LOCUS       NP_742067               1888 aa            linear   PRI 07-APR-2024
DEFINITION  E3 ubiquitin-protein ligase UBR3 [Homo sapiens].
ACCESSION   NP_742067
VERSION     NP_742067.3
DBSOURCE    REFSEQ: accession NM_172070.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 1888)
  AUTHORS   Buianova,A.A., Proskura,M.V., Cheranev,V.V., Belova,V.A.,
            Shmitko,A.O., Pavlova,A.S., Vasiliadis,I.A., Suchalko,O.N.,
            Rebrikov,D.V., Petrosyan,E.K. and Korostin,D.O.
  TITLE     Candidate Genes for IgA Nephropathy in Pediatric Patients:
            Exome-Wide Association Study
  JOURNAL   Int J Mol Sci 24 (21), 15984 (2023)
   PUBMED   37958966
  REMARK    GeneRIF: Candidate Genes for IgA Nephropathy in Pediatric Patients:
            Exome-Wide Association Study.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1888)
  AUTHORS   Jiang,Z., Zhao,Q., Chen,L., Luo,Y., Shen,L., Cao,Z. and Wang,Q.
  TITLE     UBR3 promotes inflammation and apoptosis via DUSP1/p38 pathway in
            the nucleus pulposus cells of patients with intervertebral disc
            degeneration
  JOURNAL   Hum Cell 35 (3), 792-802 (2022)
   PUBMED   35332432
  REMARK    GeneRIF: UBR3 promotes inflammation and apoptosis via DUSP1/p38
            pathway in the nucleus pulposus cells of patients with
            intervertebral disc degeneration.
REFERENCE   3  (residues 1 to 1888)
  AUTHORS   Zhao,C., Wang,L., Ma,X., Zhu,W., Yao,L., Cui,Y., Liu,Y., Li,J.,
            Liang,X., Sun,Y., Li,L. and Chen,Y.H.
  TITLE     Cardiac Nav 1.5 is modulated by ubiquitin protein ligase E3
            component n-recognin UBR3 and 6
  JOURNAL   J Cell Mol Med 19 (9), 2143-2152 (2015)
   PUBMED   26059563
  REMARK    GeneRIF: UBR3/6 regulate cardiomyocyte Nav 1.5 channel protein
            levels via the ubiquitin-proteasome pathway.
REFERENCE   4  (residues 1 to 1888)
  AUTHORS   Meisenberg,C., Tait,P.S., Dianova,I.I., Wright,K., Edelmann,M.J.,
            Ternette,N., Tasaki,T., Kessler,B.M., Parsons,J.L., Kwon,Y.T. and
            Dianov,G.L.
  TITLE     Ubiquitin ligase UBR3 regulates cellular levels of the essential
            DNA repair protein APE1 and is required for genome stability
  JOURNAL   Nucleic Acids Res 40 (2), 701-711 (2012)
   PUBMED   21933813
  REMARK    GeneRIF: The human E3 ubiquitin ligase UBR3 has a major activity
            that polyubiquitylates APE1 at multiple lysine residues clustered
            on the N-terminal tail.
REFERENCE   5  (residues 1 to 1888)
  AUTHORS   Ding,H., Xu,Y., Bao,X., Wang,X., Cui,G., Wang,W., Hui,R. and
            Wang,D.W.
  TITLE     Confirmation of genomewide association signals in Chinese Han
            population reveals risk loci for ischemic stroke
  JOURNAL   Stroke 41 (1), 177-180 (2010)
   PUBMED   19910543
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (residues 1 to 1888)
  AUTHORS   Tasaki,T., Sohr,R., Xia,Z., Hellweg,R., Hortnagl,H., Varshavsky,A.
            and Kwon,Y.T.
  TITLE     Biochemical and genetic studies of UBR3, a ubiquitin ligase with a
            function in olfactory and other sensory systems
  JOURNAL   J Biol Chem 282 (25), 18510-18520 (2007)
   PUBMED   17462990
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC009967.8, AI142128.1, BF446017.1, BX281113.1, DR731153.1,
            DA301129.1, DN831941.1, DA352029.1, DA108743.1, DA234864.1,
            BU158552.1, BC113010.2, BX494687.1, BC044060.1 and AC092641.2.
