaca gcataacctg ctaagtcctc cctttgggtg ggcaagtgga
     2701 tcccaggaca gcaacagccg ccgggcaacc actcctctct atcatggatt caaagaagta
     2761 gaagaaaact ggtctaagca tttctcatca gatgctgtcc cacaccccag attctactgt
     2821 gtcctgtccc cagaagcctc agaggatgat ttgaaccgac ttgattctgt ggcatgtgac
     2881 gtccttttct ccaagcttgt caagtatgat gagctttatg ctgcactgac agccctgctt
     2941 gcagctgggt cccagcttga tacagttagg agaaaggaaa acaagaatgt aacagccttg
     3001 gaggcctgtg cccttcaata ttacttcttg atactgtgga ggatcctagg aattttacca
     3061 ccatcaaaga cttacattaa ccagctatcc atgaactcac ctgagatgag cgaatgtgac
     3121 atcttgcaca ctctgcgatg gtcttctcgg ctccggatca gctcctatgt caactggata
     3181 aaggatcacc ttatcaaaca gggaatgaag gctgagcatg ctagctcgct tctagaactg
     3241 gcatccacca ctaagtgtag ctcagtgaaa tatgatgttg aaatagtaga ggaatacttc
     3301 gctcgacaga tctcatcctt ctgtagtatc gactgtacca ccatcttgca gctgcatgaa
     3361 attcccagtc tgcagtccat ctacaccctt gatgccgcga tctcaaaggt ccaggtctct
     3421 ttggatgagc atttttctaa gatggctgct gagactgatc ctcataagtc gtctgagatt
     3481 accaagaacc tacttccagc cacgctgcaa ctcattgaca cctatgcatc gttcaccaga
     3541 gcctatttgc tgcaaaactt taatgaagag ggaacaactg agaaaccttc caaggagaaa
     3601 ctgcaaggct ttgctgctgt tttggctatt ggctctagca ggtgcaaggc aaatactctg
     3661 ggtccgacac tggttcagaa tttgccatcg tcagtgcaga ctgtgtgtga gtcctggaac
     3721 aacatcaata ccaatgaatt tcccaatatt ggatcctggc gcaatgcctt tgccaatgac
     3781 accatccctt cagagagtta tattagtgca gtgcaggctg cacacctggg gactctctgt
     3841 agccaaagtc tgcccctggc tgcttccctg aagcataccc tcctctcact ggtcaggttg
     3901 actggagatc ttattgtttg gtcagatgag atgaacccac cacaggtaat tcggacactg
     3961 ctacctcttc ttttggaatc aagcactgag agtgttgccg agatcagtag caactccctg
     4021 gaacgcatct tgggccctgc tgagtctgat gagttcttgg ctcgtgttta tgagaagctg
     4081 atcactggtt gttacaacat tctggccaat catgcagatc ctaacagtgg actggatgaa
     4141 tccatcctgg aggaatgtct ccagtacttg gaaaagcagc tggaaagtag ccaggctcgt
     4201 aaagctatgg aggagttttt ctctgacagt ggagaacttg tacagatcat gatggcaaca
     4261 gccaatgaga acctctctgc taaattctgt aaccgagttt tgaaattctt caccaaactc
     4321 ttccagctga ctgagaagag ccctaacccg agcctgttgc atctctgtgg ctccctggca
     4381 caactggcct gtgtggaacc tgtgcgcctg caggcctggc tcacccgcat gactacatcg
     4441 cccccaaaag attctgatca gctggatgta attcaggaga accggcagct gctgcagtta
     4501 ctgaccacat acattgttcg ggaaaacagc caagttgggg aaggtgtgtg tgctgttctt
     4561 ctgggcaccc tgactcccat ggcaacagag atgctggcca acggtgatgg gactggcttc
     4621 cctgaactta tggttgtgat ggccactctg gccagtgcag gtcaaggtgc tggtcacctt
     4681 cagcttcata atgctgctgt ggattggctg agcagatgca agaaatacct gtcacagaag
     4741 aatgtagttg aaaaactgaa tgccaatgta atgcatggaa agcatgtgat gatcttggag
     4801 tgcacatgcc atatcatgtc ttacttggct gatgtcacga atgccctgag ccagagtaat
     4861 ggtcaaggcc caagtcatct ctcagtggat ggggaagagc gggccattga agtagactca
