LOCUS       NM_014671               5214 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens ubiquitin protein ligase E3C (UBE3C), mRNA.
ACCESSION   NM_014671 XM_376730 XM_379983
VERSION     NM_014671.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5214)
  AUTHORS   Cui,B., Yang,G., Yan,H., Wu,S., Wang,K., Wang,H. and Li,Y.
  TITLE     UBE3C restricts EV-A71 replication by ubiquitination-dependent
            degradation of 2C
  JOURNAL   J Virol 98 (10), e0133524 (2024)
   PUBMED   39212385
  REMARK    GeneRIF: UBE3C restricts EV-A71 replication by
            ubiquitination-dependent degradation of 2C.
REFERENCE   2  (bases 1 to 5214)
  AUTHORS   Cutrupi,A.N., Narayanan,R.K., Perez-Siles,G., Grosz,B.R., Lai,K.,
            Boyling,A., Ellis,M., Lin,R.C.Y., Neumann,B., Mao,D., Uesugi,M.,
            Nicholson,G.A., Vucic,S., Saporta,M.A. and Kennerson,M.L.
  TITLE     Novel gene-intergenic fusion involving ubiquitin E3 ligase UBE3C
            causes distal hereditary motor neuropathy
  JOURNAL   Brain 146 (3), 880-897 (2023)
   PUBMED   36380488
  REMARK    GeneRIF: Novel gene-intergenic fusion involving ubiquitin E3 ligase
            UBE3C causes distal hereditary motor neuropathy.
REFERENCE   3  (bases 1 to 5214)
  AUTHORS   Faqeih,E.A., Alghamdi,M.A., Almahroos,M.A., Alharby,E.,
            Almuntashri,M., Alshangiti,A.M., Clement,P., Calame,D.G.,
            Qebibo,L., Burglen,L., Doco-Fenzy,M., Mastrangelo,M., Torella,A.,
            Manti,F., Nigro,V., Alban,Z., Alharbi,G.S., Hashmi,J.A.,
            Alraddadi,R., Alamri,R., Mitani,T., Magalie,B., Coban-Akdemir,Z.,
            Geckinli,B.B., Pehlivan,D., Romito,A., Karageorgou,V., Martini,J.,
            Colin,E., Bonneau,D., Bertoli-Avella,A., Lupski,J.R., Pastore,A.,
            Peake,R.W.A., Dallol,A., Alfadhel,M. and Almontashiri,N.A.M.
  TITLE     Biallelic variants in HECT E3 paralogs, HECTD4 and UBE3C, encoding
            ubiquitin ligases cause neurodevelopmental disorders that overlap
            with Angelman syndrome
  JOURNAL   Genet Med 25 (2), 100323 (2023)
   PUBMED   36401616
  REMARK    GeneRIF: Biallelic variants in HECT E3 paralogs, HECTD4 and UBE3C,
            encoding ubiquitin ligases cause neurodevelopmental disorders that
            overlap with Angelman syndrome.
REFERENCE   4  (bases 1 to 5214)
  AUTHORS   Xu,Z., Chen,S., Liu,R., Chen,H., Xu,B., Xu,W. and Chen,M.
  TITLE     Circular RNA circPOLR2A promotes clear cell renal cell carcinoma
            progression by facilitating the UBE3C-induced ubiquitination of
            PEBP1 and, thereby, activating the ERK signaling pathway
  JOURNAL   Mol Cancer 21 (1), 146 (2022)
   PUBMED   35840930
  REMARK    GeneRIF: Circular RNA circPOLR2A promotes clear cell renal cell
            carcinoma progression by facilitating the UBE3C-induced
            ubiquitination of PEBP1 and, thereby, activating the ERK signaling
            pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5214)
  AUTHORS   Chen,Y.H., Huang,T.Y., Lin,Y.T., Lin,S.Y., Li,W.H., Hsiao,H.J.,
            Yan,R.L., Tang,H.W., Shen,Z.Q., Chen,G.C., Wu,K.P., Tsai,T.F. and
            Chen,R.H.
