LOCUS       NM_023079               3084 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ubiquitin conjugating enzyme E2 Z (UBE2Z), mRNA.
ACCESSION   NM_023079 XM_941930 XM_945544 XM_945547 XM_945549
VERSION     NM_023079.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3084)
  AUTHORS   Rodriguez-Perez,J.M., Posadas-Sanchez,R., Vargas-Alarcon,G.,
            Blachman-Braun,R., Garcia-Flores,E., Cazarin-Santos,B.G.,
            Castillo-Avila,R.G., Borgonio-Cuadra,V.M., Tovilla-Zarate,C.A.,
            Gonzalez-Castro,T.B., Lopez-Bautista,F. and Perez-Hernandez,N.
  TITLE     The rs46522 Polymorphism of the Ubiquitin-Conjugating Enzyme E2Z
            Gene Is Associated with Abnormal Metabolic Parameters in Patients
            with Myocardial Infarction: The Genetics of Atherosclerosis Disease
            Mexican Study
  JOURNAL   DNA Cell Biol 39 (7), 1155-1161 (2020)
   PUBMED   32392439
  REMARK    GeneRIF: UBE2Z gene rs46522 polymorphism is associated with
            abnormal metabolic parameters in Mexican patients with MI
REFERENCE   2  (bases 1 to 3084)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3084)
  AUTHORS   Shi,X., Wang,B., Chen,X., Zheng,Y., Ding,Y. and Wang,C.
  TITLE     Upregulation of ubiquitin-conjugating enzyme E2Z is associated with
            human hepatocellular carcinoma
  JOURNAL   Biochem Biophys Res Commun 523 (1), 25-32 (2020)
   PUBMED   31831168
  REMARK    GeneRIF: Upregulation of ubiquitin-conjugating enzyme E2Z is
            associated with human hepatocellular carcinoma.
REFERENCE   4  (bases 1 to 3084)
  AUTHORS   Foroughmand,A.M., Shafidelpour,S., Zakerkish,M. and Borujeni,M.P.
  TITLE     Association between the UBE2Z rs46522 and TCF7L2 rs7903146
            polymorphisms with type 2 diabetes in south western Iran
  JOURNAL   Afr Health Sci 19 (3), 2484-2490 (2019)
   PUBMED   32127821
  REMARK    GeneRIF: Association between the UBE2Z rs46522 and TCF7L2 rs7903146
            polymorphisms with type 2 diabetes in south western Iran.
REFERENCE   5  (bases 1 to 3084)
  AUTHORS   Schelpe,J., Monte,D., Dewitte,F., Sixma,T.K. and Rucktooa,P.
  TITLE     Structure of UBE2Z Enzyme Provides Functional Insight into
            Specificity in the FAT10 Protein Conjugation Machinery
  JOURNAL   J Biol Chem 291 (2), 630-639 (2016)
   PUBMED   26555268
REFERENCE   6  (bases 1 to 3084)
  AUTHORS   Aichem,A., Catone,N. and Groettrup,M.
