LOCUS       NM_032907               1409 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens ubiquitin like 7 (UBL7), transcript variant 1, mRNA.
ACCESSION   NM_032907
VERSION     NM_032907.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1409)
  AUTHORS   Jiang,W., Li,X., Xu,H., Gu,X., Li,S., Zhu,L., Lu,J., Duan,X., Li,W.
            and Fang,M.
  TITLE     UBL7 enhances antiviral innate immunity by promoting Lys27-linked
            polyubiquitination of MAVS
  JOURNAL   Cell Rep 42 (3), 112272 (2023)
   PUBMED   36943869
REFERENCE   2  (bases 1 to 1409)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1409)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1409)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 1409)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1409)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   7  (bases 1 to 1409)
  AUTHORS   Sahni,N., Yi,S., Taipale,M., Fuxman Bass,J.I.,
            Coulombe-Huntington,J., Yang,F., Peng,J., Weile,J., Karras,G.I.,
            Wang,Y., Kovacs,I.A., Kamburov,A., Krykbaeva,I., Lam,M.H.,
            Tucker,G., Khurana,V., Sharma,A., Liu,Y.Y., Yachie,N., Zhong,Q.,
            Shen,Y., Palagi,A., San-Miguel,A., Fan,C., Balcha,D., Dricot,A.,
            Jordan,D.M., Walsh,J.M., Shah,A.A., Yang,X., Stoyanova,A.K.,
            Leighton,A., Calderwood,M.A., Jacob,Y., Cusick,M.E.,
            Salehi-Ashtiani,K., Whitesell,L.J., Sunyaev,S., Berger,B.,
            Barabasi,A.L., Charloteaux,B., Hill,D.E., Hao,T., Roth,F.P.,
            Xia,Y., Walhout,A.J.M., Lindquist,S. and Vidal,M.
  TITLE     Widespread macromolecular interaction perturbations in human
            genetic disorders
  JOURNAL   Cell 161 (3), 647-660 (2015)
   PUBMED   25910212
REFERENCE   8  (bases 1 to 1409)
  AUTHORS   Chang,Y.G., Song,A.X., Gao,Y.G., Shi,Y.H., Lin,X.J., Cao,X.T.,
            Lin,D.H. and Hu,H.Y.
  TITLE     Solution structure of the ubiquitin-associated domain of human
            BMSC-UbP and its complex with ubiquitin
  JOURNAL   Protein Sci 15 (6), 1248-1259 (2006)
   PUBMED   16731964
  REMARK    GeneRIF: the solution NMR structure of the ubiquitin-associated
            domain of the human BMSC-UbP protein and its complex with ubiquitin
REFERENCE   9  (bases 1 to 1409)
  AUTHORS   Lehner,B., Semple,J.I., Brown,S.E., Counsell,D., Campbell,R.D. and
            Sanderson,C.M.
  TITLE     Analysis of a high-throughput yeast two-hybrid system and its use
            to predict the function of intracellular proteins encoded within
            the human MHC class III region
  JOURNAL   Genomics 83 (1), 153-167 (2004)
   PUBMED   14667819
REFERENCE   10 (bases 1 to 1409)
  AUTHORS   Liu,S., Yu,Y., An,H., Li,N., Lin,N., Wang,W., Zhang,W., Wan,T. and
            Cao,X.
  TITLE     Cloning and identification of a novel ubiquitin-like protein,
            BMSC-UbP, from human bone marrow stromal cells
  JOURNAL   Immunol Lett 86 (2), 169-175 (2003)
   PUBMED   12644319
  REMARK    GeneRIF: BMSC-UbP might play roles in regulation of BMSC function
            or cell differentiation through an evocator- and cell-specific
            pattern.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP192909.1 and BC007913.2.
            
            On Nov 22, 2018 this sequence version replaced NM_032907.4.
