LOCUS       NM_001363705            7891 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens ubiquitin protein ligase E3 component n-recognin 2
            (UBR2), transcript variant 3, mRNA.
ACCESSION   NM_001363705 XM_005248965
VERSION     NM_001363705.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7891)
  AUTHORS   Shih,Y.C., Chen,H.F., Wu,C.Y., Ciou,Y.R., Wang,C.W., Chuang,H.C.
            and Tan,T.H.
  TITLE     The phosphatase DUSP22 inhibits UBR2-mediated K63-ubiquitination
            and activation of Lck downstream of TCR signalling
  JOURNAL   Nat Commun 15 (1), 532 (2024)
   PUBMED   38225265
  REMARK    GeneRIF: The phosphatase DUSP22 inhibits UBR2-mediated
            K63-ubiquitination and activation of Lck downstream of TCR
            signalling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7891)
  AUTHORS   Mascia,E., Clarelli,F., Zauli,A., Guaschino,C., Sorosina,M.,
            Barizzone,N., Basagni,C., Santoro,S., Ferre,L., Bonfiglio,S.,
            Biancolini,D., Pozzato,M., Guerini,F.R., Protti,A., Liguori,M.,
            Moiola,L., Vecchio,D., Bresolin,N., Comi,G., Filippi,M.,
            Esposito,F., D'Alfonso,S. and Martinelli-Boneschi,F.
  TITLE     Burden of rare coding variants in an Italian cohort of familial
            multiple sclerosis
  JOURNAL   J Neuroimmunol 362, 577760 (2022)
   PUBMED   34922125
  REMARK    GeneRIF: Burden of rare coding variants in an Italian cohort of
            familial multiple sclerosis.
REFERENCE   3  (bases 1 to 7891)
  AUTHORS   Villa,E., Paul,R., Meynet,O., Volturo,S., Pinna,G. and Ricci,J.E.
  TITLE     The E3 ligase UBR2 regulates cell death under caspase deficiency
            via Erk/MAPK pathway
  JOURNAL   Cell Death Dis 11 (12), 1041 (2020)
   PUBMED   33288741
  REMARK    GeneRIF: The E3 ligase UBR2 regulates cell death under caspase
            deficiency via Erk/MAPK pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7891)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 7891)
  AUTHORS   Weishaupl,D., Schneider,J., Peixoto Pinheiro,B., Ruess,C.,
            Dold,S.M., von Zweydorf,F., Gloeckner,C.J., Schmidt,J., Riess,O.
            and Schmidt,T.
  TITLE     Physiological and pathophysiological characteristics of ataxin-3
            isoforms
  JOURNAL   J Biol Chem 294 (2), 644-661 (2019)
   PUBMED   30455355
REFERENCE   6  (bases 1 to 7891)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   7  (bases 1 to 7891)
  AUTHORS   Zenker,M., Mayerle,J., Lerch,M.M., Tagariello,A., Zerres,K.,
            Durie,P.R., Beier,M., Hulskamp,G., Guzman,C., Rehder,H.,
            Beemer,F.A., Hamel,B., Vanlieferinghen,P., Gershoni-Baruch,R.,
            Vieira,M.W., Dumic,M., Auslender,R., Gil-da-Silva-Lopes,V.L.,
            Steinlicht,S., Rauh,M., Shalev,S.A., Thiel,C., Ekici,A.B.,
            Winterpacht,A., Kwon,Y.T., Varshavsky,A. and Reis,A.
  TITLE     Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway,
            causes pancreatic dysfunction, malformations and mental retardation
            (Johanson-Blizzard syndrome)
  JOURNAL   Nat Genet 37 (12), 1345-1350 (2005)
   PUBMED   16311597
  REMARK    Erratum:[Nat Genet. 2006 Feb;38(2):265. Ekici, Arif B [added]]
REFERENCE   8  (bases 1 to 7891)
  AUTHORS   Kwak,K.S., Zhou,X., Solomon,V., Baracos,V.E., Davis,J.,
            Bannon,A.W., Boyle,W.J., Lacey,D.L. and Han,H.Q.
  TITLE     Regulation of protein catabolism by muscle-specific and
            cytokine-inducible ubiquitin ligase E3alpha-II during cancer
            cachexia
  JOURNAL   Cancer Res 64 (22), 8193-8198 (2004)
   PUBMED   15548684
REFERENCE   9  (bases 1 to 7891)
  AUTHORS   Yin,J., Kwon,Y.T., Varshavsky,A. and Wang,W.
