LOCUS       NM_019116               4745 bp    mRNA    linear   PRI 06-JAN-2025
DEFINITION  Homo sapiens ubiquitin family domain containing 1 (UBFD1), mRNA.
ACCESSION   NM_019116
VERSION     NM_019116.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4745)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4745)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   3  (bases 1 to 4745)
  AUTHORS   Loftus,B.J., Kim,U.J., Sneddon,V.P., Kalush,F., Brandon,R.,
            Fuhrmann,J., Mason,T., Crosby,M.L., Barnstead,M., Cronin,L.,
            Deslattes Mays,A., Cao,Y., Xu,R.X., Kang,H.L., Mitchell,S.,
            Eichler,E.E., Harris,P.C., Venter,J.C. and Adams,M.D.
  TITLE     Genome duplications and other features in 12 Mb of DNA sequence
            from human chromosome 16p and 16q
  JOURNAL   Genomics 60 (3), 295-308 (1999)
   PUBMED   10493829
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK092696.1 and AC008870.8.
            
            On Nov 22, 2018 this sequence version replaced NM_019116.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.106129.1,
                                           SRR1660805.250769.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395878.8/ ENSP00000379217.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1214              AK092696.1         1-1214
            1215-4745           AC008870.8         135176-138706       c
FEATURES             Location/Qualifiers
     source          1..4745
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p12.2"
     gene            1..4745
                     /gene="UBFD1"
                     /gene_synonym="UBPH"
                     /note="ubiquitin family domain containing 1"
                     /db_xref="GeneID:56061"
                     /db_xref="HGNC:HGNC:30565"
                     /db_xref="MIM:621059"
     exon            1..41
                     /gene="UBFD1"
                     /gene_synonym="UBPH"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..946
                     /gene="UBFD1"
                     /gene_synonym="UBPH"
                     /note="ubiquitin-binding protein homolog"
                     /codon_start=1
                     /product="ubiquitin domain-containing protein UBFD1"
                     /protein_id="NP_061989.2"
                     /db_xref="CCDS:CCDS10613.2"
                     /db_xref="GeneID:56061"
                     /db_xref="HGNC:HGNC:30565"
                     /db_xref="MIM:621059"
                     /translation="MAAAGAPDGMEEPGMDTEAETVATEAPARPVNCLEAEAAAGAAA
                     EDSGAARGSLQPAPAQPPGDPAAQASVSNGEDAGGGAGRELVDLKIIWNKTKHDVKFP
                     LDSTGSELKQKIHSITGLPPAMQKVMYKGLVPEDKTLREIKVTSGAKIMVVGSTINDV
                     LAVNTPKDAAQQDAKAEENKKEPLCRQKQHRKVLDKGKPEDVMPSVKGAQERLPTVPL
                     SGMYNKSGGKVRLTFKLEQDQLWIGTKERTEKLPMGSIKNVVSEPIEGHEDYHMMAFQ
                     LGPTEASYYWVYWVPTQYVDAIKDTVLGKWQYF"
     exon            42..371
                     /gene="UBFD1"
                     /gene_synonym="UBPH"
                     /inference="alignment:Splign:2.1.0"
     exon            372..580
                     /gene="UBFD1"
                     /gene_synonym="UBPH"
                     /inference="alignment:Splign:2.1.0"
     exon            581..646
                     /gene="UBFD1"
                     /gene_synonym="UBPH"
                     /inference="alignment:Splign:2.1.0"
     exon            647..752
                     /gene="UBFD1"
