LOCUS       NM_145049               2179 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens ubiquitin like domain containing CTD phosphatase 1
            (UBLCP1), mRNA.
ACCESSION   NM_145049
VERSION     NM_145049.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2179)
  AUTHORS   Soueid,J., Hamze,Z., Bedran,J., Chahrour,M. and Boustany,R.M.
  TITLE     A novel autism-associated UBLCP1 mutation impacts proteasome
            regulation/activity
  JOURNAL   Transl Psychiatry 13 (1), 404 (2023)
   PUBMED   38129378
  REMARK    GeneRIF: A novel autism-associated UBLCP1 mutation impacts
            proteasome regulation/activity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2179)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2179)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2179)
  AUTHORS   Liu,X., Xiao,W., Zhang,Y., Wiley,S.E., Zuo,T., Zheng,Y., Chen,N.,
            Chen,L., Wang,X., Zheng,Y., Huang,L., Lin,S., Murphy,A.N.,
            Dixon,J.E., Xu,P. and Guo,X.
  TITLE     Reversible phosphorylation of Rpn1 regulates 26S proteasome
            assembly and function
  JOURNAL   Proc Natl Acad Sci U S A 117 (1), 328-336 (2020)
   PUBMED   31843888
  REMARK    GeneRIF: Study provides evidence that Rpn1-Ser361 is a prevalent
            phosphosite that is required for proper assembly and activity of
            the 26S proteasome and identified multiple kinases, including
            PIM1/2/3, that can phosphorylate Rpn1-S361 and have demonstrated
            that UBLCP1 is a physiologically relevant phosphatase of this site.
            Blocking phosphorylation of Rpn1-S361 leads to slowed proliferation
            and mitochondrial dysfunction.
REFERENCE   5  (bases 1 to 2179)
  AUTHORS   Sun,S., Liu,S., Zhang,Z., Zeng,W., Sun,C., Tao,T., Lin,X. and
            Feng,X.H.
  TITLE     Phosphatase UBLCP1 controls proteasome assembly
  JOURNAL   Open Biol 7 (5) (2017)
   PUBMED   28539385
  REMARK    GeneRIF: Data show that UBLCP1 selectively binds to the 26S
            proteasome non-ATPase regulatory subunit 13 (19S regulatory
            particle) in regulating proteasome assembly.
REFERENCE   6  (bases 1 to 2179)
  AUTHORS   St-Denis,N., Gupta,G.D., Lin,Z.Y., Gonzalez-Badillo,B., Veri,A.O.,
            Knight,J.D.R., Rajendran,D., Couzens,A.L., Currie,K.W., Tkach,J.M.,
            Cheung,S.W.T., Pelletier,L. and Gingras,A.C.
  TITLE     Phenotypic and Interaction Profiling of the Human Phosphatases
            Identifies Diverse Mitotic Regulators
  JOURNAL   Cell Rep 17 (9), 2488-2501 (2016)
   PUBMED   27880917
REFERENCE   7  (bases 1 to 2179)
  AUTHORS   Yun,J.H., Ko,S., Lee,C.K., Cheong,H.K., Cheong,C., Yoon,J.B. and
            Lee,W.
  TITLE     Solution structure and Rpn1 interaction of the UBL domain of human
            RNA polymerase II C-terminal domain phosphatase
  JOURNAL   PLoS One 8 (5), e62981 (2013)
   PUBMED   23667555
  REMARK    GeneRIF: the high-resolution solution structure of the UBL domain
            of human UBLCP1 and its interaction with Rpn1
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2179)
  AUTHORS   Guo,X., Engel,J.L., Xiao,J., Tagliabracci,V.S., Wang,X., Huang,L.
            and Dixon,J.E.
  TITLE     UBLCP1 is a 26S proteasome phosphatase that regulates nuclear
            proteasome activity
  JOURNAL   Proc Natl Acad Sci U S A 108 (46), 18649-18654 (2011)
   PUBMED   21949367
  REMARK    GeneRIF: UBLCP1 is a 26S proteasome phosphatase that regulates
            nuclear proteasome activity
REFERENCE   9  (bases 1 to 2179)
  AUTHORS   Zheng,H., Ji,C., Gu,S., Shi,B., Wang,J., Xie,Y. and Mao,Y.