     4921 gactgggtgg aggagttggc ggtggaagag gaagattccc aggctgagga ttcagatgaa
     4981 gattctcttt gcaataaact ctgcactttt acgatcacac agaaagaatt catgaaccag
     5041 cattggtacc actgtcacac ctgtaaaatg gtggatggcg tgggtgtctg cacagtgtgt
     5101 gctaaggtgt gccacaagga tcatgagatt tcctatgcca agtatggatc cttcttctgt
     5161 gactgtggag ccaaggaaga tggcagctgt ttggctctgg tgaagagaac tcctagcagt
     5221 ggcatgagct ctaccatgaa ggagtcggca tttcagagtg aacccaggat ttcagagagt
     5281 ctagtgcgtc atgccagcac ctcctcgcca gctgacaaag ccaaggttac catcagtgat
     5341 ggaaaggttg ctgacgaaga gaagcccaag aagagcagcc tctgccgcac agtagagggc
     5401 tgccgggagg aattacagaa ccaggccaat ttctccttcg ctcctctcgt gttagacatg
     5461 cttaatttcc ttatggatgc cattcagacc aacttccagc aagcttcagc cgtcgggagc
     5521 agcagccgtg ctcagcaagc cctcagtgag ctacacactg tggagaaggc agtggagatg
     5581 acagaccagc tgatggttcc caccttaggg tcccaggaag gtgcctttga gaatgtgcgg
     5641 atgaattaca gtggagacca gggccagacc atccggcagc tgatcagtgc tcatgtgctc
     5701 aggcgggtgg ctatgtgtgt gctctcctct ccccatgggc gccgccaaca tttggctgtc
     5761 agccatgaga agggcaagat caccgttctg cagctctctg cactcctgaa gcaagcagat
     5821 tccagcaaaa ggaagttaac tctgacccgc ttggcttctg ccccagttcc ttttactgtg
     5881 ttgagcctca caggaaatcc ctgcaaggaa gactacttgg cggtttgtgg gctaaaggac
     5941 tgtcatgtgc tcacctttag tagctcaggc tctgtttcgg atcacttggt tttgcaccct
     6001 cagttggcaa cggggaactt catcatcaaa gccgtgtggt tacctggttc acagaccgag
     6061 ttagcaattg tcaccgcaga ctttgttaag atttatgacc tgtgtgttga tgccttgagt
     6121 ccaaccttct attttctcct gccaagctca aagataagag atgttacctt ccttttcaat
     6181 gaggagggaa agaacatcat tgttataatg tcttcggctg ggtacatcta tactcagctt
     6241 atggaagagg ccagcagtgc ccagcaggga cccttctatg tcactaatgt gttggaaatc
     6301 aatcatgagg acctgaagca ggacagtaac agccaggtgg cgggcggtgg tgtgtccgtg
     6361 tactactccc acgtgttgca gatgttgttc ttcagctatt gtcaaggcaa atcattcgca
     6421 gccaccatca gcaggacaac cctggaggtg ttgcaactct tccccatcaa catcaaaagt
     6481 tttgttgtct gcagttccaa tggtggcagt aagacttctc ctgctctttg ccagtggtct
     6541 gaggtgatga accaccctgg cttggtgtgc tgtgtccagc aaactacagg ggtgccgctg
     6601 gtagttatgg tgaaaccaga cacttttctt atccaggaga ttaagactct tcctgctaaa
     6661 gcgaagatcc aagacatggt tgctattagg cacacggcct gcaatgagca gcagcggaca
     6721 acaatgattc tgctgtgtga ggatggcagc ctgcgcattt acatggccaa cgtggagaac
     6781 acctcctact ggctgcagcc atccctgcag cccagcagtg tcatcagcat catgaagcct
     6841 gttcgaaagc gcaaaacagc tacaatcaca acccgcacgt ctagccaggt gactttcccc
     6901 attgactttt ttgaacacaa ccagcagctg acagatgtgg agtttggtgg taacgacctc
     6961 ctacaggtct ataatgcaca acagataaaa caccggctga attccactgg catgtatgtg
     7021 gccaacacca agcccggagg cttcaccatt gagattagta acaacaatag cactatggtg
     7081 atgacaggca tgcggatcca gattgggact caagcaatag aacgggcccc gtcatatatc
