LOCUS       NM_014235               2327 bp    mRNA    linear   PRI 12-DEC-2024
DEFINITION  Homo sapiens ubiquitin like 4A (UBL4A), mRNA.
ACCESSION   NM_014235
VERSION     NM_014235.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2327)
  AUTHORS   Chen,Z., Xu,L., Lin,S., Huang,H., Long,Q. and Liu,J.
  TITLE     GdX inhibits the occurrence and progression of breast cancer by
            negatively modulating the activity of STAT3
  JOURNAL   Cancer Biol Ther 25 (1), 2420383 (2024)
   PUBMED   39487760
  REMARK    GeneRIF: GdX inhibits the occurrence and progression of breast
            cancer by negatively modulating the activity of STAT3.
REFERENCE   2  (bases 1 to 2327)
  AUTHORS   He,S.Y., Wang,G., Pei,Y.H. and Zhu,H.P.
  TITLE     miR-34b-3p protects against acute kidney injury in sepsis mice via
            targeting ubiquitin-like protein 4A
  JOURNAL   Kaohsiung J Med Sci 36 (10), 817-824 (2020)
   PUBMED   32609950
  REMARK    GeneRIF: miR-34b-3p protects against acute kidney injury in sepsis
            mice via targeting ubiquitin-like protein 4A.
REFERENCE   3  (bases 1 to 2327)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 2327)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2327)
  AUTHORS   Peng,S.J., Yao,R.R., Yu,S.S., Chen,H.Y., Pang,X., Zhang,Y. and
            Zhang,J.
  TITLE     UBL4A Augments Innate Immunity by Promoting the K63-Linked
            Ubiquitination of TRAF6
  JOURNAL   J Immunol 203 (7), 1943-1951 (2019)
   PUBMED   31451677
  REMARK    GeneRIF: a novel positive feedback regulation of UBL4A in innate
            immune response combating virus invasion by enhancing the
            K63-linked ubiquitination of TRAF6.
REFERENCE   6  (bases 1 to 2327)
  AUTHORS   Yang,F., Skaletsky,H. and Wang,P.J.
  TITLE     Ubl4b, an X-derived retrogene, is specifically expressed in
            post-meiotic germ cells in mammals
  JOURNAL   Gene Expr Patterns 7 (1-2), 131-136 (2007)
   PUBMED   16872915
REFERENCE   7  (bases 1 to 2327)
  AUTHORS   Kim,S.C., Sprung,R., Chen,Y., Xu,Y., Ball,H., Pei,J., Cheng,T.,
            Kho,Y., Xiao,H., Xiao,L., Grishin,N.V., White,M., Yang,X.J. and
            Zhao,Y.
  TITLE     Substrate and functional diversity of lysine acetylation revealed
            by a proteomics survey
  JOURNAL   Mol Cell 23 (4), 607-618 (2006)
   PUBMED   16916647
REFERENCE   8  (bases 1 to 2327)
  AUTHORS   Chen,E.Y., Zollo,M., Mazzarella,R., Ciccodicola,A., Chen,C.N.,
            Zuo,L., Heiner,C., Burough,F., Repetto,M., Schlessinger,D. and
            D'Urso,M.
  TITLE     Long-range sequence analysis in Xq28: thirteen known and six
            candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and
            G6PD loci
  JOURNAL   Hum Mol Genet 5 (5), 659-668 (1996)
   PUBMED   8733135
REFERENCE   9  (bases 1 to 2327)
  AUTHORS   Toniolo,D., Persico,M. and Alcalay,M.
  TITLE     A 'housekeeping' gene on the X chromosome encodes a protein similar
            to ubiquitin
  JOURNAL   Proc Natl Acad Sci U S A 85 (3), 851-855 (1988)
   PUBMED   2829204
REFERENCE   10 (bases 1 to 2327)
  AUTHORS   Toniolo,D., Persico,M.G., Battistuzzi,G. and Luzzatto,L.