  TITLE     VPS34 K29/K48 branched ubiquitination governed by UBE3C and TRABID
            regulates autophagy, proteostasis and liver metabolism
  JOURNAL   Nat Commun 12 (1), 1322 (2021)
   PUBMED   33637724
  REMARK    GeneRIF: VPS34 K29/K48 branched ubiquitination governed by UBE3C
            and TRABID regulates autophagy, proteostasis and liver metabolism.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5214)
  AUTHORS   Garriock,H.A., Kraft,J.B., Shyn,S.I., Peters,E.J., Yokoyama,J.S.,
            Jenkins,G.D., Reinalda,M.S., Slager,S.L., McGrath,P.J. and
            Hamilton,S.P.
  TITLE     A genomewide association study of citalopram response in major
            depressive disorder
  JOURNAL   Biol Psychiatry 67 (2), 133-138 (2010)
   PUBMED   19846067
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association, gene-environment interaction, and
            pharmacogenomic / toxicogenomic. (HuGE Navigator)
REFERENCE   7  (bases 1 to 5214)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 5214)
  AUTHORS   Lowe,J.K., Maller,J.B., Pe'er,I., Neale,B.M., Salit,J., Kenny,E.E.,
            Shea,J.L., Burkhardt,R., Smith,J.G., Ji,W., Noel,M., Foo,J.N.,
            Blundell,M.L., Skilling,V., Garcia,L., Sullivan,M.L., Lee,H.E.,
            Labek,A., Ferdowsian,H., Auerbach,S.B., Lifton,R.P.,
            Newton-Cheh,C., Breslow,J.L., Stoffel,M., Daly,M.J., Altshuler,D.M.
            and Friedman,J.M.
  TITLE     Genome-wide association studies in an isolated founder population
            from the Pacific Island of Kosrae
  JOURNAL   PLoS Genet 5 (2), e1000365 (2009)
   PUBMED   19197348
REFERENCE   9  (bases 1 to 5214)
  AUTHORS   You,J., Wang,M., Aoki,T., Tamura,T.A. and Pickart,C.M.
  TITLE     Proteolytic targeting of transcriptional regulator TIP120B by a
            HECT domain E3 ligase
  JOURNAL   J Biol Chem 278 (26), 23369-23375 (2003)
   PUBMED   12692129
  REMARK    GeneRIF: TIP120B is a specific substrate of KIAA10; both are highly
            expressed in human skeletal muscle, suggesting that KIAA10 may
            regulate TIP120B homeostasis specifically in this tissue.
REFERENCE   10 (bases 1 to 5214)
  AUTHORS   You,J. and Pickart,C.M.
  TITLE     A HECT domain E3 enzyme assembles novel polyubiquitin chains
  JOURNAL   J Biol Chem 276 (23), 19871-19878 (2001)
   PUBMED   11278995
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC004898.3, DB454915.1, D13635.1, DB085748.1, AK127280.1,
            AA596042.1 and CD366848.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014671.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D13635.1, SRR1660805.199761.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000348165.10/ ENSP00000309198.8
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                AC004898.3         84318-84352         c
            36-536              DB454915.1         1-501
            537-1849            D13635.1           493-1805
            1850-2070           DB085748.1         345-565
            2071-2811           D13635.1           2027-2767
            2812-4623           AK127280.1         3048-4859
            4624-4961           AA596042.1         1-338               c
            4962-5214           CD366848.1         17-269              c
FEATURES             Location/Qualifiers
     source          1..5214
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.3"
     gene            1..5214
                     /gene="UBE3C"
                     /gene_synonym="HECTH2; NDSMBA; NEDSMBA; RAUL"
                     /note="ubiquitin protein ligase E3C"
