LOCUS       NM_020765              15892 bp    mRNA    linear   PRI 28-AUG-2024
DEFINITION  Homo sapiens ubiquitin protein ligase E3 component n-recognin 4
            (UBR4), mRNA.
ACCESSION   NM_020765
VERSION     NM_020765.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 15892)
  AUTHORS   Liu,Q., Zheng,Y., Sturmlechner,I., Jain,A., Own,M., Yang,Q.,
            Zhang,H., Pinto E Vairo,F., Cerosaletti,K., Buckner,J.H.,
            Warrington,K.J., Koster,M.J., Weyand,C.M. and Goronzy,J.J.
  TITLE     IKZF1 and UBR4 gene variants drive autoimmunity and Th2
            polarization in IgG4-related disease
  JOURNAL   J Clin Invest 134 (16), e178692 (2024)
   PUBMED   38885295
  REMARK    GeneRIF: IKZF1 and UBR4 gene variants drive autoimmunity and Th2
            polarization in IgG4-related disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 15892)
  AUTHORS   Haakonsen,D.L., Heider,M., Ingersoll,A.J., Vodehnal,K., Witus,S.R.,
            Uenaka,T., Wernig,M. and Rape,M.
  TITLE     Stress response silencing by an E3 ligase mutated in
            neurodegeneration
  JOURNAL   Nature 626 (8000), 874-880 (2024)
   PUBMED   38297121
REFERENCE   3  (bases 1 to 15892)
  AUTHORS   Barnsby-Greer,L., Mabbitt,P.D., Dery,M.A., Squair,D.R., Wood,N.T.,
            Lamoliatte,F., Lange,S.M. and Virdee,S.
  TITLE     UBE2A and UBE2B are recruited by an atypical E3 ligase module in
            UBR4
  JOURNAL   Nat Struct Mol Biol 31 (2), 351-363 (2024)
   PUBMED   38182926
REFERENCE   4  (bases 1 to 15892)
  AUTHORS   Jeong,D.E., Lee,H.S., Ku,B., Kim,C.H., Kim,S.J. and Shin,H.C.
  TITLE     Insights into the recognition mechanism in the UBR box of UBR4 for
            its specific substrates
  JOURNAL   Commun Biol 6 (1), 1214 (2023)
   PUBMED   38030679
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 15892)
  AUTHORS   Varland,S., Silva,R.D., Kjosas,I., Faustino,A., Bogaert,A.,
            Billmann,M., Boukhatmi,H., Kellen,B., Costanzo,M., Drazic,A.,
            Osberg,C., Chan,K., Zhang,X., Tong,A.H.Y., Andreazza,S., Lee,J.J.,
            Nedyalkova,L., Usaj,M., Whitworth,A.J., Andrews,B.J., Moffat,J.,
            Myers,C.L., Gevaert,K., Boone,C., Martinho,R.G. and Arnesen,T.
  TITLE     N-terminal acetylation shields proteins from degradation and
            promotes age-dependent motility and longevity
  JOURNAL   Nat Commun 14 (1), 6774 (2023)
   PUBMED   37891180
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 15892)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   7  (bases 1 to 15892)
  AUTHORS   Lennerz,V., Fatho,M., Gentilini,C., Frye,R.A., Lifke,A., Ferel,D.,
            Wolfel,C., Huber,C. and Wolfel,T.
  TITLE     The response of autologous T cells to a human melanoma is dominated
            by mutated neoantigens
  JOURNAL   Proc Natl Acad Sci U S A 102 (44), 16013-16018 (2005)
   PUBMED   16247014
REFERENCE   8  (bases 1 to 15892)
  AUTHORS   Nakatani,Y., Konishi,H., Vassilev,A., Kurooka,H., Ishiguro,K.,
            Sawada,J., Ikura,T., Korsmeyer,S.J., Qin,J. and Herlitz,A.M.
  TITLE     p600, a unique protein required for membrane morphogenesis and cell
            survival
  JOURNAL   Proc Natl Acad Sci U S A 102 (42), 15093-15098 (2005)
   PUBMED   16214886
  REMARK    GeneRIF: Results identify and characterize p600, a unique 600-kDa
            retinoblastoma protein- and calmodulin-binding protein.
            Erratum:[Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17882]
REFERENCE   9  (bases 1 to 15892)
  AUTHORS   Huh,K.W., DeMasi,J., Ogawa,H., Nakatani,Y., Howley,P.M. and
            Munger,K.
  TITLE     Association of the human papillomavirus type 16 E7 oncoprotein with
            the 600-kDa retinoblastoma protein-associated factor, p600
  JOURNAL   Proc Natl Acad Sci U S A 102 (32), 11492-11497 (2005)
   PUBMED   16061792
  REMARK    GeneRIF: p600 is a cellular target of the human papillomavirus type
            16 E7 oncoprotein that regulates cellular pathways that contribute
            to anchorage-independent growth and cellular transformation.
            GeneRIF: Human papillomavirus E7 oncoprotein associates with p600;
            interaction strongly contributes to cellular transformation
            independent of ability of E7 to bind pRB.
REFERENCE   10 (bases 1 to 15892)
  AUTHORS   Tasaki,T., Mulder,L.C., Iwamatsu,A., Lee,M.J., Davydov,I.V.,
            Varshavsky,A., Muesing,M. and Kwon,Y.T.
  TITLE     A family of mammalian E3 ubiquitin ligases that contain the UBR box
            motif and recognize N-degrons
  JOURNAL   Mol Cell Biol 25 (16), 7120-7136 (2005)
   PUBMED   16055722
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL357564.17, AF348492.1,
            AB037728.1, AL137127.7, AB007931.1 and AA748129.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_020765.2.
            
            Summary: The protein encoded by this gene is an E3
            ubiquitin-protein ligase that interacts with the
            retinoblastoma-associated protein in the nucleus and with
            calcium-bound calmodulin in the cytoplasm. The encoded protein
            appears to be a cytoskeletal component in the cytoplasm and part of
            the chromatin scaffold in the nucleus. In addition, this protein is
            a target of the human papillomavirus type 16 E7 oncoprotein.
