LOCUS       NM_020131               3582 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens ubiquilin 4 (UBQLN4), transcript variant 1, mRNA.
ACCESSION   NM_020131
VERSION     NM_020131.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3582)
  AUTHORS   He,L., Chen,H., Ruan,B., He,L., Luo,M., Fu,Y. and Zou,R.
  TITLE     UBQLN4 promotes the proliferation and invasion of non-small cell
            lung cancer cell by regulating PI3K/AKT pathway
  JOURNAL   J Cancer Res Clin Oncol 150 (7), 335 (2024)
   PUBMED   38969831
  REMARK    GeneRIF: UBQLN4 promotes the proliferation and invasion of
            non-small cell lung cancer cell by regulating PI3K/AKT pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3582)
  AUTHORS   Jiang,Q., Chen,H., Zhou,S., Zhu,T., Liu,W., Wu,H., Zhang,Y., Liu,F.
            and Sun,Y.
  TITLE     Ubiquilin-4 induces immune escape in gastric cancer by activating
            the notch signaling pathway
  JOURNAL   Cell Oncol (Dordr) 47 (1), 303-319 (2024)
   PUBMED   37702916
  REMARK    GeneRIF: Ubiquilin-4 induces immune escape in gastric cancer by
            activating the notch signaling pathway.
REFERENCE   3  (bases 1 to 3582)
  AUTHORS   Kobayashi,Y., Bustos,M.A., Shoji,Y., Jachimowicz,R.D., Shiloh,Y.
            and Hoon,D.S.B.
  TITLE     Genomic Amplification of UBQLN4 Is a Prognostic and Treatment
            Resistance Factor
  JOURNAL   Cells 11 (20), 3311 (2022)
   PUBMED   36291176
  REMARK    GeneRIF: Genomic Amplification of UBQLN4 Is a Prognostic and
            Treatment Resistance Factor.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3582)
  AUTHORS   Viard,J., Loe-Mie,Y., Daudin,R., Khelfaoui,M., Plancon,C.,
            Boland,A., Tejedor,F., Huganir,R.L., Kim,E., Kinoshita,M., Liu,G.,
            Haucke,V., Moncion,T., Yu,E., Hindie,V., Blehaut,H., Mircher,C.,
            Herault,Y., Deleuze,J.F., Rain,J.C., Simonneau,M. and
            Lepagnol-Bestel,A.M.
  TITLE     Chr21 protein-protein interactions: enrichment in proteins involved
            in intellectual disability, autism, and late-onset Alzheimer's
            disease
  JOURNAL   Life Sci Alliance 5 (12), e202101205 (2022)
   PUBMED   35914814
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3582)
  AUTHORS   Liu,F., Pan,R., Ding,H., Gu,L., Yang,Y., Li,C., Xu,Y., Hu,R.,
            Chen,H., Zhang,X. and Nie,Y.
  TITLE     UBQLN4 is an ATM substrate that stabilizes the anti-apoptotic
            proteins BCL2A1 and BCL2L10 in mesothelioma
  JOURNAL   Mol Oncol 15 (12), 3738-3752 (2021)
   PUBMED   34245648
REFERENCE   6  (bases 1 to 3582)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   7  (bases 1 to 3582)
  AUTHORS   Riley,B.E., Xu,Y., Zoghbi,H.Y. and Orr,H.T.
  TITLE     The effects of the polyglutamine repeat protein ataxin-1 on the
            UbL-UBA protein A1Up
  JOURNAL   J Biol Chem 279 (40), 42290-42301 (2004)
   PUBMED   15280365
REFERENCE   8  (bases 1 to 3582)
  AUTHORS   Matsuda,M., Koide,T., Yorihuzi,T., Hosokawa,N. and Nagata,K.
  TITLE     Molecular cloning of a novel ubiquitin-like protein, UBIN, that
            binds to ER targeting signal sequences
  JOURNAL   Biochem Biophys Res Commun 280 (2), 535-540 (2001)
   PUBMED   11162551
REFERENCE   9  (bases 1 to 3582)
  AUTHORS   Davidson,J.D., Riley,B., Burright,E.N., Duvick,L.A., Zoghbi,H.Y.
            and Orr,H.T.
