LOCUS       XM_047433018            8302 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens ubiquitin protein ligase E3A (UBE3A),
            transcript variant X17, mRNA.
ACCESSION   XM_047433018
VERSION     XM_047433018.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8302
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     gene            1..8302
                     /gene="UBE3A"
                     /gene_synonym="ANCR; AS; E6-AP; EPVE6AP; HPVE6A; PIX1"
                     /note="ubiquitin protein ligase E3A; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 7
                     mRNAs, 29 ESTs, 1986 long SRA reads, 9 Proteins, and 99%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 8 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:7337"
                     /db_xref="HGNC:HGNC:12496"
                     /db_xref="MIM:601623"
     CDS             335..2893
                     /gene="UBE3A"
                     /gene_synonym="ANCR; AS; E6-AP; EPVE6AP; HPVE6A; PIX1"
                     /codon_start=1
                     /product="ubiquitin-protein ligase E3A isoform X3"
                     /protein_id="XP_047288974.1"
                     /db_xref="GeneID:7337"
                     /db_xref="HGNC:HGNC:12496"
                     /db_xref="MIM:601623"
                     /translation="MKRAAAKHLIERYYHQLTEGCGNEACTNEFCASCPTFLRMDNNA
                     AAIKALELYKINAKLCDPHPSKKGASSAYLENSKGAPNNSCSEIKMNKKGARIDFKDV
                     TYLTEEKVYEILELCREREDYSPLIRVIGRVFSSAEALVQSFRKVKQHTKEELKSLQA
                     KDEDKDEDEKEKAACSAAAMEEDSEASSSRIGDSSQGDNNLQKLGPDDVSVDIDAIRR
                     VYTRLLSNEKIETAFLNALVYLSPNVECDLTYHNVYSRDPNYLNLFIIVMENRNLHSP
                     EYLEMALPLFCKAMSKLPLAAQGKLIRLWSKYNADQIRRMMETFQQLITYKVISNEFN
                     SRNLVNDDDAIVAASKCLKMVYYANVVGGEVDTNHNEEDDEEPIPESSELTLQELLGE
                     ERRNKKGPRVDPLETELGVKTLDCRKPLIPFEEFINEPLNEVLEMDKDYTFFKVETEN
                     KFSFMTCPFILNAVTKNLGLYYDNRIRMYSERRITVLYSLVQGQQLNPYLRLKVRRDH
                     IIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGM
                     FTYDESTKLFWFNPSSFETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGT
                     FRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPI
                     TNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSR
                     NLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLG
                     KLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGML"
ORIGIN      
        1 agactgccat actgttttcc acagtgactg caccatttta cattcccacc agcagtgaat
       61 aagggttcca atttctctgc atcttttcta acacttgagg ggaggtatgg tgtcaagaaa
      121 acatagtcac cattattacg aaaagtaaaa tatggaagag atgatcccta ccatcaatca
      181 gcttacaact agaggcactg acaaatgtat acagatagct gtaatgtaag gttaaaaatc
      241 tgtaagagcc tgattttaga attcaccagc tcctcagaag tttggcgaaa tatgatcagg
      301 agaacctcag tctgacgaca ttgaagctag ccgaatgaag cgagcagctg caaagcatct
      361 aatagaacgc tactaccacc agttaactga gggctgtgga aatgaagcct gcacgaatga
      421 gttttgtgct tcctgtccaa cttttcttcg tatggataat aatgcagcag ctattaaagc
      481 cctcgagctt tataagatta atgcaaaact ctgtgatcct catccctcca agaaaggagc
      541 aagctcagct taccttgaga actcgaaagg tgcccccaac aactcctgct ctgagataaa