                     /gene_synonym="UBPH"
                     /inference="alignment:Splign:2.1.0"
     exon            753..835
                     /gene="UBFD1"
                     /gene_synonym="UBPH"
                     /inference="alignment:Splign:2.1.0"
     exon            836..4745
                     /gene="UBFD1"
                     /gene_synonym="UBPH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1198..1203
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBFD1"
                     /gene_synonym="UBPH"
                     /note="hexamer: AATAAA"
     polyA_site      1216
                     /gene="UBFD1"
                     /gene_synonym="UBPH"
     regulatory      4727..4732
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBFD1"
                     /gene_synonym="UBPH"
                     /note="hexamer: ATTAAA"
     polyA_site      4745
                     /gene="UBFD1"
                     /gene_synonym="UBPH"
                     /note="major polyA site"
ORIGIN      
        1 gttgtacaca atcatcatgg cggcggccgg ggccccggat ggcatggagg aacctggcat
       61 ggacacggag gccgagactg tggctactga ggctcccgcg cggcccgtca actgcctgga
      121 ggctgaagcc gcggcggggg cggcggccga ggactccggc gccgcacgag gcagcctgca
      181 gccggccccg gcccagcccc ctggggaccc cgcagcccag gcctcggtca gcaacggcga
      241 agacgcgggc ggcggcgcgg gcagggagct ggtggacttg aagatcatct ggaataagac
      301 caagcatgac gtgaagttcc ccctggacag cacaggctcc gagctgaaac agaagatcca
      361 ctcgattaca ggtctcccgc ctgccatgca gaaagtcatg tataagggac tcgtccccga
      421 ggataaaaca ttgagagaaa taaaagtgac cagtggggcc aagatcatgg tggttggctc
      481 caccatcaat gatgttttag cagtaaacac acccaaagat gctgcgcagc aggatgcaaa
      541 ggccgaagag aacaagaagg agcctctctg caggcagaaa caacacagga aagtgttgga
      601 taaaggaaaa cctgaagatg tgatgccatc tgttaagggg gcccaggagc gcctgccaac
      661 ggtaccgctg tccggcatgt acaataaatc tggaggaaaa gtgagactca cctttaaact
      721 agaacaagac cagctgtgga ttggcactaa agagcggact gagaaattgc ccatgggctc
      781 cataaaaaat gtggtcagtg aacctatcga aggacatgaa gactaccaca tgatggcgtt
      841 tcagttgggc cccacggaag cctcttacta ctgggtgtac tgggttccaa ctcaatatgt
      901 ggatgcaatc aaagacactg tgctggggaa atggcagtat ttttgaaagc actttcacct
      961 ctggcccagg agactgaccc aaagtgaagg acattgccgg gagaggcctg cagcatccct
     1021 ggatttcaga gttctggaac tttgttcata aaaaatctat attcaatctg aggtgatgtg
     1081 gtgactgaag ccagaggtga tgtactttca ccattagctt aattttaact taaaattacc
     1141 agttcccttt cttgcagtca gcttcatacc atttttaaag tcaatacgat ggaaatcaat
     1201 aaatctgaat tccgaacatg ttgtgtggaa tactcttaag tgtgtttgag agtagatctg
     1261 ccaattatgt tgacaaggga atgatcaaaa gctttgtttt ttttaaaaaa aaaaaaagca
     1321 gtttcaattg aaatattttc atacatcttt ggttgcaaac atttggactg cattgcaatg
     1381 agttggggtg tttttttttt ccttttttgt ataaaattgt atgcaaaatg ggggtgggtt
     1441 agtaagccac atatttctgt ccattgattc agatttaatt ctttcccttt ttcattctct
     1501 cgcttcctca atttgagttt ttgttttaag aacccaaaga tgtcagttct tcttttggta
     1561 cctcatcaac gcttcctttc ctgggctccc tcccgccgtg ctgctgctgc ctgtgaacgc
     1621 acggtgggag aggaagagct gctcagtctt gggcaaggag ctctcacact tgctgtggtg
     1681 ttcgttgagc agcagagtat ctcccagtga ctcctgttta aatgtcttgc cctttgggcc
     1741 cccatctcca aggagttcca ttgctggttg gatgattgtc tgcacccctc actgagcttg
     1801 gcctagaggc ccagcctggc atggttgtgc ctgggctgtg ccgctcaaca gccccagctc
     1861 ccaagcagac aaagacctct tccaggagga gccaggtaga agatagttat acagccatat
     1921 agctgcagat ccagataacc ttctttcttt ggaagttttc aagaaattct taagcagtcc
