LOCUS       NM_130466               5730 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens ubiquitin protein ligase E3B (UBE3B), transcript
            variant 1, mRNA.
ACCESSION   NM_130466
VERSION     NM_130466.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5730)
  AUTHORS   Wang,S., Li,H., Liu,X., Yin,T., Li,T., Zheng,M., Liu,M., Meng,X.,
            Zhou,J., Wang,Y. and Chen,Y.
  TITLE     VHL suppresses UBE3B-mediated breast tumor growth and metastasis
  JOURNAL   Cell Death Dis 15 (6), 446 (2024)
   PUBMED   38914543
  REMARK    GeneRIF: VHL suppresses UBE3B-mediated breast tumor growth and
            metastasis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5730)
  AUTHORS   Albakheet,A., Almuallami,D., Almass,R., Qari,A., Kenana,R.,
            AlQudairy,H., Huma,R., Binomar,H., Wakil,S.M., Alowain,M.,
            Colak,D., Kaya,N. and AlSayed,M.D.
  TITLE     Novel UBE3B mutations: report of eight patients with Kaufman
            oculocerebrofacial syndrome with additional clinical findings from
            a highly consanguineous population
  JOURNAL   Clin Dysmorphol 33 (2), 55-62 (2024)
   PUBMED   38410982
  REMARK    GeneRIF: Novel UBE3B mutations: report of eight patients with
            Kaufman oculocerebrofacial syndrome with additional clinical
            findings from a highly consanguineous population.
REFERENCE   3  (bases 1 to 5730)
  AUTHORS   Wang,Y., Liu,X., Wang,M., Wang,Y., Wang,S., Jin,L., Liu,M., Zhou,J.
            and Chen,Y.
  TITLE     UBE3B promotes breast cancer progression by antagonizing HIF-2alpha
            degradation
  JOURNAL   Oncogene 42 (46), 3394-3406 (2023)
   PUBMED   37783786
  REMARK    GeneRIF: UBE3B promotes breast cancer progression by antagonizing
            HIF-2alpha degradation.
REFERENCE   4  (bases 1 to 5730)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 5730)
  AUTHORS   Li,K., Wang,F., Yang,Z.N., Zhang,T.T., Yuan,Y.F., Zhao,C.X.,
            Yeerjiang,Z., Cui,B., Hua,F., Lv,X.X., Zhang,X.W., Yu,J.J.,
            Liu,S.S., Yu,J.M., Shang,S., Xiao,Y. and Hu,Z.W.
  TITLE     TRIB3 promotes MYC-associated lymphoma development through
            suppression of UBE3B-mediated MYC degradation
  JOURNAL   Nat Commun 11 (1), 6316 (2020)
   PUBMED   33298911
  REMARK    GeneRIF: TRIB3 promotes MYC-associated lymphoma development through
            suppression of UBE3B-mediated MYC degradation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5730)
  AUTHORS   Szafranski,K., Schindler,S., Taudien,S., Hiller,M., Huse,K.,
            Jahn,N., Schreiber,S., Backofen,R. and Platzer,M.
  TITLE     Violating the splicing rules: TG dinucleotides function as
            alternative 3' splice sites in U2-dependent introns
  JOURNAL   Genome Biol 8 (8), R154 (2007)
   PUBMED   17672918
  REMARK    GeneRIF: the apparent occurrence of an unusual TG 3' splice site in
            intron 25 is discussed
REFERENCE   7  (bases 1 to 5730)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   8  (bases 1 to 5730)
  AUTHORS   Gong,T.W., Huang,L., Warner,S.J. and Lomax,M.I.
  TITLE     Characterization of the human UBE3B gene: structure, expression,
            evolution, and alternative splicing
  JOURNAL   Genomics 82 (2), 143-152 (2003)
   PUBMED   12837265
  REMARK    GeneRIF: UBE3B is a novel E3 ligase, with a HECT-domain which
            constitutes the active site for ubiquitin transfer
REFERENCE   9  (bases 1 to 5730)
  AUTHORS   Lomax,M.I., Gong,T.W., Cho,Y., Huang,L., Oh,S.H., Adler,H.J.,
            Raphael,Y. and Altschuler,R.A.