                     /db_xref="GeneID:9690"
                     /db_xref="HGNC:HGNC:16803"
                     /db_xref="MIM:614454"
     exon            1..413
                     /gene="UBE3C"
                     /gene_synonym="HECTH2; NDSMBA; NEDSMBA; RAUL"
                     /inference="alignment:Splign:2.1.0"
     CDS             348..3599
                     /gene="UBE3C"
                     /gene_synonym="HECTH2; NDSMBA; NEDSMBA; RAUL"
                     /EC_number="2.3.2.26"
                     /note="ubiquitin-protein isopeptide ligase (E3); HECT-type
                     ubiquitin transferase E3C; RTA-associated ubiquitin
                     ligase; homologous to E6AP carboxyl terminus homologous
                     protein 2"
                     /codon_start=1
                     /product="ubiquitin-protein ligase E3C"
                     /protein_id="NP_055486.2"
                     /db_xref="CCDS:CCDS34789.1"
                     /db_xref="GeneID:9690"
                     /db_xref="HGNC:HGNC:16803"
                     /db_xref="MIM:614454"
                     /translation="MFSFEGDFKTRPKVSLGGASRKEEKASLLHRTQEERRKREEERR
                     RLKNAIIIQSFIRGYRDRKQQYSIQRSAFDRCATLSQSGGAFPIANGPNLTLLVRQLL
                     FFYKQNEDSKRLIWLYQNLIKHSSLFVKQLDGSERLTCLFQIKRLMSLCCRLLQNCND
                     DSLNVALPMRMLEVFSSENTYLPVLQDASYVVSVIEQILHYMIHNGYYRSLYLLINSK
                     LPSSIEYSDLSRVPIAKILLENVLKPLHFTYNSCPEGARQQVFTAFTEEFLAAPFTDQ
                     IFHFIIPALADAQTVFPYEPFLNALLLIESRCSRKSGGAPWLFYFVLTVGENYLGALS
                     EEGLLVYLRVLQTFLSQLPVSPASASCHDSASDSEEESEEADKPSSPEDGRLSVSYIT
                     EECLKKLDTKQQTNTLLNLVWRDSASEEVFTTMASVCHTLMVQHRMMVPKVRLLYSLA
                     FNARFLRHLWFLISSMSTRMITGSMVPLLQVISRGSPMSFEDSSRIIPLFYLFSSLFS
                     HSLISIHDNEFFGDPIEVVGQRQSSMMPFTLEELIMLSRCLRDACLGIIKLAYPETKP
                     EVREEYITAFQSIGVTTSSEMQQCIQMEQKRWIQLFKVITNLVKMLKSRDTRRNFCPP
                     NHWLSEQEDIKADKVTQLYVPASRHVWRFRRMGRIGPLQSTLDVGLESPPLSVSEERQ
                     LAVLTELPFVVPFEERVKIFQRLIYADKQEVQGDGPFLDGINVTIRRNYIYEDAYDKL
                     SPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEG
                     LLYPNPAAQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTSADVDI
                     HHLASLDPEVYKNLLFLKSYEDDVEELGLNFTVVNNDLGEAQVVELKFGGKDIPVTSA
                     NRIAYIHLVADYRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPIS
                     LEDLKSFTNYSGGYSADHPVIKVFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELY
                     PAFCIHNGGSDLERLPTASTCMNLLKLPEFYDETLLRSKLLYAIECAAGFELS"
     exon            414..467
                     /gene="UBE3C"
                     /gene_synonym="HECTH2; NDSMBA; NEDSMBA; RAUL"
                     /inference="alignment:Splign:2.1.0"
     exon            468..542
                     /gene="UBE3C"
                     /gene_synonym="HECTH2; NDSMBA; NEDSMBA; RAUL"
                     /inference="alignment:Splign:2.1.0"
     exon            543..689
                     /gene="UBE3C"
                     /gene_synonym="HECTH2; NDSMBA; NEDSMBA; RAUL"
                     /inference="alignment:Splign:2.1.0"
     exon            690..805
                     /gene="UBE3C"
                     /gene_synonym="HECTH2; NDSMBA; NEDSMBA; RAUL"
                     /inference="alignment:Splign:2.1.0"
     exon            806..963
                     /gene="UBE3C"
                     /gene_synonym="HECTH2; NDSMBA; NEDSMBA; RAUL"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1117