  TITLE     Cloning and characterization of a novel RNA polymerase II
            C-terminal domain phosphatase
  JOURNAL   Biochem Biophys Res Commun 331 (4), 1401-1407 (2005)
   PUBMED   15883030
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA930581.1, AY444562.1 and AC011418.5.
            
            On Nov 22, 2018 this sequence version replaced NM_145049.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY444562.1, SRR3476690.926666.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296786.8/ ENSP00000296786.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                DA930581.1         210-292
            84-1387             AY444562.1         105-1408
            1388-1389           AC011418.5         58373-58374         c
            1390-2179           AY444562.1         1410-2199
FEATURES             Location/Qualifiers
     source          1..2179
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q33.3"
     gene            1..2179
                     /gene="UBLCP1"
                     /gene_synonym="CPUB1"
                     /note="ubiquitin like domain containing CTD phosphatase 1"
                     /db_xref="GeneID:134510"
                     /db_xref="HGNC:HGNC:28110"
                     /db_xref="MIM:609867"
     exon            1..71
                     /gene="UBLCP1"
                     /gene_synonym="CPUB1"
                     /inference="alignment:Splign:2.1.0"
     exon            72..271
                     /gene="UBLCP1"
                     /gene_synonym="CPUB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..1074
                     /gene="UBLCP1"
                     /gene_synonym="CPUB1"
                     /EC_number="3.1.3.16"
                     /note="CTD phosphatase-like with ubiquitin domain 1;
                     CTD-like phosphatase domain-containing protein; nuclear
                     proteasome inhibitor UBLCP1"
                     /codon_start=1
                     /product="ubiquitin-like domain-containing CTD phosphatase
                     1"
                     /protein_id="NP_659486.2"
                     /db_xref="CCDS:CCDS4345.1"
                     /db_xref="GeneID:134510"
                     /db_xref="HGNC:HGNC:28110"
                     /db_xref="MIM:609867"
                     /translation="MALPIIVKWGGQEYSVTTLSEDDTVLDLKQFLKTLTGVLPERQK
                     LLGLKVKGKPAENDVKLGALKLKPNTKIMMMGTREESLEDVLGPPPDNDDVVNDFDIE
                     DEVVEVENREENLLKISRRVKEYKVEILNPPREGKKLLVLDVDYTLFDHRSCAETGVE
                     LMRPYLHEFLTSAYEDYDIVIWSATNMKWIEAKMKELGVSTNANYKITFMLDSAAMIT
                     VHTPRRGLIDVKPLGVIWGKFSEFYSKKNTIMFDDIGRNFLMNPQNGLKIRPFMKAHL
                     NRDKDKELLKLTQYLKEIAKLDDFLDLNHKYWERYLSKKQGQ"
     exon            272..363
                     /gene="UBLCP1"
                     /gene_synonym="CPUB1"
                     /inference="alignment:Splign:2.1.0"
     exon            364..449
                     /gene="UBLCP1"
                     /gene_synonym="CPUB1"
                     /inference="alignment:Splign:2.1.0"
     exon            450..565
                     /gene="UBLCP1"
                     /gene_synonym="CPUB1"
                     /inference="alignment:Splign:2.1.0"
     exon            566..664
                     /gene="UBLCP1"
                     /gene_synonym="CPUB1"
                     /inference="alignment:Splign:2.1.0"
     exon            665..702
                     /gene="UBLCP1"
                     /gene_synonym="CPUB1"
                     /inference="alignment:Splign:2.1.0"
     exon            703..801