            [provided by RefSeq, Aug 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF348492.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375254.8/ ENSP00000364403.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AL357564.17        55790-55803         c
            15-18               AL357564.17        55786-55789         c
            19-6063             AF348492.1         1-6045
            6064-6318           AB037728.1         3712-3966
            6319-7231           AB037728.1         3970-4882
            7232-7247           AF348492.1         7214-7229
            7248-7448           AL137127.7         92946-93146         c
            7449-11886          AF348492.1         7431-11868
            11887-15888         AB007931.1         3149-7150
            15889-15892         AA748129.1         13-16               c
FEATURES             Location/Qualifiers
     source          1..15892
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.13"
     gene            1..15892
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /note="ubiquitin protein ligase E3 component n-recognin 4"
                     /db_xref="GeneID:23352"
                     /db_xref="HGNC:HGNC:30313"
                     /db_xref="MIM:609890"
     exon            1..194
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..15570
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /EC_number="2.3.2.27"
                     /note="retinoblastoma-associated factor 600-like protein;
                     N-recognin-4; zinc finger UBR1-type protein 1;
                     retinoblastoma-associated factor of 600 kDa; RING-type E3
                     ubiquitin transferase UBR4"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase UBR4"
                     /protein_id="NP_065816.2"
                     /db_xref="CCDS:CCDS189.1"
                     /db_xref="GeneID:23352"
                     /db_xref="HGNC:HGNC:30313"
                     /db_xref="MIM:609890"
                     /translation="MATSGGEEAAAAAPAPGTPATGADTTPGWEVAVRPLLSASYSAF
                     EMKELPQLVASVIESESEILHHEKQYEPFYSSFVALSTHYITTVCSLIPRNQLQSVAA
                     ACKVLIEFSLLRLENPDEACAVSQKHLILLIKGLCTGCSRLDRTEIITFTAMMKSAKL
                     PQTVKTLSDVEDQKELASPVSPELRQKEVQMNFLNQLTSVFNPRTVASQPISTQTLVE
                     GENDEQSSTDQASAIKTKNVFIAQNVASLQELGGSEKLLRVCLNLPYFLRYINRFQDA
                     VLANSFFIMPATVADATAVRNGFHSLVIDVTMALDTLSLPVLEPLNPSRLQDVTVLSL
                     SCLYAGVSVATCMAILHVGSAQQVRTGSTSSKEDDYESDAATIVQKCLEIYDMIGQAI
                     SSSRRAGGEHYQNFQLLGAWCLLNSLFLILNLSPTALADKGKEKDPLAALRVRDILSR
                     TKEGVGSPKLGPGKGHQGFGVLSVILANHAIKLLTSLFQDLQVEALHKGWETDGPPAA
                     LSIMAQSTSIQRIQRLIDSVPLMNLLLTLLSTSYRKACVLQRQRKGSMSSDASASTDS
                     NTYYEDDFSSTEEDSSQDDDSEPILGQWFEETISPSKEKAAPPPPPPPPPLESSPRVK
                     SPSKQAPGEKGNILASRKDPELFLGLASNILNFITSSMLNSRNNFIRNYLSVSLSEHH
                     MATLASIIKEVDKDGLKGSSDEEFAAALYHFNHSLVTSDLQSPNLQNTLLQQLGVAPF
                     SEGPWPLYIHPQSLSVLSRLLLIWQHKASAQGDPDVPECLKVWDRFLSTMKQNALQGV
                     VPSETEDLNVEHLQMLLLIFHNFTETGRRAILSLFVQIIQELSVNMDAQMRFVPLILA
                     RLLLIFDYLLHQYSKAPVYLFEQVQHNLLSPPFGWASGSQDSNSRRATTPLYHGFKEV
                     EENWSKHFSSDAVPHPRFYCVLSPEASEDDLNRLDSVACDVLFSKLVKYDELYAALTA
                     LLAAGSQLDTVRRKENKNVTALEACALQYYFLILWRILGILPPSKTYINQLSMNSPEM
                     SECDILHTLRWSSRLRISSYVNWIKDHLIKQGMKAEHASSLLELASTTKCSSVKYDVE
                     IVEEYFARQISSFCSIDCTTILQLHEIPSLQSIYTLDAAISKVQVSLDEHFSKMAAET
                     DPHKSSEITKNLLPATLQLIDTYASFTRAYLLQNFNEEGTTEKPSKEKLQGFAAVLAI
                     GSSRCKANTLGPTLVQNLPSSVQTVCESWNNINTNEFPNIGSWRNAFANDTIPSESYI
                     SAVQAAHLGTLCSQSLPLAASLKHTLLSLVRLTGDLIVWSDEMNPPQVIRTLLPLLLE
                     SSTESVAEISSNSLERILGPAESDEFLARVYEKLITGCYNILANHADPNSGLDESILE
                     ECLQYLEKQLESSQARKAMEEFFSDSGELVQIMMATANENLSAKFCNRVLKFFTKLFQ
                     LTEKSPNPSLLHLCGSLAQLACVEPVRLQAWLTRMTTSPPKDSDQLDVIQENRQLLQL
                     LTTYIVRENSQVGEGVCAVLLGTLTPMATEMLANGDGTGFPELMVVMATLASAGQGAG
                     HLQLHNAAVDWLSRCKKYLSQKNVVEKLNANVMHGKHVMILECTCHIMSYLADVTNAL
                     SQSNGQGPSHLSVDGEERAIEVDSDWVEELAVEEEDSQAEDSDEDSLCNKLCTFTITQ
                     KEFMNQHWYHCHTCKMVDGVGVCTVCAKVCHKDHEISYAKYGSFFCDCGAKEDGSCLA
                     LVKRTPSSGMSSTMKESAFQSEPRISESLVRHASTSSPADKAKVTISDGKVADEEKPK
                     KSSLCRTVEGCREELQNQANFSFAPLVLDMLNFLMDAIQTNFQQASAVGSSSRAQQAL
                     SELHTVEKAVEMTDQLMVPTLGSQEGAFENVRMNYSGDQGQTIRQLISAHVLRRVAMC
                     VLSSPHGRRQHLAVSHEKGKITVLQLSALLKQADSSKRKLTLTRLASAPVPFTVLSLT
                     GNPCKEDYLAVCGLKDCHVLTFSSSGSVSDHLVLHPQLATGNFIIKAVWLPGSQTELA
                     IVTADFVKIYDLCVDALSPTFYFLLPSSKIRDVTFLFNEEGKNIIVIMSSAGYIYTQL
                     MEEASSAQQGPFYVTNVLEINHEDLKDSNSQVAGGGVSVYYSHVLQMLFFSYCQGKSF
                     AATISRTTLEVLQLFPINIKSSNGGSKTSPALCQWSEVMNHPGLVCCVQQTTGVPLVV
                     MVKPDTFLIQEIKTLPAKAKIQDMVAIRHTACNEQQRTTMILLCEDGSLRIYMANVEN
                     TSYWLQPSLQPSSVISIMKPVRKRKTATITTRTSSQVTFPIDFFEHNQQLTDVEFGGN
                     DLLQVYNAQQIKHRLNSTGMYVANTKPGGFTIEISNNNSTMVMTGMRIQIGTQAIERA
                     PSYIEIFGRTMQLNLSRSRWFDFPFTREEALQADKKLNLFIGASVDPAGVTMIDAVKI