                     /gene="UBE3C"
                     /gene_synonym="HECTH2; NDSMBA; NEDSMBA; RAUL"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1338
                     /gene="UBE3C"
                     /gene_synonym="HECTH2; NDSMBA; NEDSMBA; RAUL"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1490
                     /gene="UBE3C"
                     /gene_synonym="HECTH2; NDSMBA; NEDSMBA; RAUL"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1678
                     /gene="UBE3C"
                     /gene_synonym="HECTH2; NDSMBA; NEDSMBA; RAUL"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1765
                     /gene="UBE3C"
                     /gene_synonym="HECTH2; NDSMBA; NEDSMBA; RAUL"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..1923
                     /gene="UBE3C"
                     /gene_synonym="HECTH2; NDSMBA; NEDSMBA; RAUL"
                     /inference="alignment:Splign:2.1.0"
     exon            1924..2156
                     /gene="UBE3C"
                     /gene_synonym="HECTH2; NDSMBA; NEDSMBA; RAUL"
                     /inference="alignment:Splign:2.1.0"
     exon            2157..2261
                     /gene="UBE3C"
                     /gene_synonym="HECTH2; NDSMBA; NEDSMBA; RAUL"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..2349
                     /gene="UBE3C"
                     /gene_synonym="HECTH2; NDSMBA; NEDSMBA; RAUL"
                     /inference="alignment:Splign:2.1.0"
     exon            2350..2447
                     /gene="UBE3C"
                     /gene_synonym="HECTH2; NDSMBA; NEDSMBA; RAUL"
                     /inference="alignment:Splign:2.1.0"
     exon            2448..2580
                     /gene="UBE3C"
                     /gene_synonym="HECTH2; NDSMBA; NEDSMBA; RAUL"
                     /inference="alignment:Splign:2.1.0"
     exon            2581..2828
                     /gene="UBE3C"
                     /gene_synonym="HECTH2; NDSMBA; NEDSMBA; RAUL"
                     /inference="alignment:Splign:2.1.0"
     exon            2829..3041
                     /gene="UBE3C"
                     /gene_synonym="HECTH2; NDSMBA; NEDSMBA; RAUL"
                     /inference="alignment:Splign:2.1.0"
     exon            3042..3230
                     /gene="UBE3C"
                     /gene_synonym="HECTH2; NDSMBA; NEDSMBA; RAUL"
                     /inference="alignment:Splign:2.1.0"
     exon            3231..3297
                     /gene="UBE3C"
                     /gene_synonym="HECTH2; NDSMBA; NEDSMBA; RAUL"
                     /inference="alignment:Splign:2.1.0"
     exon            3298..3428
                     /gene="UBE3C"
                     /gene_synonym="HECTH2; NDSMBA; NEDSMBA; RAUL"
                     /inference="alignment:Splign:2.1.0"
     exon            3429..5214
                     /gene="UBE3C"
                     /gene_synonym="HECTH2; NDSMBA; NEDSMBA; RAUL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4407..4412
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBE3C"
                     /gene_synonym="HECTH2; NDSMBA; NEDSMBA; RAUL"
                     /note="hexamer: ATTAAA"
     polyA_site      4427
                     /gene="UBE3C"
                     /gene_synonym="HECTH2; NDSMBA; NEDSMBA; RAUL"
                     /note="major polyA site"
     regulatory      4938..4943
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBE3C"
                     /gene_synonym="HECTH2; NDSMBA; NEDSMBA; RAUL"
