LOCUS       NM_014517               4175 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens upstream binding protein 1 (UBP1), transcript variant
            1, mRNA.
ACCESSION   NM_014517
VERSION     NM_014517.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4175)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4175)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4175)
  AUTHORS   Kotarba,G., Krzywinska,E., Grabowska,A.I., Taracha,A. and
            Wilanowski,T.
  TITLE     TFCP2/TFCP2L1/UBP1 transcription factors in cancer
  JOURNAL   Cancer Lett 420, 72-79 (2018)
   PUBMED   29410248
  REMARK    GeneRIF: Studies reveal that TFCP2, TFCP2L1, UBP1 belong to a
            transcription factors subfamily and involved in various aspects of
            cancer types and development as either proto-oncogenes or tumor
            suppressors. They can directly interact with each other; TFCP2,
            TFCP2L1 and UBP1 can form heteromeric DNA-binding complexes. In
            addition, TFCP2L1 can modulate the activity of TFCP2 and UBP1.
            [review]
            Review article
REFERENCE   4  (bases 1 to 4175)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   5  (bases 1 to 4175)
  AUTHORS   Ravasi,T., Suzuki,H., Cannistraci,C.V., Katayama,S., Bajic,V.B.,
            Tan,K., Akalin,A., Schmeier,S., Kanamori-Katayama,M., Bertin,N.,
            Carninci,P., Daub,C.O., Forrest,A.R., Gough,J., Grimmond,S.,
            Han,J.H., Hashimoto,T., Hide,W., Hofmann,O., Kamburov,A., Kaur,M.,
            Kawaji,H., Kubosaki,A., Lassmann,T., van Nimwegen,E.,
            MacPherson,C.R., Ogawa,C., Radovanovic,A., Schwartz,A.,
            Teasdale,R.D., Tegner,J., Lenhard,B., Teichmann,S.A., Arakawa,T.,
            Ninomiya,N., Murakami,K., Tagami,M., Fukuda,S., Imamura,K., Kai,C.,
            Ishihara,R., Kitazume,Y., Kawai,J., Hume,D.A., Ideker,T. and
            Hayashizaki,Y.
  TITLE     An atlas of combinatorial transcriptional regulation in mouse and
            man
  JOURNAL   Cell 140 (5), 744-752 (2010)
   PUBMED   20211142
  REMARK    Erratum:[Cell. 2010 Apr 16;141(2):369. Kamburov, Atanas [added];
            Kaur, Mandeep [added]; MacPherson, Cameron Ross [added];
            Radovanovic, Aleksandar [added]; Schwartz, Ariel [added]]
REFERENCE   6  (bases 1 to 4175)
  AUTHORS   Huang,N. and Miller,W.L.
  TITLE     LBP proteins modulate SF1-independent expression of P450scc in
            human placental JEG-3 cells
  JOURNAL   Mol Endocrinol 19 (2), 409-420 (2005)
   PUBMED   15471945
  REMARK    GeneRIF: LBP-1b is an important SF1-independent transcriptional
            activator stimulating P450scc expression in human placental JEG-3
            cells, whereas LBP-9 modulates the action of LBP-1b, exerting both
            positive and negative effects
REFERENCE   7  (bases 1 to 4175)
  AUTHORS   Huang,N. and Miller,W.L.
  TITLE     Cloning of factors related to HIV-inducible LBP proteins that
            regulate steroidogenic factor-1-independent human placental
            transcription of the cholesterol side-chain cleavage enzyme,
            P450scc
  JOURNAL   J Biol Chem 275 (4), 2852-2858 (2000)
   PUBMED   10644752
REFERENCE   8  (bases 1 to 4175)
  AUTHORS   Parada,C.A., Yoon,J.B. and Roeder,R.G.
  TITLE     A novel LBP-1-mediated restriction of HIV-1 transcription at the
            level of elongation in vitro
  JOURNAL   J Biol Chem 270 (5), 2274-2283 (1995)
   PUBMED   7836461
REFERENCE   9  (bases 1 to 4175)
  AUTHORS   Yoon,J.B., Li,G. and Roeder,R.G.
  TITLE     Characterization of a family of related cellular transcription
            factors which can modulate human immunodeficiency virus type 1
            transcription in vitro
  JOURNAL   Mol Cell Biol 14 (3), 1776-1785 (1994)
   PUBMED   8114710
REFERENCE   10 (bases 1 to 4175)
  AUTHORS   Kato,H., Horikoshi,M. and Roeder,R.G.
