LOCUS       NP_777576               1749 aa            linear   PRI 28-APR-2025
DEFINITION  E3 ubiquitin-protein ligase UBR1 [Homo sapiens].
ACCESSION   NP_777576
VERSION     NP_777576.1
DBSOURCE    REFSEQ: accession NM_174916.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 1749)
  AUTHORS   Yuan,W., Han,J., Chen,C., Qiu,Y., Xu,Y., Huang,Y., Chen,Z., Xu,A.
            and Sun,M.
  TITLE     UBR1 is a prognostic biomarker and therapeutic target associated
            with immune cell infiltration in gastric cancer
  JOURNAL   Aging (Albany NY) 16 (16), 12029-12049 (2024)
   PUBMED   39181686
  REMARK    GeneRIF: UBR1 is a prognostic biomarker and therapeutic target
            associated with immune cell infiltration in gastric cancer.
REFERENCE   2  (residues 1 to 1749)
  AUTHORS   Zhao,W., Zhang,Y., Lin,S., Li,Y., Zhu,A.J., Shi,H. and Liu,M.
  TITLE     Identification of Ubr1 as an amino acid sensor of steatosis in
            liver and muscle
  JOURNAL   J Cachexia Sarcopenia Muscle 14 (3), 1454-1467 (2023)
   PUBMED   37057345
  REMARK    GeneRIF: Identification of Ubr1 as an amino acid sensor of
            steatosis in liver and muscle.
REFERENCE   3  (residues 1 to 1749)
  AUTHORS   Wang,B.B., Xu,H., Isenmann,S., Huang,C., Elorza-Vidal,X.,
            Rychkov,G.Y., Estevez,R., Schittenhelm,R.B., Lukacs,G.L. and
            Apaja,P.M.
  TITLE     Ubr1-induced selective endophagy/autophagy protects against the
            endosomal and Ca2+-induced proteostasis disease stress
  JOURNAL   Cell Mol Life Sci 79 (3), 167 (2022)
   PUBMED   35233680
  REMARK    GeneRIF: Ubr1-induced selective endophagy/autophagy protects
            against the endosomal and Ca(2+)-induced proteostasis disease
            stress.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1749)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (residues 1 to 1749)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (residues 1 to 1749)
  AUTHORS   Dgany,O., Avidan,N., Delaunay,J., Krasnov,T., Shalmon,L.,
            Shalev,H., Eidelitz-Markus,T., Kapelushnik,J., Cattan,D.,
            Pariente,A., Tulliez,M., Cretien,A., Schischmanoff,P.O.,
            Iolascon,A., Fibach,E., Koren,A., Rossler,J., Le Merrer,M.,
            Yaniv,I., Zaizov,R., Ben-Asher,E., Olender,T., Lancet,D.,
            Beckmann,J.S. and Tamary,H.
  TITLE     Congenital dyserythropoietic anemia type I is caused by mutations
            in codanin-1
  JOURNAL   Am J Hum Genet 71 (6), 1467-1474 (2002)
   PUBMED   12434312
REFERENCE   7  (residues 1 to 1749)
  AUTHORS   Kwon,Y.T., Reiss,Y., Fried,V.A., Hershko,A., Yoon,J.K., Gonda,D.K.,
            Sangan,P., Copeland,N.G., Jenkins,N.A. and Varshavsky,A.
  TITLE     The mouse and human genes encoding the recognition component of the
            N-end rule pathway
  JOURNAL   Proc Natl Acad Sci U S A 95 (14), 7898-7903 (1998)
   PUBMED   9653112
REFERENCE   8  (residues 1 to 1749)
  AUTHORS   Varshavsky,A.
  TITLE     The N-end rule: functions, mysteries, uses
  JOURNAL   Proc Natl Acad Sci U S A 93 (22), 12142-12149 (1996)
   PUBMED   8901547
  REMARK    Review article
REFERENCE   9  (residues 1 to 1749)
  AUTHORS   Chiannilkulchai,N., Pasturaud,P., Richard,I., Auffray,C. and
            Beckmann,J.S.
  TITLE     A primary expression map of the chromosome 15q15 region containing
            the recessive form of limb-girdle muscular dystrophy (LGMD2A) gene
  JOURNAL   Hum Mol Genet 4 (4), 717-725 (1995)
   PUBMED   7633422
REFERENCE   10 (residues 1 to 1749)
  AUTHORS   Shelton,C., LaRusch,J. and Whitcomb,D.C.
  TITLE     Pancreatitis Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   24624459
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BE873236.1, AY061886.1,
            AK127478.1 and BX648400.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: The N-end rule pathway is one proteolytic pathway of the
            ubiquitin system. The recognition component of this pathway,
            encoded by this gene, binds to a destabilizing N-terminal residue
            of a substrate protein and participates in the formation of a
            substrate-linked multiubiquitin chain. This leads to the eventual
            degradation of the substrate protein. The protein described in this
            record has a RING-type zinc finger and a UBR-type zinc finger.
