LOCUS       NM_173569              14692 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ubinuclein 2 (UBN2), mRNA.
ACCESSION   NM_173569 XM_376679 XM_379933 XM_939098
VERSION     NM_173569.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 14692)
  AUTHORS   Xie,Y., Tan,L., Wu,K., Li,D. and Li,C.
  TITLE     MiR-455-3p mediates PPARalpha through UBN2 to promote apoptosis and
            autophagy in acute myeloid leukemia cells
  JOURNAL   Exp Hematol 128, 77-88 (2023)
   PUBMED   37805161
  REMARK    GeneRIF: MiR-455-3p mediates PPARalpha through UBN2 to promote
            apoptosis and autophagy in acute myeloid leukemia cells.
REFERENCE   2  (bases 1 to 14692)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 14692)
  AUTHORS   Pieragostino,D., Agnifili,L., Fasanella,V., D'Aguanno,S.,
            Mastropasqua,R., Di Ilio,C., Sacchetta,P., Urbani,A. and Del
            Boccio,P.
  TITLE     Shotgun proteomics reveals specific modulated protein patterns in
            tears of patients with primary open angle glaucoma naive to therapy
  JOURNAL   Mol Biosyst 9 (6), 1108-1116 (2013)
   PUBMED   23580065
REFERENCE   4  (bases 1 to 14692)
  AUTHORS   Banumathy,G., Somaiah,N., Zhang,R., Tang,Y., Hoffmann,J.,
            Andrake,M., Ceulemans,H., Schultz,D., Marmorstein,R. and Adams,P.D.
  TITLE     Human UBN1 is an ortholog of yeast Hpc2p and has an essential role
            in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells
  JOURNAL   Mol Cell Biol 29 (3), 758-770 (2009)
   PUBMED   19029251
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC009220.10, AI239540.1, AK125956.1, AI803206.1 and BM673408.1.
            
            On Aug 8, 2018 this sequence version replaced NM_173569.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK125956.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000473989.8/ ENSP00000418648.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-248               AC009220.10        79948-80195
            249-384             AI239540.1         31-166              c
            385-468             AC009220.10        80332-80415
            469-1066            AK125956.1         1-598
            1067-1107           AI803206.1         457-497
            1108-4708           AK125956.1         640-4240
            4709-14536          AC009220.10        146964-156791
            14537-14692         BM673408.1         18-173              c
FEATURES             Location/Qualifiers
     source          1..14692
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q34"
     gene            1..14692
                     /gene="UBN2"
                     /note="ubinuclein 2"
                     /db_xref="GeneID:254048"
                     /db_xref="HGNC:HGNC:21931"
                     /db_xref="MIM:613841"
     exon            1..716
                     /gene="UBN2"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..4292
                     /gene="UBN2"
                     /codon_start=1
                     /product="ubinuclein-2"
                     /protein_id="NP_775840.3"
                     /db_xref="CCDS:CCDS43655.2"
                     /db_xref="GeneID:254048"
                     /db_xref="HGNC:HGNC:21931"