  TITLE     Differential Gene Expression Following Noise Trauma in Birds and
            Mammals
  JOURNAL   Noise Health 3 (11), 19-35 (2001)
   PUBMED   12689446
REFERENCE   10 (bases 1 to 5730)
  AUTHORS   Lomax,M.I., Huang,L., Cho,Y., Gong,T.L. and Altschuler,R.A.
  TITLE     Differential display and gene arrays to examine auditory plasticity
  JOURNAL   Hear Res 147 (1-2), 293-302 (2000)
   PUBMED   10962193
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA771082.1, BC144684.1,
            BC032301.1, AF251046.2, BQ889238.1 and DR760197.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_130466.3.
            
            Summary: The modification of proteins with ubiquitin is an
            important cellular mechanism for targeting abnormal or short-lived
            proteins for degradation. Ubiquitination involves at least three
            classes of enzymes: E1 ubiquitin-activating enzymes, E2
            ubiquitin-conjugating enzymes, and E3 ubiquitin-protein ligases.
            This gene encodes a member of the E3 ubiquitin-conjugating enzyme
            family which accepts ubiquitin from an E2 ubiquitin-conjugating
            enzyme and transfers the ubiquitin to the targeted substrates. A
            HECT (homology to E6-AP C-terminus) domain in the C-terminus of the
            longer isoform of this protein is the catalytic site of ubiquitin
            transfer and forms a complex with E2 conjugases. Shorter isoforms
            of this protein which lack the C-terminal HECT domain are therefore
            unlikely to bind E2 enzymes. Alternatively spliced transcript
            variants encoding distinct isoforms have been identified for this
            gene. [provided by RefSeq, Jul 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript, and encodes the longer protein (isoform 1). Variants 1
            and 3 encode the same protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF251046.2, SRR1660805.197067.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000342494.8/ ENSP00000340596.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                DA771082.1         12-24
            14-2514             BC144684.1         1-2501
            2515-3681           BC032301.1         2159-3325
            3682-4495           AF251046.2         3663-4476
            4496-4979           BQ889238.1         194-677
            4980-4982           AF251046.2         4961-4963
            4983-5730           DR760197.1         10-757              c
FEATURES             Location/Qualifiers
     source          1..5730
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.11"
     gene            1..5730
                     /gene="UBE3B"
                     /gene_synonym="BPIDS; KOS"
                     /note="ubiquitin protein ligase E3B"
                     /db_xref="GeneID:89910"
                     /db_xref="HGNC:HGNC:13478"
                     /db_xref="MIM:608047"
     exon            1..476
                     /gene="UBE3B"
                     /gene_synonym="BPIDS; KOS"
                     /inference="alignment:Splign:2.1.0"
     exon            477..582
                     /gene="UBE3B"
                     /gene_synonym="BPIDS; KOS"
                     /inference="alignment:Splign:2.1.0"
     exon            583..764
                     /gene="UBE3B"
                     /gene_synonym="BPIDS; KOS"
                     /inference="alignment:Splign:2.1.0"