                     YGKTKEQFGWPDEPPEEFPSASVSNICPSNLNQSNGTGDSDSAAPTTTSGTVLERLVV
                     SSLEALESCFAVGPIIEKERNKNAAQELATLLLSLPAPASVQQQSKSLLASLHTSRSA
                     YHSHKDQALLSKAVQCLNTSSKEGKDLDPEVFQRLVITARSIAIMRPNNLVHFTESKL
                     PQMETEGMDEGKEPQKQLEGDCCSFITQLVNHFWKLHASKPKNAFLAPACLPGLTHIE
                     ATVNALVDIIHGYCTCELDCINTASKIYMQMLLCPDPAVSFSCKQALIRVLRPRNKRR
                     HVTLPSSPRSNTPMGDKDDDDDDDADEKMQSSGIPNGGHIRQESQEQSEVDHGDFEMV
                     SESMVLETAENVNNGNPSPLEALLAGAEGFPPMLDIPPDADDETMVELAIALSLQQDQ
                     QGSSSSALGLQSLGLSGQAPSSSSLDAGTLSDTTASAPASDDEGSTAATDGSTLRTSP
                     ADHGGSVGSESGGSAVDSVAGEHSVSGRSSAYGDATAEGHPAGPGSVSSSTGAISTTT
                     GHQEGDGSEGEGEGETEGDVHTSNRLHMVRLMLLERLLQTLPQLRNVGGVRAIPYMQV
                     ILMLTTDLDGEDEKDKGALDNLLSQLIAELGMDKKDVSKKNERSALNEVHLVVMRLLS
                     VFMSRTKSGSKSSICESSSLISSATAAALLSSGAVDYCLHVLKSLLEYWKSQQNDEEP
                     VATSQLLKPHTTSSPPDMSPFFLRQYVKGHAADVFEAYTQLLTEMVLRLPYQIKKITD
                     TNSRIPPPVFDHSWFYFLSEYLMIQQTPFVRRQVRKLLLFICGSKEKYRQLRDLHTLD
                     SHVRGIKKLLEEQGIFLRASVVTASSGSALQYDTLISLMEHLKACAEIAAQRTINWQK
                     FCIKDDSVLYFLLQVSFLVDEGVSPVLLQLLSCALCGSKVLAALAASSGSSSASSSSA
                     PVAASSGQATTQSKSSTKKSKKEEKEKEKDGETSGSQEDQLCTALVNQLNKFADKETL
                     IQFLRCFLLESNSSSVRWQAHCLTLHIYRNSSKSQQELLLDLMWSIWPELPAYGRKAA
                     QFVDLLGYFSLKTPQTEKKLKEYSQKAVEILRTQNHILTNHPNSNIYNTLSGLVEFDG
                     YYLESDPCLVCNNPEVPFCYIKLSSIKVDTRYTTTQQVVKLIGSHTISKVTVKIGDLK
                     RTKMVRTINLYYNNRTVQAIVELKNKPARWHKAKKVQLTPGQTEVKIDLPLPIVASNL
                     MIEFADFYENYQASTETLQCPRCSASVPANPGVCGNCGENVYQCHKCRSINYDEKDPF
                     LCNACGFCKYARFDFMLYAKPCCAVDPIENEEDRKKAVSNINTLLDKADRVYHQLMGH
                     RPQLENLLCKVNEAAPEKPQDDSGTAGGISSTSASVNRYILQLAQEYCGDCKNSFDEL
                     SKIIQKVFASRKELLEYDLQQREAATKSSRTSVQPTFTASQYRALSVLGCGHTSSTKC
                     YGCASAVTEHCITLLRALATNPALRHILVSQGLIRELFDYNLRRGAAAMREEVRQLMC
                     LLTRDNPEATQQMNDLIIGKVSTALKGHWANPDLASSLQYEMLLLTDSISKEDSCWEL
                     RLRCALSLFLMAVNIKTPVVVENITLMCLRILQKLIKPPAPTSKKNKDVPVEALTTVK
                     PYCNEIHAQAQLWLKRDPKASYDAWKKCLPIRGIDGNGKAPSKSELRHLYLTEKYVWR
                     WKQFLSRRGKRTSPLDLKLGHNNWLRQVLFTPATQAARQAACTIVEALATIPSRKQQV
                     LDLLTSYLDELSIAGECAAEYLALYQKLITSAHWKVYLAARGVLPYVGNLITKEIARL
                     LALEEATLSTDLQQGYALKSLTGLLSSFVEVESIKRHFKSRLVGTVLNGYLCLRKLVV
                     QRTKLIDETQDMLLEMLEDMTTGTESETKAFMAVCIETAKRYNLDDYRTPVFIFERLC
                     SIIYPEENEVTEFFVTLEKDPQQEDFLQGRMPGNPYSSNEPGIGPLMRDIKNKICQDC
                     DLVALLEDDSGMELLVNNKIISLDLPVAEVYKKVWCTTNEGEPMRIVYRMRGLLGDAT
                     EEFIESLDSTTDEEEDEEEVYKMAGVMAQCGGLECMLNRLAGIRDFKQGRHLLTVLLK
                     LFSYCVKVKVNRQQLVKLEMNTLNVMLGTLNLALVAEQESKDSGGAAVAEQVLSIMEI
                     ILDESNAEPLSEDKGNLLLTGDKDQLVMLLDQINSTFVRSNPSVLQGLLRIIPYLSFG
                     EVEKMQILVERFKPYCNFDKYDEDHSGDDKVFLDCFCKIAAGIKNNSNGHQLKDLILQ
                     KGITQNALDYMKKHIPSAKNLDADIWKKFLSRPALPFILRLLRGLAIQHPGTQVLIGT
                     DSIPNLHKLEQVSSDEGIGTLAENLLEALREHPDVNKKIDAARRETRAEKKRMAMAMR
                     QKALGTLGMTTNEKGQVVTKTALLKQMEELIEEPGLTCCICREGYKFQPTKVLGIYTF
                     TKRVALEEMENKPRKQQGYSTVSHFNIVHYDCHLAAVRLARGREEWESAALQNANTKC
                     NGLLPVWGPHVPESAFATCLARHNTYLQECTGQREPTYQLNIHDIKLLFLRFAMEQSF
                     SADTGGGGRESNIHLIPYIIHTVLYVLNTTRATSREEKNLQGFLEQPKEKWVESAFEV
                     DGPYYFTVLALHILPPEQWRATRVEILRRLLVTSQARAVAPGGATRLTDKAVKDYSAY
                     RSSLLFWALVDLIYNMFKKVPTSNTEGGWSCSLAEYIRHNDMPIYEAADKALKTFQEE
                     FMPVETFSEFLDVAGLLSEITDPESFLKDLLNSVP"
     exon            195..292
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            293..396
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            397..526
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            527..666
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            667..769
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            770..911
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1036
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1161
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1221
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1412
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1512
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1650
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1768
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..1956
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1957..2116
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2117..2202
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2203..2372
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2373..2655
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2656..2791
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2792..2871
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2872..3000
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3001..3183
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3184..3309
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3310..3539