  TITLE     RECQL4, mutated in the Rothmund-Thomson and RAPADILINO syndromes,
            interacts with ubiquitin ligases UBR1 and UBR2 of the N-end rule
            pathway
  JOURNAL   Hum Mol Genet 13 (20), 2421-2430 (2004)
   PUBMED   15317757
REFERENCE   10 (bases 1 to 7891)
  AUTHORS   Kwon,Y.T., Xia,Z., An,J.Y., Tasaki,T., Davydov,I.V., Seo,J.W.,
            Sheng,J., Xie,Y. and Varshavsky,A.
  TITLE     Female lethality and apoptosis of spermatocytes in mice lacking the
            UBR2 ubiquitin ligase of the N-end rule pathway
  JOURNAL   Mol Cell Biol 23 (22), 8255-8271 (2003)
   PUBMED   14585983
  REMARK    GeneRIF: Study provides functional data for the mouse ubiquitin
            protein ligase E3 component n-recognin 2 protein.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL136223.11, AL391814.16 and
            AL049843.18.
            
            On May 21, 2020 this sequence version replaced NM_001363705.1.
            
            Transcript Variant: This variant (3) lacks an alternate in-frame
            exon and contains another alternate in-frame exon of the same size
            compared to variant 1. The resulting isoform (3) is the same size
            but has an alternate internal sequence compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853567.25637.1,
                                           SRR18074967.3213510.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372901.2/ ENSP00000361992.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-369               AL136223.11        56219-56587
            370-629             AL136223.11        65924-66183
            630-708             AL136223.11        84341-84419
            709-822             AL136223.11        86381-86494
            823-953             AL136223.11        95778-95908
            954-1092            AL136223.11        97911-98049
            1093-1155           AL136223.11        98779-98841
            1156-1276           AL391814.16        586-706
            1277-1384           AL391814.16        3486-3593
            1385-1473           AL391814.16        4417-4505
            1474-1572           AL391814.16        5824-5922
            1573-1736           AL049843.18        107440-107603       c
            1737-1836           AL049843.18        107251-107350       c
            1837-1965           AL049843.18        104609-104737       c
            1966-2149           AL049843.18        102961-103144       c
            2150-2211           AL049843.18        99885-99946         c
            2212-2322           AL049843.18        98463-98573         c
            2323-2388           AL049843.18        97674-97739         c
            2389-2511           AL049843.18        95819-95941         c
            2512-2575           AL049843.18        95619-95682         c
            2576-2700           AL049843.18        94565-94689         c
            2701-2753           AL049843.18        91985-92037         c
            2754-2856           AL049843.18        89769-89871         c
            2857-2905           AL049843.18        88084-88132         c
            2906-3060           AL049843.18        87510-87664         c
            3061-3163           AL049843.18        84432-84534         c
            3164-3273           AL049843.18        82022-82131         c
            3274-3354           AL049843.18        81835-81915         c
            3355-3533           AL049843.18        81331-81509         c
            3534-3733           AL049843.18        80300-80499         c
            3734-3827           AL049843.18        77878-77971         c
            3828-3989           AL049843.18        76736-76897         c
            3990-4093           AL049843.18        74643-74746         c
            4094-4172           AL049843.18        73910-73988         c
            4173-4321           AL049843.18        69915-70063         c
            4322-4377           AL049843.18        69440-69495         c
            4378-4474           AL049843.18        66268-66364         c