  TITLE     Investigations into the auto-FAT10ylation of the bispecific E2
            conjugating enzyme UBA6-specific E2 enzyme 1
  JOURNAL   FEBS J 281 (7), 1848-1859 (2014)
   PUBMED   24528925
REFERENCE   7  (bases 1 to 3084)
  AUTHORS   Schunkert,H., Konig,I.R., Kathiresan,S., Reilly,M.P., Assimes,T.L.,
            Holm,H., Preuss,M., Stewart,A.F., Barbalic,M., Gieger,C.,
            Absher,D., Aherrahrou,Z., Allayee,H., Altshuler,D., Anand,S.S.,
            Andersen,K., Anderson,J.L., Ardissino,D., Ball,S.G.,
            Balmforth,A.J., Barnes,T.A., Becker,D.M., Becker,L.C., Berger,K.,
            Bis,J.C., Boekholdt,S.M., Boerwinkle,E., Braund,P.S., Brown,M.J.,
            Burnett,M.S., Buysschaert,I., Carlquist,J.F., Chen,L., Cichon,S.,
            Codd,V., Davies,R.W., Dedoussis,G., Dehghan,A., Demissie,S.,
            Devaney,J.M., Diemert,P., Do,R., Doering,A., Eifert,S.,
            Mokhtari,N.E., Ellis,S.G., Elosua,R., Engert,J.C., Epstein,S.E., de
            Faire,U., Fischer,M., Folsom,A.R., Freyer,J., Gigante,B.,
            Girelli,D., Gretarsdottir,S., Gudnason,V., Gulcher,J.R.,
            Halperin,E., Hammond,N., Hazen,S.L., Hofman,A., Horne,B.D.,
            Illig,T., Iribarren,C., Jones,G.T., Jukema,J.W., Kaiser,M.A.,
            Kaplan,L.M., Kastelein,J.J., Khaw,K.T., Knowles,J.W., Kolovou,G.,
            Kong,A., Laaksonen,R., Lambrechts,D., Leander,K., Lettre,G., Li,M.,
            Lieb,W., Loley,C., Lotery,A.J., Mannucci,P.M., Maouche,S.,
            Martinelli,N., McKeown,P.P., Meisinger,C., Meitinger,T.,
            Melander,O., Merlini,P.A., Mooser,V., Morgan,T., Muhleisen,T.W.,
            Muhlestein,J.B., Munzel,T., Musunuru,K., Nahrstaedt,J.,
            Nelson,C.P., Nothen,M.M., Olivieri,O., Patel,R.S., Patterson,C.C.,
            Peters,A., Peyvandi,F., Qu,L., Quyyumi,A.A., Rader,D.J.,
            Rallidis,L.S., Rice,C., Rosendaal,F.R., Rubin,D., Salomaa,V.,
            Sampietro,M.L., Sandhu,M.S., Schadt,E., Schafer,A., Schillert,A.,
            Schreiber,S., Schrezenmeir,J., Schwartz,S.M., Siscovick,D.S.,
            Sivananthan,M., Sivapalaratnam,S., Smith,A., Smith,T.B.,
            Snoep,J.D., Soranzo,N., Spertus,J.A., Stark,K., Stirrups,K.,
            Stoll,M., Tang,W.H., Tennstedt,S., Thorgeirsson,G.,
            Thorleifsson,G., Tomaszewski,M., Uitterlinden,A.G., van Rij,A.M.,
            Voight,B.F., Wareham,N.J., Wells,G.A., Wichmann,H.E., Wild,P.S.,
            Willenborg,C., Witteman,J.C., Wright,B.J., Ye,S., Zeller,T.,
            Ziegler,A., Cambien,F., Goodall,A.H., Cupples,L.A., Quertermous,T.,
            Marz,W., Hengstenberg,C., Blankenberg,S., Ouwehand,W.H., Hall,A.S.,
            Deloukas,P., Thompson,J.R., Stefansson,K., Roberts,R.,
            Thorsteinsdottir,U., O'Donnell,C.J., McPherson,R., Erdmann,J. and
            Samani,N.J.
  CONSRTM   Cardiogenics; CARDIoGRAM Consortium
  TITLE     Large-scale association analysis identifies 13 new susceptibility
            loci for coronary artery disease
  JOURNAL   Nat Genet 43 (4), 333-338 (2011)
   PUBMED   21378990
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3084)
  AUTHORS   Gu,X., Zhao,F., Zheng,M., Fei,X., Chen,X., Huang,S., Xie,Y. and
            Mao,Y.
  TITLE     Cloning and characterization of a gene encoding the human putative
            ubiquitin conjugating enzyme E2Z (UBE2Z)
  JOURNAL   Mol Biol Rep 34 (3), 183-188 (2007)
   PUBMED   17160626
  REMARK    GeneRIF: UBE2Z was widely expressed in human tissues and is located
            on chromosome 17q21.