                     /db_xref="MIM:613841"
                     /translation="MAEPRRVAFISLSPVRRREAEYPGPEREPEYPREPPRLEPQPYR
                     EPARAEPPAPREPAPRSDAQPPSREKPLPQREVSRAEPPMSLQREPPRPEPPPPFPPL
                     PLQPPPPRESASRAEQPPRPPRETVRLELVLKDPTDESCVEFSYPELLLCGEQRKKLI
                     HTEDPFNDEHQERQEVEMLAKKFEMKYGGKPRKHRKDRLQDLIDIGFGYDETDPFIDN
                     SEAYDELVPASLTTKYGGFYINTGTLQFRQASDTEEDDITDNQKHKPPKVPKIKEDDI
                     EMKKRKRKEEGEKEKKPRKKVPKQLGVVALNSHKSEKKKKRYKDSLSLAAMIRKFQKE
                     KDALKKESNPKVPVTLSTPSLNKPPCAAAALGNDVPDLNLSSGDPDLPIFVSTNEHEL
                     FQEAENALEMLDDFDFDRLLDAASDGSPLSESGGENGTTTQPTYTSQVMPKVVPTLPE
                     GLPVLLEKRIEDLRVAAKLFDEEGRKKFFTQDMNNILLDIELQLQELGPVIRSGVYSH
                     LEAFVPCNKETLVKRLKKLHLNVQDDRLREPLQKLKLAVSNVMPEQLFKYQEDCQARS
                     QAKCAKLQTDEEREKNGSEEDDDEKPGKRVIGPRKKFHWDDTIRTLLCNLVEIKLGCY
                     ELEPNKSQSAEDYLKSFMETEVKPLWPKGWMQARMLFKESRSVHNHLTSAPAKKKVIP
                     APKPKVKEVMVKTLPLHSFPTMLKECSPKKDQKTPTSLVASVSGPPTSSSTAAIAAAS
                     SSSAPAQETICLDDSLDEDLSFHSPSLDLVSEALAVINNGNKGPPVGSRISMPTTKPR
                     PGLREEKLASIMSKLPLATPKKLDSTQTTHSSSLIAGHTGPVPKKPQDLAHTGISSGL
                     IAGSSIQNPKVSLEPLPARLLQQGLQRSSQIHTSSSSQTHVSSSSQAQIAASSHALGT
                     SEAQDASSLTQVTKVHQHSAVQQNYVSPLQATISKSQTNPVVKLSNNPQLSCSSSLIK
                     TSDKPLMYRLPLSTPSPGNGSQGSHPLVSRTVPSTTTSSNYLAKAMVSQISTQGFKSP
                     FSMAASPKLAASPKPATSPKPLPSPKPSASPKPSLSAKPSVSTKLISKSNPTPKPTVS
                     PSSSSPNALVAQGSHSSTNSPVHKQPSGMNISRQSPTLNLLPSSRTSGLPPTKNLQAP
                     SKLTNSSSTGTVGKNSLSGIAMNVPASRGSNLNSSGANRTSLSGGTGSGTQGATKPLS
                     TPHRPSTASGSSVVTASVQSTAGASLLANASPLTLMTSPLSVTNQNVTPFGMLGGLVP
                     VTMPFQFPLEIFGFGTDTAGVTTTSGSTSAAFHHSLTQNLLKGLQPGGAQHAATLSHS
                     PLPAHLQQAFHDGGQSKGDTKLPRKSQ"
     exon            717..809
                     /gene="UBN2"
                     /inference="alignment:Splign:2.1.0"
     exon            810..911
                     /gene="UBN2"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1049
                     /gene="UBN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1153
                     /gene="UBN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1643
                     /gene="UBN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..1714
                     /gene="UBN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1844
                     /gene="UBN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1845..1963
                     /gene="UBN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2077
                     /gene="UBN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2078..2221
                     /gene="UBN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2222..2272
                     /gene="UBN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2273..2315
                     /gene="UBN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2316..2366
                     /gene="UBN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2367..3917