            4475-4542           AL049843.18        65962-66029         c
            4543-4678           AL049843.18        63964-64099         c
            4679-4769           AL049843.18        63282-63372         c
            4770-4900           AL049843.18        61486-61616         c
            4901-5009           AL049843.18        60323-60431         c
            5010-5066           AL049843.18        57044-57100         c
            5067-5144           AL049843.18        55284-55361         c
            5145-5315           AL049843.18        51769-51939         c
            5316-5417           AL049843.18        50485-50586         c
            5418-7891           AL049843.18        46650-49123         c
FEATURES             Location/Qualifiers
     source          1..7891
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.1"
     gene            1..7891
                     /gene="UBR2"
                     /gene_synonym="bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3"
                     /note="ubiquitin protein ligase E3 component n-recognin 2"
                     /db_xref="GeneID:23304"
                     /db_xref="HGNC:HGNC:21289"
                     /db_xref="MIM:609134"
     exon            1..369
                     /gene="UBR2"
                     /gene_synonym="bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3"
                     /inference="alignment:Splign:2.1.0"
     CDS             292..5559
                     /gene="UBR2"
                     /gene_synonym="bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3"
                     /EC_number="2.3.2.27"
                     /note="isoform 3 is encoded by transcript variant 3;
                     ubiquitin-protein ligase E3-alpha-2; ubiquitin-protein
                     ligase E3-alpha-II; RING-type E3 ubiquitin transferase
                     UBR2"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase UBR2 isoform 3"
                     /protein_id="NP_001350634.1"
                     /db_xref="CCDS:CCDS87404.1"
                     /db_xref="GeneID:23304"
                     /db_xref="HGNC:HGNC:21289"
                     /db_xref="MIM:609134"
                     /translation="MASELEPEVQAIDRSLLECSAEEIAGKWLQATDLTREVYQHLAH
                     YVPKIYCRGPNPFPQKEDMLAQHVLLGPMEWYLCGEDPAFGFPKLEQANKPSHLCGRV
                     FKVGEPTYSCRDCAVDPTCVLCMECFLGSIHRDHRYRMTTSGGGGFCDCGDTEAWKEG
                     PYCQKHELNTSEIEEEEDPLVHLSEDVIARTYNIFAITFRYAVEILTWEKESELPADL
                     EMVEKSDTYYCMLFNDEVHTYEQVIYTLQKAVNCTQKEAIGFATTVDRDGRRSVRYGD
                     FQYCEQAKSVIVRNTSRQTKPLKVQVMHSSIVAHQNFGLKLLSWLGSIIGYSDGLRRI
                     LCQVGLQEGPDGENSSLVDRLMLSDSKLWKGARSVYHQLFMSSLLMDLKYKKLFAVRF
                     AKNYERLQSDYVTDDHDREFSVADLSVQIFTVPSLARMLITEENLMSIIIKTFMDHLR
                     HRDAQGRFQFERYTALQAFKFRRVQSLILDLKYVLISKPTEWSDELRQKFLEGFDAFL
                     ELLKCMQGMDPITRQVGQHIEMEPEWEAAFTLQMKLTHVISMMQDWCASDEKVLIEAY
                     KKCLAVLMQCHGGYTDGEQPITLSICGHSVETIRYCVSQEKVSIHLPVSRLLAGLHVL
                     LSKSEVAYKFPELLPLSELSPPMLIEHPLRCLVLCAQVHAGMWRRNGFSLVNQIYYYH
                     NVKCRREMFDKDVVMLQTGVSMMDPNHFLMIMLSRFELYQIFSTPDYGKRFSSEITHK
                     DVVQQNNTLIEEMLYLIIMLVGERFSPGVGQVNATDEIKREIIHQLSIKPMAHSELVK
                     SLPEDENKETGMESVIEAVAHFKKPGLTGRGMYELKPECAKEFNLYFYHFSRAEQSKA
                     EEAQRKLKRQNREDTALPPPVLPPFCPLFASLVNILQSDVMLCIMGTILQWAVEHNGY
                     AWSESMLQRVLHLIGMALQEEKQHLENVTEEHVVTFTFTQKISKPGEAPKNSPSILAM
                     LETLQNAPYLEVHKDMIRWILKTFNAVKKMRESSPTSPVAETEGTIMEESSRDKDKAE
                     RKRKAEIARLRREKIMAQMSEMQRHFIDENKELFQQTLELDASTSAVLDHSPVASDMT
                     LTALGPAQTQVPEQRQFVTCILCQEEQEVKVESRAMVLAAFVQRSTVLSKNRSKFIQD
                     PEKYDPLFMHPDLSCGTHTSSCGHIMHAHCWQRYFDSVQAKEQRRQQRLRLHTSYDVE
                     NGEFLCPLCECLSNTVIPLLLPPRNIFNNRLNFSDQPNLTQWIRTISQQIKALQFLRK
                     EESTPNNASTKNSENVDELQLPEGFRPDFRPKIPYSESIKEMLTTFGTATYKVGLKVH
                     PNEEDPRVPIMCWGSCAYTIQSIERILSDEDKPLFGPLPCRLDDCLRSLTRFAAAHWT