      601 aatgaacaag aaaggcgcta gaattgattt taaagatgtg acttacttaa cagaagagaa
      661 ggtatatgaa attcttgaat tatgtagaga aagagaggat tattcccctt taatccgtgt
      721 tattggaaga gttttttcta gtgctgaggc attggtacag agcttccgga aagttaaaca
      781 acacaccaag gaagaactga aatctcttca agcaaaagat gaagacaaag atgaagatga
      841 aaaggaaaaa gctgcatgtt ctgctgctgc tatggaagaa gactcagaag catcttcctc
      901 aaggataggt gatagctcac agggagacaa caatttgcaa aaattaggcc ctgatgatgt
      961 gtctgtggat attgatgcca ttagaagggt ctacaccaga ttgctctcta atgaaaaaat
     1021 tgaaactgcc tttctcaatg cacttgtata tttgtcacct aacgtggaat gtgacttgac
     1081 gtatcacaat gtatactctc gagatcctaa ttatctgaat ttgttcatta tcgtaatgga
     1141 gaatagaaat ctccacagtc ctgaatatct ggaaatggct ttgccattat tttgcaaagc
     1201 gatgagcaag ctaccccttg cagcccaagg aaaactgatc agactgtggt ctaaatacaa
     1261 tgcagaccag attcggagaa tgatggagac atttcagcaa cttattactt ataaagtcat
     1321 aagcaatgaa tttaacagtc gaaatctagt gaatgatgat gatgccattg ttgctgcttc
     1381 gaagtgcttg aaaatggttt actatgcaaa tgtagtggga ggggaagtgg acacaaatca
     1441 caatgaagaa gatgatgaag agcccatccc tgagtccagc gagctgacac ttcaggaact
     1501 tttgggagaa gaaagaagaa acaagaaagg tcctcgagtg gaccccctgg aaactgaact
     1561 tggtgttaaa accctggatt gtcgaaaacc acttatccct tttgaagagt ttattaatga
     1621 accactgaat gaggttctag aaatggataa agattatact tttttcaaag tagaaacaga
     1681 gaacaaattc tcttttatga catgtccctt tatattgaat gctgtcacaa agaatttggg
     1741 attatattat gacaatagaa ttcgcatgta cagtgaacga agaatcactg ttctctacag
     1801 cttagttcaa ggacagcagt tgaatccata tttgagactc aaagttagac gtgaccatat
     1861 catagatgat gcacttgtcc ggctagagat gatcgctatg gaaaatcctg cagacttgaa
     1921 gaagcagttg tatgtggaat ttgaaggaga acaaggagtt gatgagggag gtgtttccaa
     1981 agaatttttt cagctggttg tggaggaaat cttcaatcca gatattggta tgttcacata
     2041 cgatgaatct acaaaattgt tttggtttaa tccatcttct tttgaaactg agggtcagtt
     2101 tactctgatt ggcatagtac tgggtctggc tatttacaat aactgtatac tggatgtaca
     2161 ttttcccatg gttgtctaca ggaagctaat ggggaaaaaa ggaacttttc gtgacttggg
     2221 agactctcac ccagttctat atcagagttt aaaagattta ttggagtatg aagggaatgt
     2281 ggaagatgac atgatgatca ctttccagat atcacagaca gatctttttg gtaacccaat
     2341 gatgtatgat ctaaaggaaa atggtgataa aattccaatt acaaatgaaa acaggaagga
     2401 atttgtcaat ctttattctg actacattct caataaatca gtagaaaaac agttcaaggc
     2461 ttttcggaga ggttttcata tggtgaccaa tgaatctccc ttaaagtact tattcagacc
     2521 agaagaaatt gaattgctta tatgtggaag ccggaatcta gatttccaag cactagaaga
     2581 aactacagaa tatgacggtg gctataccag ggactctgtt ctgattaggg agttctggga
     2641 aatcgttcat tcatttacag atgaacagaa aagactcttc ttgcagttta caacgggcac
     2701 agacagagca cctgtgggag gactaggaaa attaaagatg attatagcca aaaatggccc
     2761 agacacagaa aggttaccta catctcatac ttgctttaat gtgcttttac ttccggaata
     2821 ctcaagcaaa gaaaaactta aagagagatt gttgaaggcc atcacgtatg ccaaaggatt
     2881 tggcatgctg taaaacaaaa caaaacaaaa taaaacaaaa aaaaggaagg aaaaaaaaag
     2941 aaaaaattta aaaaatttta aaaatataac gagggataaa tttttggtgg tgatagtgtc
     3001 ccagtacaaa aaggctgtaa gatagtcaac cacagtagtc acctatgtct gtgcctccct
     3061 tctttattgg ggacatgtgg gctggaacag cagatttcag ctacatatat gaacaaatcc
     3121 tttattatta ttataattat ttttttgcgt gaaagtgtta catattcttt cacttgtatg