                     /gene="UBN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3918..4149
                     /gene="UBN2"
                     /inference="alignment:Splign:2.1.0"
     exon            4150..4242
                     /gene="UBN2"
                     /inference="alignment:Splign:2.1.0"
     exon            4243..14692
                     /gene="UBN2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      14670..14675
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBN2"
                     /note="hexamer: AATAAA"
     polyA_site      14692
                     /gene="UBN2"
                     /note="major polyA site"
ORIGIN      
        1 ctgcttctat ttatgtgggg gatccaacat ggcggccgcg gcgaccctgg cgatggcggt
       61 gaagcccatc agaacgtagt agcggggaag gggacacggt ccgcactcac cgtggcgccg
      121 gcggagacgg ctgagggtgg tggagggaag aaaagcgaca gagagcaaga ggaagggcgg
      181 gcaggcacgc agcgcgccgt agaagcgagc gccggctcga gcaaaagcgg agggccagaa
      241 cagtggggat ggcggagccg cgcagagtag cgttcattag cttgtcaccg gtgcggcggc
      301 gcgaggccga gtacccgggg cccgagcgtg agcccgagta cccccgcgag cccccccggc
      361 tggagccgca gccgtaccgc gagccggccc gggcggagcc gccggccccg cgggagcctg
      421 ccccccgctc ggacgcgcag cccccgtcgc gggagaagcc gctcccccag cgcgaggtca
      481 gccgcgccga gccgcccatg tcgctgcagc gggagccccc gcggcccgag ccgccgccgc
      541 cgttcccgcc gctgcccttg cagccgcccc cgccgcggga gtcggcttcc cgggctgagc
      601 agccgccgcg gccgccgagg gagacggtgc gcctggagct ggtgcttaag gaccccaccg
      661 acgagagctg cgtggagttc agttacccgg agctgctgct gtgcggagaa caacggaaga
      721 agctcattca cacagaagac ccatttaatg atgaacatca ggagaggcaa gaggtggaaa
      781 tgttggctaa gaagtttgaa atgaaatatg gtgggaaacc ccgtaaacac cggaaggatc
      841 ggctacaaga tttaattgat ataggctttg gctatgatga gacagatcca tttattgata
      901 actcagaggc ttatgatgaa ttagttcccg cttctctaac aacaaaatat ggaggctttt
      961 atatcaacac tggcactcta cagtttcgcc aagcttcaga tactgaagaa gatgatatta
     1021 cagacaacca aaagcacaag ccacccaagg tccccaaaat aaaagaagat gatattgaga
     1081 tgaagaagcg gaagcggaaa gaggaagggg aaaaggagaa gaagccaagg aaaaaagttc
     1141 ccaaacaact gggagttgtg gctctaaatt cacacaagtc tgaaaaaaag aagaaacgtt
     1201 ataaagattc tctttctcta gctgccatga ttagaaaatt ccagaaagag aaggatgcat
     1261 taaagaagga gtctaacccc aaagtcccag tgaccttgtc aaccccttct ctgaataaac
     1321 ccccatgtgc tgctgcagca ctggggaatg acgtcccgga cttaaatctg agcagcggtg
     1381 atccagacct tcccattttt gttagcacaa atgaacatga gctgtttcag gaagctgaaa
     1441 atgccctaga gatgctagat gattttgact tcgacagatt actggatgct gcttctgatg
     1501 gtagccccct atctgagtcg gggggtgaaa atggaaccac cacccagcca acctacactt
     1561 ctcaggttat gcccaaagtg gtacctacac tcccagaggg tctacctgta cttcttgaaa
     1621 aacgtatcga agaccttcgt gtagctgcca aactttttga tgaagaagga aggaaaaaat
     1681 tctttacaca ggatatgaat aatattcttc tggacattga gttacagcta caagaactag
     1741 gccctgtcat tcgcagtggt gtctactccc accttgaagc ttttgtgcca tgcaataaag
     1801 aaacactagt aaaacgtctg aagaagttac atctcaatgt ccaggatgat cgtttaagag
     1861 aacctctgca aaaactgaaa ctggctgtta gcaatgtcat gcctgaacag ctatttaaat
     1921 accaggagga ctgccaggct cgtagtcaag ctaagtgtgc caaattgcag acagatgaag
     1981 aacgagaaaa aaatggatct gaagaggatg atgatgagaa accaggaaaa cgtgtcatag