  TITLE     Partial purification and characterization of the messenger RNA for
            human glucose-6-phosphate dehydrogenase
  JOURNAL   Mol Biol Med 2 (2), 89-103 (1984)
   PUBMED   6533418
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA012854.1, BC043346.2, DR003955.1, BM711450.1 and CK826435.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014235.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.947839.1,
                                           SRR3476690.929292.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2155550, SAMEA2163105
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369660.9/ ENSP00000358674.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                DA012854.1         56-77
            23-595              BC043346.2         5-577
            596-596             DR003955.1         591-591
            597-931             BC043346.2         579-913
            932-1324            BM711450.1         98-490
            1325-1709           CK826435.1         213-597
            1710-2327           BC043346.2         1692-2309
FEATURES             Location/Qualifiers
     source          1..2327
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..2327
                     /gene="UBL4A"
                     /gene_synonym="DX254E; DXS254E; G6PD; GDX; GET5; MDY2;
                     TMA24; UBL4"
                     /note="ubiquitin like 4A"
                     /db_xref="GeneID:8266"
                     /db_xref="HGNC:HGNC:12505"
                     /db_xref="MIM:312070"
     exon            1..79
                     /gene="UBL4A"
                     /gene_synonym="DX254E; DXS254E; G6PD; GDX; GET5; MDY2;
                     TMA24; UBL4"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..505
                     /gene="UBL4A"
                     /gene_synonym="DX254E; DXS254E; G6PD; GDX; GET5; MDY2;
                     TMA24; UBL4"
                     /note="ubiquitin-like 4; ubiquitin-like protein GDX"
                     /codon_start=1
                     /product="ubiquitin-like protein 4A"
                     /protein_id="NP_055050.1"
                     /db_xref="CCDS:CCDS14754.1"
                     /db_xref="GeneID:8266"
                     /db_xref="HGNC:HGNC:12505"
                     /db_xref="MIM:312070"
                     /translation="MQLTVKALQGRECSLQVPEDELVSTLKQLVSEKLNVPVRQQRLL
                     FKGKALADGKRLSDYSIGPNSKLNLVVKPLEKVLLEEGEAQRLADSPPPQVWQLISKV
                     LARHFSAADASRVLEQLQRDYERSLSRLTLDDIERLASRFLHPEVTETMEKGFSK"
     exon            80..185
                     /gene="UBL4A"
                     /gene_synonym="DX254E; DXS254E; G6PD; GDX; GET5; MDY2;
                     TMA24; UBL4"
                     /inference="alignment:Splign:2.1.0"
     exon            186..394
                     /gene="UBL4A"
                     /gene_synonym="DX254E; DXS254E; G6PD; GDX; GET5; MDY2;
                     TMA24; UBL4"
                     /inference="alignment:Splign:2.1.0"
     exon            395..2327
                     /gene="UBL4A"
                     /gene_synonym="DX254E; DXS254E; G6PD; GDX; GET5; MDY2;
                     TMA24; UBL4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2301..2306
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBL4A"
