LOCUS       NM_145053               2307 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens ubiquilin like (UBQLNL), mRNA.
ACCESSION   NM_145053
VERSION     NM_145053.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2307)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2307)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2307)
  AUTHORS   Marin,I.
  TITLE     The ubiquilin gene family: evolutionary patterns and functional
            insights
  JOURNAL   BMC Evol Biol 14, 63 (2014)
   PUBMED   24674348
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK057255.1, BC034977.2 and AC087380.3.
            
            On May 17, 2019 this sequence version replaced NM_145053.4.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC034977.2, SRR5189667.276623.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380184.2/ ENSP00000369531.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               AK057255.1         31-180
            151-768             BC034977.2         147-764
            769-2259            AC087380.3         160185-161675       c
            2260-2307           BC034977.2         2256-2303
FEATURES             Location/Qualifiers
     source          1..2307
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..2307
                     /gene="UBQLNL"
                     /note="ubiquilin like"
                     /db_xref="GeneID:143630"
                     /db_xref="HGNC:HGNC:28294"
     exon            1..2307
                     /gene="UBQLNL"
                     /inference="alignment:Splign:2.1.0"
     CDS             259..1686
                     /gene="UBQLNL"
                     /codon_start=1
                     /product="ubiquilin-like protein"
                     /protein_id="NP_659490.4"
                     /db_xref="CCDS:CCDS31385.1"
                     /db_xref="GeneID:143630"
                     /db_xref="HGNC:HGNC:28294"
                     /translation="MWHAISRTSRMSQSGCPSGLLADKNISSSATRVIVKTAGNQKDF
                     MVADDISVRQFKEMLLAHFQCQMDQLVLVFMGCLLKDHDTLSQRGIMDGHTIYLVIKS
                     KQGSRSLAHSFRDLPTNDPCHRDRNTKGNSSRVHQPTGMNQAPVELAHFVGSDAPKVH
                     TQNLEVSHPECKAQMLENPSIQRLLSNMEFMWQFISEHLDTQQLMQQNPEVSRLLLDN
                     SEILLQTLELARNLAMIQEIMQIQQPSQNLEYPLNPQPYLGLETMPGGNNALGQNYAD
                     INDQMLNSMQDPFGGNPFTALLAGQVLEQVQSSPPPPPPSQEQQDQLTQHPATRVIYN
                     SSGGFSSNTSANDTLNKVNHTSKANTAMISTKGQSHICATRQPAWIPALPSIELTQQL
                     QEEYKDATVSLSSSRQTLKGDLQLSDEQSSSQITGGMMQLLMNNPYLAAQIMLFTSMP
                     QLSEQWRQQLPTFLQQTQISDLLSA"
     regulatory      2279..2284
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBQLNL"
                     /note="hexamer: AATAAA"
     polyA_site      2307
                     /gene="UBQLNL"
                     /note="major polyA site"
ORIGIN      
        1 gtccaccatg ggtgaattat gaatcagtag ctatgccagg cctcagctgg gccacatctg
       61 gagaactggg gtgagggcac aacatcacaa aatatctggc cccagtctgg tcactcatcc
      121 cttttagggc aacaaggaaa ctatcctgtg gcctgagagc acaatacctg agacaaaggc
      181 cagcagaaac atttgtctgc cctcaccctt tctgccccag cttccacctg ctccccatct
      241 gcccacccac taaagcccat gtggcatgcc atctctcgaa catccaggat gtcccagagt
      301 ggatgtccat caggtctgct ggcagacaaa aatatctctt caagtgccac tcgagtgata
      361 gtgaagactg caggcaacca gaaagacttt atggtagctg atgacatctc ggtaaggcag
      421 ttcaaggaga tgctattggc tcacttccaa tgccagatgg accaactagt gctggtcttc
      481 atgggttgcc ttctcaaaga ccatgacaca ctgagccaga ggggcatcat ggatggccac
      541 accatctact tggtcatcaa gtccaagcag ggctccagat ctctagccca ttccttccgg
      601 gacctgccaa cgaatgatcc ctgccaccgg gacagaaaca ccaaaggaaa cagcagcaga
      661 gtgcaccaac caactggtat gaatcaagct ccagtggaac tggcccactt tgtggggtct
      721 gatgcaccca aagtgcatac ccaaaacttg gaagtgagcc acccagagtg caaagcacag
      781 atgctggaga atcctagcat ccagcggctt ctgtccaaca tggagttcat gtggcagttc
      841 atttcagaac atctagacac gcaacaattg atgcagcaga acccagaagt ttcccgcctt
      901 cttcttgata attctgagat cctattgcag actctggagc tggccaggaa ccttgctatg
      961 atccaagaga taatgcagat ccaacaacct tcacaaaacc ttgagtatcc actgaaccca
     1021 cagccatatc tgggcttaga gacaatgcca ggtgggaata atgccctggg tcagaactat
     1081 gctgatatca atgatcaaat gctgaacagc atgcaagatc cttttggagg aaaccctttc
     1141 acagctctcc tggcaggaca agtgctagaa caagtccagt cttcaccccc acctccacca
     1201 ccatcacagg aacaacaaga ccagctcaca cagcatcctg caacccgagt catctataat
     1261 agctctggtg gtttctcttc aaacacctca gccaatgaca cccttaacaa ggtcaaccac
     1321 acttccaaag ccaacactgc tatgatttcc accaagggcc agagccatat ctgtgccact
     1381 cggcagccag cttggatacc agccttacct agcatagagc ttacccagca gcttcaagaa
     1441 gaatacaagg atgccactgt ttctctaagt agctccagac agacattaaa gggtgatctc
     1501 cagctgtcag atgagcagag cagctcccag atcacaggag gcatgatgca gttgcttatg
     1561 aacaacccct acctggcagc tcagattatg ttgttcacaa gtatgcccca gctgagtgaa
     1621 cagtggaggc agcagctgcc cacattcctg cagcagacac agatttctga tctgcttagt
     1681 gcttaggcaa ccctaaagca ttccaagcaa tattgcagat tgagcaggcc ctccagctgc
     1741 tggccacaga ggctcctgtt cttctgcctt gggttgcacc ctacctatgg ggcctgggtt
     1801 ggcttcctgc ccccagctgc agctatcctg acacagtgcc ctgttcctgg aatgtttcag
     1861 atacagctga gcccaaggga cctgagtgct gccacaagcc tggaacagtc ctgcagaggc
     1921 tacaatcccc ggatggggac ccttcccacc ctctgcaagc tcctgagatt tgttttagca
     1981 aacagatgga ttctctccag gccatgggat ttgggaacca ccatgccaat ctacaggcac
     2041 tcattgctac tgaaggggac accaatgctg ctatccgcaa gctcaagaga tcccagagat
     2101 tctaaccacc atgcctactt gtttgcttgc tacctgcctg ctgacccacc tgaccatctc
     2161 atttgccttt tgcacctttc ctgatgcttc cagccaggag aagtcctgga ataagagtta
     2221 tcaaccaatg tgtcttgtac tgaataatag atcattggtc gtggctgaaa catctgtcaa
     2281 taaaatggct acactcactt gctgcga
//