     2041 gaccaagaaa gaaattccac tgggatgaca ctatcagaac tttgttatgt aaccttgttg
     2101 agatcaaatt gggatgctat gagttagaac caaataaaag ccagtctgct gaagattatc
     2161 ttaagtcttt tatggagaca gaagtgaagc ccctgtggcc taagggctgg atgcaggcaa
     2221 gaatgctttt taaggaaagc cggagtgttc ataatcatct tacttctgct ccggcaaaga
     2281 aaaaggtgat tcctgcacct aaacccaaag taaaggaggt gatggtaaag acccttcctc
     2341 tccattcttt ccccactatg cttaaggagt gtagtccaaa aaaggaccag aaaactccaa
     2401 catccctggt ggcttcggtt agcggtcctc caacgagctc cagcacagct gccattgctg
     2461 cagctagctc tagctctgca ccagcccaag aaaccatctg cctcgacgac tcactagatg
     2521 aagacctttc tttccattca ccttcactgg atcttgtttc tgaagcttta gcggttatca
     2581 acaatgggaa caagggccct ccagttggct caaggataag catgccaacc acaaagcctc
     2641 gtccaggact gagagaagaa aaattagcaa gtatcatgag taagctgcca ctagctactc
     2701 ccaaaaaact agattctact cagactacac attcttcaag tcttattgct ggtcacacag
     2761 ggccagtacc aaagaaaccc caggatttag ctcatactgg catctcttca ggccttattg
     2821 ctggttcttc cattcagaac cctaaagttt ctttagaacc tttgccagcc aggctacttc
     2881 aacaaggact tcagaggtca agccagattc acacttcttc ctcttcacag acccatgtct
     2941 cctcttcttc ccaagcccaa attgctgcct cttctcatgc tctgggaaca tccgaggccc
     3001 aagatgcttc ttcgttaaca caagtaacaa aggtgcacca gcattcagct gtccagcaga
     3061 actatgtgtc tccattacag gccaccatca gtaaatccca gaccaacccc gtcgtgaagt
     3121 taagtaataa tccccaactc tcctgttcct cctcacttat taagacttca gataagccac
     3181 ttatgtaccg ccttccctta tctaccccct cacctggaaa tggttctcaa gggtcccacc
     3241 ccctggtttc taggacagta cctagcacca ctacctccag taactattta gccaaggcta
     3301 tggtgtcaca gatctccacg cagggtttca aatctccctt ctcgatggct gcctccccaa
     3361 aacttgccgc atctcccaag cctgccacat ctcctaaacc cctgccctcg cctaagcctt
     3421 ctgcctcacc caagccctct ctgtcagcta agccttcagt atcaactaaa cttatttcta
     3481 aatccaaccc aactcccaag cctactgtat ccccaagtag ttccagtcca aatgcactag
     3541 ttgcccaggg tagccactcc agcactaaca gcccagtcca taaacagccc agtggaatga
     3601 acatcagcag acagtctccc accttgaatt tattgccctc tagtcgcact tcaggccttc
     3661 cacctacaaa aaatcttcag gccccctcaa agctaacaaa ctcatcatcc actggaactg
     3721 ttgggaagaa cagcttgagt ggaattgcaa tgaatgtacc tgccagcaga ggtagcaacc
     3781 ttaactcaag cggagctaat aggactagtc tgtctggggg aacaggaagt ggaacacagg
     3841 gtgctaccaa accattgtct actccacata gaccatccac tgcctcaggg tcttcagtgg
     3901 taacagccag tgtgcagtcc acagcaggag catcattatt ggctaatgcc tcacctctga
     3961 ctctcatgac atcacctttg tctgtaacaa atcaaaatgt gactcctttt gggatgctgg
     4021 gtggccttgt tccagtgacc atgcccttcc agtttccctt ggagatattt ggctttggaa
     4081 cggacacagc tggagtgaca accacctcgg gatctacctc agccgctttc caccatagcc
     4141 taactcagaa tttactaaag ggtttacagc caggaggagc tcagcatgca gcaacgcttt
     4201 cccactcacc tctgcctgca cacttacagc aagcatttca cgatggaggc caaagtaaag
     4261 gggacactaa attaccacgg aaatctcagt gactgcccag caagcaaagg agacgaaatg
     4321 tttagttgac tgatggaatc tacctgatgg gaaagtactt atgtggtcat agggctgctg
     4381 tttctgtcga tgtttacatt ctctcgtccc aagcactgtg gtgaggagga aaaagaaaag
     4441 aaaacattac ttgagcaaag ccaggtgcag gaggaagaaa tgcttttgtg caaagttagt
     4501 gacctttggt ctcttctaaa gaatgacaga gttaccgtat taacagactt gaaagagact