                     VASVSVVQGHFCKLFASLVPNDSHEELPCILDIDMFHLLVGLVLAFPALQCQDFSGIS
                     LGTGDLHIFHLVTMAHIIQILLTSCTEENGMDQENPPCEEESAVLALYKTLHQYTGSA
                     LKEIPSGWHLWRSVRAGIMPFLKCSALFFHYLNGVPSPPDIQVPGTSHFEHLCSYLSL
                     PNNLICLFQENSEIMNSLIESWCRNSEVKRYLEGERDAIRYPRESNKLINLPEDYSSL
                     INQASNFSCPKSGGDKSRAPTLCLVCGSLLCSQSYCCQTELEGEDVGACTAHTYSCGS
                     GVGIFLRVRECQVLFLAGKTKGCFYSPPYLDDYGETDQGLRRGNPLHLCKERFKKIQK
                     LWHQHSVTEEIGHAQEANQTLVGIDWQHL"
     exon            370..629
                     /gene="UBR2"
                     /gene_synonym="bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3"
                     /inference="alignment:Splign:2.1.0"
     exon            630..708
                     /gene="UBR2"
                     /gene_synonym="bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3"
                     /inference="alignment:Splign:2.1.0"
     exon            709..822
                     /gene="UBR2"
                     /gene_synonym="bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3"
                     /inference="alignment:Splign:2.1.0"
     exon            823..953
                     /gene="UBR2"
                     /gene_synonym="bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1092
                     /gene="UBR2"
                     /gene_synonym="bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1155
                     /gene="UBR2"
                     /gene_synonym="bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1276
                     /gene="UBR2"
                     /gene_synonym="bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1384
                     /gene="UBR2"
                     /gene_synonym="bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1473
                     /gene="UBR2"
                     /gene_synonym="bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1572
                     /gene="UBR2"
                     /gene_synonym="bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1736
                     /gene="UBR2"
                     /gene_synonym="bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1737..1836
                     /gene="UBR2"
                     /gene_synonym="bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..1965
                     /gene="UBR2"
                     /gene_synonym="bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1966..2149
                     /gene="UBR2"
                     /gene_synonym="bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3"
                     /inference="alignment:Splign:2.1.0"
     exon            2150..2211
                     /gene="UBR2"
                     /gene_synonym="bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3"
                     /inference="alignment:Splign:2.1.0"
     exon            2212..2322
                     /gene="UBR2"
                     /gene_synonym="bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3"
                     /inference="alignment:Splign:2.1.0"
     exon            2323..2388
                     /gene="UBR2"
                     /gene_synonym="bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3"
                     /inference="alignment:Splign:2.1.0"
     exon            2389..2511
                     /gene="UBR2"
                     /gene_synonym="bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3"
                     /inference="alignment:Splign:2.1.0"
     exon            2512..2575
                     /gene="UBR2"
                     /gene_synonym="bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3"
                     /inference="alignment:Splign:2.1.0"
     exon            2576..2700
                     /gene="UBR2"
                     /gene_synonym="bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3"
                     /inference="alignment:Splign:2.1.0"
     exon            2701..2753
                     /gene="UBR2"