  TITLE     Identification and characterization of an ataxin-1-interacting
            protein: A1Up, a ubiquitin-like nuclear protein
  JOURNAL   Hum Mol Genet 9 (15), 2305-2312 (2000)
   PUBMED   11001934
REFERENCE   10 (bases 1 to 3582)
  AUTHORS   Fogli,A., Giglio,S., Arrigo,G., Lo Nigro,C., Zollo,M., Viggiano,L.,
            Rocchi,M., Archidiacono,N., Zuffardi,O. and Carrozzo,R.
  TITLE     Identification of two paralogous regions mapping to the short and
            long arms of human chromosome 2 comprising LIS1 pseudogenes
  JOURNAL   Cytogenet Cell Genet 86 (3-4), 225-232 (1999)
   PUBMED   10575211
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY061664.1, DC334851.1, BC063841.1, AL355388.30 and AI074831.1.
            
            On Nov 23, 2018 this sequence version replaced NM_020131.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063841.1, AB209566.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368309.4/ ENSP00000357292.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                HY061664.1         32-55
            25-73               DC334851.1         35-83
            74-2658             BC063841.1         1-2585
            2659-2659           AL355388.30        129902-129902       c
            2660-3580           BC063841.1         2587-3507
            3581-3582           AI074831.1         12-13               c
FEATURES             Location/Qualifiers
     source          1..3582
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q22"
     gene            1..3582
                     /gene="UBQLN4"
                     /gene_synonym="A1U; A1Up; C1orf6; CIP75; UBIN"
                     /note="ubiquilin 4"
                     /db_xref="GeneID:56893"
                     /db_xref="HGNC:HGNC:1237"
                     /db_xref="MIM:605440"
     exon            1..205
                     /gene="UBQLN4"
                     /gene_synonym="A1U; A1Up; C1orf6; CIP75; UBIN"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..1903
                     /gene="UBQLN4"
                     /gene_synonym="A1U; A1Up; C1orf6; CIP75; UBIN"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ataxin-1 ubiquitin-like interacting protein; ataxin-1
                     ubiquitin-like-interacting protein A1U;
                     connexin43-interacting protein of 75 kDa; ataxin-1
                     interacting ubiquitin-like protein; Cx43-interacting
                     protein of 75 kDa"
                     /codon_start=1
                     /product="ubiquilin-4 isoform 1"
                     /protein_id="NP_064516.2"
                     /db_xref="CCDS:CCDS1127.1"
                     /db_xref="GeneID:56893"
                     /db_xref="HGNC:HGNC:1237"
                     /db_xref="MIM:605440"
                     /translation="MAEPSGAETRPPIRVTVKTPKDKEEIVICDRASVKEFKEEISRR
                     FKAQQDQLVLIFAGKILKDGDTLNQHGIKDGLTVHLVIKTPQKAQDPAAATASSPSTP
                     DPASAPSTTPASPATPAQPSTSGSASSDAGSGSRRSSGGGPSPGAGEGSPSATASILS
                     GFGGILGLGSLGLGSANFMELQQQMQRQLMSNPEMLSQIMENPLVQDMMSNPDLMRHM
                     IMANPQMQQLMERNPEISHMLNNPELMRQTMELARNPAMMQEMMRNQDRALSNLESIP
                     GGYNALRRMYTDIQEPMFSAAREQFGNNPFSSLAGNSDSSSSQPLRTENREPLPNPWS
                     PSPPTSQAPGSGGEGTGGSGTSQVHPTVSNPFGINAASLGSGMFNSPEMQALLQQISE
                     NPQLMQNVISAPYMRSMMQTLAQNPDFAAQMMVNVPLFAGNPQLQEQLRLQLPVFLQQ