     4561 cagttgtcaa acccacagaa atacaaattt gatttttccc gggggaggaa gaaggaagtg
     4621 aagagaattt gggtaaactc catccatcct gggggttgga tctgaacact tacagacata
     4681 attggtaata aaaggcatta aaaactggaa ttaggccagt ttgtcaggaa taatgatcat
     4741 gtctatttga atggactgtg tagcagattt gccacaaaaa gaaataataa tgattctatc
     4801 tccgatagac agtagctgca tagcacaccc tcgaaaatcc tgaacaaact tgaatctcct
     4861 ccagtgtgta gcaacttccc tcaatcagtg gactaaagat ccttcaggaa agttatttta
     4921 gcacagtgat atatattatt aaatcatcta gatttttaaa aatcaggaag ttgagcctgt
     4981 tgctcttaag agatgaaacc tagatgtccc ctttttgtaa aagggtcaat ttcatcttcc
     5041 gttcagaagc aggtacttaa ctcttttctt caggtgattt gtgcatctag tattgactgg
     5101 ttaattctta tttccattct tgatgttaaa atgtgactgt gttcacattt ttctcctgag
     5161 aaatggggat ctttacaggg ttattgcttt gctgctttta gcccttgcag caacataaac
     5221 tctaagtttc cccagttcat ctaacttcac aacttctcct tctgttcttt tagctagtgg
     5281 tccttcaggt gattattagc tattggtata aacaggtaga agtgtacact atgtttcttc
     5341 attggtcatt caaatggcat gaatatagtt tttgaatttt taagatggta ttttaaaggg
     5401 aggaatcaca ttaggatcac aatcacgaca tatttttact ccctgtatcc agtgtagtga
     5461 aattgtttgg agcatttgag atcctaaagc ttcactattt actcagtgta ttggtatgtg
     5521 agtaaatctg cagaaaataa gactccttag ttattatagc ttccttatgc aaatagcata
     5581 ttcaacaaag gatgttaagg gaaaaattta tggttctcct tggatacatt tgatttgatg
     5641 ggtttttttg ccgcattatt ctagtttttt aagcttctga atattttcat actatatcag
     5701 agaatggtgt aaactctaaa tggtataagc ttcatccatt tataatgaca ctaacctaaa
     5761 aaaaatagac tggtagtgac aagatttatt gcatatgtgt ttattataca ttaccctata
     5821 ccattagatt tactcaatta agagtattaa ccaggccctt ttttctttta tacacaaaag
     5881 tcccagatac cctacaggac tgtgaataaa taaccacaga tcggttcaga tctgtatgcc
     5941 tatattttga cttcaaagtc acattggctt gcttcatagc gaaaaagtta ataaataact
     6001 gaaaacttta gttccaagaa cttgttacag taaagggaaa ggattatttc aaaggaatca
     6061 ctgatataat ttcttgactc taagaattta gtttatcaat aaaacaaata tggatgtagt
     6121 atgaacccca gtagatattt tggaaggata ctgggaggat gttgcagaga ggtttgactt
     6181 gaattcagta tgtttgatga agatttgctt ggtttcaatt aaggaagctt gcccaatttt
     6241 tttaattttt tcaaatgtag tggacctctt gcttttacga aatatgaata aaaaggtctt
     6301 tgcttcatac taggggaagt gatgggattt tcctttggga aggtagcctt tgttttactt
     6361 ctcataccac aagagaagtc gaagtgcgta ttaatttctc ttcctgaata cttgtatata
     6421 tgtttgtctg tatgtatata tacatacaca catacattca tataaatgac tagtttgagt
     6481 caaaaaatca tttgaatttc ttaaaaccat caattctgaa tcatgccata tgaagatccc
     6541 tggtgactgt catcattaga aaagaacaag ataatcagtt cttttccctg taacatttta
     6601 tactaaccag taaaaatatc tgaaggccct tggctccaag aatacaatgt ggagattctt
     6661 ctgtgttctc tttagtcttg attccttgag gactactgtc agatccctac cttaaacccc
     6721 cacctgcact gacgacttac attcatttca gtcaggaccc cccttttatg ttgtatgaat
     6781 cagtcaaaca tcgttgtatt tctgtataga taaagtatga tcagagagtt tctacatgta
     6841 aatagtaatc tatttctttc ctagatcata acattgaaaa aggtgcccat actttatggt
     6901 cacctgtctt taccgttttt attactaaaa acaaacatat aaattggtta ttttttagca
     6961 cagagacttg tgactcatac tgtatttttg cacttaaaaa tcaaattatg ttatttttta
     7021 aaatggtgag tcattggaaa ggatatctat agagcaacgt gtatttctga agagcattag
