LOCUS       NM_007106               4317 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens ubiquitin like 3 (UBL3), mRNA.
ACCESSION   NM_007106
VERSION     NM_007106.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4317)
  AUTHORS   Faber,S., Letteboer,S.J.F., Junger,K., Butcher,R., Tammana,T.V.S.,
            van Beersum,S.E.C., Ueffing,M., Collin,R.W.J., Liu,Q., Boldt,K. and
            Roepman,R.
  TITLE     PDE6D Mediates Trafficking of Prenylated Proteins NIM1K and UBL3 to
            Primary Cilia
  JOURNAL   Cells 12 (2), 312 (2023)
   PUBMED   36672247
  REMARK    GeneRIF: PDE6D Mediates Trafficking of Prenylated Proteins NIM1K
            and UBL3 to Primary Cilia.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4317)
  AUTHORS   Takanashi,Y., Kahyo,T., Kamamoto,S., Zhang,H., Chen,B., Ping,Y.,
            Mizuno,K., Kawase,A., Koizumi,K., Satou,M., Funai,K., Shiiya,N. and
            Setou,M.
  TITLE     Ubiquitin-like 3 as a new protein-sorting factor for small
            extracellular vesicles
  JOURNAL   Cell Struct Funct 47 (1), 1-18 (2022)
   PUBMED   35197392
  REMARK    GeneRIF: Ubiquitin-like 3 as a new protein-sorting factor for small
            extracellular vesicles.
            Review article
REFERENCE   3  (bases 1 to 4317)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 4317)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 4317)
  AUTHORS   Zhao,X., Yongchun,Z., Qian,H., Sanhui,G., Jie,L., Hong,Y.,
            Yanfei,Z., Guizhen,W., Yunchao,H. and Guangbiao,Z.
  TITLE     Identification of a potential tumor suppressor gene, UBL3, in
            non-small cell lung cancer
  JOURNAL   Cancer Biol Med 17 (1), 76-87 (2020)
   PUBMED   32296577
  REMARK    GeneRIF: Identification of a potential tumor suppressor gene, UBL3,
            in non-small cell lung cancer.
REFERENCE   6  (bases 1 to 4317)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 4317)
  AUTHORS   Downes,B.P., Saracco,S.A., Lee,S.S., Crowell,D.N. and Vierstra,R.D.
  TITLE     MUBs, a family of ubiquitin-fold proteins that are plasma
            membrane-anchored by prenylation
  JOURNAL   J Biol Chem 281 (37), 27145-27157 (2006)
   PUBMED   16831869
REFERENCE   8  (bases 1 to 4317)
  AUTHORS   Dunham,A., Matthews,L.H., Burton,J., Ashurst,J.L., Howe,K.L.,
            Ashcroft,K.J., Beare,D.M., Burford,D.C., Hunt,S.E.,
            Griffiths-Jones,S., Jones,M.C., Keenan,S.J., Oliver,K., Scott,C.E.,
            Ainscough,R., Almeida,J.P., Ambrose,K.D., Andrews,D.T.,
            Ashwell,R.I., Babbage,A.K., Bagguley,C.L., Bailey,J., Bannerjee,R.,
            Barlow,K.F., Bates,K., Beasley,H., Bird,C.P., Bray-Allen,S.,
            Brown,A.J., Brown,J.Y., Burrill,W., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M.E., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S.C., Cobley,V., Collins,J.E., Corby,N., Coville,G.J.,
            Deloukas,P., Dhami,P., Dunham,I., Dunn,M., Earthrowl,M.E.,
            Ellington,A.G., Faulkner,L., Frankish,A.G., Frankland,J.,
            French,L., Garner,P., Garnett,J., Gilbert,J.G., Gilson,C.J.,
            Ghori,J., Grafham,D.V., Gribble,S.M., Griffiths,C., Hall,R.E.,
            Hammond,S., Harley,J.L., Hart,E.A., Heath,P.D., Howden,P.J.,
            Huckle,E.J., Hunt,P.J., Hunt,A.R., Johnson,C., Johnson,D., Kay,M.,
            Kimberley,A.M., King,A., Laird,G.K., Langford,C.J., Lawlor,S.,
            Leongamornlert,D.A., Lloyd,D.M., Lloyd,C., Loveland,J.E.,
            Lovell,J., Martin,S., Mashreghi-Mohammadi,M., McLaren,S.J.,
            McMurray,A., Milne,S., Moore,M.J., Nickerson,T., Palmer,S.A.,
            Pearce,A.V., Peck,A.I., Pelan,S., Phillimore,B., Porter,K.M.,
            Rice,C.M., Searle,S., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Steward,C.A., Sycamore,N., Tester,J., Thomas,D.W.,
            Tracey,A., Tromans,A., Tubby,B., Wall,M., Wallis,J.M., West,A.P.,
            Whitehead,S.L., Willey,D.L., Wilming,L., Wray,P.W., Wright,M.W.,
            Young,L., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E., Beck,S.,
            Bentley,D.R., Rogers,J. and Ross,M.T.