REFERENCE   9  (bases 1 to 3084)
  AUTHORS   Jin,J., Li,X., Gygi,S.P. and Harper,J.W.
  TITLE     Dual E1 activation systems for ubiquitin differentially regulate E2
            enzyme charging
  JOURNAL   Nature 447 (7148), 1135-1138 (2007)
   PUBMED   17597759
  REMARK    GeneRIF: In tissue culture cells, Uba6 is required for charging a
            previously uncharacterized Uba6-specific E2 (Use1), whereas Ube1 is
            required for charging the cell-cycle E2s Cdc34A and Cdc34B
REFERENCE   10 (bases 1 to 3084)
  AUTHORS   Park,K.M., Kang,E., Jeon,Y.J., Kim,N., Kim,N.S., Yoo,H.S.,
            Yeom,Y.I. and Kim,S.J.
  TITLE     Identification of novel regulators of apoptosis using a
            high-throughput cell-based screen
  JOURNAL   Mol Cells 23 (2), 170-174 (2007)
   PUBMED   17464193
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091133.11, BC015890.1, AL713782.1 and AK122770.1.
            
            On Nov 23, 2018 this sequence version replaced NM_023079.4.
            
            Summary: This gene encodes an enzyme which ubiquitinates proteins
            which participate in signaling pathways and apoptosis. [provided by
            RefSeq, Feb 2012].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC015890.1, SRR1163658.207730.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360943.10/ ENSP00000354201.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                AC091133.11        132267-132360       c
            95-942              BC015890.1         1-848
            943-1290            AL713782.1         137-484
            1291-2367           AK122770.1         1227-2303
            2368-3084           BC015890.1         2274-2990
FEATURES             Location/Qualifiers
     source          1..3084
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.32"
     gene            1..3084
                     /gene="UBE2Z"
                     /gene_synonym="HOYS7; USE1"
                     /note="ubiquitin conjugating enzyme E2 Z"
                     /db_xref="GeneID:65264"
                     /db_xref="HGNC:HGNC:25847"
                     /db_xref="MIM:611362"
     exon            1..414
                     /gene="UBE2Z"
                     /gene_synonym="HOYS7; USE1"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..1162
                     /gene="UBE2Z"
                     /gene_synonym="HOYS7; USE1"
                     /EC_number="2.3.2.23"
                     /note="UBA6-specific enzyme E2; ubiquitin-protein ligase
                     Z; ubiquitin carrier protein Z; uba6-specific E2
                     conjugating enzyme 1; E2 ubiquitin-conjugating enzyme Z;
                     ubiquitin conjugating enzyme E2Z"
                     /codon_start=1
                     /product="ubiquitin-conjugating enzyme E2 Z"
                     /protein_id="NP_075567.2"
                     /db_xref="CCDS:CCDS11540.2"
                     /db_xref="GeneID:65264"
                     /db_xref="HGNC:HGNC:25847"
                     /db_xref="MIM:611362"
                     /translation="MAESPTEEAATAGAGAAGPGASSVAGVVGVSGSGGGFGPPFLPD
                     VWAAAAAAGGAGGPGSGLAPLPGLPPSAAAHGAALLSHWDPTLSSDWDGERTAPQCLL
                     RIKRDIMSIYKEPPPGMFVVPDTVDMTKIHALITGPFDTPYEGGFFLFVFRCPPDYPI