     7081 caacatccaa atgcaaaaat aatcagcaca catgattata tcccactcct tgggattctt
     7141 gattcaggaa gattaagctg tttgttttca actgttttat attttaaatt gccttcactg
     7201 atatataagc tgttactgta catacaagtt aatcctcagt attcacaagc aataacagtc
     7261 agcagggttg tcctcggaga tagctgtgct gagcctcagt tggagactgg gagcaaagtg
     7321 tcaagctcat tcagagcatc cagaataaat gcaagcaata atttccatta taattcaatt
     7381 ataattcttg tatgcttttg aggtcagagg gtaaatgaaa tcgtgatttt aaaacagcct
     7441 gaagaaaaag gttttgggaa aggaaatgag gctaatctgt agtcataaaa ttctgatact
     7501 ttgcggaaat tagaagatgg tgatagtgca ttcttttgtg cccacccccc ctctgatgga
     7561 tgttgttagc ccaaattaca tttttcatat catggacatt gaatagggtt tattgaatca
     7621 ggaaggtaag gggaagaacc gggcacatat gtgttggaat actgtgggtt tgacacctgg
     7681 ttgaaaacaa cttattggac atgattttta acccaggata tttttttccc aaagcagatc
     7741 taaattgttt actacccagg gttggaaagg gcaggcacct ctaatctagt ctttgtcctc
     7801 tggttgccct ctcccacacc cctttccacc tatacttggt tcaagacatt ttctgaaacg
     7861 aaaattctgc tgttgttcaa actgccattg gttatgagaa ctctgcgtcc tttgggatca
     7921 tctcttagaa ctccagtgat ctatcatatt tgctgctaca tttgtaaaat gaactttgcc
     7981 tgtattggtt gactttaatt tacagttctt tatttctagg atgttttgtc ctctagtttg
     8041 actcatgtat agaattagga tactttattt taggagtgta ccgtaaaagc acactggtcc
     8101 ctttgttgtt tttattattt aggtttggaa tttgtttgct ttttttttgt ttgttttttg
     8161 ttttgtttct gtttttgttt ttttttaaag ttggaaatag aagaatgaga aaaatctata
     8221 atcaggccaa acttgagaac tttcctgtgc ttcagcactg taattctgct gacctaatgt
     8281 tctcaaaaga ggcactttta ctttctattg tgcatgtatg attgttgttt tttgcttttg
     8341 agggggcttt tgtgtttgta ataatgaagc agaagaaaag tgcagtagta gataaatgat
     8401 cacaacatgt tatgcaattt tattttataa aattttaagg ggaaaagttt aactctttgt
     8461 aaatcatttc ttagctctgg taaaatgctt atattactcc tctaaaacat gctcaattca
     8521 ggcctttgtc tttgttaagt gccttttttc tttctttttt cctctctttt gaaactgttg
     8581 tcacattatc ttaaagtaca gactgataag tcaggggatt caggaggaag aatctcacac
     8641 ttgtcaacat catgtcatgc tgtgtaaccc tcttcctttg ctttctatgt atatggatat
     8701 atgtgtaaga tacatacatt acatatatat aaaactagga gctgctgtac cattgcatcc
     8761 tttccaaaca ctcccctttc catgtttgca aaacttctgc cttgtttatt ccattgcttt
     8821 tagttgatta aagtgggtgg attagaaaag tatcttttcg gccgggtgcg gtggctcacg
     8881 cctgtaatcc cagctctttg ggaggctgag gcaggtggat cacgaggtca ggagatcgag
     8941 accatcctgg ctaatatggt gaaaccccgt ctctactaaa aatacaaaaa attagccagg
     9001 cgtggtggca ggcgcctgta gtcccagcta cttgggaggc tgaggcagga gaatgacata
     9061 aacccgggag gcggaagttg cagtgagctg agatcgcgcc actgcactcc agcctgggcg
     9121 acagagcaag actccgtctc aaaaaaagaa aataaaagta tagaaaagta tcttttcaca
     9181 agaggccacc ttcgcccttt gaatatctgc ttgtagaagt taacaataac aacacacaca
     9241 cacacacaca cacacacgtc agttactaca agtaaaataa acttagtgaa tcattgacta
     9301 ttcttggata taacccactt ttctgtgctc tttaaacttg gcataagtaa tataggagac
     9361 agcattggaa taacaagagt accttgcaag tcacattggt aaggtgcgct agactaaaca
     9421 tgtgacaagg ctagcgttag aaccgcagtt tggtgtctaa gtttagaagc aggttagcaa
     9481 ctgtcaacat gaaaaatgta tcatattttc ttctggaaaa tgatttttga agaaatcata
     9541 tagctgcata tctatctgtt aaaaggttaa taaactcaga agtagaaaga cttcagatgc
     9601 tgaggaaaac atataatcta tagcattctt gagagatttt ccatttgctt tttatttgct