                     /gene_synonym="DX254E; DXS254E; G6PD; GDX; GET5; MDY2;
                     TMA24; UBL4"
                     /note="hexamer: AATAAA"
     polyA_site      2327
                     /gene="UBL4A"
                     /gene_synonym="DX254E; DXS254E; G6PD; GDX; GET5; MDY2;
                     TMA24; UBL4"
                     /note="major polyA site"
ORIGIN      
        1 gccggcccga gtggacgccg tcgcgaccgc catgcagctg acggtgaagg cgctgcaggg
       61 ccgcgagtgc agcctgcagg tgccagagga cgagctggtg tccacgctga agcagctggt
      121 ctccgagaag ctgaacgtcc cagtgcgcca gcagcggctg ctgttcaagg gcaaggccct
      181 ggcagatggg aaacgactct cggattatag catcgggccc aactccaagc tcaacctagt
      241 ggtcaaaccc ctggagaagg tgctactaga agaaggcgag gcccagaggc tggccgactc
      301 cccacccccg caggtctggc agctgatctc caaagtcttg gcccgccact tcagtgcggc
      361 agatgccagc agggtcctgg aacagctaca gagggattac gagaggtccc tgagtcgcct
      421 gacgctggac gacatcgaac ggttggccag ccgcttcctg caccctgaag tgactgagac
      481 aatggagaag ggcttctcca aatagaattc tcggagcatg gggaggtgcc caacgccagg
      541 ctaccgctgc atgtcgcact aagtgtgttc tcctgttgca gttgggctca tcatcatcat
      601 agctggcatg tacctggctc tggccaggtg ctaggcactc ctcacagctt gacctgggtt
      661 tgcttccaca ccctcagaag aggagagccg gcacagcaga ggcaccggcg atgaagtggc
      721 acagccccag tcggaatcca gcggcttctg aaagtgcctt ggtgtgagaa ggaggaaggg
      781 gccgcttgga gagctgggct ctcgcatgtc atgtttagcc cactgagaat ataccctcag
      841 gtgactccct cccgatcctg aaagggaaag cagctgtcac ctgacttctg gcgggtccaa
      901 catagccctc agcttacctc tgcaggaggc caagtgacag ccagccctgg aaccccccga
      961 cccccgcagc tgctgcagcc agtgtgccag tgtgcgttcg acaaatggaa aagcagattg
     1021 gggccaggga gtcagcaagg caccccagct ctgtgatgtg actttgggcg agtctcagtg
     1081 ccacttggtc cccagccatg gactctatac agtgagggcc actcaccgac ctgagtcagt
     1141 gtcctctgtc tcacagggcc cctctccctt ctgttcagta aacaaactga agccaaaaat
     1201 gaagccgtgg ccaagtgtga cccagagatg gggtgtcctg gcccttagtg acacagctcc
     1261 tctctggggc accctatctg cttgtctcgt ccaggaagcg ttagggctga tgggtgactc
     1321 agcaaggcag tgtcagagct gggactgggc gtaggccttt gtcctcatcc ccagcactgg
     1381 cctccctgtg gaagatgaac atatcccagc cacctgtgta caggggctca ctttgtgtgc
     1441 tccttgttgc ctgagaagaa accttggggt gccagggtgg gggcagaagc atggactggg
     1501 ttccggttca tcctcctcca ccctgccgtg tgtgtgggca caagaggaca tctaaccacc
     1561 tgctccttgg aggaggcccc caggggtggt agaggctgga aggaagccac atcaggagga
     1621 cgccactccg gcccttcacc cttgccaagt gagctgctca cagtgtggtc agggctgcgc
     1681 gtgctggagg ccctcctgcc tgggccttgt ggggcaaata ttgggtcccc aggctggaaa
     1741 gatggacaga ggcccaatgg gtgaaggctt tgaagagcac acagaagccc ctggcccccc
     1801 acgagagctg gagagccatg tatatggctt caaagccacc tacggcaggg acacactcgt
     1861 gagcatgtgt ggcctgcagt tcaggtgata catttaccag tgttcttgtt tgtgtggtgc
     1921 caggaaattg attttggaaa aagtgaaata acattaaagg tgaatgtgag gcttctactt
     1981 ttatccaaaa ggagctatat tagctaggct gtttctgata tccaatcatt ggtttaacaa
     2041 taaaggcaat ttgtttaatc agttaacgga aatttcttgg cttatgaaag tgaaaagtcc
     2101 agtggtattg gcattggcag caggtgagca atttcaccca gtgtcttctg cctccctctg
     2161 cgttggtatc tgctacatcc caggccacca cctccgagga tgaaaagatg gctgcctgca
     2221 gcttccacgg aatccctccc tcactgccag agcagcatct tctctgtgta ccacctctgc
     2281 tgtctcagat gcccccagca aataaacact cttctcgttg gtcagaa
//