                     /note="hexamer: AATAAA"
     polyA_site      4961
                     /gene="UBE3C"
                     /gene_synonym="HECTH2; NDSMBA; NEDSMBA; RAUL"
     regulatory      5194..5199
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBE3C"
                     /gene_synonym="HECTH2; NDSMBA; NEDSMBA; RAUL"
                     /note="hexamer: ATTAAA"
     polyA_site      5214
                     /gene="UBE3C"
                     /gene_synonym="HECTH2; NDSMBA; NEDSMBA; RAUL"
                     /note="major polyA site"
ORIGIN      
        1 gcacgcactg acggctgacc gccatcttcc ctcccgaggc ggcagttcca ggtgcaagcg
       61 ccgggtttgc tgcccgctgg gcgcccctgc agcggcccga gctgtggccg gcgtggatga
      121 ggggcaggcg aggcagggcc gcccctccag tattgccgcc cctcccgccc cagggcaggg
      181 ctgggagggt acagcccggg ggcgggctcg ggtcgcctcc cggccgccgc gtcctcgctg
      241 ccccgggccg ggcgggcggg cgccgagagc ctcccagccc gccccgtgcc ccgcccgccc
      301 ggctgcttcc gcggcggcgc tgcccgcaca tgggctaggc tgccaggatg ttcagcttcg
      361 aaggcgactt caagacgcgg cccaaggtgt cccttggcgg cgcgagcagg aaggaggaaa
      421 aggcttctct tttacatcgt actcaggaag aaagaagaaa gagagaggaa gaaaggcgaa
      481 ggttgaaaaa tgcaataatt atccagtcat ttattcgagg ctatagagac agaaaacagc
      541 aatattccat ccaaagaagt gcatttgatc gctgtgctac cttgtcacag tccgggggcg
      601 cttttcccat tgctaatggc cccaacctta cccttttggt aaggcagctt ctgttttttt
      661 acaaacaaaa tgaagactca aaacgtttga tatggctgta tcagaactta attaaacaca
      721 gctctctgtt tgtcaagcag ttggatggat ctgagagact tacatgctta tttcagataa
      781 aaagattgat gagcctctgt tgcaggttgc tgcaaaactg taatgatgac agtttgaatg
      841 ttgcacttcc aatgagaatg cttgaagtat tttcgtctga gaatacttac ttgcctgttt
      901 tacaagatgc tagctatgtg gtgtcagtga ttgaacaaat tttgcactac atgattcaca
      961 atgggtatta taggtctcta tatttgttga ttaacagcaa gcttccatca agtattgaat
     1021 attctgattt atctcgagtt cctatagcaa aaattttgct agagaatgtt ctaaaaccat
     1081 tgcactttac ttacaactcc tgtccggaag gtgcgaggca acaagttttt acagccttca
     1141 cagaggagtt tctggcagca ccttttacag atcagatttt tcatttcatc attccggcgc
     1201 ttgcagatgc gcagaccgtt ttcccttacg agccctttct gaatgcactg ttgttaatag
     1261 agagtagatg ttcaagaaag agtggtggag caccctggct tttctatttc gttttaactg
     1321 ttggcgaaaa ttatttgggg gccctctctg aggaagggct gctggtgtat ttgcgggtgc
     1381 tgcagacctt cctctctcag ttaccagtct ctcctgccag cgcgagctgt cacgactcag
     1441 ccagtgactc tgaggaggag agtgaagaag ccgacaagcc ctcaagcccg gaggatggca
     1501 gactgtcagt atcatacata acagaggaat gcctgaagaa gctggacaca aagcagcaga
     1561 ccaacaccct gctcaacctg gtgtggaggg actctgcgag cgaggaggtc ttcaccacca
     1621 tggcctccgt ctgccacacg ctgatggtgc agcaccgcat gatggtaccc aaagtcaggc
     1681 ttctctacag tttagccttt aatgccaggt ttctgagaca tctttggttt ctaatatctt
     1741 ccatgtcaac acggatgatc acagggtcta tggtaccgtt gcttcaggtg atatccaggg
     1801 gttctcctat gtcttttgaa gattctagtc gaatcatccc actcttttat ctttttagct
     1861 ccttgtttag tcattcacta atttccatac atgataacga attcttcggt gatcccatag
     1921 aagttgtagg tcaaagacaa tcatcaatga tgccttttac tttagaagag ctgataatgt
     1981 tgtctcgatg ccttcgagat gcatgcctgg ggatcatcaa gttggcttat ccagaaacca
     2041 agccagaagt tcgagaagaa tatattacag catttcagag tattggagtt actactagct
     2101 ctgaaatgca acaatgcata cagatggaac agaaaagatg gattcagtta tttaaggtta
     2161 tcaccaatct agtgaaaatg ttgaagtcca gagacacgag gagaaatttt tgtcctccaa
     2221 accactggct gtcagaacaa gaagatatta aagcagataa ggtcactcag ctctatgtgc
     2281 cagcatccag acatgtgtgg aggttccggc ggatggggag gataggcccg ctgcagtcca
     2341 ccctggacgt gggtttggag tccccgccgc tgtctgtgtc tgaggaaaga cagcttgctg