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3540..3661
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3662..3759
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3760..3917
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3918..4127
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            4128..4229
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            4230..4330
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            4331..4529
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            4530..4718
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            4719..4782
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            4783..4974
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            4975..5045
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            5046..5193
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            5194..5424
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            5425..5595
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            5596..5778
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            5779..5937
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            5938..6090
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            6091..6318
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            6319..6476
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            6477..6648
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            6649..6850
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            6851..7014
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            7015..7231
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            7232..7448
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            7449..7512
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            7513..7647
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            7648..7822
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            7823..7963
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            7964..8085
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            8086..8197
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            8198..8328
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            8329..8506
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            8507..8611
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            8612..8749
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            8750..8924
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            8925..9021
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            9022..9129
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            9130..9246
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            9247..9456
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            9457..9606
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            9607..9834
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            9835..9913
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            9914..10159
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            10160..10328
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            10329..10473
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            10474..10559
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            10560..10647
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            10648..10841
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            10842..11081
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            11082..11220
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            11221..11346
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            11347..11475
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            11476..11819
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            11820..11910
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            11911..11995
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            11996..12123
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            12124..12253
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            12254..12411
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            12412..12521
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            12522..12663
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            12664..12745
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            12746..12919
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            12920..13041
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            13042..13239
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            13240..13320
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            13321..13408
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            13409..13536
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            13537..13644
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            13645..13764
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            13765..13955
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            13956..14129