                     MQNPESLSILTNPRAMQALLQIQQGLQTLQTEAPGLVPSLGSFGISRTPAPSAGSNAG
                     STPEAPTSSPATPATSSPTGASSAQQQLMQQMIQLLAGSGNSQVQTPEVRFQQQLEQL
                     NSMGFINREANLQALIATGGDINAAIERLLGSQLS"
     exon            206..357
                     /gene="UBQLN4"
                     /gene_synonym="A1U; A1Up; C1orf6; CIP75; UBIN"
                     /inference="alignment:Splign:2.1.0"
     exon            358..575
                     /gene="UBQLN4"
                     /gene_synonym="A1U; A1Up; C1orf6; CIP75; UBIN"
                     /inference="alignment:Splign:2.1.0"
     exon            576..838
                     /gene="UBQLN4"
                     /gene_synonym="A1U; A1Up; C1orf6; CIP75; UBIN"
                     /inference="alignment:Splign:2.1.0"
     exon            839..997
                     /gene="UBQLN4"
                     /gene_synonym="A1U; A1Up; C1orf6; CIP75; UBIN"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1223
                     /gene="UBQLN4"
                     /gene_synonym="A1U; A1Up; C1orf6; CIP75; UBIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1363
                     /gene="UBQLN4"
                     /gene_synonym="A1U; A1Up; C1orf6; CIP75; UBIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1447
                     /gene="UBQLN4"
                     /gene_synonym="A1U; A1Up; C1orf6; CIP75; UBIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1563
                     /gene="UBQLN4"
                     /gene_synonym="A1U; A1Up; C1orf6; CIP75; UBIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1750
                     /gene="UBQLN4"
                     /gene_synonym="A1U; A1Up; C1orf6; CIP75; UBIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..3582
                     /gene="UBQLN4"
                     /gene_synonym="A1U; A1Up; C1orf6; CIP75; UBIN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3555..3560
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBQLN4"
                     /gene_synonym="A1U; A1Up; C1orf6; CIP75; UBIN"
                     /note="hexamer: AATAAA"
     polyA_site      3582
                     /gene="UBQLN4"
                     /gene_synonym="A1U; A1Up; C1orf6; CIP75; UBIN"
                     /note="major polyA site"
ORIGIN      
        1 gagtgttgga ggcgcagaag ccgagccggg ccggccgggc gggcggggag gaggaggagc
       61 cgggcgggct ggcgggcggc cgggtggcgg cggcggcatg gcggagccga gcggggccga
      121 gacgaggccc cccattcggg tcaccgtcaa gacccccaag gacaaggagg aaattgtgat
      181 ctgcgatcga gcctcggtca aggagttcaa agaggaaatc tcccggaggt ttaaggctca
      241 gcaggatcag ctggtcctga tcttcgcagg caagatcctc aaggatgggg acacactgaa
      301 ccagcacgga atcaaggacg ggctcactgt ccatctggtc atcaagaccc ctcagaaggc
      361 tcaagatcca gctgctgcca ctgcttcttc cccctccaca cctgaccctg cctcagcacc
      421 ctccaccacg cctgcttcac ccgccacccc tgcccagccc tccacctctg gcagtgcctc
      481 ttcagatgct ggcagtggaa gccggaggag cagtggtggg gggccctctc cgggggctgg
      541 ggagggatcc cccagtgcta ctgcgtccat actctctggc tttgggggca tcctggggct
      601 gggcagccta ggcctgggct ctgccaactt catggagctg cagcagcaga tgcagcggca
      661 gctgatgtcc aatcctgaga tgctgtcaca gatcatggag aaccccctgg tccaggatat
      721 gatgtctaac cctgatctga tgcgtcacat gattatggcc aacccccaga tgcagcagtt
      781 gatggagcgg aaccctgaga tcagccacat gctcaataac cctgaactca tgaggcagac
      841 aatggagctt gctcggaatc cagccatgat gcaagagatg atgcggaacc aggaccgggc