     1981 aaggatgatt tcaattatgc ttctccattg ggtccttctg ctcatgcatt cagttcaagt
     2041 gtcctttatc ccaggttcag agatgctgcc tttctgaaga agacatctga ccctagcagg
     2101 ttggccagtg ttattgaaca acaaaaatgg gataaattgc tttcatgatt agctcacctt
     2161 cttctggttt tagcccttct gttctctgta cacgtgaact tctgtcatct ccttctggct
     2221 tggttgcctc tgaaaggagg gaaagtctct tggtaaatta tctcttttgt gctgtttgct
     2281 gtttctctgc tgccgtcttt gcagttctcc tctcactggt tgcaggcttt catagtaagg
     2341 tttggcgaga aatgttccaa acatcacatt ttggattcta ggctgtcacc cctcattctg
     2401 tgaaacgtat tagcatgtgt tcgcccaaga tgactattcc ttgtgagcca gttaatgatg
     2461 atattctacg cccttccctt ctaagctgta gttcaggaat ccagcccaca tagacagact
     2521 cttgctttcc atggtgtagt caatgccaag tgatgcatct aggcaggaaa atctactctt
     2581 tgcttttttg ggggcaatta gtacatttgt gaagtgcagc atccaagaaa cagcctgttt
     2641 tttcatccct tgagaaagga gcagtcattg cagcttttct gtccttgtcg gcctgcagtt
     2701 cctggggaaa agagtacatc tgagctactt gtccaagcct ctgtctgcag gtgacaggtt
     2761 ttgggggaaa tgagatgcat taagtagaac atcatctcgg gtcagacatt gccccttttg
     2821 tttgccaatg ccccagtcct agagacttgt cctgacagtg ccgcacacct acttttgatc
     2881 tctcagagca ggtggctcca tccccagact agcctggctg ctctccgagg cccctccacc
     2941 tgctcccctt attgccccat tcttgtggct tgccgggcca cttggcctcc cttcttgccg
     3001 gtgacagcgt tccatcatct ccccgctccc caagggccaa ctgcttctca ctcaggctgg
     3061 tgtcatttca ggaggaccaa agcctgcgtg agccttttta ttttcagtaa aatggtgctt
     3121 ttttccttac ttcgagatac tatatataaa taataatgta aatgacacct tttcgtacgg
     3181 agctgtttga gtattgcttt acagagctca ctaaatcagc ttcaacaatc ttgagctctg
     3241 tggctcctca ccctgtctgc atggaagacc ttgctggacg ctctcgggag agcagacata
     3301 gcaccagaag ccactgggag aagtgttttc gatccgtgtc tgggccacag tagtattcac
     3361 tgtttagtct ttgagttccg taagcagtct cttcatacat ttcttacagt ctggagtgta
     3421 ctgactaaat ctgtgtaagc aaattgaaat actctttctt ttaggtagcg tcacagtggt
     3481 tttttttttc ctcaggataa tttctataca atttccttac tgtcagaggg accagatctt
     3541 tccctcactg tggcaggggc cgtgcaggtg gataaaggaa gagctggttt ccggagagtg
     3601 actgtaacag cgttgactcg aagctagaga tggagggggt ggccgtctct tagacattgg
     3661 acacctctca gagcctcctg agggcttctt tgtcttctag aatctctacc ggtggtcctc
     3721 ctgcaggttc tggctcacag acatcatcat gccttttttt ccctccctga ggcgccttgg
     3781 cagaagagcg tgaccctgtg agccaggccc cccttagctc tgcttcagat cacagaacac
     3841 agacagactc gcgagttgct ggacctcttt ggtattaagt gtttgaatcc atggtgggcc
     3901 ttttgcaagt agcgttagct ctttttaaat gttgaactga gctaaggatg cactttcttg
     3961 tggacataga aggggcccac gtaaggccct gagtaggctc cttagttgct gctttacctg
     4021 atgagggcca aagagattaa ctctgcctcg ttgccatgtc tcagaaaagt tgccatattt
     4081 cacccagaag gggcttgttt tcctcttact cttactttaa ccatgtgcct ggaggagcca
     4141 ttctgggctc ttgcacttgc ccagcctttc tttgccaggg gcagagaagg gaaagggggt
     4201 agattgagtg tgccaagggc cgtgcaaggg caggcttgct ttccacccat ctgctgaggg
     4261 agccctctcc tctcgctcct tgcctctgtt cacacctgtt gtcttggaag aggatggtcc
     4321 ctttgtctta aggctttgtg ataaagtcat ctccagttag gatctgcacc tgtttccttc
     4381 gtaatagtgc ctggcggcct ttctgaagtt acaggtggtt gggagccctc tcgcatgcag
     4441 aacatctggt agattgatct gccaggctgg gtggttctac tgctttctca atttctaaga
     4501 accttttttt tttcttaaag agttctgctg aattatttga caatatttgt aagtaccatg
     4561 tttccttgtg gtgtatgctc tgttctggtt tctgttttca aatcaaatgc ctgtttggga
     4621 ggagatgaac gtatttagtc tattagattt gcactgctgg attttttttt taaagtgtaa
     4681 ccttgaatag ctgtcttatt gtttatcctg taagattagt caatcgatta aagtttgata
     4741 attaa
//