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            14130..14229
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            14230..14448
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            14449..14562
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            14563..14705
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            14706..14831
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            14832..15026
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            15027..15251
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            15252..15342
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            15343..15505
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            15506..15892
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      15862..15867
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /note="hexamer: AATAAA"
     regulatory      15866..15871
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /note="hexamer: AACAAG"
     polyA_site      15885
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
     polyA_site      15892
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /note="major polyA site"
ORIGIN      
        1 gcagtagtac gacggaagat ggcgacgagc ggcggcgaag aggcggcggc agcggctccg
       61 gcgccgggga ccccggcaac gggggcggac acgaccccgg gctgggaggt ggctgtgcgg
      121 cccctgctgt ccgcgtccta ctccgccttc gagatgaagg agttgccgca gctggtggcc
      181 tcagtcatcg agagtgaatc agaaatcctg caccatgaga agcagtacga gccattctac
      241 tcatcttttg ttgcactttc cacacactat attacaacag tttgcagtct cattccccgg
      301 aaccaacttc agtcagtggc agcagcctgt aaagttctaa ttgagttttc tctcctgcgt
      361 ctggagaatc cagatgaggc ttgtgctgtg tcccagaaac acttgattct cctaatcaag
      421 ggcctgtgca ctggctgtag ccgactagat agaactgaaa ttatcacatt tacagcaatg
      481 atgaaatccg ccaagctgcc ccaaacagtg aagacacttt cagacgtgga agatcagaaa
      541 gagctggcct caccagtaag ccctgagttg aggcaaaagg aggtacagat gaattttttg
      601 aaccagctga cctcagtttt taaccctaga actgtagcat cacaacctat cagtacacag
      661 actctggtgg aaggagaaaa tgatgagcag tcatctacag atcaagcctc agctatcaaa
      721 accaagaatg tgttcatagc tcagaacgtg gctagtcttc aagagcttgg tggctcggag
      781 aagctactgc gtgtatgttt gaacctgcca tatttcctac gctatatcaa tcggttccaa
      841 gatgcagttt tagctaattc cttcttcata atgcctgcaa cagtagcaga tgccactgct
      901 gttcgtaatg gctttcattc attggtgatt gatgtaacta tggcattgga taccctttct
      961 ctacctgtgt tggaacctct caatccttct cgtctacaag atgtgacagt cctcagccta
     1021 agttgtctgt atgcaggtgt gagtgtggca acgtgcatgg ccatcctcca tgtgggtagt
     1081 gcccagcaag tgcggacagg gtccacgagc tccaaagaag atgactatga aagtgacgca
     1141 gctacaattg tccagaaatg tctcgaaatc tatgacatga ttggacaagc aatcagcagt
     1201 tctcgccggg ctggtggtga gcactatcag aatttccaat tgctgggtgc ttggtgcttg
     1261 ttaaacagcc ttttcctcat actgaacctc agtcctactg cgttggctga taaggggaaa
     1321 gagaaggacc cactggctgc cctccgagtc agagacatcc tttctcgtac taaagaggga
     1381 gtgggctccc ctaaactggg gcctggaaaa gggcatcagg gatttggggt actctcagta
     1441 atattggcaa accatgccat caaactgcta acgtctctct ttcaagacct acaagtggag
     1501 gcccttcaca agggttggga gacagatggc ccccctgcag ccttgagcat tatggcccag
     1561 agcacctcca tacagaggat tcaacggctg attgactctg tcccactgat gaacctgctc
     1621 ttgacgttac tttcaacttc ctacagaaag gcatgtgtcc tgcagcggca gaggaagggc
     1681 tccatgagca gcgatgccag cgcctccacc gactccaata cttactatga ggacgatttc
     1741 agtagcacgg aggaggacag cagccaagac gatgacagtg agcctatttt ggggcaatgg
     1801 tttgaggaga ctatttctcc cagtaaagag aaagcagcac ctccgcctcc tcccccacct
     1861 cctccactgg aaagctctcc tcgggttaaa agccccagta agcaggcccc tggtgagaag
     1921 ggcaacattc tggcgagtcg caaagatcct gagttgttct taggtctggc ttccaacatt
     1981 ttgaacttca tcacctcttc catgctgaac tctcggaaca attttatccg aaactatctg
     2041 agtgtatctc tttcagaaca ccatatggcc accctagcca gtatcatcaa ggaggtggac
     2101 aaagatggac tcaagggttc atcagatgaa gagtttgctg cagctctcta tcacttcaac
     2161 cactcactgg taacctctga ccttcagtca cctaacctgc agaacacact gttgcagcag
     2221 ctaggagtgg ctcctttttc tgagggccct tggcccttgt acattcaccc tcaaagcctc
     2281 tctgtgcttt cacgcctcct gctcatctgg caacataaag ccagtgctca aggtgaccct
     2341 gacgtcccag aatgccttaa agtttgggac aggtttttgt ctacaatgaa gcagaatgcc
     2401 ctgcaaggtg tggtgcccag tgagacagag gatctgaatg tagaacacct gcagatgctc
     2461 ctcctcattt tccacaattt caccgagaca ggccggcggg ccatattgtc gctttttgtc
     2521 cagatcatcc aggagttgag cgtcaacatg gatgctcaga tgcgcttcgt gccgcttatc
     2581 ttggctcgcc tccttctcat ctttgattat ctgcttcatc agtactccaa agcccctgtg
     2641 tatctatttg agcaggtaca gcataacctg ctaagtcctc cctttgggtg ggcaagtgga
     2701 tcccaggaca gcaacagccg ccgggcaacc actcctctct atcatggatt caaagaagta
     2761 gaagaaaact ggtctaagca tttctcatca gatgctgtcc cacaccccag attctactgt
     2821 gtcctgtccc cagaagcctc agaggatgat ttgaaccgac ttgattctgt ggcatgtgac
     2881 gtccttttct ccaagcttgt caagtatgat gagctttatg ctgcactgac agccctgctt
     2941 gcagctgggt cccagcttga tacagttagg agaaaggaaa acaagaatgt aacagccttg
     3001 gaggcctgtg cccttcaata ttacttcttg atactgtgga ggatcctagg aattttacca
     3061 ccatcaaaga cttacattaa ccagctatcc atgaactcac ctgagatgag cgaatgtgac
     3121 atcttgcaca ctctgcgatg gtcttctcgg ctccggatca gctcctatgt caactggata
     3181 aaggatcacc ttatcaaaca gggaatgaag gctgagcatg ctagctcgct tctagaactg