     CDS             604..3810
                     /gene="UBE3B"
                     /gene_synonym="BPIDS; KOS"
                     /EC_number="2.3.2.26"
                     /note="isoform 1 is encoded by transcript variant 1;
                     HECT-type ubiquitin transferase E3B"
                     /codon_start=1
                     /product="ubiquitin-protein ligase E3B isoform 1"
                     /protein_id="NP_569733.2"
                     /db_xref="CCDS:CCDS9129.1"
                     /db_xref="GeneID:89910"
                     /db_xref="HGNC:HGNC:13478"
                     /db_xref="MIM:608047"
                     /translation="MFTLSQTSRAWFIDRARQAREERLVQKERERAAVVIQAHVRSFL
                     CRSRLQRDIRREIDDFFKADDPESTKRSALCIFKIARKLLFLFRIKEDNERFEKLCRS
                     ILSSMDAENEPKVWYVSLACSKDLTLLWIQQIKNILWYCCDFLKQLKPEILQDSRLIT
                     LYLTMLVTFTDTSTWKILRGKGESLRPAMNHICANIMGHLNQHGFYSVLQILLTRGLA
                     RPRPCLSKGTLTAAFSLALRPVIAAQFSDNLIRPFLIHIMSVPALVTHLSTVTPERLT
                     VLESHDMLRKFIIFLRDQDRCRDVCESLEGCHTLCLMGNLLHLGSLSPRVLEEETDGF
                     VSLLTQTLCYCRKYVSQKKSNLTHWHPVLGWFSQSVDYGLNESMHLITKQLQFLWGVP
                     LIRIFFCDILSKKLLESQEPAHAQPASPQNVLPVKSLLKRAFQKSASVRNILRPVGGK
                     RVDSAEVQKVCNICVLYQTSLTTLTQIRLQILTGLTYLDDLLPKLWAFICELGPHGGL
                     KLFLECLNNDTEESKQLLAMLMLFCDCSRHLITILDDIEVYEEQISFKLEELVTISSF
                     LNSFVFKMIWDGIVENAKGETLELFQSVHGWLMVLYERDCRRRFTPEDHWLRKDLKPS
                     VLFQELDRDRKRAQLILQYIPHVIPHKNRVLLFRTMVTKEKEKLGLVETSSASPHVTH
                     ITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIK
                     RVFDPALNLFKTTSGDERLYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIVVDVPFAS
                     FFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLGLTLSYDEDVMGQ
                     LVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRM
                     FSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPDERAMF
                     LKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRL
                     PTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGFELS"
     exon            765..885
                     /gene="UBE3B"
                     /gene_synonym="BPIDS; KOS"
                     /inference="alignment:Splign:2.1.0"
     exon            886..945
                     /gene="UBE3B"
                     /gene_synonym="BPIDS; KOS"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1050
                     /gene="UBE3B"
                     /gene_synonym="BPIDS; KOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1147
                     /gene="UBE3B"
                     /gene_synonym="BPIDS; KOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1233
                     /gene="UBE3B"
                     /gene_synonym="BPIDS; KOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1316
                     /gene="UBE3B"
                     /gene_synonym="BPIDS; KOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1422
                     /gene="UBE3B"
                     /gene_synonym="BPIDS; KOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1543
                     /gene="UBE3B"
                     /gene_synonym="BPIDS; KOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1721
                     /gene="UBE3B"
                     /gene_synonym="BPIDS; KOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1885