                     /gene_synonym="bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3"
                     /inference="alignment:Splign:2.1.0"
     exon            2754..2856
                     /gene="UBR2"
                     /gene_synonym="bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3"
                     /inference="alignment:Splign:2.1.0"
     exon            2857..2905
                     /gene="UBR2"
                     /gene_synonym="bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3"
                     /inference="alignment:Splign:2.1.0"
     exon            2906..3060
                     /gene="UBR2"
                     /gene_synonym="bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3"
                     /inference="alignment:Splign:2.1.0"
     exon            3061..3163
                     /gene="UBR2"
                     /gene_synonym="bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3"
                     /inference="alignment:Splign:2.1.0"
     exon            3164..3273
                     /gene="UBR2"
                     /gene_synonym="bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3"
                     /inference="alignment:Splign:2.1.0"
     exon            3274..3354
                     /gene="UBR2"
                     /gene_synonym="bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3"
                     /inference="alignment:Splign:2.1.0"
     exon            3355..3533
                     /gene="UBR2"
                     /gene_synonym="bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3"
                     /inference="alignment:Splign:2.1.0"
     exon            3534..3733
                     /gene="UBR2"
                     /gene_synonym="bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3"
                     /inference="alignment:Splign:2.1.0"
     exon            3734..3827
                     /gene="UBR2"
                     /gene_synonym="bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3"
                     /inference="alignment:Splign:2.1.0"
     exon            3828..3989
                     /gene="UBR2"
                     /gene_synonym="bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3"
                     /inference="alignment:Splign:2.1.0"
     exon            3990..4093
                     /gene="UBR2"
                     /gene_synonym="bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3"
                     /inference="alignment:Splign:2.1.0"
     exon            4094..4172
                     /gene="UBR2"
                     /gene_synonym="bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3"
                     /inference="alignment:Splign:2.1.0"
     exon            4173..4321
                     /gene="UBR2"
                     /gene_synonym="bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3"
                     /inference="alignment:Splign:2.1.0"
     exon            4322..4377
                     /gene="UBR2"
                     /gene_synonym="bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3"
                     /inference="alignment:Splign:2.1.0"
     exon            4378..4474
                     /gene="UBR2"
                     /gene_synonym="bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3"
                     /inference="alignment:Splign:2.1.0"
     exon            4475..4542
                     /gene="UBR2"
                     /gene_synonym="bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3"
                     /inference="alignment:Splign:2.1.0"
     exon            4543..4678
                     /gene="UBR2"
                     /gene_synonym="bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3"
                     /inference="alignment:Splign:2.1.0"
     exon            4679..4769
                     /gene="UBR2"
                     /gene_synonym="bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3"
                     /inference="alignment:Splign:2.1.0"
     exon            4770..4900