     3181 tacagagagg tttttctgaa tatttatttt aagggttaaa tcacttttgc ttgtgtttat
     3241 tactgcttga ggttgagcct tttgagtatt taaaaaatat ataccaacag aactactctc
     3301 ccaaggaaaa tattgccacc atttgtagac cacgtaacct tcaagtatgt gctacttttt
     3361 tgtccctgta tctaactcaa atcaggaact gtattttttt taatgatttg cttttgaaac
     3421 ttgaagtctt gaaaacagtg tgatgcaatt actgctgttc tagcccccaa agagttttct
     3481 gtgcaaaatc ttgagaatca atcaataaag aaagatggaa ggaagggaga aattggaatg
     3541 ttttaactgc agccctcaga actttagtaa cagcacaaca aattaaaaac aaaaacaact
     3601 catgccacag tatgtcgtct tcatgtgtct tgcaatgaac tgtttcagta gccaatcctc
     3661 tttcttagta tatgaaagga cagggatttt tgttcttgtt gttctcgttg ttgttttaag
     3721 tttactgggg aaagtgcatt tggccaaatg aaatggtagt caagcctatt gcaacaaagt
     3781 taggaagttt gttgtttgtt tattataaac aaaaagcatg tgaaagtgca cttaagatag
     3841 agtttttatt aattacttac ttattaccta gattttaaat agacaatcca aagtctcccc
     3901 ttcgtgttgc catcatcttg ttgaatcagc cattttatcg aggcacgtga tcagtgttgc
     3961 aacataatga aaaagatggc tactgtgcct tgtgttactt aatcatacag taagctgacc
     4021 tggaaatgaa tgaaactatt actcctaaga attacattgt atagccccac agattaaatt
     4081 taattaatta attcaaaaca tgttaaacgt tactttcatg tactatggaa aagtacaagt
     4141 aggtttacat tactgatttc cagaagtaag tagtttcccc tttcctagtc ttctgtgtat
     4201 gtgatgttgt taatttcttt tattgcatta taaaataaaa ggattatgta tttttaacta
     4261 aggtgagaca ttgatatatc cttttgctac aagctatagc taatgtgctg agcttgtgcc
     4321 ttggtgattg attgattgat tgactgattg ttttaactga ttactgtaga tcaacctgat
     4381 gatttgtttg tttgaaattg gcaggaaaaa tgcagctttc aaatcattgg ggggagaaaa
     4441 aggatgtctt tcaggattat tttaattaat ttttttcata attgagacag aactgtttgt
     4501 tatgtaccat aatgctaaat aaaactgtgg cacttttcac cataatttaa tttagtggaa
     4561 aaagaagaca atgctttcca tattgtgata aggtaacatg gggtttttct gggccagcct
     4621 ttagaacact gttagggtac atacgctacc ttgatgaaag ggaccttcgt gcaactgtag
     4681 tcatcttaaa ggcttctcat ccactgtgct tcttaatgtg taattaaagt gaggagaaat
     4741 taaatactct gagggcgttt tatataataa attcgtgaag aaatgtgtgc tcttcagttc
     4801 tcaagtttta ttattatggt atttattaaa gttctacaat tgtaataacg tatccatatg
     4861 acaagtttta aagtggtaat tgaaataggt tatcagatat agagttgttc acatcaagta
     4921 gacttttaac agagtcagaa tgaacctacc cttaaaattt tagagaaaaa aaatcgtcgg
     4981 ttgcacagaa tagctgctct agcttgctta attatgccgg gcatgttgtc actcctctta
     5041 cttttgctgc cttttcatta ctatttaatg gaatgtccct gaacaataag gaagagcaaa
     5101 acatagacat tttgactaca gtggatactt cctctacccc aaatgttatg ttataaaagt
     5161 actttttttg cccaggtact ctattatata ttttggtttt ctttgaatta gacctcaatc
     5221 tccaggaagc tctggaggga aaaaaaggaa ccataaacta aagtaactgg ttttccaaat
     5281 aaatgtaaac ttttttaacc ttttattatt atagaacatt tcaaacatac ataaaacatg
     5341 aaaacagcct gcagccaaac ttttctggac cttggcagct ccagcaaatg agctggtcat
     5401 cctaaccctg gtttcctgag acaactactt ttggggatgc ttgcttgtat agggagatga
     5461 tagatagata gatacatatc aaaaagaaac ttgaaaaagg cttcgaacag aacttgccga
     5521 tgttactcat ccctcctcgg tacagacatt ctgttagaac agatggttgt aatggggcag
     5581 catcactccc tattcccatt aaaaacatga ccattctgag atttcaggcc ccttcgagga
     5641 atttttctca agaattccat acaaactgtc agaggaagaa atgtcgtccc aagactagtc
     5701 cctgtgtagt cttgatccct ttacctgctt actgtaattt tttttctctg actttccgcc