  TITLE     The DNA sequence and analysis of human chromosome 13
  JOURNAL   Nature 428 (6982), 522-528 (2004)
   PUBMED   15057823
REFERENCE   9  (bases 1 to 4317)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   10 (bases 1 to 4317)
  AUTHORS   Chadwick,B.P., Kidd,T., Sgouros,J., Ish-Horowicz,D. and
            Frischauf,A.M.
  TITLE     Cloning, mapping and expression of UBL3, a novel ubiquitin-like
            gene
  JOURNAL   Gene 233 (1-2), 189-195 (1999)
   PUBMED   10375635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA246318.1, DA400786.1, AK311846.1, AL080177.1, BM453277.1 and
            AL158193.13.
            
            On May 17, 2019 this sequence version replaced NM_007106.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC044582.1, SRR11853562.8627.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380680.5/ ENSP00000370055.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-352               DA246318.1         30-381
            353-891             DA400786.1         1-539
            892-971             AK311846.1         1-80
            972-1794            AL080177.1         2-824
            1795-1902           BM453277.1         117-224
            1903-2730           AL080177.1         933-1760
            2731-3384           AL158193.13        144735-145388       c
            3385-4280           AL080177.1         2419-3314
            4281-4317           AL158193.13        143802-143838       c
FEATURES             Location/Qualifiers
     source          1..4317
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q12.3"
     gene            1..4317
                     /gene="UBL3"
                     /gene_synonym="HCG-1; PNSC1"
                     /note="ubiquitin like 3"
                     /db_xref="GeneID:5412"
                     /db_xref="HGNC:HGNC:12504"
                     /db_xref="MIM:604711"
     exon            1..1106
                     /gene="UBL3"
                     /gene_synonym="HCG-1; PNSC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             1080..1433
                     /gene="UBL3"
                     /gene_synonym="HCG-1; PNSC1"
                     /note="MUB; hsMUB; protein HCG-1; membrane-anchored
                     ubiquitin-fold protein"
                     /codon_start=1
                     /product="ubiquitin-like protein 3"
                     /protein_id="NP_009037.1"
                     /db_xref="CCDS:CCDS9334.1"
                     /db_xref="GeneID:5412"
                     /db_xref="HGNC:HGNC:12504"
                     /db_xref="MIM:604711"
                     /translation="MSSNVPADMINLRLILVSGKTKEFLFSPNDSASDIAKHVYDNWP
                     MDWEEEQVSSPNILRLIYQGRFLHGNVTLGALKLPFGKTTVMHLVARETLPEPNSQGQ
                     RNREKTGESNCCVIL"
     exon            1107..1215
                     /gene="UBL3"
                     /gene_synonym="HCG-1; PNSC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1302
                     /gene="UBL3"
                     /gene_synonym="HCG-1; PNSC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1380
                     /gene="UBL3"
                     /gene_synonym="HCG-1; PNSC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..4317