     2401 tcctgacaga gttgcctttt gtggttccat ttgaggaacg agtaaagatc tttcagaggt
     2461 tgatttatgc agataagcaa gaagttcaag gagatggtcc atttctggat ggaattaatg
     2521 tcacaataag aagaaattac atttatgaag atgcttatga caaactttct ccagaaaatg
     2581 agcctgattt gaaaaagcgg atccgtgtgc acttgctcaa tgcccatggc ctggatgaag
     2641 ctggcattga tggtggtggt attttcagag agtttttaaa tgaactactg aagtcaggat
     2701 ttaaccccaa ccaggggttc tttaagacta ctaatgaagg gcttctgtac cccaacccgg
     2761 ctgctcagat gcttgtggga gattcttttg ccagacatta ctacttccta ggcagaatgc
     2821 ttggaaaggc tctctatgag aacatgctgg tggagctgcc ctttgcaggc ttctttcttt
     2881 ccaagttgct tggaaccagt gccgacgtgg acattcacca cctcgcctcc ctagaccctg
     2941 aggtgtataa gaatttgctc tttctgaaga gctacgaaga cgatgtggag gagcttgggc
     3001 tgaacttcac tgtggtgaac aatgacctgg gagaggcgca ggtagttgaa ctaaaattcg
     3061 gtgggaaaga catccctgtc accagcgcca accggattgc gtacatccac ttggtggcag
     3121 actacaggct gaacaggcag atccgccagc actgcctggc tttccgccag ggccttgcca
     3181 atgtcgtcag cctcgagtgg ctccgaatgt ttgatcagca agaaattcag gtattaattt
     3241 ctggtgcaca agttcccata agcctagagg acctaaaatc ctttacaaac tattcaggag
     3301 gctattctgc agaccatcct gttattaagg tcttctggag agttgtggaa gggttcactg
     3361 atgaagaaaa gcgcaaactg ctgaagtttg taacaagctg ctctcgaccc cctctcttgg
     3421 ggtttaagga gttgtatccc gcattttgta ttcacaacgg aggctccgac cttgagcggc
     3481 tccccacagc cagcacctgc atgaacctgc tgaagctccc cgagttctat gacgagacac
     3541 ttttgcgaag taaacttctc tatgcgattg aatgtgccgc tggctttgag ctgagctgaa
     3601 gctgatgctg gggtcagacc cctacagaga accagtgctt ccttcgtcag cagcgcctcc
     3661 ccagacccac gaggatactc acactgcacg cctgaggctc tcctaagctc cttctttcat
     3721 tctgccattc ctccctccct tcctttttta aatgattttt attacggtgt ggtcacttat
     3781 ttagatggac attgcttttc aaataactta aaataacacg ttatgtgcca tgtggctact
     3841 ttagtaatat tgccaagaag agcacagttt ttacactagt ggcatctcag tgaaattaac
     3901 caaagatgaa gctttggctt tgctggtgag atcagagccc tcctgagcag gcagcgccac
     3961 tccagggttc agacagggct gcacaggcgg cagagataca gggtctgagg gctgagacgc
     4021 catggggccg ctgctgctta tgtggttgga ttgtttacaa gcctcattat taaaactgaa
     4081 ggcatttttt ttttctgctg cctttcccaa agtggttagg tttggaaaag agatgatgat
     4141 ggtaatattt tatttgtgct ttttaagcca tttccccaaa tgggactagc atgcttgttt
     4201 tcagtatacc gtggcctgcc tcatgatggt ttggagatac tgtctgtgga tgtgaggtgg
     4261 ggacttcatt cattgtccta tttctatctc cactttgtgc ctggagagct ttcaggggag
     4321 gtggaggagg agggtctgcc aagctactgc aacatctgtc acccactata cccagttact
     4381 tgggggagga cagacactgt ggtgtcatta aagttgtttg aaccaaagtg gcggctgcat
     4441 ctttgtcccg atgctagccg tgccggtctc ccatcatccg ctcgccctcc tttcccctgg
     4501 gctgcgccca cttgtcttcc tggatatttg ggggtgactc gccatgcttg gcaccctctg
     4561 cttcctggtg ctgctctgac tcgaagacgg gacagtccct ggtgcacatc cagggaagag
     4621 gagtgtcggt agttcttgca gtaggcactt tatcaggacc tgacctgttg ctgggtgatt
     4681 ttagtctcta caaacagaaa gcgtttcaaa gcgtcagctg tgggagcaga gtgacccttt
     4741 gctgatgctg gggggagggg atctaaatcc tcatttatct cttctatgtc tcgtatttta
     4801 ctgtcactgg aggctctgtg ggctgtcata gttaattgac cataattagc aatatacttt
     4861 taaagtggga aagctgaatg acacttttaa gacaatgaac attatcaaaa caaaatgtat
     4921 aatttcttaa tttgaataat aaattaagcg tttaaatgct atttgtagtc ttgatataca
     4981 gaaataaaat aattagggtt ggtctttttt attttaggtt gttttatgtt gaatgttcta
     5041 tatcttatta gttaatttgt atattttatt agtattttgg aaatagcata tctgagactg
     5101 aagagaaatt gacaattcac ttatttgtgg tttttttctc agctattctg agcttattta
     5161 tttatttgta tgttctaatg gctaaacatt tacattaaat gttttttttc ccaa
//