            Mutations in this gene have been associated with Johanson-Blizzard
            syndrome. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC113505.1, AY061886.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000290650.9/ ENSP00000290650.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1749
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.2"
     Protein         1..1749
                     /product="E3 ubiquitin-protein ligase UBR1"
                     /EC_number="2.3.2.27"
                     /note="ubiquitin ligase E3 alpha-I; ubiquitin-protein
                     ligase E3-alpha; E3a ligase; N-recognin-1;
                     ubiquitin-protein ligase E3-alpha-1; ubiquitin-protein
                     ligase E3-alpha-I; RING-type E3 ubiquitin transferase
                     UBR1"
                     /calculated_mol_wt=200081
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0007744|PubMed:19369195; propagated from
                     UniProtKB/Swiss-Prot (Q8IWV7.1)"
     Site            21
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:18691976,
                     ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:19690332,
                     ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569;
                     propagated from UniProtKB/Swiss-Prot (Q8IWV7.1)"
     Region          98..168
                     /region_name="UBR-box_UBR1"
                     /note="UBR-box found in ubiquitin-protein ligase
                     E3-alpha-1 (UBR1) and similar proteins; cd19678"
                     /db_xref="CDD:439076"
     Site            order(99,112,115,124,127,133,136,149,151,163,166)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:439076"
     Region          221..301
                     /region_name="ClpS"
                     /note="ATP-dependent Clp protease adaptor protein ClpS;
                     pfam02617"
                     /db_xref="CDD:460621"
     Region          842..868
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8IWV7.1)"
     Region          1019..1054
                     /region_name="UBC2-binding region (U2BR).
                     /evidence=ECO:0000250|UniProtKB:P19812"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8IWV7.1)"
     Region          1094..1212
                     /region_name="RING-H2_UBR1"
                     /note="RING finger, H2 subclass, found in
                     ubiquitin-protein ligase E3-alpha-1 (UBR1) and similar
                     proteins; cd16685"
                     /db_xref="CDD:438346"
     Site            1179
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17525332; propagated from
                     UniProtKB/Swiss-Prot (Q8IWV7.1)"
     Region          1297..1724
                     /region_name="PRT6_C"
                     /note="Proteolysis_6 C-terminal; pfam18995"
                     /db_xref="CDD:465944"
     CDS             1..1749
                     /gene="UBR1"
                     /gene_synonym="JBS"
                     /coded_by="NM_174916.3:17..5266"
                     /db_xref="CCDS:CCDS10091.1"
                     /db_xref="GeneID:197131"
                     /db_xref="HGNC:HGNC:16808"
                     /db_xref="MIM:605981"
ORIGIN      
        1 madeeaggte rmeisaelpq tpqrlaswwd qqvdfytafl hhlaqlvpei yfaemdpdle
       61 kqeesvqmsi ftplewylfg edpdiclekl khsgafqlcg rvfksgetty scrdcaidpt
      121 cvlcmdcfqd svhknhrykm htstgggfcd cgdteawktg pfcvnhepgr agtikensrc
      181 plneevivqa rkifpsviky vvemtiweee kelppelqir ekneryycvl fndehhsydh
      241 viyslqrald celaeaqlht taidkegrra vkagayaacq eakedikshs envsqhplhv
      301 evlhseimah qkfalrlgsw mnkimsyssd frqifcqacl reepdsenpc lisrlmlwda
      361 klykgarkil helifssffm emeykklfam efvkyykqlq keyisddhdr sisitalsvq
      421 mftvptlarh lieeqnvisv itetllevlp eyldrnnkfn fqgysqdklg rvyavicdlk
      481 yiliskptiw terlrmqfle gfrsflkilt cmqgmeeirr qvgqhievdp dweaaiaiqm
      541 qlknillmfq ewcacdeell lvaykechka vmrcstsfis ssktvvqscg hsletksyrv
      601 sedlvsihlp lsrtlaglhv rlsrlgavsr lhefvsfedf qvevlveypl rclvlvaqvv
      661 aemwrrngls lisqvfyyqd vkcreemydk diimlqigas lmdpnkflll vlqryelaea
      721 fnktistkdq dlikqyntli eemlqvliyi vgeryvpgvg nvtkeevtmr eiihllciep
      781 mphsaiaknl penennetgl envinkvatf kkpgvsghgv yelkdeslkd fnmyfyhysk
      841 tqhskaehmq kkrrkqenkd ealppppppe fcpafskvin llncdimmyi lrtvferaid
      901 tdsnlwtegm lqmafhilal glleekqqlq kapeeevtfd fyhkasrlgs samniqmlle
      961 klkgipqleg qkdmitwilq mfdtvkrlre ksclivatts gsesikndei thdkekaerk
     1021 rkaeaarlhr qkimaqmsal qknfiethkl mydntsempg kedsimeees tpavsdysri
     1081 algpkrgpsv tekevltcil cqeeqevkie nnamvlsacv qkstaltqhr gkpielsgea
     1141 ldplfmdpdl aygtytgscg hvmhavcwqk yfeavqlssq qrihvdlfdl esgeylcplc
     1201 kslcntvipi iplqpqkins enadalaqll tlarwiqtvl arisgynirh akgenpipif
     1261 fnqgmgdstl efhsilsfgv essikysnsi kemvilfatt iyriglkvpp derdprvpml
     1321 twstcaftiq aienllgdeg kplfgalqnr qhnglkalmq favaqritcp qvliqkhlvr
     1381 llsvvlpnik sedtpcllsi dlfhvlvgav lafpslywdd pvdlqpssvs ssynhlylfh
     1441 litmahmlqi lltvdtglpl aqvqedseea hsassffaei sqytsgsigc dipgwylwvs
     1501 lkngitpylr caalffhyll gvtppeelht nsaegeysal csylslptnl fllfqeywdt
     1561 vrpllqrwca dpallnclkq kntvvryprk rnslielpdd yscllnqash frcprsadde
     1621 rkhpvlclfc gailcsqnic cqeivngeev gacifhalhc gagvciflki recrvvlveg
     1681 kargcaypap yldeygetdp glkrgnplhl sreryrklhl vwqqhciiee iarsqetnqm
     1741 lfgfnwqll
//