     3241 gcatccacca ctaagtgtag ctcagtgaaa tatgatgttg aaatagtaga ggaatacttc
     3301 gctcgacaga tctcatcctt ctgtagtatc gactgtacca ccatcttgca gctgcatgaa
     3361 attcccagtc tgcagtccat ctacaccctt gatgccgcga tctcaaaggt ccaggtctct
     3421 ttggatgagc atttttctaa gatggctgct gagactgatc ctcataagtc gtctgagatt
     3481 accaagaacc tacttccagc cacgctgcaa ctcattgaca cctatgcatc gttcaccaga
     3541 gcctatttgc tgcaaaactt taatgaagag ggaacaactg agaaaccttc caaggagaaa
     3601 ctgcaaggct ttgctgctgt tttggctatt ggctctagca ggtgcaaggc aaatactctg
     3661 ggtccgacac tggttcagaa tttgccatcg tcagtgcaga ctgtgtgtga gtcctggaac
     3721 aacatcaata ccaatgaatt tcccaatatt ggatcctggc gcaatgcctt tgccaatgac
     3781 accatccctt cagagagtta tattagtgca gtgcaggctg cacacctggg gactctctgt
     3841 agccaaagtc tgcccctggc tgcttccctg aagcataccc tcctctcact ggtcaggttg
     3901 actggagatc ttattgtttg gtcagatgag atgaacccac cacaggtaat tcggacactg
     3961 ctacctcttc ttttggaatc aagcactgag agtgttgccg agatcagtag caactccctg
     4021 gaacgcatct tgggccctgc tgagtctgat gagttcttgg ctcgtgttta tgagaagctg
     4081 atcactggtt gttacaacat tctggccaat catgcagatc ctaacagtgg actggatgaa
     4141 tccatcctgg aggaatgtct ccagtacttg gaaaagcagc tggaaagtag ccaggctcgt
     4201 aaagctatgg aggagttttt ctctgacagt ggagaacttg tacagatcat gatggcaaca
     4261 gccaatgaga acctctctgc taaattctgt aaccgagttt tgaaattctt caccaaactc
     4321 ttccagctga ctgagaagag ccctaacccg agcctgttgc atctctgtgg ctccctggca
     4381 caactggcct gtgtggaacc tgtgcgcctg caggcctggc tcacccgcat gactacatcg
     4441 cccccaaaag attctgatca gctggatgta attcaggaga accggcagct gctgcagtta
     4501 ctgaccacat acattgttcg ggaaaacagc caagttgggg aaggtgtgtg tgctgttctt
     4561 ctgggcaccc tgactcccat ggcaacagag atgctggcca acggtgatgg gactggcttc
     4621 cctgaactta tggttgtgat ggccactctg gccagtgcag gtcaaggtgc tggtcacctt
     4681 cagcttcata atgctgctgt ggattggctg agcagatgca agaaatacct gtcacagaag
     4741 aatgtagttg aaaaactgaa tgccaatgta atgcatggaa agcatgtgat gatcttggag
     4801 tgcacatgcc atatcatgtc ttacttggct gatgtcacga atgccctgag ccagagtaat
     4861 ggtcaaggcc caagtcatct ctcagtggat ggggaagagc gggccattga agtagactca
     4921 gactgggtgg aggagttggc ggtggaagag gaagattccc aggctgagga ttcagatgaa
     4981 gattctcttt gcaataaact ctgcactttt acgatcacac agaaagaatt catgaaccag
     5041 cattggtacc actgtcacac ctgtaaaatg gtggatggcg tgggtgtctg cacagtgtgt
     5101 gctaaggtgt gccacaagga tcatgagatt tcctatgcca agtatggatc cttcttctgt
     5161 gactgtggag ccaaggaaga tggcagctgt ttggctctgg tgaagagaac tcctagcagt
     5221 ggcatgagct ctaccatgaa ggagtcggca tttcagagtg aacccaggat ttcagagagt
     5281 ctagtgcgtc atgccagcac ctcctcgcca gctgacaaag ccaaggttac catcagtgat
     5341 ggaaaggttg ctgacgaaga gaagcccaag aagagcagcc tctgccgcac agtagagggc
     5401 tgccgggagg aattacagaa ccaggccaat ttctccttcg ctcctctcgt gttagacatg
     5461 cttaatttcc ttatggatgc cattcagacc aacttccagc aagcttcagc cgtcgggagc
     5521 agcagccgtg ctcagcaagc cctcagtgag ctacacactg tggagaaggc agtggagatg
     5581 acagaccagc tgatggttcc caccttaggg tcccaggaag gtgcctttga gaatgtgcgg
     5641 atgaattaca gtggagacca gggccagacc atccggcagc tgatcagtgc tcatgtgctc
     5701 aggcgggtgg ctatgtgtgt gctctcctct ccccatgggc gccgccaaca tttggctgtc
     5761 agccatgaga agggcaagat caccgttctg cagctctctg cactcctgaa gcaagcagat
     5821 tccagcaaaa ggaagttaac tctgacccgc ttggcttctg ccccagttcc ttttactgtg
     5881 ttgagcctca caggaaatcc ctgcaaggaa gactacttgg cggtttgtgg gctaaaggac
     5941 tgtcatgtgc tcacctttag tagctcaggc tctgtttcgg atcacttggt tttgcaccct
     6001 cagttggcaa cggggaactt catcatcaaa gccgtgtggt tacctggttc acagaccgag
     6061 ttagcaattg tcaccgcaga ctttgttaag atttatgacc tgtgtgttga tgccttgagt
     6121 ccaaccttct attttctcct gccaagctca aagataagag atgttacctt ccttttcaat
     6181 gaggagggaa agaacatcat tgttataatg tcttcggctg ggtacatcta tactcagctt
     6241 atggaagagg ccagcagtgc ccagcaggga cccttctatg tcactaatgt gttggaaatc
     6301 aatcatgagg acctgaagga cagtaacagc caggtggcgg gcggtggtgt gtccgtgtac
     6361 tactcccacg tgttgcagat gttgttcttc agctattgtc aaggcaaatc attcgcagcc
     6421 accatcagca ggacaaccct ggaggtgttg caactcttcc ccatcaacat caaaagttcc
     6481 aatggtggca gtaagacttc tcctgctctt tgccagtggt ctgaggtgat gaaccaccct
     6541 ggcttggtgt gctgtgtcca gcaaactaca ggggtgccgc tggtagttat ggtgaaacca
     6601 gacacttttc ttatccagga gattaagact cttcctgcta aagcgaagat ccaagacatg
     6661 gttgctatta ggcacacggc ctgcaatgag cagcagcgga caacaatgat tctgctgtgt
     6721 gaggatggca gcctgcgcat ttacatggcc aacgtggaga acacctccta ctggctgcag
     6781 ccatccctgc agcccagcag tgtcatcagc atcatgaagc ctgttcgaaa gcgcaaaaca
     6841 gctacaatca caacccgcac gtctagccag gtgactttcc ccattgactt ttttgaacac
     6901 aaccagcagc tgacagatgt ggagtttggt ggtaacgacc tcctacaggt ctataatgca
     6961 caacagataa aacaccggct gaattccact ggcatgtatg tggccaacac caagcccgga
     7021 ggcttcacca ttgagattag taacaacaat agcactatgg tgatgacagg catgcggatc
     7081 cagattggga ctcaagcaat agaacgggcc ccgtcatata tcgagatctt cggcagaact
     7141 atgcagctca acctgagtcg ctcacgctgg tttgacttcc ccttcaccag agaagaagcc
     7201 ctgcaggctg ataagaagct gaacctcttc attggggcct cggtggatcc agcaggtgtc
     7261 accatgatag atgctgtaaa aatttatggc aagactaagg agcagtttgg ctggcctgat
     7321 gagcccccag aagaattccc ttctgcctct gtcagcaaca tctgcccttc aaatctgaac
     7381 cagagcaacg gcactggaga tagcgactca gctgccccca ctacgaccag tggaactgtc