            
            On Nov 22, 2007 this sequence version replaced NP_742067.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1965299,
                              SAMEA1966682 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000272793.11/ ENSP00000272793.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1888
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q31.1"
     Protein         1..1888
                     /product="E3 ubiquitin-protein ligase UBR3"
                     /EC_number="2.3.2.27"
                     /note="zinc finger protein 650; N-recognin-3;
                     ubiquitin-protein ligase E3-alpha-3; ubiquitin-protein
                     ligase E3-alpha-III; RING-type E3 ubiquitin transferase
                     UBR3; ubiquitin protein ligase E3 component n-recognin 3
                     (putative)"
                     /calculated_mol_wt=212303
     Region          1..24
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6ZT12.2)"
     Region          120..188
                     /region_name="UBR-box_UBR3"
                     /note="UBR-box found in ubiquitin-protein ligase
                     E3-alpha-3 (UBR3) and similar proteins; cd19673"
                     /db_xref="CDD:439071"
     Site            order(120,136,145,148,154,170,172,184)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:439071"
     Region          339..362
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6ZT12.2)"
     Site            343
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q5U430; propagated from
                     UniProtKB/Swiss-Prot (Q6ZT12.2)"
     Site            344
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q5U430; propagated from
                     UniProtKB/Swiss-Prot (Q6ZT12.2)"
     Site            761..781
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6ZT12.2)"
     Site            919..939
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6ZT12.2)"
     Region          1008..1028
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6ZT12.2)"
     Region          1164..1186
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6ZT12.2)"
     Site            1199
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q5U430; propagated from
                     UniProtKB/Swiss-Prot (Q6ZT12.2)"
     Region          1320..1372
                     /region_name="RING-H2_UBR3"
                     /note="RING finger, H2 subclass, found in
                     ubiquitin-protein ligase E3-alpha-3 (UBR3) and similar
                     proteins; cd16483"
                     /db_xref="CDD:438146"
     Region          1426..1871
                     /region_name="PRT6_C"
                     /note="Proteolysis_6 C-terminal; pfam18995"
                     /db_xref="CDD:465944"
     Site            1806..1826
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6ZT12.2)"
     CDS             1..1888
                     /gene="UBR3"
                     /gene_synonym="ZNF650"
                     /coded_by="NM_172070.4:55..5721"
                     /db_xref="CCDS:CCDS2238.2"
                     /db_xref="GeneID:130507"
                     /db_xref="HGNC:HGNC:30467"
                     /db_xref="MIM:613831"
ORIGIN      
        1 maaaaaaavg gqqpsqpelp apglaldkaa taahlkaals rpdnragaee lqallervls
       61 aerplaaaag gedaaaaggg ggpgaaeeea lewckcllag gggydefcaa vraydpaalc
      121 glvwtanfva yrcrtcgisp cmslcaecfh qgdhtghdfn mfrsqaggac dcgdsnvmre
      181 sgfckrhqik sssnipcvpk dllmmsefvl prfifcliqy lregynepaa dgpsekdlnk
      241 vlqllepqis fledltkmgg amrsvltqvl tnqqnykdlt sglgenacvk kshekylial
      301 kssgltyped klvygvqeps agtsslavqg figatgtlgq vdssdeddqd gsqglgkrkr
      361 vklssgtkdq simdvlkhks fleellfwti kyefpqkmvt fllnmlpdqe ykvaftktfv
      421 qhyafimktl kkshesdtms nrivhisvql fsneelarqv teecqlldim vtvllymmes
      481 clikselqde enslhvvvnc geallknnty wplvsdfini lshqsvakrf ledhgllvtw
      541 mnfvsffqgm nlnkrelneh vefesqtyya afaaeleaca qpmwgllshc kvretqeytr
      601 nvvrycleal qdwfdainfv depapnqvtf hlplhryyam flskavkcqe ldldsvlpdq
      661 emlmklmihp lqiqaslaei hsnmwvrngl qikgqamtyv qshfcnsmid pdiyllqvca
      721 srldpdyfis svferfkvvd lltmasqhqn tvldaehers mlegaltflv illslrlhlg
      781 msddeilrae mvaqlcmndr thsslldlip enpnpksgii pgsysfesvl savadfkapv
      841 fepggsmqqg mytpkaevwd qefdpvmvil rtvyrrdvqs amdrytaflk qsgkfpgnpw
      901 ppykkrtslh psykglmrll hcktlhivlf tllykilmdh qnlsehvlcm vlylielgle
      961 nsaeeesdee asvggperch dswfpgsnlv snmrhfinyv rvrvpetape vkrdspasts
     1021 sdnlgslqns gtaqvfslva errkkfqeii nrssseanqv vrpktsskws apgsapqltt
     1081 aileikesil slliklhhkl sgkqnsyypp wlddieiliq peipkyshgd gitaverill
     1141 kaasqsrmnk riieeicrkv tppvppkkvt aaekktldke errqkarerq qkllaefasr
     1201 qksfmetamd vdspendipm eittaepqvs eavydcvicg qsgpssedrp tglvvllqas
     1261 svlgqcrdnv epkklpisee eqiypwdtca avhdvrlsll qryfkdsscl lavsigwegg
     1321 vyvqtcghtl hidchksyme slrndqvlqg fsvdkgeftc plcrqfansv lpcypgsnve
     1381 nnpwqrpsnk siqdlikeve elqgrpgafp setnlskeme svmkdikntt qkkyrdyskt
     1441 pgspdndflf mysvartnle lelihrggnl csggastagk rsclnqlfhv lalhmrlysi
     1501 dseynpwrkl tqleemnpql gyeeqqpevp ilyhdvtsll liqilmmpqp lrkdhftciv
     1561 kvlftllytq alaalsvkcs eedrsawkha galkkstcda eksyevllsf viselfkgkl
     1621 yheegtqeca mvnpiawspe smekclqdfc lpflritsll qhhlfgedlp scqeeeefsv
     1681 lasclgllpt fyqtehpfis ascldwpvpa fdiitqwcfe iksfterhae qgkalliqes
     1741 kwklphllql penyntifqy yhrktcsvct kvpkdpavcl vcgtfvclkg lcckqqsyce
     1801 cvlhsqncga gtgifllina sviiiirghr fclwgsvyld ahgeedrdlr rgkplyicke
     1861 rykvleqqwi shtfdhinkr wgphyngl
//