                     /gene="UBR2"
                     /gene_synonym="bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3"
                     /inference="alignment:Splign:2.1.0"
     exon            4901..5009
                     /gene="UBR2"
                     /gene_synonym="bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3"
                     /inference="alignment:Splign:2.1.0"
     exon            5010..5066
                     /gene="UBR2"
                     /gene_synonym="bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3"
                     /inference="alignment:Splign:2.1.0"
     exon            5067..5144
                     /gene="UBR2"
                     /gene_synonym="bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3"
                     /inference="alignment:Splign:2.1.0"
     exon            5145..5315
                     /gene="UBR2"
                     /gene_synonym="bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3"
                     /inference="alignment:Splign:2.1.0"
     exon            5316..5417
                     /gene="UBR2"
                     /gene_synonym="bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3"
                     /inference="alignment:Splign:2.1.0"
     exon            5418..7891
                     /gene="UBR2"
                     /gene_synonym="bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5645..5650
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBR2"
                     /gene_synonym="bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3"
                     /note="hexamer: AATAAA"
     polyA_site      5668
                     /gene="UBR2"
                     /gene_synonym="bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3"
                     /note="major polyA site"
     regulatory      7866..7871
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBR2"
                     /gene_synonym="bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3"
                     /note="hexamer: AATAAA"
     polyA_site      7891
                     /gene="UBR2"
                     /gene_synonym="bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3"
                     /note="major polyA site"
ORIGIN      
        1 gtagtggcca gcgagagtgt caggcctggg gttttctgtg tccttccctg ggtcagggac
       61 gagccagtga cttgactctt gggcgctaag cttgggaggg agcgcaggag gccgctgtcc
      121 ttcctttccg gttcacgtca cccttctctc cctctgttgc tccacctgca gccacttgga
      181 cggctccggg actgattgcc tggggcaggg gtggcagtcg aggccgccgg ggccgaggtg
      241 aggctgcagc tctccgggcg gcggtagcgc tggggaggag gaggagagaa gatggcgtcg
      301 gagctagagc cagaggtgca ggccatcgac cggagcttgc tggaatgttc ggccgaggag
      361 attgcgggga aatggctgca agcaactgac ctcactagag aagtgtacca gcatttagcc
      421 cactatgtac ccaaaatcta ctgcaggggt cccaaccctt ttccacagaa agaagacatg
      481 ctggcacagc atgttttgtt gggaccaatg gaatggtacc tttgtggtga agatcctgca
      541 tttggatttc caaaacttga gcaagcaaac aaaccttctc atctttgtgg tcgtgttttt
      601 aaagtaggag agcctacata ttcttgcaga gactgtgcag ttgatccaac ttgtgttttg
      661 tgcatggagt gctttttggg aagtattcac agagatcatc gatataggat gacaacatca
      721 ggaggtggag gtttctgtga ctgtggtgat actgaagcct ggaaagaggg tccttactgt
      781 caaaaacatg aacttaacac ctctgaaatt gaggaagaag aggatcctct tgttcattta
      841 tcagaagatg tgatagcaag aacttataac atttttgcta ttacgtttcg gtatgcagta
      901 gaaatattaa cctgggaaaa agaaagtgaa ttgccagcag atttagagat ggtagagaag
      961 agtgacacct actattgcat gctgtttaat gatgaggttc acacctatga acaagttatt
     1021 tatactcttc agaaagctgt taactgtaca caaaaagaag ctattggttt tgcaactaca
     1081 gtagatcgag atgggcgtag gtctgttcga tatggagatt ttcagtattg tgagcaagca
     1141 aaatcagtaa ttgtgagaaa taccagtaga cagacaaagc cactcaaagt tcaagttatg
     1201 cattcgtcta ttgtcgcaca tcagaatttt ggtttgaaac ttttgtcttg gctgggaagt
     1261 attattggat attcagatgg ccttcgccgg attttatgtc aagttggttt acaagaaggg
     1321 ccagatggtg aaaactcttc tctagtggac agactgatgc ttagtgattc caaattatgg
     1381 aaaggtgcta ggagtgtata tcatcagttg ttcatgagca gtctgcttat ggatttgaaa