     7141 gagatcttcg gcagaactat gcagctcaac ctgagtcgct cacgctggtt tgacttcccc
     7201 ttcaccagag aagaagccct gcaggctgat aagaagctga acctcttcat tggggcctcg
     7261 gtggatccag caggtgtcac catgatagat gctgtaaaaa tttatggcaa gactaaggag
     7321 cagtttggct ggcctgatga gcccccagaa gaattccctt ctgcctctgt cagcaacatc
     7381 tgcccttcaa atctgaacca gagcaacggc actggagata gcgactcagc tgcccccact
     7441 acgaccagtg gaactgtcct ggagagttct gaaactgagt ccctaaccaa gctggaccgg
     7501 ctggttgtga gttctttaga agccctggaa agctgctttg ccgttggccc aatcatcgag
     7561 aaggagagaa acaagaatgc tgctcaggag ctggccactt tgctgttgtc cctgccagca
     7621 cctgccagtg tccagcagca gtccaagagc cttctggcca gcctgcacac cagccgctcg
     7681 gcctaccaca gccacaagga tcaggccttg ctgagcaaag ctgtgcagtg tctcaacaca
     7741 tctagcaaag agggcaagga tttggaccct gaggtgttcc agaggctagt gatcacagct
     7801 cgctccattg ccatcatgcg ccccaacaac cttgtccact ttacggagtc aaagctgccc
     7861 cagatggaaa cagactgttt ttttcctaga tgtgcctgct ggagtctagg gatagttggc
     7921 atattgattg gggccccact tgaaactccc tccccagaag gaatggatga agggaaggaa
     7981 ccgcagaagc agttggaagg agattgctgt agtttcatca cccagcttgt gaaccacttc
     8041 tggaaactcc atgcatccaa acccaagaat gccttcttgg cacctgcctg ccttccagga
     8101 ctaactcata ttgaagctac tgtcaatgct ctggtggaca tcatccatgg ctactgtacc
     8161 tgtgagctgg attgtattaa cacagcatcc aagatctaca tgcagatgct cttgtgtcct
     8221 gatcctgctg tgagcttctc ttgtaaacaa gctctaattc gagtcctaag gcccaggaac
     8281 aaacggagac atgtgacttt accctcttcc cctcgaagca acactccaat gggagacaag
     8341 gatgatgatg acgatgatga tgcagatgag aaaatgcagt catcagggat cccgaatggt
     8401 ggtcacatcc gtcaggaaag ccaggaacag agtgaggtgg accatggaga ttttgagatg
     8461 gtgtctgagt cgatggtcct ggagacagct gaaaatgtca acaatggcaa cccctctccc
     8521 ctggaggccc tgctggcagg cgcagagggc ttccccccca tgctggacat cccacctgat
     8581 gcagatgacg agaccatggt tgaactagcc attgccctga gcctgcagca ggaccaacaa
     8641 ggcagcagca gcagtgccct gggcctgcag agcctgggac tgtccggcca ggcacccagc
     8701 tcttcctctc tggacgcagg aaccctctct gacaccacag catcagctcc agcctcagac
     8761 gacgagggca gtacagcagc gacagatggt tctacccttc ggacctctcc tgctgaccac
     8821 ggtggtagtg tgggctcgga gagcgggggc agtgcagtgg actcagtggc tggcgagcac
     8881 agtgtatctg gccggagcag tgcttatggc gatgctacag ctgaggggca tccggctgga
     8941 ccaggaagtg tcagctcaag cactggagcc atcagcacca ccactgggca ccaggaggga
     9001 gatggctccg agggagaagg agaaggagaa actgaaggag atgtccacac tagcaacagg
     9061 ctgcacatgg tccgtctaat gctgttggag agattactgc agaccctgcc tcaattacga
     9121 aacgttggcg gtgtccgggc catcccatac atgcaggtca ttctaatgct cactacagat
     9181 ctggatggag aagatgagaa agacaagggg gccctagaca acctgctctc ccagcttatt
     9241 gctgagttgg gtatggataa aaaggatgtc tccaagaaga atgagcgcag cgccctgaat
     9301 gaagtccatc tggtagtaat gagactcctg agtgtcttca tgtcccgcac caaatctgga