     9661 agataattac atttggctta atctgatttt atggttattt agatttctcc cttgagcaaa
     9721 ataacataat tttcagtatc taagattcat cgattttttg ttgaaaacaa atagatgtga
     9781 catgttaagg gagaccaagt tgaaccatcc ctcagaccca gtacaaatat acctagtaag
     9841 tgcccccctt tcaatacatt ctaattggga agaagaagag actagtggct taaaaggaga
     9901 aagcagaagc tcctggtagt gttacctgat agcagaactt accaggcagt tggaattcac
     9961 gagtgttatt cttgaatgac tatgtctagg gggaatattg tttaaccttc gtgcctcaga
    10021 ttacccatta gacaattggg tataatcata ttcacctacc tcccagggat atcagagact
    10081 ttactatttc aaaaatattt tgagtttttg taaaatgtcc tatataatta aaaatagtat
    10141 tatcatcttc ctgcagaggc taaaaaatgt tttccttata atgagtataa aaagcaccct
    10201 atggttttta aatttaaaaa aatcactgga attttaattt agatacatat ttgttattta
    10261 aacattatct ttgaggtggg ataaaatgtt tagtttcagg ttaacaaggg agagaaataa
    10321 cactaagttt aagtagtttt ttttagcctt ttacggtgtt actgtgattt ttcgtcaagg
    10381 ttgtggagct aaagttagat aaagttatga tgcttggtta ttggagttga taaatgatcc
    10441 tggaagtttt aactgtctca cttttccatc ttctcagtct aatttccttt tattgcttgt
    10501 ttgaggacgg atagctaagc tttttaactt tctaagaatg agtatgatgt ctcattcttg
    10561 caaatcagag attgtgtact aattccatta actgtaggtg tatccagctc tgcactgaag
    10621 gggtgagcac tacacacagt cagctggata ctcttgtagc cattgcacct ttgtaattca
    10681 tgcttcttca acccatgaaa gaggtggagc catcagctgc tcaggttgta agaaaatggg
    10741 agacggaagg caggattcac tttctaactg ggtcggggtg gggaaggtca gggtagaagg
    10801 aaacatgttt tccccagctc ccaggaggag acgaagatca ttttatccca ccttccatcc
    10861 ctgtatatta agtagtacta ctacatagaa ttttcccgtt atcgtttaaa ataatagcaa
    10921 caggaaaaga aaaatggatg ctgcagtttt agttggggct aaatgctgag caacgattgt
    10981 tggagtgtgt gtgtaaattt aaattgtagc acatattcag ggtcaggaaa gcaaaatgtt
    11041 ggggatgagg aaccagtgtt accaggttca agtgagttag tagaaagcac caggtccaag
    11101 cagacaaagc atctggttaa tttccagaat tggctaaggt ccactgaatc tctaatgata
    11161 gggtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtctgt aagtcacttt ttggattttt
    11221 gttgcttttt ccagataagg ccttagtagc ctctaaatat caactatgca gataaacata
    11281 ctcctttttt ttttcacatg tccctgtctt ttccattctc agataacaaa tgttaagacc
    11341 caaagaaata aggcataagg gtttttgttg aatgtgtgtt tgttcttcta gggaaaatta
    11401 acagaagcat aaaatagaga tactttgtgt gttcatctat cgtaaaatgt gaactctgta
    11461 ttcaaaaact atctacagat gctttcactg gtgcaaagct gtagttagta tcatggaatg
    11521 tctttgggtt gttaatgata aaatcatccc agtgttcaat tctgagagtt ttagattata
    11581 tgacacaatg ttcaggttta tagagctgaa tgggtgatca aactctaatt aaaaatagct
    11641 ttgaatatta atgttgaatt cttctttctt ggtttccttt agtcttcatt ctttattcag
    11701 agctcttaat catattgcta cactagaata tgaattgtat attaggagtc tggggaggaa
    11761 aggttaaatt gtcttttaca tcctcttctc actcactctg gcaacctatc ctgtgtcccc
    11821 atagaactga gaagtaaagc cctgtgcagg cctgctttag aagactttac atcccagcag
    11881 aggattcagg cagggactct caggatttta atcagactgc ctttgaataa tgtgatatta
    11941 aattttattt ttctcataga ctctcaaagt accacttgct tgaaagtagc tacttgtgat
    12001 ctttaatttc cttatattgt gatagttcta cttttcagtc tttcctgtgt atctccattt
    12061 catagtgcgt tagtacttaa acttcggaca cttttccaaa ctgttaaaca agtcaggaat
    12121 gcttttcaga atcgcagtag tattattagg gtctctgtgt ctaggactta cagtcatcag