                     /gene="UBE3B"
                     /gene_synonym="BPIDS; KOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..2053
                     /gene="UBE3B"
                     /gene_synonym="BPIDS; KOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2054..2225
                     /gene="UBE3B"
                     /gene_synonym="BPIDS; KOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2226..2344
                     /gene="UBE3B"
                     /gene_synonym="BPIDS; KOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2345..2459
                     /gene="UBE3B"
                     /gene_synonym="BPIDS; KOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2460..2559
                     /gene="UBE3B"
                     /gene_synonym="BPIDS; KOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2560..2679
                     /gene="UBE3B"
                     /gene_synonym="BPIDS; KOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2680..2856
                     /gene="UBE3B"
                     /gene_synonym="BPIDS; KOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2857..2967
                     /gene="UBE3B"
                     /gene_synonym="BPIDS; KOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2968..3105
                     /gene="UBE3B"
                     /gene_synonym="BPIDS; KOS"
                     /inference="alignment:Splign:2.1.0"
     exon            3106..3171
                     /gene="UBE3B"
                     /gene_synonym="BPIDS; KOS"
                     /inference="alignment:Splign:2.1.0"
     exon            3172..3230
                     /gene="UBE3B"
                     /gene_synonym="BPIDS; KOS"
                     /inference="alignment:Splign:2.1.0"
     exon            3231..3413
                     /gene="UBE3B"
                     /gene_synonym="BPIDS; KOS"
                     /inference="alignment:Splign:2.1.0"
     exon            3414..3525
                     /gene="UBE3B"
                     /gene_synonym="BPIDS; KOS"
                     /inference="alignment:Splign:2.1.0"
     exon            3526..3618
                     /gene="UBE3B"
                     /gene_synonym="BPIDS; KOS"
                     /inference="alignment:Splign:2.1.0"
     exon            3619..5730
                     /gene="UBE3B"
                     /gene_synonym="BPIDS; KOS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4029..4034
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBE3B"
                     /gene_synonym="BPIDS; KOS"
                     /note="hexamer: AATAAA"
     polyA_site      4051
                     /gene="UBE3B"
                     /gene_synonym="BPIDS; KOS"
     regulatory      5709..5714
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBE3B"
                     /gene_synonym="BPIDS; KOS"
                     /note="hexamer: ATTAAA"
     polyA_site      5730
                     /gene="UBE3B"
                     /gene_synonym="BPIDS; KOS"
                     /note="major polyA site"
ORIGIN      
        1 gaacaccgcg gggcaagatg gcggtagtgc gtcggctgct gccccgggtc tggcagaact
       61 cgggtgtttt gggctgagac agtggcagct gcggccccga ccccaagtgc ggggacctcc
      121 ggcgaataaa ggtcggcctg cgggtaggcc ggtagggcct gcggtccggc ctgcgggaga
      181 actgggtcgt cagtcctccg agtggtgggg ctggggactt tgagggagtt ggctctaggg
      241 cacagtccct gcctggccag gtcggaggaa caagtgctgg gatctggcgt gtgtgctcca