     9361 tccaagtctt ccatatgtga gtcatcttcc ctcatctcca gtgccacagc agcagctcta
     9421 ctgagctctg gggctgtgga ctactgcctg cacgtgctca aatcactgct ggaatattgg
     9481 aagagccaac agaatgacga ggagcctgtg gctaccagcc agttgctgaa accacatact
     9541 acctcctccc cacctgacat gagcccattc tttctccgcc agtatgtgaa gggtcatgct
     9601 gctgatgtgt ttgaggccta tactcagctt ctaacagaaa tggtactgag gcttccttac
     9661 caaatcaaaa agattactga caccaattct cgaatcccac ctcctgtctt tgaccactcg
     9721 tggttttact ttctctccga gtacctcatg atccagcaga ctccatttgt gcgccgtcaa
     9781 gtccgcaaac ttctgctctt catctgtgga tccaaagaga agtaccgcca gctccgggat
     9841 ttgcacaccc tggactctca cgtgcgtggg atcaagaagc tgctagaaga gcaggggata
     9901 ttcctccggg caagtgtggt tacagccagc tcaggctccg ccttgcaata tgacacactc
     9961 atcagcctga tggagcacct gaaagcctgt gcagagattg ccgcccagcg aaccatcaac
    10021 tggcagaaat tctgcatcaa agatgactcc gtcctgtact tcctcctcca agtcagtttc
    10081 cttgtggatg agggcgtgtc cccagtgctg ctgcaactgc tctcctgtgc tctgtgcggc
    10141 agcaaggtgc tcgctgcact ggcagcctct tcgggatcct ccagtgcttc ttcctcctca
    10201 gcccctgtgg ctgccagttc tggacaagcc acaacacagt ccaagtcttc cactaaaaag
    10261 agcaagaaag aagaaaaaga aaaggagaaa gatggtgaga cctctggcag ccaggaggac
    10321 cagctgtgca cagctctggt gaaccagctg aacaaatttg ccgataagga aaccctgatc
    10381 cagttcctgc gttgtttcct gttagagtcc aattcttcct cggtgcgctg gcaggcccac
    10441 tgtctgacac tgcacatcta cagaaattcc agcaaatctc aacaggagct cctgctagat
    10501 ctgatgtggt ccatctggcc agaactccca gcctatggtc gtaaggctgc ccagtttgtg
    10561 gacctactag gatatttctc cctgaaaact ccacaaacag agaagaagtt gaaggagtat
    10621 tcacagaagg ctgtggagat tctgcggact caaaaccata ttcttaccaa ccaccccaac
    10681 tcgaacattt ataacacttt gtctggctta gtggagtttg atggctatta cctggagagc
    10741 gatccctgcc tggtgtgtaa taacccggaa gtaccgttct gttatatcaa gctgtcttcc
    10801 attaaagtgg acacgcggta caccaccacc cagcaggttg tgaagctcat tggcagtcac
    10861 accatcagca aagtgacagt gaaaatcggg gatctgaaac ggaccaagat ggtgcggacc
    10921 atcaacctgt attataacaa ccgaaccgtg caggccatcg tggagttgaa aaacaagcca
    10981 gctcgctggc acaaagccaa gaaggttcag ctgacccctg gacagacaga ggtgaagatt
    11041 gacctgccgt tgcccattgt ggcctccaat ctgatgattg agtttgcaga cttctatgaa
    11101 aactaccagg cctccacaga gaccctgcag tgccctcgct gtagtgcctc ggtccctgcc
    11161 aacccaggag tctgtggcaa ctgtggagag aatgtgtacc agtgtcacaa atgcagatcc
    11221 atcaactacg atgaaaagga tcccttcctc tgcaatgcct gtggcttctg taaatatgcc
    11281 cgcttcgact tcatgctcta tgccaagcct tgctgtgcag tggatcccat tgagaatgaa
    11341 gaagaccgga agaaggctgt atccaacatc aatacacttt tggacaaagc tgatcgagtg
    11401 tatcatcagc tgatgggaca ccggccacag ctggagaacc tgctctgcaa agtgaatgag
    11461 gcagctccag aaaagccaca ggatgactca ggaacagcag ggggcatcag ctccacttct
    11521 gccagtgtga atcgttacat cctgcagttg gctcaggagt attgtggaga ctgcaagaac