     1441 tacaagaaac tatttgctgt tcgatttgca aaaaactatg agcgtttgca gagtgattat
     1501 gtgacagatg accacgacag agagttttca gtcgcagacc tctcggttca gatattcacg
     1561 gttccttcac ttgctcgaat gctcatcaca gaagaaaact taatgagcat tatcattaag
     1621 acttttatgg atcatttgag acatcgagat gcccagggca gatttcagtt tgaacgatac
     1681 actgctttac aagccttcaa atttaggaga gtacagagcc ttattttaga tctcaagtat
     1741 gtgttaatta gcaaaccaac tgaatggtca gatgagctga ggcagaagtt cctagaaggg
     1801 tttgatgcct ttttggaatt actaaaatgt atgcagggaa tggatccaat tacacgtcaa
     1861 gtaggacaac atattgaaat ggaaccagag tgggaagcag ccttcacact acaaatgaaa
     1921 ttaacacatg tcatttcaat gatgcaggac tggtgtgctt cagatgaaaa agtgttaatc
     1981 gaagcttaca agaaatgtct cgctgtactg atgcagtgtc atggtggtta tactgatggt
     2041 gaacagccaa tcacactaag catttgtgga cattcagtgg aaactatcag atactgtgtt
     2101 tcccaagaaa aagttagcat tcacctccca gtttctcgct tacttgcagg tttacatgta
     2161 ttattaagca aaagtgaagt ggcatataaa tttccagagc tcctacctct aagtgaactt
     2221 agcccaccca tgttgataga acaccctctt agatgtcttg ttctgtgtgc ccaagtacat
     2281 gccggaatgt ggagaagaaa tgggttctct ctagtaaacc agatttatta ctaccataat
     2341 gtgaaatgca gacgtgagat gtttgacaag gatgtagtaa tgcttcagac aggtgtctcc
     2401 atgatggatc caaatcattt cctgatgatc atgctcagcc gctttgaact ttatcagatt
     2461 ttcagtactc cagactatgg aaaaagattt agttctgaga ttacccataa ggatgttgtt
     2521 cagcagaaca atactctaat agaagaaatg ctatacctca ttataatgct tgttggagag
     2581 agatttagtc ctggagttgg acaggtaaat gctacagatg aaatcaagcg agagattatc
     2641 catcagttga gtatcaagcc tatggctcat agtgaattgg taaagtcttt acctgaagat
     2701 gagaacaagg agactggcat ggagagtgta atcgaagcag ttgcccattt caagaaacct
     2761 ggattaacag gacgaggcat gtatgaactg aaaccagaat gtgccaaaga gttcaacttg
     2821 tatttctatc acttttcaag ggcagaacag tccaaggcag aagaagcgca acggaaattg
     2881 aaaagacaaa atagagaaga tacagcactc ccacctccgg tgttgcctcc attctgccct
     2941 ctgtttgcaa gcctggttaa cattttgcag tcagatgtca tgttgtgcat catgggaaca
     3001 attctgcaat gggctgtgga acataatgga tatgcctggt cagagtccat gctgcaaagg
     3061 gtgttacatt taattggcat ggcactacaa gaagaaaaac aacatttaga gaatgtcacg
     3121 gaagagcatg tagtaacatt taccttcact cagaagatat caaaacctgg tgaagcgcca
     3181 aaaaattctc ctagcatact agctatgctg gaaacactac aaaatgctcc ctacctagaa
     3241 gtccacaaag acatgattcg gtggatattg aagactttta atgctgttaa aaagatgagg
     3301 gagagttcac ctaccagtcc cgtggcagag acagaaggaa ccataatgga agagagttca
     3361 agggacaaag acaaagctga gaggaagaga aaagcagaga ttgccagact gcgcagagaa
     3421 aagatcatgg ctcagatgtc tgaaatgcag cggcatttta ttgatgaaaa caaagaactc
     3481 tttcagcaga cattagaact ggatgcctca acctctgctg ttcttgatca tagccctgtg
     3541 gcttcagata tgacacttac agcactgggc cccgcacaaa ctcaggttcc tgaacaaaga
     3601 caattcgtta catgtatatt gtgtcaagag gagcaagaag ttaaagtgga aagcagggca
     3661 atggtcttgg cagcatttgt tcagagatca actgtattat caaaaaacag aagtaaattt
     3721 attcaagatc cagaaaaata tgatccatta ttcatgcacc ctgatctgtc ttgtggaaca
     3781 cacactagta gctgtgggca cattatgcat gcccattgtt ggcaaaggta ttttgattcc
     3841 gttcaagcta aagaacagcg aaggcaacag agattacgct tacatacgag ctatgatgta
     3901 gaaaacggag aattcctttg ccccctttgt gaatgcttga gtaatactgt tattcctctg
     3961 ctgcttcctc caagaaatat ttttaacaac aggttaaatt tttcagacca accaaatctg
     4021 actcagtgga ttagaacaat atctcagcaa ataaaagcat tacagtttct taggaaagaa
     4081 gaaagtactc ctaataatgc ctctacaaag aattcagaaa atgtggatga attacagctc
     4141 cctgaagggt tcaggcctga ttttcgtcct aagatccctt attctgagag cataaaagaa
     4201 atgctaacga catttggaac tgctacctac aaggtgggac taaaggttca tcccaatgaa
     4261 gaggatcctc gtgttcccat aatgtgttgg ggtagctgcg cgtacaccat ccaaagcata
     4321 gaaagaattt tgagtgatga agataaacca ttgtttggtc ctttaccttg cagactggat
     4381 gactgtctta ggtcattgac gagatttgcc gcagcacact ggacagtggc atcagtttca
     4441 gtggtgcaag gacatttttg taaacttttt gcatcactgg tgcctaatga cagccatgag
     4501 gaacttccat gcatattaga tattgacatg tttcatttat tggtgggctt ggtgcttgca
     4561 tttcctgcgt tgcagtgtca ggatttttca gggatcagcc ttggcactgg agaccttcac
     4621 attttccatc tggttactat ggcacacatc atacagatct tacttacctc atgtacagaa