      301 ggggctcttt ccgcggccct ttccacctct tttcactttg gggacggtag gcctttataa
      361 acggactaat gctgggtgat ttgttcctgt ggttgttgat gccgaggaaa gactctgggc
      421 cccaggactc acctaaactg gagttcgaat actgttcgct cgctgtgtga ccttggaaaa
      481 aataacaagc ttttctgaag tgagaagctg ttctcagcca cgagtcctgt gcaagatcac
      541 taatgattac ctggcatttc tgcgacacag gcaggtcctc agggtttgtg caagtttgca
      601 aacatgttca ccctgtctca gacctcgaga gcatggttca tcgatagagc ccgtcaggca
      661 cgagaagaaa ggcttgtgca gaaggaacgg gagcgggcag ctgttgtgat ccaggcccat
      721 gtccggagtt ttctctgtcg gagtcgactg cagagagata tcaggagaga gattgatgac
      781 ttttttaaag cagatgaccc tgagtccact aaaagaagtg cactttgtat tttcaagatt
      841 gccaggaaac tgctgttcct attcagaatc aaagaggata atgagagatt tgagaagttg
      901 tgtcgcagca tcctgagcag catggatgct gagaatgagc ctaaggtgtg gtatgtgtcc
      961 ctggcttgtt ctaaggacct caccctcctt tggattcaac agatcaagaa cattttgtgg
     1021 tactgctgtg attttctcaa gcagctcaag cctgaaatcc tgcaggactc ccgactcatc
     1081 accctgtacc tcacgatgct tgtcaccttc acagacactt caacgtggaa aattcttcgg
     1141 ggaaaaggtg aaagtcttcg accagcgatg aaccacattt gtgcaaatat aatgggacat
     1201 ctcaaccagc atggatttta ttctgtgctg cagatattgt taacccgtgg cctggcaaga
     1261 ccccgtcctt gtctatccaa aggcacttta acagcagctt tttctctagc gttacgccct
     1321 gtgattgctg cacagttctc agacaatctg attcggccgt tcctcatcca catcatgtct
     1381 gtgcctgctc tggtgactca tctcagcaca gtgacccctg agcgcctcac tgttttagaa
     1441 tcccatgaca tgcttcgtaa attcatcata tttttaagag accaagatcg atgccgtgat
     1501 gtatgtgaaa gtttagaagg atgccatacg ctttgtctaa tgggcaacct cctacacttg
     1561 ggctccctca gccccagagt gttagaggag gagacagatg ggttcgtgag tttgctcacc
     1621 cagacgctgt gctactgtcg gaagtatgtg tctcagaaga agtccaacct gacccactgg
     1681 catcctgtcc ttggctggtt ctcccaatct gtggattatg gccttaacga gtcaatgcac
     1741 ttgatcacca aacagctgca gttcttgtgg ggggtgcctc tgatccggat cttcttctgt
     1801 gacatcctga gcaagaagct actggagagc caggagccag cccacgcaca gccagcatcc
     1861 cctcagaatg tgctcccagt gaagagtctc ctaaagcgtg cttttcaaaa gtcggcatca
     1921 gtccggaata ttctcaggcc tgtcgggggt aaacgggtcg actctgcaga agtccagaag
     1981 gtttgcaaca tctgtgtcct ctaccagacc tcgctgacaa ctctcacaca gattcggctg
     2041 cagatactca caggtctcac ttaccttgat gacctgcttc ccaaactgtg ggcatttatc
     2101 tgtgagctcg ggccccacgg agggttaaag ctcttcttgg aatgcctgaa caatgacact
     2161 gaagagtcca agcaactctt ggccatgctg atgctgttct gtgactgttc gcggcacctc
     2221 atcacaatcc ttgatgacat tgaagtttat gaagaacaga tttcattcaa actggaagag
     2281 ctggtcacta tctcctcttt cctgaattct tttgtgttta agatgatctg ggatggaatt
     2341 gtagagaacg ccaagggtga gaccttggag ctgttccagt ctgtccacgg gtggcttatg
     2401 gtgctgtacg agcgggactg ccggcggcgc ttcacccccg aggaccactg gctgcgaaag
     2461 gatctcaaac ctagcgtgct cttccaagaa ctcgacaggg acagaaaacg ggcacagttg
     2521 atcctgcagt acatcccaca tgtcatccct cacaaaaaca gagttctact gtttcgaacc
     2581 atggttacca aggagaagga gaaactgggg ctggtggaaa ccagctctgc ctccccgcat
     2641 gtcactcaca tcaccatccg ccggtccagg atgctggagg acggctacga gcagcttagg
     2701 cagctctccc agcacgccat gaagggggtc atccgtgtga agtttgtcaa tgacctcggg
     2761 gtggacgaag cagggattga tcaagacggt gtttttaagg agttcttgga agagatcatc
     2821 aagagagttt ttgacccagc actcaatctg ttcaagacaa ccagtgggga tgagaggctg
     2881 tacccctcac ccacatccta catccatgag aattacctgc agctcttcga gtttgtgggg
     2941 aagatgctgg ggaaggctgt gtatgaggga attgtggtgg acgtgccatt tgcatccttc