    11581 tcttttgatg aactctccaa aatcatccag aaagtctttg cttcgcgcaa agagttgttg
    11641 gaatatgacc tacagcagag ggaagcagcc actaaatcat cccggacctc cgtgcagccc
    11701 acattcactg ccagccagta ccgtgcctta tccgtcctgg gctgtggcca cacatcctcc
    11761 accaagtgct atggctgcgc ctcggctgtc acagaacatt gtatcacact acttcgggcc
    11821 ctggccacca acccagcctt gaggcacatc cttgtctccc agggccttat ccgggagctc
    11881 tttgattata atcttcgccg aggggctgcg gccatgcggg aggaggtccg ccagctcatg
    11941 tgcctcctaa ctcgagacaa cccagaagcc acccaacaga tgaatgacct gattattggc
    12001 aaggtctcca cagccctgaa gggccactgg gccaaccccg atctggcaag tagcctgcag
    12061 tatgaaatgc tgctgctgac ggattctatc tccaaggagg acagctgctg ggagctccgg
    12121 ttacgctgtg ctctcagcct tttcctcatg gctgtgaaca ttaagactcc tgtggtggtt
    12181 gaaaacatta ccctcatgtg cctgaggatc ttgcagaagc tgataaaacc acctgctccc
    12241 actagcaaga agaacaagga tgtccccgtt gaggccctca ccacggtgaa gccatactgc
    12301 aatgagatcc atgcccaggc tcaactgtgg ctcaagagag accccaaggc atcctatgat
    12361 gcctggaaga agtgtcttcc tatcagaggg atagatggca atgggaaagc ccccagcaaa
    12421 tcagagctcc gccatctcta tttgactgag aagtatgtgt ggaggtggaa acagttcctg
    12481 agtcgtcggg ggaagaggac ctcccccttg gatctcaaac tggggcataa caactggctg
    12541 cgacaagtgc ttttcactcc agcaacgcag gccgcacggc aggcagcctg taccattgtg
    12601 gaagctctag ccaccattcc cagccgcaag cagcaggtcc tggacctgct taccagttac
    12661 ctggatgagc tgagcatagc tggggagtgt gcagctgagt acctggctct ctaccagaag
    12721 ctcatcactt ctgcgcactg gaaagtctac ttggcagctc ggggagtcct accctatgtg
    12781 ggcaacctca tcaccaagga aatagctcgt ctgctggccc tggaggaggc taccctgagt
    12841 accgatctgc agcagggtta tgcccttaaa agtctcacag gccttctctc ctcctttgtt
    12901 gaggtggaat ccatcaaaag acattttaaa agtcgcttgg tgggtactgt gctgaatgga
    12961 tacctgtgct tgcggaagct ggtggtgcag aggaccaagc tgatcgatga gacgcaggac
    13021 atgctgctgg agatgctgga ggacatgacc acaggtacag aatcagaaac caaggccttc
    13081 atggctgtgt gcattgagac agccaagcgc tacaatctgg atgactaccg gaccccggtg
    13141 ttcatcttcg agaggctctg cagcatcatt tatcctgagg agaatgaagt cactgagttc
    13201 tttgtgaccc tggagaagga tccccaacaa gaagacttct tacagggcag gatgcctggg
    13261 aacccgtata gcagcaatga gccaggcatc gggccgctga tgagggatat aaagaacaag
    13321 atttgccagg actgtgactt agtggccctc ctggaagatg acagtggcat ggagcttcta
    13381 gtgaacaata aaatcattag tttggacctt cctgtggctg aagtttacaa gaaagtctgg
    13441 tgtaccacga atgagggaga gcccatgagg attgtttatc gtatgcgggg gctgctgggc
    13501 gatgccacag aggagttcat tgagtccctg gactctacta cagatgaaga agaagatgaa
    13561 gaagaagtgt ataaaatggc tggtgtgatg gcccagtgtg ggggcctgga atgcatgctt
    13621 aacagactcg cagggatcag agatttcaag cagggacgcc accttctaac agtgctactg
    13681 aaattgttca gttactgcgt gaaggtgaaa gtcaaccggc agcaactggt caaactggaa
    13741 atgaacacct tgaacgtcat gctggggacc ctaaacctgg cccttgtagc tgaacaagaa