     4681 gagaatggca tggatcaaga aaatccccct tgtgaagaag aatcagcagt tcttgctttg
     4741 tataaaacac ttcaccagta tacgggaagt gccttgaaag aaataccatc cggctggcat
     4801 ctgtggagga gtgtcagagc tggaatcatg cctttcctga agtgttctgc tttatttttt
     4861 cattacttaa atggagttcc ttccccaccc gacattcaag ttcctggaac aagccatttt
     4921 gaacatttat gtagctatct ttccctacca aacaacctca tttgcctttt tcaagaaaat
     4981 agtgagataa tgaattcact gattgaaagt tggtgccgta acagtgaagt taaaagatat
     5041 ctagaaggtg aaagagatgc tataagatat ccaagagaat ctaacaaatt aataaacctt
     5101 ccagaggatt acagcagcct cattaatcaa gcatccaatt tctcgtgccc gaaatcaggt
     5161 ggtgataaga gcagagcccc aactctgtgc cttgtgtgcg gatctctgct gtgctcccag
     5221 agttactgct gccagactga actggaaggg gaggatgtag gagcctgcac agctcacacc
     5281 tactcctgtg gctctggagt gggcatcttc ctgagagtac gggaatgtca ggtgctattt
     5341 ttagctggca aaaccaaagg ctgtttttat tctcctcctt accttgatga ctatggggag
     5401 accgaccagg gactcagacg gggaaatcct ttacatttat gcaaagagcg attcaagaag
     5461 attcagaagc tctggcacca acacagtgtc acagaggaaa ttggacatgc acaggaagcc
     5521 aatcagacac tggttggcat tgactggcaa catttataat tattgcacca ccaaaaaaca
     5581 caaacttgga tttttttaac ccagttggct ttttaagaaa gaaagaagtt ctgctgaatt
     5641 tggaaataaa ttctttattt aaactttcct tcccagtttt atagtttctg gttctgagga
     5701 ctgatgaaaa tcatcttcca tcagcagatt ttcttgcact gtttgctgtg cccctcaaat
     5761 ataatgtctt gggttttaag atcgagcaag gagcttctct tcctagattg gatcccagcc
     5821 cctttgtggg ggtctgactg catagtccca gccattatgt gatatttcac gttattgatg
     5881 atagtgaacc gtgggtccga agctgactca acggaggcag ggaacaaagt ctctgtggtc
     5941 tgttgggtca tacttcctgg ttccactgag tggcccaaca ctgggactgg gttggtgtcc
     6001 cctctgctga caggacccta ctcctaggag caaagtggtt gattttgaag gcagtgttcc
     6061 cttctctcca ttgactatga gagagttggg ggacacacat gcagaagaag cccgtgggga
     6121 gaaggtggat tcctggtgtg ctggctggtt tttcagggct gttagaggtt tttttttttt
     6181 cttttttttt ttatggcaag acttttggct ttgagaaaac tcacttagag ggctttccaa
     6241 aaacttagga tggtctaaaa aattaggata ttcttttaga attaggaaga aaaattagga
     6301 tattctaaaa gaatatggat taaaaattta ggatattctt ttagatatcc taatatctag
     6361 atgagaggcc ttccttcata agatctggtt gtttgggctg tggttggcat aagtgatatt
     6421 tattttggcc tctgtcacat ccagtttctt gagcttttaa ggtaagcttc ttttggcttt
     6481 ttttcagatg ttcaccaagc ttaagtttaa aataataggt attctaaaag agtatcctaa
     6541 ttttcttatc tgtattcttt tagaataccc taatgtttca gacagtgata ttctcttgtt
     6601 atttctaagg ctaaattggc agagtatatc atctaaagcc aaacactgaa gaaggtgaga
     6661 acccactccc acccagccag catttcctgg aacagacaag ctgctgcttc cttgctggct
     6721 cacttagtgc attcctggga tggtctggca cccaggcttt ttattctttt tgatcattgt
     6781 tcttactgag gtgccttcct agaacaagag ccacttacaa aatagcttat aattattatg
     6841 taccacacaa ctactattgt ttgatgtatg actgctgaga gcttgaatac atgcagagag
     6901 tgactgaaga cttagtagag gaataaattc tgagcctgtc taaggtgggg ctaaggaaca
     6961 gatgagtaat aagaggctct tggatttttt taaccaatgc aactgaccct ttcaatcagt
     7021 tttctttgaa ttacatctac aagttttgtt ccactcagct accagtcaac taggcatgct
     7081 ccacagtatc acaggaagaa ggtcagaaat ctggaactga agctaaaaga agtgaggatg
     7141 tagaagccac attcctctcc aaggtagtgt gtgaaagaac cgccccctct tgacaggagg
     7201 atgaccgtcg ccattcttgc gtgggactga ctcacccagc tgagaggagg accaatagaa
     7261 agaaaattca catttgagtc cacctctctc cccctttttc tggccttcat tcataagatc
     7321 tggttgtttg ggctgtaggt ggcataattc atgtttattt tggcctctgt cacatccagt
     7381 ttctttagct tttaaggtaa gcttcttttg gctttttttc atatgttcac caagctaaaa
     7441 tttaaaataa taagaccagg tttctctctg tacaagtgga ttataaacat tttcaccaaa
     7501 tcataacaat actccagctt tccggtccga cttcctagga gcctggagtt agcaaaggtt
     7561 gtctctggat ttcattctct gagaatatca cagagcctgg gagaagatga atttacatga
     7621 aattgcaaca tacacacctt tttattttct ggtgttaagc tagttgtctt tcctacctta
     7681 caaatcatgt tagttttatg atttgttccg catgttttat gtttattgta gaaatgttta
     7741 tataacatac gctttccata tcagggaaaa tcatatctgt ttaataaatt ggctataact
     7801 ttaatatctg tggacaactt gtaaaatttg gaatgtatca tatgtaaaaa gtttaaagat
     7861 atccaaataa atgctttagg tgttggcatt a
//
