LOCUS       NM_001048241             407 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens ubiquitin like 5 (UBL5), transcript variant 2, mRNA.
ACCESSION   NM_001048241
VERSION     NM_001048241.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 407)
  AUTHORS   Kolathur,K.K., Mallya,S., Barve,S., Bojja,S.L. and Wagle,M.M.
  TITLE     Moonlighting functions of the ubiquitin-like protein, Hub1/UBL-5
  JOURNAL   Int J Biochem Cell Biol 162, 106445 (2023)
   PUBMED   37453225
  REMARK    GeneRIF: Moonlighting functions of the ubiquitin-like protein,
            Hub1/UBL-5.
            Review article
REFERENCE   2  (bases 1 to 407)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 407)
  AUTHORS   Oka,Y., Bekker-Jensen,S. and Mailand,N.
  TITLE     Ubiquitin-like protein UBL5 promotes the functional integrity of
            the Fanconi anemia pathway
  JOURNAL   EMBO J 34 (10), 1385-1398 (2015)
   PUBMED   25862789
  REMARK    GeneRIF: Findings establish UBL5 as a factor that promotes the
            functionality of the FA DNA repair pathway.
REFERENCE   4  (bases 1 to 407)
  AUTHORS   Oka,Y., Varmark,H., Vitting-Seerup,K., Beli,P., Waage,J.,
            Hakobyan,A., Mistrik,M., Choudhary,C., Rohde,M., Bekker-Jensen,S.
            and Mailand,N.
  TITLE     UBL5 is essential for pre-mRNA splicing and sister chromatid
            cohesion in human cells
  JOURNAL   EMBO Rep 15 (9), 956-964 (2014)
   PUBMED   25092792
  REMARK    GeneRIF: our results show that UBL5 plays an evolutionary conserved
            role in pre-mRNA splicing, the integrity of which is essential for
            the fidelity of chromosome segregation.
REFERENCE   5  (bases 1 to 407)
  AUTHORS   Hasson,S.A., Kane,L.A., Yamano,K., Huang,C.H., Sliter,D.A.,
            Buehler,E., Wang,C., Heman-Ackah,S.M., Hessa,T., Guha,R.,
            Martin,S.E. and Youle,R.J.
  TITLE     High-content genome-wide RNAi screens identify regulators of parkin
            upstream of mitophagy
  JOURNAL   Nature 504 (7479), 291-295 (2013)
   PUBMED   24270810
REFERENCE   6  (bases 1 to 407)
  AUTHORS   Wilkinson,C.R., Dittmar,G.A., Ohi,M.D., Uetz,P., Jones,N. and
            Finley,D.
  TITLE     Ubiquitin-like protein Hub1 is required for pre-mRNA splicing and
            localization of an essential splicing factor in fission yeast
  JOURNAL   Curr Biol 14 (24), 2283-2288 (2004)
   PUBMED   15620657
  REMARK    Erratum:[Curr Biol. 2006 Dec 19;16(24):2488]
REFERENCE   7  (bases 1 to 407)
  AUTHORS   Jowett,J.B., Elliott,K.S., Curran,J.E., Hunt,N., Walder,K.R.,
            Collier,G.R., Zimmet,P.Z. and Blangero,J.
  TITLE     Genetic variation in BEACON influences quantitative variation in
            metabolic syndrome-related phenotypes
  JOURNAL   Diabetes 53 (9), 2467-2472 (2004)
   PUBMED   15331561
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 407)
  AUTHORS   McNally,T., Huang,Q., Janis,R.S., Liu,Z., Olejniczak,E.T. and
            Reilly,R.M.
  TITLE     Structural analysis of UBL5, a novel ubiquitin-like modifier
  JOURNAL   Protein Sci 12 (7), 1562-1566 (2003)
   PUBMED   12824502
REFERENCE   9  (bases 1 to 407)
  AUTHORS   Kantham,L., Kerr-Bayles,L., Godde,N., Quick,M., Webb,R.,
            Sunderland,T., Bond,J., Walder,K., Augert,G. and Collier,G.