  TITLE     Repression of HIV-1 transcription by a cellular protein
  JOURNAL   Science 251 (5000), 1476-1479 (1991)
   PUBMED   2006421
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC093114.2, BC047235.1, AK023274.1, AF198487.1 and AL831847.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014517.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (LBP-1b). Variants 1 and
            3 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC047235.1, SRR14038192.3709577.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000283629.8/ ENSP00000283629.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                AC093114.2         82923-82949
            28-419              BC047235.1         2-393
            420-835             AK023274.1         25-440
            836-2735            AF198487.1         453-2352
            2736-4175           AL831847.1         395-1834
FEATURES             Location/Qualifiers
     source          1..4175
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p22.3"
     gene            1..4175
                     /gene="UBP1"
                     /gene_synonym="LBP-1a; LBP-1B; LBP1A; LBP1B"
                     /note="upstream binding protein 1"
                     /db_xref="GeneID:7342"
                     /db_xref="HGNC:HGNC:12507"
                     /db_xref="MIM:609784"
     exon            1..670
                     /gene="UBP1"
                     /gene_synonym="LBP-1a; LBP-1B; LBP1A; LBP1B"
                     /inference="alignment:Splign:2.1.0"
     CDS             558..2180
                     /gene="UBP1"
                     /gene_synonym="LBP-1a; LBP-1B; LBP1A; LBP1B"
                     /note="isoform LBP-1b is encoded by transcript variant 1;
                     transcription factor LBP-1"
                     /codon_start=1
                     /product="upstream-binding protein 1 isoform LBP-1b"
                     /protein_id="NP_055332.3"
                     /db_xref="CCDS:CCDS2659.1"
                     /db_xref="GeneID:7342"
                     /db_xref="HGNC:HGNC:12507"
                     /db_xref="MIM:609784"
                     /translation="MAWVLKMDEVIESGLVHDFDASLSGIGQELGAGAYSMSDVLALP
                     IFKQEDSSLPLDGETEHPPFQYVMCAATSPAVKLHDETLTYLNQGQSYEIRMLDNRKM
                     GDMPEINGKLVKSIIRVVFHDRRLQYTEHQQLEGWKWNRPGDRLLDLDIPMSVGIIDT
                     RTNPSQLNAVEFLWDPAKRTSAFIQVHCISTEFTPRKHGGEKGVPFRIQVDTFKQNEN
                     GEYTDHLHSASCQIKVFKPKGADRKQKTDREKMEKRTAHEKEKYQPSYDTTILTEMRL
                     EPIIEDAVEHEQKKSSKRTLPADYGDSLAKRGSCSPWPDAPTAYVNNSPSPAPTFTSP
                     QQSTCSVPDSNSSSPNHQGDGASQTSGEQIQPSATIQETQQWLLKNRFSSYTRLFSNF
                     SGADLLKLTKEDLVQICGAADGIRLYNSLKSRSVRPRLTIYVCREQPSSTVLQGQQQA
                     ASSASENGSGAPYVYHAIYLEEMIASEVARKLALVFNIPLHQINQVYRQGPTGIHILV
                     SDQMVQNFQDESCFLFSTVKAESSDGIHIILK"
     exon            671..822
                     /gene="UBP1"
                     /gene_synonym="LBP-1a; LBP-1B; LBP1A; LBP1B"
                     /inference="alignment:Splign:2.1.0"
     exon            823..899
                     /gene="UBP1"
                     /gene_synonym="LBP-1a; LBP-1B; LBP1A; LBP1B"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1005
                     /gene="UBP1"
                     /gene_synonym="LBP-1a; LBP-1B; LBP1A; LBP1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1112
                     /gene="UBP1"
                     /gene_synonym="LBP-1a; LBP-1B; LBP1A; LBP1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1265
                     /gene="UBP1"
                     /gene_synonym="LBP-1a; LBP-1B; LBP1A; LBP1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1376
                     /gene="UBP1"