      901 cctgagcaac cttgagagca tccctggagg gtataatgcc ctccgccgca tgtacacgga
      961 catccaggag cccatgttca gtgctgcccg ggaacagttt ggcaacaatc ccttctcttc
     1021 cctggccggg aactccgaca gctcatcctc ccagcctctg cggactgaga atcgagagcc
     1081 cctccctaac ccctggagcc cctcgccccc cacctcccag gcccccgggt ccggtgggga
     1141 gggcaccgga ggatcgggga ccagccaggt gcacccgaca gtctcgaacc cctttgggat
     1201 caatgcggct agcctggggt cagggatgtt caatagccca gaaatgcaag ccctcctcca
     1261 gcagatctct gagaaccccc agctgatgca gaatgtgatc tcagcaccct acatgcgcag
     1321 catgatgcag acgcttgccc agaaccccga ctttgctgct cagatgatgg tgaatgtgcc
     1381 gctcttcgcg gggaaccccc aactgcagga gcagctccgc ctgcagctcc cagtcttcct
     1441 gcagcagatg cagaacccag agtcactctc catccttacc aatccccgag ccatgcaggc
     1501 attgctgcag atccagcagg gactacagac cttgcagacc gaggcccctg ggctggtacc
     1561 cagccttggc tcctttggga tatcccggac cccagcaccc tcagcaggca gcaacgcagg
     1621 gtctacgccc gaggccccca cttcctcacc agccacgcca gccacatctt ctccaacagg
     1681 ggcttccagc gcccagcagc aactcatgca gcagatgatc cagcttttgg ctggaagtgg
     1741 aaactcacag gtgcagacgc cagaagtgag atttcagcag cagctggagc agctcaactc
     1801 catgggcttc atcaatcgtg aggctaacct gcaggccctg attgccacag gaggggacat
     1861 caacgcagct atcgagagac tgctgggctc ccagctctcc taatccctcg gcccatgcct
     1921 cctgcctctc ccctccctcg atgtcagcat tcggttcttc tgtcaatcct taccctctgc
     1981 agcttgtcct cccttccgtc ttctccctca tcctttccaa acagcagggt gactttagag
     2041 gcatgggctc caacccctta gctctgtctg agaattatgg ttttactgct acgtctctaa
     2101 cagactcttc tctcctggtc tccttgagca gtgctactta aacagttttc acagtttcat
     2161 tgattgactc tacctccttg ccccacacca cttttgcaat ctttaaactt tcagtggctg
     2221 tgcagagtcg agggaggaac cagctctctg gtttactgga acatagtctt ccatctatac
     2281 cactagggtt ttgtcttatg tttacttttg gtaactctct tccttctttt tctccctacc
     2341 ccccaacccc tagcccaacc aatgctagaa tttcttgctc tgaaggagga gcaggtgaaa
     2401 caggtggtaa ttttccttct cggcccctat tctggttcat tcagcacttt ttggtgggaa
     2461 ctgttggaaa ttccagggta aggaggaaga tgcctgttct ccctgtctga agagggagat
     2521 gagacagctc tctggacagg aattaacaaa cgctggagca gcccagagga aattcgtgtg
     2581 aaagaggagg gaatgagatt attcggagga agggaatggg ggagacagcc tgagtaaaag
     2641 gcttggaagt tggaattaac agtggggagc agaagcactc atagctcttt taggcagaag
     2701 aatccaggcc cgagctggca gaagagactt agagatgcta atggaattta aactgaaaaa
     2761 aggagcccaa tgaagctaag cgccacgccc cacaaggggt catattggct ttagttcctc
     2821 aagcatatgt gcttatatgc acacacacac acatttccat ggacccaggt cttgcttgtg
     2881 tccccaggca ccagtagttt gagcccccct caaaagacat gaagggggtt ggggtctgtg
     2941 tgagtagtgg ggaggtgcat gtgtatccac atgtgtgcat acactcttaa gttgggtggg
     3001 aagtggattc cttgttggtt tctggttcag agtgctctcc caccaccaga gacaagtggg
     3061 taaaaaggtc agtccattgc aggaatatat atccgggaga gctaggtccc ttggggctct
     3121 ggatgctggg taacccagag gtaatgtggg taccctttct gaagctgtca gggctgtgac
     3181 tagcaccctt atcacccctc actgccttgt gggaatagta gagggttttt ttcctccaga
     3241 gcccctggcc tttcagttct taactatttc cctccaggcc agaaagtttt ctttgaggaa
     3301 ggagaggaga gggtggcaat gatgcctttg atctggaatt ggacatttct ctgtcagagc
     3361 acagaggagg ctcatatcac ctcttccctc tcctacttgg cccagctgct tggaggaccg
     3421 accccatggc tgagaatatg acggcaagag gaacagagtt tgctccaagt gggaaagggt
     3481 cccaagcagt ccagagaaga tgtctgtgtg gctttccctc cctgcctccc ccagctccca
     3541 cactggcctt tgtaaataaa tggcgtggtc tttgttgtga ga
//