    13801 agcaaggaca gtgggggtgc agctgtggct gagcaggtgc ttagcatcat ggagatcatt
    13861 ctagatgagt ccaatgctga gcccctgagt gaggacaagg gcaacctcct cctgacaggt
    13921 gacaaggatc aactggtgat gctcttggac cagatcaaca gcacctttgt tcgctccaac
    13981 cccagtgtgc tccagggcct gcttcgcatc atcccgtacc tttcctttgg agaggtggag
    14041 aaaatgcaga tcttggtgga gcgattcaaa ccatactgca actttgataa atatgatgaa
    14101 gatcacagtg gtgatgataa agtcttcctg gactgcttct gtaaaatagc tgctggcatc
    14161 aagaacaaca gcaatgggca ccagctgaag gatctgattc tccagaaggg gatcacccag
    14221 aatgcacttg actacatgaa aaagcacatc cctagcgcca agaatttgga tgccgacatc
    14281 tggaaaaagt ttttgtctcg cccagccttg ccatttatcc taaggctgct tcggggcctg
    14341 gccatccagc accctggcac ccaggttctg attggaactg attccatccc gaacctgcat
    14401 aagctggagc aggtgtccag tgatgagggc attgggacct tggcagagaa cctgctggaa
    14461 gccctgcggg aacaccctga cgtaaacaag aagattgacg cagcccgcag ggagacccgg
    14521 gcagagaaga agcgcatggc catggcaatg aggcagaagg ccctgggcac cctgggcatg
    14581 acgacaaatg aaaagggcca ggtcgtgacc aagacagcac tcctgaagca gatggaagag
    14641 ctgatcgagg agcctggcct cacgtgctgc atctgcaggg agggatacaa gttccagccc
    14701 acaaaggtcc tgggcattta taccttcacg aagcgggtag ccttggagga gatggagaat
    14761 aagccccgga aacagcaggg ctacagcacc gtgtcccact tcaacattgt gcactacgac
    14821 tgccatctgg ctgccgtcag gttggctcga ggccgggaag agtgggagag tgccgccctg
    14881 cagaatgcca acaccaagtg caacgggctc cttccggtct ggggacctca tgtccctgaa
    14941 tcagcttttg ccacttgctt ggcaagacac aacacttacc tccaggaatg tacaggccag
    15001 cgggagccca cgtatcagct caacatccat gacatcaaac tgctcttcct gcgcttcgcc
    15061 atggagcagt cgttcagcgc agacactggc gggggcggcc gggagagcaa catccacctg
    15121 atcccgtaca tcattcacac tgtgctttac gtcctgaaca caacccgagc aacttcccga
    15181 gaagagaaga acctccaagg ctttctggaa cagcccaagg agaagtgggt ggagagtgcc
    15241 tttgaagtgg acgggcccta ctatttcaca gtcttggccc ttcacatcct gccccctgag
    15301 cagtggagag ccacacgtgt ggaaatcttg cggaggctgt tggtgacctc gcaggctcgg
    15361 gcagtggctc caggtggagc caccaggctg acagataagg cagtgaagga ctattccgct
    15421 taccgttctt cccttctctt ttgggccctc gtcgatctca tttacaacat gtttaagaag
    15481 gtgcctacca gtaacacaga gggaggctgg tcctgctctc tcgctgagta catccgccac
    15541 aacgacatgc ccatctacga agctgccgac aaagccctga aaaccttcca ggaggagttc
    15601 atgccagtgg agaccttctc agagttcctc gatgtggccg gtcttttatc agaaatcacc
    15661 gatccagaga gcttcctgaa ggacctgttg aactcagtcc cctgaccacc acacagcagc
    15721 tgcggcggcg aagacgaagc tggcttgcct tccaccctct gttctccctc cttgtgcatt
    15781 aagttccctc cgcgggatgc tgcattgtta ccccgccctc ccctctctca tttttcttgg
    15841 tgtggcttgg ggtttttagg cttcctgttt tatctcgtgt gtgtggtgca ccagctatga
    15901 ggttgtctgt aacccaagcc atcaaagggc ctgtacatac ctaggagcca tgagttgtcc
    15961 cggccagctt catacttgag tgtgcacatc ttgagaaata aacaagtgac ttaacacaca
    16021 ttgaaaa
//