     7441 ctggagaggc tggttgtgag ttctttagaa gccctggaaa gctgctttgc cgttggccca
     7501 atcatcgaga aggagagaaa caagaatgct gctcaggagc tggccacttt gctgttgtcc
     7561 ctgccagcac ctgccagtgt ccagcagcag tccaagagcc ttctggccag cctgcacacc
     7621 agccgctcgg cctaccacag ccacaaggat caggccttgc tgagcaaagc tgtgcagtgt
     7681 ctcaacacat ctagcaaaga gggcaaggat ttggaccctg aggtgttcca gaggctagtg
     7741 atcacagctc gctccattgc catcatgcgc cccaacaacc ttgtccactt tacggagtca
     7801 aagctgcccc agatggaaac agaaggaatg gatgaaggga aggaaccgca gaagcagttg
     7861 gaaggagatt gctgtagttt catcacccag cttgtgaacc acttctggaa actccatgca
     7921 tccaaaccca agaatgcctt cttggcacct gcctgccttc caggactaac tcatattgaa
     7981 gctactgtca atgctctggt ggacatcatc catggctact gtacctgtga gctggattgt
     8041 attaacacag catccaagat ctacatgcag atgctcttgt gtcctgatcc tgctgtgagc
     8101 ttctcttgta aacaagctct aattcgagtc ctaaggccca ggaacaaacg gagacatgtg
     8161 actttaccct cttcccctcg aagcaacact ccaatgggag acaaggatga tgatgacgat
     8221 gatgatgcag atgagaaaat gcagtcatca gggatcccga atggtggtca catccgtcag
     8281 gaaagccagg aacagagtga ggtggaccat ggagattttg agatggtgtc tgagtcgatg
     8341 gtcctggaga cagctgaaaa tgtcaacaat ggcaacccct ctcccctgga ggccctgctg
     8401 gcaggcgcag agggcttccc ccccatgctg gacatcccac ctgatgcaga tgacgagacc
     8461 atggttgaac tagccattgc cctgagcctg cagcaggacc aacaaggcag cagcagcagt
     8521 gccctgggcc tgcagagcct gggactgtcc ggccaggcac ccagctcttc ctctctggac
     8581 gcaggaaccc tctctgacac cacagcatca gctccagcct cagacgacga gggcagtaca
     8641 gcagcgacag atggttctac ccttcggacc tctcctgctg accacggtgg tagtgtgggc
     8701 tcggagagcg ggggcagtgc agtggactca gtggctggcg agcacagtgt atctggccgg
     8761 agcagtgctt atggcgatgc tacagctgag gggcatccgg ctggaccagg aagtgtcagc
     8821 tcaagcactg gagccatcag caccaccact gggcaccagg agggagatgg ctccgaggga
     8881 gaaggagaag gagaaactga aggagatgtc cacactagca acaggctgca catggtccgt
     8941 ctaatgctgt tggagagatt actgcagacc ctgcctcaat tacgaaacgt tggcggtgtc
     9001 cgggccatcc catacatgca ggtcattcta atgctcacta cagatctgga tggagaagat
     9061 gagaaagaca agggggccct agacaacctg ctctcccagc ttattgctga gttgggtatg
     9121 gataaaaagg atgtctccaa gaagaatgag cgcagcgccc tgaatgaagt ccatctggta
     9181 gtaatgagac tcctgagtgt cttcatgtcc cgcaccaaat ctggatccaa gtcttccata
     9241 tgtgagtcat cttccctcat ctccagtgcc acagcagcag ctctactgag ctctggggct
     9301 gtggactact gcctgcacgt gctcaaatca ctgctggaat attggaagag ccaacagaat
     9361 gacgaggagc ctgtggctac cagccagttg ctgaaaccac atactacctc ctccccacct
     9421 gacatgagcc cattctttct ccgccagtat gtgaagggtc atgctgctga tgtgtttgag
     9481 gcctatactc agcttctaac agaaatggta ctgaggcttc cttaccaaat caaaaagatt
     9541 actgacacca attctcgaat cccacctcct gtctttgacc actcgtggtt ttactttctc
     9601 tccgagtacc tcatgatcca gcagactcca tttgtgcgcc gtcaagtccg caaacttctg
     9661 ctcttcatct gtggatccaa agagaagtac cgccagctcc gggatttgca caccctggac
     9721 tctcacgtgc gtgggatcaa gaagctgcta gaagagcagg ggatattcct ccgggcaagt
     9781 gtggttacag ccagctcagg ctccgccttg caatatgaca cactcatcag cctgatggag
     9841 cacctgaaag cctgtgcaga gattgccgcc cagcgaacca tcaactggca gaaattctgc
     9901 atcaaagatg actccgtcct gtacttcctc ctccaagtca gtttccttgt ggatgagggc
     9961 gtgtccccag tgctgctgca actgctctcc tgtgctctgt gcggcagcaa ggtgctcgct
    10021 gcactggcag cctcttcggg atcctccagt gcttcttcct cctcagcccc tgtggctgcc
    10081 agttctggac aagccacaac acagtccaag tcttccacta aaaagagcaa gaaagaagaa
    10141 aaagaaaagg agaaagatgg tgagacctct ggcagccagg aggaccagct gtgcacagct
    10201 ctggtgaacc agctgaacaa atttgccgat aaggaaaccc tgatccagtt cctgcgttgt
    10261 ttcctgttag agtccaattc ttcctcggtg cgctggcagg cccactgtct gacactgcac
    10321 atctacagaa attccagcaa atctcaacag gagctcctgc tagatctgat gtggtccatc
    10381 tggccagaac tcccagccta tggtcgtaag gctgcccagt ttgtggacct actaggatat
    10441 ttctccctga aaactccaca aacagagaag aagttgaagg agtattcaca gaaggctgtg
    10501 gagattctgc ggactcaaaa ccatattctt accaaccacc ccaactcgaa catttataac
    10561 actttgtctg gcttagtgga gtttgatggc tattacctgg agagcgatcc ctgcctggtg
    10621 tgtaataacc cggaagtacc gttctgttat atcaagctgt cttccattaa agtggacacg
    10681 cggtacacca ccacccagca ggttgtgaag ctcattggca gtcacaccat cagcaaagtg
    10741 acagtgaaaa tcggggatct gaaacggacc aagatggtgc ggaccatcaa cctgtattat
    10801 aacaaccgaa ccgtgcaggc catcgtggag ttgaaaaaca agccagctcg ctggcacaaa
    10861 gccaagaagg ttcagctgac ccctggacag acagaggtga agattgacct gccgttgccc
    10921 attgtggcct ccaatctgat gattgagttt gcagacttct atgaaaacta ccaggcctcc
    10981 acagagaccc tgcagtgccc tcgctgtagt gcctcggtcc ctgccaaccc aggagtctgt
    11041 ggcaactgtg gagagaatgt gtaccagtgt cacaaatgca gatccatcaa ctacgatgaa
    11101 aaggatccct tcctctgcaa tgcctgtggc ttctgtaaat atgcccgctt cgacttcatg
    11161 ctctatgcca agccttgctg tgcagtggat cccattgaga atgaagaaga ccggaagaag
    11221 gctgtatcca acatcaatac acttttggac aaagctgatc gagtgtatca tcagctgatg
    11281 ggacaccggc cacagctgga gaacctgctc tgcaaagtga atgaggcagc tccagaaaag
    11341 ccacaggatg actcaggaac agcagggggc atcagctcca cttctgccag tgtgaatcgt
    11401 tacatcctgc agttggctca ggagtattgt ggagactgca agaactcttt tgatgaactc
    11461 tccaaaatca tccagaaagt ctttgcttcg cgcaaagagt tgttggaata tgacctacag
    11521 cagagggaag cagccactaa atcatcccgg acctccgtgc agcccacatt cactgccagc
    11581 cagtaccgtg ccttatccgt cctgggctgt ggccacacat cctccaccaa gtgctatggc
    11641 tgcgcctcgg ctgtcacaga acattgtatc acactacttc gggccctggc caccaaccca