                     /gene="UBL3"
                     /gene_synonym="HCG-1; PNSC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3404..3409
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBL3"
                     /gene_synonym="HCG-1; PNSC1"
                     /note="hexamer: ATTAAA"
     polyA_site      3438
                     /gene="UBL3"
                     /gene_synonym="HCG-1; PNSC1"
                     /note="major polyA site"
     regulatory      4256..4261
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBL3"
                     /gene_synonym="HCG-1; PNSC1"
                     /note="hexamer: ATTAAA"
     polyA_site      4280
                     /gene="UBL3"
                     /gene_synonym="HCG-1; PNSC1"
                     /note="major polyA site"
     polyA_site      4317
                     /gene="UBL3"
                     /gene_synonym="HCG-1; PNSC1"
                     /note="major polyA site"
ORIGIN      
        1 agtcgcactc aggcagccgc cgccgccgcc gctgccgcca tgttggtttg agaggcgatg
       61 acaggaggcg gccgcggcgt gtgggactga aaagtgaagg aggaggagga gaaacaaagc
      121 tctgagagga aaccattccc gggctgagga gaaggaggac ccggcctctt ccggggacca
      181 gccgaagtcg gcgtcgcccg gagctcgcga ggccggggag gggaggggaa gggaaggcgg
      241 agaccgggga ggcggcggcg gggaaggcgg aggcagaaga ggagtggcga ggagccggag
      301 acgatgcgcc ccgaccccag ctgctgtccg gaggcgcccg cggcctgagc ccagaggggc
      361 tgtggagtgt cccggccggc cccgagcacc cccgcgctgt cggtcccccg ctccggtctt
      421 tcgctttggc ttccaactag ttaaatgccc ttgagcgcgg gtttccgcgg cccggctctt
      481 cgcccccgcg gcgcgagttg agccgtttcc ccgcgctgtc cgcgcgggcg ctccgacagc
      541 ggctctgcag ggtccgcggc cagcgtccgg ccaccgctcg gccgccactc aaggctcacg
      601 cgtcgatgtg tagctacata gttatctgtg tacatccacg ctggggcatt tttctcctgc
      661 ttaatgagga cttgactcgg gagcaagtgt gaatcattgc cggggctggg aaaggaggaa
      721 ggcgcattta accccctccc acccctctcc atgtccgtgt gtcactcggc tcggtccacc
      781 tggcgcggcc ggtcctgggg ctgctgctgc tgttgacgac gacgacgacg acgggggctg
      841 cctctgctgt cccgggagtt tcctcctgct ccggccacac agctcctggg gattgttcct
      901 cttcgaacca gaacctcggc ctgaccggca ctttggctcc aaaataactt tatttttggg
      961 ggagaaagca catcacgaac cagtcaaaat cgtggtttat ttctgtaacg tgaagacttc
     1021 tgctcttttt tctttgtttg tttttttcgt aaacatctgg gtgtatatca aacggcaaga
     1081 tgtccagtaa tgtcccggcg gatatgataa atttgcgcct cattttggta agcggaaaaa
     1141 caaaagagtt cctgttttct cctaacgatt ctgcttctga cattgcaaag catgtatatg
     1201 acaattggcc aatggactgg gaagaagagc aggtcagcag tccaaatatt ctacgactta
     1261 tttatcaagg acgatttcta catggaaatg tcacattagg agcattaaaa cttccttttg
     1321 gcaaaacaac agtgatgcat ttggtggcca gagagacatt accagagcca aactctcaag
     1381 gtcagaggaa tcgtgagaag actggagaga gtaattgttg tgtaatcctg taaacactgt
     1441 ctgcctagtg tgatgtgata tagtctttgt ctttcatgct gctgggacag aaaagacccg
     1501 acattgcttc agaaaccgtt cagaacagtc tgcctgtaaa cacatggaac tgaattacca
     1561 catgaacact gtcatctttt ctcatgaaag taaaaagaac caagaacatt tttcactctg
     1621 attttttatt tcttgtattt tttgttgagc tgttttaaca catattggtt tttgaatgca
     1681 gtcaatctcc aggggaaaag ttaacaagtt atctttcgta gcagaaacca ttttgctgcc
     1741 acaaaatttt catcatcaga actaataaat caagtgttcc aaatacaatt tgcattaaaa
