LOCUS       NP_009037                117 aa            linear   PRI 28-APR-2025
DEFINITION  ubiquitin-like protein 3 [Homo sapiens].
ACCESSION   NP_009037
VERSION     NP_009037.1
DBSOURCE    REFSEQ: accession NM_007106.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 117)
  AUTHORS   Faber,S., Letteboer,S.J.F., Junger,K., Butcher,R., Tammana,T.V.S.,
            van Beersum,S.E.C., Ueffing,M., Collin,R.W.J., Liu,Q., Boldt,K. and
            Roepman,R.
  TITLE     PDE6D Mediates Trafficking of Prenylated Proteins NIM1K and UBL3 to
            Primary Cilia
  JOURNAL   Cells 12 (2), 312 (2023)
   PUBMED   36672247
  REMARK    GeneRIF: PDE6D Mediates Trafficking of Prenylated Proteins NIM1K
            and UBL3 to Primary Cilia.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 117)
  AUTHORS   Takanashi,Y., Kahyo,T., Kamamoto,S., Zhang,H., Chen,B., Ping,Y.,
            Mizuno,K., Kawase,A., Koizumi,K., Satou,M., Funai,K., Shiiya,N. and
            Setou,M.
  TITLE     Ubiquitin-like 3 as a new protein-sorting factor for small
            extracellular vesicles
  JOURNAL   Cell Struct Funct 47 (1), 1-18 (2022)
   PUBMED   35197392
  REMARK    GeneRIF: Ubiquitin-like 3 as a new protein-sorting factor for small
            extracellular vesicles.
            Review article
REFERENCE   3  (residues 1 to 117)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (residues 1 to 117)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (residues 1 to 117)
  AUTHORS   Zhao,X., Yongchun,Z., Qian,H., Sanhui,G., Jie,L., Hong,Y.,
            Yanfei,Z., Guizhen,W., Yunchao,H. and Guangbiao,Z.
  TITLE     Identification of a potential tumor suppressor gene, UBL3, in
            non-small cell lung cancer
  JOURNAL   Cancer Biol Med 17 (1), 76-87 (2020)
   PUBMED   32296577
  REMARK    GeneRIF: Identification of a potential tumor suppressor gene, UBL3,
            in non-small cell lung cancer.
REFERENCE   6  (residues 1 to 117)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (residues 1 to 117)
  AUTHORS   Downes,B.P., Saracco,S.A., Lee,S.S., Crowell,D.N. and Vierstra,R.D.
  TITLE     MUBs, a family of ubiquitin-fold proteins that are plasma
            membrane-anchored by prenylation
  JOURNAL   J Biol Chem 281 (37), 27145-27157 (2006)
   PUBMED   16831869
REFERENCE   8  (residues 1 to 117)
  AUTHORS   Dunham,A., Matthews,L.H., Burton,J., Ashurst,J.L., Howe,K.L.,
            Ashcroft,K.J., Beare,D.M., Burford,D.C., Hunt,S.E.,
            Griffiths-Jones,S., Jones,M.C., Keenan,S.J., Oliver,K., Scott,C.E.,
            Ainscough,R., Almeida,J.P., Ambrose,K.D., Andrews,D.T.,
            Ashwell,R.I., Babbage,A.K., Bagguley,C.L., Bailey,J., Bannerjee,R.,
            Barlow,K.F., Bates,K., Beasley,H., Bird,C.P., Bray-Allen,S.,
            Brown,A.J., Brown,J.Y., Burrill,W., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M.E., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S.C., Cobley,V., Collins,J.E., Corby,N., Coville,G.J.,
            Deloukas,P., Dhami,P., Dunham,I., Dunn,M., Earthrowl,M.E.,
            Ellington,A.G., Faulkner,L., Frankish,A.G., Frankland,J.,
            French,L., Garner,P., Garnett,J., Gilbert,J.G., Gilson,C.J.,
            Ghori,J., Grafham,D.V., Gribble,S.M., Griffiths,C., Hall,R.E.,
            Hammond,S., Harley,J.L., Hart,E.A., Heath,P.D., Howden,P.J.,
            Huckle,E.J., Hunt,P.J., Hunt,A.R., Johnson,C., Johnson,D., Kay,M.,
            Kimberley,A.M., King,A., Laird,G.K., Langford,C.J., Lawlor,S.,
            Leongamornlert,D.A., Lloyd,D.M., Lloyd,C., Loveland,J.E.,
            Lovell,J., Martin,S., Mashreghi-Mohammadi,M., McLaren,S.J.,
            McMurray,A., Milne,S., Moore,M.J., Nickerson,T., Palmer,S.A.,
            Pearce,A.V., Peck,A.I., Pelan,S., Phillimore,B., Porter,K.M.,
            Rice,C.M., Searle,S., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Steward,C.A., Sycamore,N., Tester,J., Thomas,D.W.,
            Tracey,A., Tromans,A., Tubby,B., Wall,M., Wallis,J.M., West,A.P.,
            Whitehead,S.L., Willey,D.L., Wilming,L., Wray,P.W., Wright,M.W.,
            Young,L., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E., Beck,S.,
            Bentley,D.R., Rogers,J. and Ross,M.T.
  TITLE     The DNA sequence and analysis of human chromosome 13
  JOURNAL   Nature 428 (6982), 522-528 (2004)
   PUBMED   15057823
REFERENCE   9  (residues 1 to 117)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   10 (residues 1 to 117)
  AUTHORS   Chadwick,B.P., Kidd,T., Sgouros,J., Ish-Horowicz,D. and
            Frischauf,A.M.
  TITLE     Cloning, mapping and expression of UBL3, a novel ubiquitin-like
            gene
  JOURNAL   Gene 233 (1-2), 189-195 (1999)
   PUBMED   10375635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA246318.1, DA400786.1, AK311846.1, AL080177.1, BM453277.1 and
            AL158193.13.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC044582.1, SRR11853562.8627.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380680.5/ ENSP00000370055.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..117
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q12.3"
     Protein         1..117
                     /product="ubiquitin-like protein 3"
                     /note="MUB; hsMUB; protein HCG-1; membrane-anchored
                     ubiquitin-fold protein"
                     /calculated_mol_wt=13026
     mat_peptide     1..114
                     /product="Ubiquitin-like protein 3. /id=PRO_0000114862"
                     /note="propagated from UniProtKB/Swiss-Prot (O95164.1)"
                     /calculated_mol_wt=12832
     Region          10..91
                     /region_name="Ubl_UBL3"
                     /note="ubiquitin-like (Ubl) domain found in ubiquitin-like
                     protein 3 (UBL3) and similar proteins; cd17048"
                     /db_xref="CDD:340568"
     Site            114
                     /site_type="methylation"
                     /note="Cysteine methyl ester. /evidence=ECO:0000305;
                     propagated from UniProtKB/Swiss-Prot (O95164.1)"
     CDS             1..117
                     /gene="UBL3"
                     /gene_synonym="HCG-1; PNSC1"
                     /coded_by="NM_007106.4:1080..1433"
                     /db_xref="CCDS:CCDS9334.1"
                     /db_xref="GeneID:5412"
                     /db_xref="HGNC:HGNC:12504"
                     /db_xref="MIM:604711"
ORIGIN      
        1 mssnvpadmi nlrlilvsgk tkeflfspnd sasdiakhvy dnwpmdweee qvsspnilrl
       61 iyqgrflhgn vtlgalklpf gkttvmhlva retlpepnsq gqrnrektge snccvil
//