    11701 gccttgaggc acatccttgt ctcccagggc cttatccggg agctctttga ttataatctt
    11761 cgccgagggg ctgcggccat gcgggaggag gtccgccagc tcatgtgcct cctaactcga
    11821 gacaacccag aagccaccca acagatgaat gacctgatta ttggcaaggt ctccacagcc
    11881 ctgaagggcc actgggccaa ccccgatctg gcaagtagcc tgcagtatga aatgctgctg
    11941 ctgacggatt ctatctccaa ggaggacagc tgctgggagc tccggttacg ctgtgctctc
    12001 agccttttcc tcatggctgt gaacattaag actcctgtgg tggttgaaaa cattaccctc
    12061 atgtgcctga ggatcttgca gaagctgata aaaccacctg ctcccactag caagaagaac
    12121 aaggatgtcc ccgttgaggc cctcaccacg gtgaagccat actgcaatga gatccatgcc
    12181 caggctcaac tgtggctcaa gagagacccc aaggcatcct atgatgcctg gaagaagtgt
    12241 cttcctatca gagggataga tggcaatggg aaagccccca gcaaatcaga gctccgccat
    12301 ctctatttga ctgagaagta tgtgtggagg tggaaacagt tcctgagtcg tcgggggaag
    12361 aggacctccc ccttggatct caaactgggg cataacaact ggctgcgaca agtgcttttc
    12421 actccagcaa cgcaggccgc acggcaggca gcctgtacca ttgtggaagc tctagccacc
    12481 attcccagcc gcaagcagca ggtcctggac ctgcttacca gttacctgga tgagctgagc
    12541 atagctgggg agtgtgcagc tgagtacctg gctctctacc agaagctcat cacttctgcg
    12601 cactggaaag tctacttggc agctcgggga gtcctaccct atgtgggcaa cctcatcacc
    12661 aaggaaatag ctcgtctgct ggccctggag gaggctaccc tgagtaccga tctgcagcag
    12721 ggttatgccc ttaaaagtct cacaggcctt ctctcctcct ttgttgaggt ggaatccatc
    12781 aaaagacatt ttaaaagtcg cttggtgggt actgtgctga atggatacct gtgcttgcgg
    12841 aagctggtgg tgcagaggac caagctgatc gatgagacgc aggacatgct gctggagatg
    12901 ctggaggaca tgaccacagg tacagaatca gaaaccaagg ccttcatggc tgtgtgcatt
    12961 gagacagcca agcgctacaa tctggatgac taccggaccc cggtgttcat cttcgagagg
    13021 ctctgcagca tcatttatcc tgaggagaat gaagtcactg agttctttgt gaccctggag
    13081 aaggatcccc aacaagaaga cttcttacag ggcaggatgc ctgggaaccc gtatagcagc
    13141 aatgagccag gcatcgggcc gctgatgagg gatataaaga acaagatttg ccaggactgt
    13201 gacttagtgg ccctcctgga agatgacagt ggcatggagc ttctagtgaa caataaaatc
    13261 attagtttgg accttcctgt ggctgaagtt tacaagaaag tctggtgtac cacgaatgag
    13321 ggagagccca tgaggattgt ttatcgtatg cgggggctgc tgggcgatgc cacagaggag
    13381 ttcattgagt ccctggactc tactacagat gaagaagaag atgaagaaga agtgtataaa
    13441 atggctggtg tgatggccca gtgtgggggc ctggaatgca tgcttaacag actcgcaggg
    13501 atcagagatt tcaagcaggg acgccacctt ctaacagtgc tactgaaatt gttcagttac
    13561 tgcgtgaagg tgaaagtcaa ccggcagcaa ctggtcaaac tggaaatgaa caccttgaac
    13621 gtcatgctgg ggaccctaaa cctggccctt gtagctgaac aagaaagcaa ggacagtggg
    13681 ggtgcagctg tggctgagca ggtgcttagc atcatggaga tcattctaga tgagtccaat
    13741 gctgagcccc tgagtgagga caagggcaac ctcctcctga caggtgacaa ggatcaactg
    13801 gtgatgctct tggaccagat caacagcacc tttgttcgct ccaaccccag tgtgctccag
    13861 ggcctgcttc gcatcatccc gtacctttcc tttggagagg tggagaaaat gcagatcttg
    13921 gtggagcgat tcaaaccata ctgcaacttt gataaatatg atgaagatca cagtggtgat
    13981 gataaagtct tcctggactg cttctgtaaa atagctgctg gcatcaagaa caacagcaat
    14041 gggcaccagc tgaaggatct gattctccag aaggggatca cccagaatgc acttgactac
    14101 atgaaaaagc acatccctag cgccaagaat ttggatgccg acatctggaa aaagtttttg
    14161 tctcgcccag ccttgccatt tatcctaagg ctgcttcggg gcctggccat ccagcaccct
    14221 ggcacccagg ttctgattgg aactgattcc atcccgaacc tgcataagct ggagcaggtg
    14281 tccagtgatg agggcattgg gaccttggca gagaacctgc tggaagccct gcgggaacac
    14341 cctgacgtaa acaagaagat tgacgcagcc cgcagggaga cccgggcaga gaagaagcgc
    14401 atggccatgg caatgaggca gaaggccctg ggcaccctgg gcatgacgac aaatgaaaag
    14461 ggccaggtcg tgaccaagac agcactcctg aagcagatgg aagagctgat cgaggagcct
    14521 ggcctcacgt gctgcatctg cagggaggga tacaagttcc agcccacaaa ggtcctgggc
    14581 atttatacct tcacgaagcg ggtagccttg gaggagatgg agaataagcc ccggaaacag
    14641 cagggctaca gcaccgtgtc ccacttcaac attgtgcact acgactgcca tctggctgcc
    14701 gtcaggttgg ctcgaggccg ggaagagtgg gagagtgccg ccctgcagaa tgccaacacc
    14761 aagtgcaacg ggctccttcc ggtctgggga cctcatgtcc ctgaatcagc ttttgccact
    14821 tgcttggcaa gacacaacac ttacctccag gaatgtacag gccagcggga gcccacgtat
    14881 cagctcaaca tccatgacat caaactgctc ttcctgcgct tcgccatgga gcagtcgttc
    14941 agcgcagaca ctggcggggg cggccgggag agcaacatcc acctgatccc gtacatcatt
    15001 cacactgtgc tttacgtcct gaacacaacc cgagcaactt cccgagaaga gaagaacctc
    15061 caaggctttc tggaacagcc caaggagaag tgggtggaga gtgcctttga agtggacggg
    15121 ccctactatt tcacagtctt ggcccttcac atcctgcccc ctgagcagtg gagagccaca
    15181 cgtgtggaaa tcttgcggag gctgttggtg acctcgcagg ctcgggcagt ggctccaggt
    15241 ggagccacca ggctgacaga taaggcagtg aaggactatt ccgcttaccg ttcttccctt
    15301 ctcttttggg ccctcgtcga tctcatttac aacatgttta agaaggtgcc taccagtaac
    15361 acagagggag gctggtcctg ctctctcgct gagtacatcc gccacaacga catgcccatc
    15421 tacgaagctg ccgacaaagc cctgaaaacc ttccaggagg agttcatgcc agtggagacc
    15481 ttctcagagt tcctcgatgt ggccggtctt ttatcagaaa tcaccgatcc agagagcttc
    15541 ctgaaggacc tgttgaactc agtcccctga ccaccacaca gcagctgcgg cggcgaagac
    15601 gaagctggct tgccttccac cctctgttct ccctccttgt gcattaagtt ccctccgcgg
    15661 gatgctgcat tgttaccccg ccctcccctc tctcattttt cttggtgtgg cttggggttt
    15721 ttaggcttcc tgttttatct cgtgtgtgtg gtgcaccagc tatgaggttg tctgtaaccc
    15781 aagccatcaa agggcctgta catacctagg agccatgagt tgtcccggcc agcttcatac
    15841 ttgagtgtgc acatcttgag aaataaacaa gtgacttaac acacattgaa aa
//