     1801 agattggcat tattttcctc atcagcagaa tttataacag tgtgtggtat ctagaaatac
     1861 ttatatatac aattccacac tggaagacac tcagcaatta atgaagttaa ttactgggcc
     1921 aacttgagag gaaaaaatgg aaaagaaact aaaatgttgg gtgaattcta ccaaagtcag
     1981 ccgtggtggc tgcactggca cagaatacta aactgagtgt gactattttc actgcaacaa
     2041 atgaaaaaac aaaatgtgcc tgtttaaagc actcagtaga gggctgatga aactaatttt
     2101 ttttccttta agacatgcac tcttgagtcc tacagtaact gagtgtttgt ttagacagca
     2161 caagaagggg tgagagtgcg tctcctagcc ttaatgtggg agggtagttt cagtcactca
     2221 tcggctttca ttattgtgca gaaatattag aaaacctcat tgatcaattt tatgtatttg
     2281 aatatcagca aattgaaatt ttccataatt atcattaatt tgtaaccaca tccagtgtca
     2341 tgcttactcc ttagagttca gatgaattct taaaattaaa aaaaaactcc atagtactaa
     2401 ttttgtttct ttatatagtt tgcgtttgat attagtgctt gcaattgtat taaagtcaaa
     2461 agctgatttt tatggcatac acaagaatgc cactttttct tttatttcat accaataatt
     2521 taaagattga tatgctaaaa acaatttgca cagcactaaa gcatgagcta ctttcatcta
     2581 aacctgtaaa aatatgaaag atttttatat tttttcactg ggaagaaatt cttcctggat
     2641 gaaattacaa atatgtgtag aatatattta ataaaagact tataaaatac ctaactacag
     2701 gacttaaaat atagattggc gcgtagtata cagaacaata ttccatataa ataagtttag
     2761 cctttataaa aatgaagttg caggctgaca ttacattctg tactaagtgt caacagccct
     2821 tacaaacatt aaatgtaaat ggtttcaaat ggtcagcgtt gtttaaatgt aatcatgtta
     2881 ttttattcat tgttaatgct ttgatgaaaa ggctttatat gcagtagatc tacgaaaata
     2941 ttgttcatac tgatcagaat taaatttgta tagagcagag ttttaaaatg aatgtaaata
     3001 gcactaaacg ttttctttct gcaacctgta cttacagatt cttcctgtaa actaaataaa
     3061 aaaaaaatga tagtgcattt tggtggtaat tttaaaggtc ttgattaggt caataattgt
     3121 ttaagcaccg tctcattcat gttttctact ttcatttctt aagcttttaa aattcattta
     3181 attaatattc tgttgttgtt ttggggagta ttcccaatgt atctttgata tttaacctgg
     3241 ttaatttgtg gacagtcaca acaatggata gaattatgta gtctccgtta tcactaaaat
     3301 gttatcttca agagatgtta aatatttata tgctttgttg actagctgaa atgtgaattc
     3361 tgttagtgtt gactaaagaa tctggtagtt gcttaattgg gcaattaaac aatttatggc
     3421 tctattttgt aaaacaaact actggtaatt atttttaata cctattttca ttctgattac
     3481 tcttttttta agttaaagac tatcagttaa ttaagattga gtttttatga tggttaaaaa
     3541 taattctcta ttggtttttc aatatatttt tctgtgtgtt ctcagattat atatttccct
     3601 caatttagag tttgctaagt gaaataaact ggttcactag tagagaaaga attacgtcgc
     3661 ttaataccta atatcatagt tgtacaatat gaaaaaaaag aataaaaagt agcagtaaaa
     3721 ttatatactg aaaacaccaa aaatttagat gccttaatag tatatacgtg aaatactcag
     3781 ctgtcccttt aaaaataatt ccttggactg cctggtggtt aaaatacgat tcctcatatc
     3841 caaggctact tttgaagatc cctctgccaa aaatatagct cacttatcta aaggtgagag
     3901 ctgcatagat ccagtaatgt acataaagcc tgaatgatga gcctatgtcc ctgcctaacg
     3961 ctggtgtctc actcatctct tttacctaaa ttgtcctgaa ctttgttaag tgttctggac
     4021 aaggccaagc ttttctttat taaaacctca gcatgtctcc ctgatctgaa ctatttgctt
     4081 tctcttcaag ataagttgta ttttaccatg gaaaaataca gtatctaaca ttaccattca
     4141 cgttaaatga agtttcctca taacatttat ctttagtttt atgaagtcat cgtgaccaat
     4201 gttacagtaa tttctgttag ctgattgtgg taaacaatgt ttaatgtgaa aagaaattaa
     4261 aactttcttc atctgttgta gaatatttct cttctttaaa atggcttcta ttcataa
//