                     /gene_synonym="LBP-1a; LBP-1B; LBP1A; LBP1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1484
                     /gene="UBP1"
                     /gene_synonym="LBP-1a; LBP-1B; LBP1A; LBP1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1588
                     /gene="UBP1"
                     /gene_synonym="LBP-1a; LBP-1B; LBP1A; LBP1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1643
                     /gene="UBP1"
                     /gene_synonym="LBP-1a; LBP-1B; LBP1A; LBP1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..1737
                     /gene="UBP1"
                     /gene_synonym="LBP-1a; LBP-1B; LBP1A; LBP1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1828
                     /gene="UBP1"
                     /gene_synonym="LBP-1a; LBP-1B; LBP1A; LBP1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..1947
                     /gene="UBP1"
                     /gene_synonym="LBP-1a; LBP-1B; LBP1A; LBP1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..2090
                     /gene="UBP1"
                     /gene_synonym="LBP-1a; LBP-1B; LBP1A; LBP1B"
                     /inference="alignment:Splign:2.1.0"
     exon            2091..2142
                     /gene="UBP1"
                     /gene_synonym="LBP-1a; LBP-1B; LBP1A; LBP1B"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..4175
                     /gene="UBP1"
                     /gene_synonym="LBP-1a; LBP-1B; LBP1A; LBP1B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4080..4085
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBP1"
                     /gene_synonym="LBP-1a; LBP-1B; LBP1A; LBP1B"
                     /note="hexamer: AATAAA"
     polyA_site      4101
                     /gene="UBP1"
                     /gene_synonym="LBP-1a; LBP-1B; LBP1A; LBP1B"
     regulatory      4148..4153
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBP1"
                     /gene_synonym="LBP-1a; LBP-1B; LBP1A; LBP1B"
                     /note="hexamer: AATAAA"
     polyA_site      4175
                     /gene="UBP1"
                     /gene_synonym="LBP-1a; LBP-1B; LBP1A; LBP1B"
                     /note="major polyA site"
ORIGIN      
        1 ggaagcggcg cgtgaaccta agtcggagtc gcgttgaagc cagcgtccgg ccggcagagc
       61 ggcgtcggcg gggttggccg gggcggtgtg gcgctagagc ctgggcgggc cgggggcaag
      121 gagtcaaggc ttgggggcgg gtgacgggcg ggcggagggc ttgcccccgt gtggtcctcg
      181 gagcggcccg aggtccagcc tcccagcggt cccggaggag gatgcgaccg gggggccccg
      241 ggcggggcgg tcggcggcgg ctgcagcgct agcggcgcgg gggctgggcg gcggcgccgg
      301 catgaggcgc agggccggtg tccgcgggag ggtggcgctg ccggcggccc ggccgctccc
      361 gctgcaattg ctcgctgggc tcgtcgtgcc ctgccagtgg ggcccccgca gctctcgtcc
      421 cggccgccgc tggtgaccac tcgccgcccc tccggaggct tcacccgcgc cctcccccag
      481 gacgcgccag cggagctccg gctccttcgc cctggacgcg gaggccgcgg tgtgcggggc
      541 gacggcgagg ccggaagatg gcctgggtgc tcaagatgga cgaggtgatc gagtccgggc
      601 tggtgcacga cttcgacgcc agcctctcgg gcatcgggca ggaactgggc gccggcgctt
      661 acagcatgag tgatgtcttg gcattgccca ttttcaagca ggaagattcc agccttccat
      721 tggatggtga aacagagcac ccaccctttc agtatgtgat gtgtgctgca acgtcaccag
      781 cagtaaaact gcatgatgaa acgcttactt atttgaacca aggtcagtca tatgaaattc
      841 ggatgctgga taatcggaaa atgggtgata tgcctgagat caatggaaaa ttagtaaaga
      901 gcatcataag ggttgtattc catgacagac ggctacaata cacagagcat cagcaacttg
      961 aaggatggaa gtggaatcgc ccaggagaca gacttcttga tttagatatt ccaatgtctg
     1021 tgggaataat tgacacaagg acgaatccaa gccagttaaa tgcggttgaa tttctgtggg
     1081 acccagcaaa acgcacctct gctttcattc aggtacactg catcagcaca gaatttactc
     1141 cacggaagca cggaggtgaa aagggagtgc cctttaggat ccaggttgac acctttaagc