     5761 agtgtctaag ggccatctgt acccctccca cccttccatg agccactgta taatccaaaa
     5821 acacaccttc catttgctcc ctcacttgtc tccttttacc tcaacagtgt tagtgtgtaa
     5881 agaattgcct ggggagggta gagggtttta caagtacaga gtcccaagtc ttttctcccc
     5941 tccccgttag tgggttggca tttattaata ggcactgcaa gattttgatg caggtgtggg
     6001 gtagatatca ctgtgaaagg ctactaatgc atggtagttt caccgaaagt acagtcttca
     6061 aggatcctta taatctcctc attgccaaaa tcagtaacat ctataacctt gacaacaccc
     6121 tagcttgggc tgttgcttct ctggctactt gtttttccat cccagtttac ccagatttta
     6181 gatggatact cctccaattc tgcttaaagt ccttacctgt tcttgcccag ttccctctag
     6241 tcaacctcag tcactcccaa agattcttcc ccaatcccat atcttttgct cagacctctg
     6301 tctctgggat ttctttgtta cctcatagtc agtagtccta aaaacaaaat tcttcatctt
     6361 gcatctctat cgaccgacca ttctttgttt ctttttaaga aatgtaacct tcaccccaat
     6421 catcaaaatc tctcattcct caattgtcac aggttgtcac ttctttcccc ctaaacctct
     6481 cccatcattc cttccttctt tatactgccc ttacaggtcc tgatcctctg actcacccgg
     6541 acattcttag cagctgccta atttcactcc ctgactctca tctccctctt ccaatccttt
     6601 tcattgtgct agaacactat cttgctaatt ttaatatcct ctgcattcag tgcctccaca
     6661 gattgccccc tcactgacct ttccaatttg gccttgtgtt acacactttc ctcgctgcat
     6721 tcctacccag catcttcact tgtcatattt ctcaaatact cttcatgacc agatatttaa
     6781 agtacctcat ccatgaagac ttcatcaacc cccaaagtgc ctccaatgct tccgtggtag
     6841 cacagcataa tggggtacat ttcttagttg aacagtgagg agtcactggg attcttacag
     6901 agtgtcttag ggtctcctct tgatactctt tccacatttc agttaaggaa ttttcttaca
     6961 tctttttttc ttctaataac ctttgcctgg agtgtaagta aattcatgat agagactgtc
     7021 atttttaaaa aaaaaaacaa accattttgc ctttcacatg ttattacctc catctttctg
     7081 ttatcttgtc agtgttgcca cctaaatgat tgaaaatgac cgagcatgca gtagaatgta
     7141 gtgaagtttc ctatttcatc cattttttgc ataagtgcat tggtatctgt atatccatct
     7201 gcccaagcac cagttgttga aaagactatt atttccccat gaatggtcct ggtacccttg
     7261 tcaaagaaca gttgaccata aatataagac tttctggatt ctcagtctta ctccattgcc
     7321 ctatatgtct gtcgttatac cagcaccgca ctgtcttgat ggctgtagct tggtagtaag
     7381 tttagatttg ggatgtgcaa gtcctccatt tttttttttt ttttccccaa aatcattttg
     7441 tctgttttgg gtcccttgca ttgcatatga atttttatat gatcattgtg tcaattcctg
     7501 caaaacagct gggatcttga tagggattta gttgaattgg tagataaatt tgagaaataa
     7561 ctgctatttt aatggtgtta ggttttctgt tccatgactg tgggatgtct ttgcatttgc
     7621 ttaggtcttt atttcagtga tgttttagag atttcagtgt gcaagtcttg acgtctttaa
     7681 tttttttcta agtattttac tgatgccact ttaattatat gattattttc taatttttat
     7741 ttttgtattc atcactggtg ttagaaataa aattaatttt tgtatattga ttttgtatat
     7801 tgtagctttt ctaaaattct ttttttgtca cttagtattt tttgcatatg agatcatgca
     7861 tctgtgaaca gaaatacttt tacttcttcc tttccagtct agattcctat tatttcattt
     7921 tcttgcctta gtgtgctggc tagcacctcc agtacaatat tggatagaag tgacaagagc
     7981 agacatcttt ttcttgttcc tgattttaag gggaaagcat tcagtctttc accattgagt
     8041 atgatgttag ctagctgtgg gtttgcttca agttgaggaa attcttttat taaacctagt
     8101 ttactgagtg ttttttaatc aaaaaaaaaa aaaggagggg ctgtgggttt tgttaaatgc
     8161 ttcttctgta tcaagatttt catgttgttt tgtcctttat taatatgttg tattaatgga
     8221 cttttgtata ttgaattaac tttgcattcc tgggataatc tcagttgtcc atgctacata
     8281 aaccttgttc tatgctgctg ga
//