    12181 tggtcatcac tgggactaga ggtgttcttt tttttcctct tctcctttgt attaaaaaat
    12241 agattttgct actgtataat gcggcatttc atgacttcct cttgttactt ttcaaggtta
    12301 ttctaaagag atggagatct tcattagagg ctatttctca taatagtctg ccttgcttat
    12361 tttcatactc cccctgaaat aagcctactt ttgcaaacag gccatatgaa tcaaatttta
    12421 tgtttgttcc tcacaaaatt ttctacacat tatttgttcc cactttgcta ataataatat
    12481 aatgatttta ttgtaaatct gtgttttaaa tattttataa cagagcacta atggaaacct
    12541 aataaataca aacaagataa ctattaccca agataacatg gaaatacttc tgtttttgaa
    12601 gttaacaaca ccgtctgccc tcaaagcaca tttaggagta tcaaccaaga ccagccagtt
    12661 gacatgtttt tctgtgtggc aacctgccct taaattgtca gatcttaact atcttgtgtt
    12721 tgctgtgctt gcagccataa gctttcctcc ttttttgctt atccctgctg tttgtagggt
    12781 tagtgtgccc tctgtcagaa aattgggttt tctttactat acctgcaaaa ttaccaaggg
    12841 ttaccccaat attgtctaga ggaattaaaa agaacttatt ctcagttgac aaaagtatta
    12901 ctgttataca tagttaattg gaaagttggc caactttggt cacctatttt tgagtcttgg
    12961 ctatgccttt gtaattagtt acatatacct tctgagacct tcagataatc aatgggcctt
    13021 tccccattag aggtaggttc ccagcctaca agtatttcct gtgatccatg gcaagcctcc
    13081 agagaaaaga ttcaagcttt gcactgccct tttgttgatt gtcattgaaa acttacttta
    13141 tttcagaaag tatcaaaaat accaaattgg tctttcagag agtatgtaaa tctggggctt
    13201 gcccttggat ttcacttgtt aaacaccctc aaacttaaaa gaagaaaata gatctccagc
    13261 tggtgaaaat tttgtgcccc aaataatata ttaatccaag tctaccaagg taactaagta
    13321 atggatgttt tctctctttt attacaagca agaaagttca tttgcagttg taaaaatgat
    13381 taccgaactc cagacctatt tgctataact gattggaaat aatgattctg atttttagtc
    13441 tgggtaaaca catacttcgg tgtgaatttt gataagggaa agacttgttt ggtagcccaa
    13501 ggaaaaacag gatgtattta tacagtgaat gttcactctg cagaggaact tccctccagt
    13561 tacatcttcc tcatacatta gccacctcca cacttgacat agatgccaac atgtttcaaa
    13621 accaatcttg aaggagccta aagagttgat ggtcctctag gtgaaagaca agaattactg
    13681 tattgcattt gcttataggg aggtgtgttt ttgctaactt gaagggatat actgtatttc
    13741 aaataagtgt gtgacttaat attttgggat ttttttttcc tcctttaaaa actggacctg
    13801 aacacaagct ttgagttgat gtttgtaata atctcaggac ctgaaagatt gtagcattta
    13861 gtgtgtctta aaaattatgt actgtaccag ccatggattt ttgtaaatat acctgtctcc
    13921 cttttttgta ttttagtaaa aaaaaaaaaa aataaattta aataaaaggg ggtggtgatg
    13981 acatgtgaat gggtgcgggt atgtgtgcgt gtgtgtttgt ataaggctct tttgagatga
    14041 actggtgctt gtttaatttc cagctcaaat cggagcagga atatggacaa actgctgcta
    14101 ctgaaccctg cactgagccg aggtatttcc atttggttaa ctaaacgcta gctaccagga
    14161 aatgacgcag aagtcacgtt cttcttccca ctgccatctt gcctttgcat tctcagttct
    14221 acgtgccctt tgaactttaa tggtaaaaca tttcacactt tggatggttt gcttgtctct
    14281 agtttttaga aagctcttat cactccttcc taagaaaaaa gaagggcagg taaatttttt
    14341 taaccaaaaa aaaatcacac atttcataaa accctgatga attttggata tgtgagaggg
    14401 cataaacatt cctaaatatg gacctgtgaa tttagtaaat tacccccatg aatatactcc
    14461 ttcagtgcag ggatttttgt gttttttttt tttttttaat ttttttgcaa cagccttgct
    14521 catattccag gtgtagctag caaacccctg tttttgaagc aagagcctta tttgattcag
    14581 tgtagatgtt tcctgtctat cctttgtgac agggcctttt aatgagtgtt ttttcttttt
    14641 gtatatgtta cgtgtttgtt gttgtattaa ataaagagga atgtacatac ta
//