  TITLE     Beacon interacts with cdc2/cdc28-like kinases
  JOURNAL   Biochem Biophys Res Commun 304 (1), 125-129 (2003)
   PUBMED   12705895
REFERENCE   10 (bases 1 to 407)
  AUTHORS   Friedman,J.S., Koop,B.F., Raymond,V. and Walter,M.A.
  TITLE     Isolation of a ubiquitin-like (UBL5) gene from a screen identifying
            highly expressed and conserved iris genes
  JOURNAL   Genomics 71 (2), 252-255 (2001)
   PUBMED   11161819
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP213482.1, BC110839.1 and CA418471.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001048241.2.
            
            Summary: This gene encodes a member of a group of proteins similar
            to ubiquitin. The encoded protein is not thought to degrade
            proteins like ubiquitin but to affect their function through being
            bound to target proteins by an isopeptide bond. The gene product
            has been studied as a link to predisposition to obesity based on
            its expression in Psammomys obesus, the fat sand rat, which is an
            animal model for obesity studies. Variation in this gene was found
            to be significantly associated with some metabolic traits (PMID:
            15331561) but not associated with childhood obesity (PMID:
            19189687). Pseudogenes of this gene are located on chromosomes 3, 5
            and 17. Multiple alternatively spliced variants, encoding the same
            protein, have been identified. [provided by RefSeq, Jan 2013].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB108812.1, CB107673.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000586895.6/ ENSP00000468656.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                BP213482.1         27-72
            47-406              BC110839.1         1-360
            407-407             CA418471.1         25-25               c
FEATURES             Location/Qualifiers
     source          1..407
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..407
                     /gene="UBL5"
                     /gene_synonym="HUB1"
                     /note="ubiquitin like 5"
                     /db_xref="GeneID:59286"
                     /db_xref="HGNC:HGNC:13736"
                     /db_xref="MIM:606849"
     exon            1..67
                     /gene="UBL5"
                     /gene_synonym="HUB1"
                     /inference="alignment:Splign:2.1.0"
     exon            68..134
                     /gene="UBL5"
                     /gene_synonym="HUB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..300
                     /gene="UBL5"
                     /gene_synonym="HUB1"
                     /note="beacon; testicular tissue protein Li 217"
                     /codon_start=1
                     /product="ubiquitin-like protein 5"
                     /protein_id="NP_001041706.1"
                     /db_xref="CCDS:CCDS12219.1"
                     /db_xref="GeneID:59286"
                     /db_xref="HGNC:HGNC:13736"
                     /db_xref="MIM:606849"
                     /translation="MIEVVCNDRLGKKVRVKCNTDDTIGDLKKLIAAQTGTRWNKIVL
                     KKWYTIFKDHVSLGDYEIHDGMNLELYYQ"
     exon            135..218
                     /gene="UBL5"
                     /gene_synonym="HUB1"
                     /inference="alignment:Splign:2.1.0"
     exon            219..256
                     /gene="UBL5"
                     /gene_synonym="HUB1"
                     /inference="alignment:Splign:2.1.0"
     exon            257..407
                     /gene="UBL5"
                     /gene_synonym="HUB1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      389..394
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBL5"
                     /gene_synonym="HUB1"
                     /note="hexamer: AATAAA"
     polyA_site      407
                     /gene="UBL5"
                     /gene_synonym="HUB1"
                     /note="major polyA site"
ORIGIN      
        1 aactgcgacc ggggttcagc gctcgggtga ggagctggtg gcgtcggcag gttcgaggcg
       61 attcgagctc cagctaggat gatcgaggtt gtttgcaacg accgtctggg gaagaaggtc
      121 cgcgttaaat gcaacacgga tgataccatc ggggacctta agaagctgat tgcagcccaa
      181 actggtaccc gttggaacaa gattgtcctg aagaagtggt acacgatttt taaggaccac
      241 gtgtctctgg gggactatga aatccacgat gggatgaacc tggagcttta ttatcaatag
      301 atgagaatcc tcatcttcct gccccgcttt cctctcccat cctcatcccc cacactggga
      361 tagatgcttg tttgtaaaaa ctcaccttaa taaagactta gatgttg
//