                     /gene="UBLCP1"
                     /gene_synonym="CPUB1"
                     /inference="alignment:Splign:2.1.0"
     exon            802..918
                     /gene="UBLCP1"
                     /gene_synonym="CPUB1"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1046
                     /gene="UBLCP1"
                     /gene_synonym="CPUB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..2179
                     /gene="UBLCP1"
                     /gene_synonym="CPUB1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2159..2164
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBLCP1"
                     /gene_synonym="CPUB1"
                     /note="hexamer: AATAAA"
     polyA_site      2179
                     /gene="UBLCP1"
                     /gene_synonym="CPUB1"
                     /note="major polyA site"
ORIGIN      
        1 acttccggtc gctttcggtc tctcagcggc cggtttctgc gtccgctgcc gcaggttcca
       61 ccgcgctcca ggtatttttt tttctgaagg aaagctgctt cctcatatgt ttcaagaatg
      121 gctctcccta tcattgtaaa atggggtgga caggagtatt cagtgaccac actttcagaa
      181 gatgatactg tgctcgatct caaacagttt ctcaagaccc ttacaggagt tcttccagaa
      241 cgccaaaagt tacttggact caaagttaaa ggcaaacctg cagaaaatga tgttaagctt
      301 ggagctctca aactgaaacc aaatactaaa atcatgatga tgggaactcg tgaggagagc
      361 ttggaagatg tcttaggtcc accccctgac aatgatgatg ttgttaatga ctttgatatt
      421 gaagatgaag tagttgaagt agaaaatagg gaagaaaacc tactgaaaat ttctcgcaga
      481 gtgaaagagt acaaagtgga aattttgaat cctcccaggg aagggaaaaa gcttttggtg
      541 ctagatgttg attatacatt atttgaccac aggtcttgtg cagagactgg ggtagaatta
      601 atgcggccat atcttcatga atttctaaca tctgcctatg aagattatga cattgttatt
      661 tggtctgcaa caaatatgaa gtggattgaa gctaaaatga aagagctggg agtgagcaca
      721 aatgcaaatt ataagattac tttcatgttg gatagtgctg ctatgataac agtacatact
      781 ccaaggagag gattaataga cgtaaagcct cttggtgtta tatggggaaa gttttcggag
      841 ttttacagca agaaaaacac cattatgttt gatgacatag ggagaaattt tctaatgaac
      901 ccacagaatg gactaaagat aaggcctttt atgaaagcgc acctaaatcg tgataaagac
      961 aaagaacttt taaaattaac tcagtacctc aaggagatag caaaattaga tgactttttg
     1021 gatctaaatc acaaatattg ggaaagatat ctctcaaaga agcaaggaca gtagttacaa
     1081 gttatactgg cagttattga agatacttaa gatccaagaa cttcttgctt ttatgctaga
     1141 aatcattatg atagtgctgg acactgaagc aaataccata ctgcttatac ttggtcttcc
     1201 agttttttgt aaatttaatt ttatattttt tgaagatgat agcaatatgc taaaaaatgc
     1261 ttgtccccta tatgaatatt ctgttacgct tgaaaaatat tttctccagc gttggttact
     1321 gaccacccca ccctcccacc acacacacac acacacacac acacacacac acacacacac
     1381 acacacaaag tggagaaaaa tgtatactca acaatgtcat tttgtgactt tggaaacaag
     1441 ttatgttttg tgtttttgtc tcattgtgtt attgtctgac taaatctaaa accaaaccca
     1501 tgttgaaact agtacttttc cctttaaaaa caaaccaaaa aaaaaaacaa aaaaaaactt
     1561 tttaattaaa gaacctagtt tgctatgctt aaaattacca agaatttttt atttctttgt
     1621 catagacaca atttctcttc tgtatgccac tagttacatt tctaaattct gagcggtctc
     1681 agttaggcct gtatgtgtgt acatgtccaa gtaaagctgg aaaatgtcag tcttgacaca
     1741 gctgtgtctt agtatgagaa acagaagact gaagaataaa aactaaggaa caagaatgag
     1801 tctctttttg gtggctaagt agaatcttcc taaaaccatt gtcataaaag cagttaaagg
     1861 caataaattt ttaaaaggga catatcactg attcattcct aaaaagcatg aacaaaaagt
     1921 ttttgttctg ttccagctat atcttgtcta agtgctaaca ctgtttcagt gaaaatatct
     1981 agccataaga ttaaaaaaat atattatttg caatgcttaa gcctgcagat acgtaatgtg
     2041 accactgttt tgtgttgaca atattgcttt atacagttct tgtatttgaa aggaattgat
     2101 ccttttaaag aaacatggtg tatattgttc ttacaggact aatttcagtg gtgtaaataa
     2161 taaatatctt ttcttaaaa
//