     3001 ttcctgagcc aactgcttgg gcaccaccac agcgtcttct atagctcggt ggatgaactg
     3061 ccttctctgg actccgagtt ctataaaaac ctcacctcca tcaagcgcta tgatggggac
     3121 atcactgacc tgggcctgac gctgtcttac gacgaggacg tcatgggtca gcttgtttgc
     3181 catgaactga ttcctggagg gaagaccatt cctgttacaa atgaaaataa aattagctac
     3241 atccatctga tggcacattt tcgaatgcac actcaaataa aaaaccaaac agctgccctc
     3301 attagcggat tccgttccat tatcaaaccc gagtggatcc gaatgttctc aactcctgaa
     3361 ctgcagcgtc tcatctctgg cgacaatgct gagattgatc tggaagattt aaagaagcac
     3421 acagtctact acggtggttt ccatggaagt cacagagtca tcatctggct ctgggatatt
     3481 ctggcctccg acttcacacc ggatgagaga gctatgtttc tgaagttcgt gaccagctgc
     3541 tccagacccc cgctcctggg attcgcctac ctcaagcctc cattctccat ccgctgcgtg
     3601 gaggtgtcgg acgatcagga caccggggac actctgggca gcgtcctccg gggcttcttc
     3661 accatccgca agcgggagcc aggcggccgc ctgcccacct cctccacctg cttcaacctg
     3721 ctcaagctgc ccaactacag caagaagagc gtcctccgcg agaagctgcg ctacgccatc
     3781 agcatgaaca cgggctttga actctcctag ctcctgtccc agccctgcct ccagggctcc
     3841 tgggctgcca gggaccttca gctcccagag gcagtgtggt cctgggaatg tgaccaacat
     3901 gccaggtgac attggcccct agaccctctc tatagccatg agactccttg tggcctcaag
     3961 aaatttagac gcccacgaca gcactacaca gcatctccag gtgatgccca aggcacaggg
     4021 ctgcagaaaa taaacctcca gattccacca acacgggtcc attcttcctg gtgatggcag
     4081 aggggcttct tttagctagt ttgatctttt gggagtctgt ctttccttag ccgtctgagt
     4141 gagctgtgta tgaacaagtc ccaggagttc caagagtcta gagtggtttt tgcagcatgg
     4201 gttgagtgta caaagcctac tgtgcgtgag atcctctcct tccgtttctg aaatctctta
     4261 ctcaggtaag gcctcgccaa gcctctatgc accccacaaa gtttctgcct ccatgccgtc
     4321 cacagcgcct cttcccagac agccaggccc atctgctgcc cagggaagcg caggcgcctg
     4381 ctagggacgc tatggacacc gtgagtccaa ggcgctgctc ctgccttgaa gccacgcgct
     4441 ccacgccgcg gccctcccat tttctgcgtc ctcagcgggc tgagctgcca gagagtcttc
     4501 ccggacctat tcccgtccta tgcattcaca ttggcatcct ggtttggggg aagaaaaaca
     4561 acggccctta gcagcagccc cgtttccaga atgtgctgcc tgttccccaa agcctgcttg
     4621 tcccgcggag gacggctgcc tttgaccctg cttatttgtc tcactggtta tctaatgagg
     4681 aacaaacact aacctaaggt acacatccca tctgggcggt ggcttcactc ctgagtctgc
     4741 aaaatcccag gaaacttggg tcttgctgcc catccttcct cagcacaggg aacccggaag
     4801 cccgttgcac tgacagaggc tcacaccctc tgggtttttt gttttttttt taaacttcat
     4861 ttctcttcca acccattgtg ttcctctgcc ctcattcttt acctttgttg taagaacttt
     4921 agctccaggg aactgaggca gaggccctgt ttgtggtctg tgttgacagc cacccaccct
     4981 ctcccacctc atgctcctgc acctgcacca ccaaggttga tgccggattc gaagccagga
     5041 aggcccagtc cctcctctgc tctcctcaaa gacgcaaaac attttccaac aagagctgtc
     5101 acagtggcag caaagcaggg gccacccgtc tccacagtcc ttcagagttt cagctgcatc
     5161 ctggtgtccc acccaggtcg agcccccagg cttctggaaa agagtgtgtg ctctactttg
     5221 atggaaacat ggcaaggaat ttaaagacag gaatgtatta atattattga aggtgtgttc
     5281 gtaacctctg attctgtgga cttgccactt tctccaaacg ctcggttcct ttgaagattt
     5341 cttctgaacg tgtgtgcgca cgctgggcgg gttcgtgcat acatgcgggg accccagact
     5401 gtcagcacag ggaagatgga tcccatccta atttttatca cctgaaggtt ggaaccagtg
     5461 agggactggg agagagtgat ttataagcac caatatcaac ttcatgtgga tttttgacaa
     5521 ggaggggtag tttgtaattt catttaaatt cttttcagca gctggaaata ttgcactatc
     5581 tgaaacactg aatctccttt tgtaactggt gttcactgac accttgatgg ctcttgatgg
     5641 ctctaaaaag ttgtaggatt ttttgttttt gtagctaact tatggattga gatgtgatca
     5701 aaggctttat taaatttgta cttcagcata
//