            
            Transcript Variant: This variant (1) encodes the shorter isoform
            (a). Variants 1-4 encode the same isoform.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.757667.1,
                                           SRR5189661.122976.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395081.7/ ENSP00000378518.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-124               BP192909.1         19-142
            125-1409            BC007913.2         436-1720
FEATURES             Location/Qualifiers
     source          1..1409
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q24.1"
     gene            1..1409
                     /gene="UBL7"
                     /gene_synonym="BMSC-UbP; TCBA1"
                     /note="ubiquitin like 7"
                     /db_xref="GeneID:84993"
                     /db_xref="HGNC:HGNC:28221"
                     /db_xref="MIM:609748"
     exon            1..124
                     /gene="UBL7"
                     /gene_synonym="BMSC-UbP; TCBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            125..337
                     /gene="UBL7"
                     /gene_synonym="BMSC-UbP; TCBA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..1296
                     /gene="UBL7"
                     /gene_synonym="BMSC-UbP; TCBA1"
                     /note="isoform a is encoded by transcript variant 1;
                     ubiquitin-like protein SB132; ubiquitin-like protein 7;
                     ubiquitin-like 7 (bone marrow stromal cell-derived)"
                     /codon_start=1
                     /product="ubiquitin-like protein 7 isoform a"
                     /protein_id="NP_116296.1"
                     /db_xref="CCDS:CCDS10263.1"
                     /db_xref="GeneID:84993"
                     /db_xref="HGNC:HGNC:28221"
                     /db_xref="MIM:609748"
                     /translation="MSLSDWHLAVKLADQPLTPKSILRLPETELGEYSLGGYSISFLK
                     QLIAGKLQESVPDPELIDLIYCGRKLKDDQTLDFYGIQPGSTVHVLRKSWPEPDQKPE
                     PVDKVAAMREFRVLHTALHSSSSYREAVFKMLSNKESLDQIIVATPGLSSDPIALGVL
                     QDKDLFSVFADPNMLDTLVPAHPALVNAIVLVLHSVAGSAPMPGTDSSSRSMPSSSYR
                     DMPGGFLFEGLSDDEDDFHPNTRSTPSSSTPSSRPASLGYSGAAGPRPITQSELATAL
                     ALASTPESSSHTPTPGTQGHSSGTSPMSSGVQSGTPITNDLFSQALQHALQASGQPSL
                     QSQWQPQLQQLRDMGIQDDELSLRALQATGGDIQAALELIFAGGAP"
     exon            338..457
                     /gene="UBL7"
                     /gene_synonym="BMSC-UbP; TCBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            458..540
                     /gene="UBL7"
                     /gene_synonym="BMSC-UbP; TCBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            541..625
                     /gene="UBL7"
                     /gene_synonym="BMSC-UbP; TCBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            626..683
                     /gene="UBL7"
                     /gene_synonym="BMSC-UbP; TCBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            684..817
                     /gene="UBL7"
                     /gene_synonym="BMSC-UbP; TCBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            818..867
                     /gene="UBL7"
                     /gene_synonym="BMSC-UbP; TCBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1035
                     /gene="UBL7"
                     /gene_synonym="BMSC-UbP; TCBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1158
                     /gene="UBL7"
                     /gene_synonym="BMSC-UbP; TCBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1409
                     /gene="UBL7"
                     /gene_synonym="BMSC-UbP; TCBA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1387..1392
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBL7"
                     /gene_synonym="BMSC-UbP; TCBA1"
                     /note="hexamer: AATATA"
     polyA_site      1409
                     /gene="UBL7"
                     /gene_synonym="BMSC-UbP; TCBA1"
                     /note="major polyA site"
ORIGIN      
        1 agagtgagtg tttacaccgg cggcagtgcg gccgggttcc ttccgcggga cgggtgaggg
       61 cgctggggcc ctgggcagcg cgggctcgat gtgtgtcagc caagtagctg gtcccactgg
      121 agcgggagaa agagagagcg cgaaagagag aggatgtctc tctcagactg gcacctggcg
      181 gtgaagctgg ctgaccagcc acttactcca aagtctattc ttcggttgcc agagacagaa
      241 ctgggagaat actcgctagg gggctatagt atttcatttc tgaagcagct tattgctggc
      301 aaactccagg agtctgttcc agaccctgag ctgattgatc tgatctactg tggtcggaag
      361 ctaaaagatg accagacact tgacttctat ggcattcaac ctgggtccac tgtccatgtt
      421 ctgcgaaagt cctggcctga acctgatcag aaaccggaac ctgtggacaa agtggctgcc
      481 atgagagagt tccgggtgtt gcacactgcc ctgcacagca gctcctctta cagggaggcg
      541 gtctttaaga tgctcagcaa taaggagtct ctggatcaga tcattgtggc caccccaggc
      601 ctcagcagtg accctattgc tcttggggtt ctccaggaca aggacctctt ctctgtcttc
      661 gctgatccca atatgcttga tacgttggtg cctgctcacc cagccctcgt caatgccatt
      721 gtcctggttc tgcactccgt agcaggcagt gccccaatgc ctgggactga ctcctcttcc
      781 cggagcatgc cctccagctc ataccgggat atgccaggtg gcttcctgtt tgaagggctc
      841 tcagatgatg aggatgactt tcacccaaac accaggtcca caccctctag cagtactccc
      901 agctcccgcc cagcctccct ggggtacagt ggagctgctg ggccccggcc catcacccag
      961 agtgagctgg ccaccgcctt ggccctggcc agcactccgg agagcagctc tcacacaccg
     1021 actcctggca cccagggtca ttcctcaggg acctcaccaa tgtcctctgg tgtccagtca
     1081 gggacgccca tcaccaatga tctcttcagc caagccctac agcatgccct tcaggcctct
     1141 gggcagccca gccttcagag ccagtggcag ccccagctgc agcagctacg tgacatgggc
     1201 atccaggacg atgagctgag cctgcgggcc ctgcaggcca ccggtgggga catccaagca
     1261 gccctggagc tcatctttgc tggaggagcc ccatgaactc cctgcttccc ctgaaccccc
     1321 agcaagttgc agaggctact gcccttggga ggcactcatg aaggtgcctc catctctccc
     1381 ttccccaata tacctgatgg tcaactctc
//