     1201 agaatgaaaa tggagaatac acagatcatc tacactcagc tagctgccaa atcaaagttt
     1261 ttaagcctaa aggtgcagac aggaaacaaa aaactgaccg agagaagatg gagaagagaa
     1321 cagctcatga aaaagaaaag tatcagccgt cctatgatac cacaatcctc acagagatga
     1381 ggcttgagcc tataattgaa gatgcagttg aacatgagca gaaaaagtcc agcaagcgga
     1441 ctttgccagc agactacggt gattctctgg caaagcgagg cagttgttct ccgtggcccg
     1501 atgcccccac agcctatgtg aataacagcc cttccccagc gcccactttc acctccccac
     1561 agcagagcac ttgcagtgtc ccagacagca attcttcttc cccaaatcat cagggagatg
     1621 gagcttcaca gacctctggt gaacaaattc agccttcagc tacgatccag gaaacacagc
     1681 aatggctgct caaaaacaga ttctcttcct acacaagact gttctctaat ttttcaggtg
     1741 ccgacttatt aaaactgaca aaggaggatt tagttcaaat ttgtggtgca gccgatggaa
     1801 ttcggctcta taattcactg aagtcaaggt cggttagacc ccgtttaacc atctatgtct
     1861 gccgggagca gccaagcagc acagtgctgc aagggcagca gcaagctgca agcagtgcaa
     1921 gcgagaatgg cagtggggca ccctatgttt atcatgcaat ctacttggaa gaaatgattg
     1981 cctcagaagt tgctcgaaaa cttgcgctgg tgtttaatat ccctctccac caaattaatc
     2041 aggtttacag acagggtccc accggtattc acattcttgt tagtgatcag atggttcaga
     2101 attttcaaga tgagagttgt tttttattct ccacagtaaa agctgaaagt agtgatggca
     2161 tccacataat tttgaagtga tgtcttatat agactgaact gtattcagta ccaaatagtc
     2221 acgcttaaaa gtgtgtgaag actgaatcca agaagtcttg ggattggatt ttaccatatg
     2281 aaatgtttca tattgaaaac acaagatgac ctttctaatg agctgtatga gaggtgaatc
     2341 tcctcactgt cactgccata gccaagcatc ctcatgagag tgagcacatc ggcacagcat
     2401 gcatccagct ctggaggcca cggtgcaggc atagctgcct gctgctctgg cagaggccag
     2461 taaatacagt tcctagaagc agcctttgct gtctttttac actgtatgcg gtttggaaat
     2521 gaatgtagaa acttactgtg ggcatttacc tttctgtgcc agtttggctt ttattgcctg
     2581 aaccttatgc tgacctggag aggagatggg ggacagtgct gttgtggggc cagcagtgaa
     2641 tctgtatgcg gagagttgtg ttgtgctgat gtggccgttg gtggtcaggt aagaggctcg
     2701 gcaccttctt ggaagaaatc atgtctgagg gtgtacgttt gatatgatca tgccagattg
     2761 gagaagatcc aagccaggaa gatgggcttg aagcaaactg cattatcagg agtaccttgg
     2821 tgagaggatc agtgtaaatc ctaataggta caaagacttt tgtgttttgg ctttgtcaca
     2881 gatttattga aaaacttttt tgcttctgct tccattttta gcattttagt ttctggtttt
     2941 catttttgga gattccttgc cttttaaact cgtggttttt ctctcatttt cttccctctc
     3001 tccctccatc tctgaccacc cccaccctaa ccccccaccc ccaccatcct attaaacatt
     3061 tttaaagccc taccccagac attggaaata ggtgacccaa gtagggggag aaagtattat
     3121 tgttgatagc ttctgactag gtgttaaggg atcttcatta tgaacaagat gaattttttt
     3181 ctggaaacac tagatgttat caatcaaaca ctaaaatgta ccatacaaat cccttaagcc
     3241 tctcaaatat tgagctttag tacaatcatg gatagacatt ctggtgatga tttaggggct
     3301 ttttatacac cacatactag cttctttctc tataagagtg cctctttcat aaaaccaaat
     3361 gcttgtctgc tagcatactt ttcaaaggga atccactgtt ttctcacttt cctcccatat
     3421 ctccgtcctt catccaaaac cttcccagaa tccatcagca agcatgtttg aggcctgtgg
     3481 tgtaggggac tgaatttttt ttttaacttc tattccattt taattgtagg atatctttgt
     3541 ccatataccc aggtgtcctg atttgaatgt actatttgat cctcattgtg ttcaggcaaa
     3601 aaataggaaa tgagtaattt tgagtttgaa atctctccca gaagacaaac tacttcagtg
     3661 agtaaaagct ttgacatttt atgttttatt cataaagggg gttaattatt tgctacaaag
     3721 aagcacgatc tattttcatc atcgatttga aaatatctgt aactcctata gatcctatag
     3781 gcagagagtt ttcctttctg actttttccc tttgctttcg tgtgaccaca tgttttctgt
     3841 accagtcact ggggaaagaa gtgagtttat ctcgtttgtt ttaaaagttt tgcttgtcta
     3901 tttagcattc ctttttgggt ctcaagattt atggaacaat aaatgtcatt taatgctgtg
     3961 tgcttatttt gaattcctca tcaggtttta gaagcggggt aaaaatactt agatgcttat
     4021 cagacttgaa attatactga gtggcattga acgtgagttt gtcccagtga aacaggctaa
     4081 ataaattttg gcaccagcaa atttgttact ttgttttttt aatagtagga tgtacacatt
     4141 tcagtataat aaatgttttc tgattgtttt gcaaa
//