                     HPPRVKLMTTGNNTVRFNPNFYRNGKVCLSILGTWTGPAWSPAQSISSVLISIQSLMT
                     ENPYHNEPGFEQERHPGDSKNYNECIRHETIRVAVCDMMEGKCPCPEPLRGVMEKSFL
                     EYYDFYEVACKDRLHLQGQTMQDPFGEKRGHFDYQSLLMRLGLIRQKVLERLHNENAE
                     MDSDSSSSGTETDLHGSLRV"
     exon            415..487
                     /gene="UBE2Z"
                     /gene_synonym="HOYS7; USE1"
                     /inference="alignment:Splign:2.1.0"
     exon            488..675
                     /gene="UBE2Z"
                     /gene_synonym="HOYS7; USE1"
                     /inference="alignment:Splign:2.1.0"
     exon            676..787
                     /gene="UBE2Z"
                     /gene_synonym="HOYS7; USE1"
                     /inference="alignment:Splign:2.1.0"
     exon            788..900
                     /gene="UBE2Z"
                     /gene_synonym="HOYS7; USE1"
                     /inference="alignment:Splign:2.1.0"
     exon            901..991
                     /gene="UBE2Z"
                     /gene_synonym="HOYS7; USE1"
                     /inference="alignment:Splign:2.1.0"
     exon            992..3084
                     /gene="UBE2Z"
                     /gene_synonym="HOYS7; USE1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3063..3068
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBE2Z"
                     /gene_synonym="HOYS7; USE1"
                     /note="hexamer: AATAAA"
     polyA_site      3084
                     /gene="UBE2Z"
                     /gene_synonym="HOYS7; USE1"
                     /note="major polyA site"
ORIGIN      
        1 actctggccc ggttctcggt ggtgcgggag cgggcgggag cagcggccgc tctggtcggc
       61 ggacgtgctg ccgagtagtc ccggaagcga agcagcgatg gcggagagtc cgactgagga
      121 ggcggcaacg gcgggcgccg gggcggcggg ccccggggcg agcagcgttg ctggtgttgt
      181 tggcgttagc ggcagcggcg gcgggttcgg gccgcctttc ctgccggatg tgtgggcggc
      241 ggcggcggca gcgggcgggg ccgggggccc ggggagcggc ctggctccgc tgcccgggct
      301 cccgccctca gccgctgccc acggggccgc gctgcttagc cactgggacc ccacgctcag
      361 ctccgactgg gacggcgagc gcaccgcgcc gcagtgtcta ctccggatca agcgggatat
      421 catgtccatt tataaggagc ctcctccagg aatgttcgtt gtacctgata ctgttgacat
      481 gactaagatt catgcattga tcacaggccc atttgacact ccttatgaag ggggtttctt
      541 cctgttcgtg tttcggtgtc cgcccgacta tcccatccac ccacctcggg tcaaactgat
      601 gacaacgggc aataacacag tgaggtttaa ccccaacttc taccgcaatg ggaaagtctg
      661 cttgagtatt ctaggtacat ggactggacc tgcctggagc ccagcccaga gcatctcctc
      721 agtgctcatc tctatccagt ccctgatgac tgagaacccc tatcacaatg agcccggctt
      781 tgaacaggag agacatccag gagacagcaa aaactataat gaatgtatcc ggcacgagac
      841 catcagagtt gcagtctgtg acatgatgga aggaaagtgt ccctgtcctg aacccctacg
      901 aggggtgatg gagaagtcct ttctggagta ttacgacttc tacgaggtgg cctgcaaaga
      961 tcgcctgcac cttcaaggcc aaactatgca ggaccctttt ggagagaagc ggggccactt
     1021 tgactaccag tccctcttga tgcgcctggg actgatacgt cagaaagtgc tggagaggct
     1081 ccataatgag aatgcagaaa tggactctga tagcagttca tctgggacag agacagacct
     1141 tcatgggagc ctgagggttt agaccctgct cccatctccc cttcccccac tcaagagtcc
     1201 cagcagaatc ccttcccccc accccaggga tggagaggca ctgtgtatct ccctccagac
     1261 tcgaagtcat cctgcaagat ggcaagaacc aagcaagctc cgatcccagg gtgtgggagt
     1321 gggggcctgt tcccggtctg acctccttgg cactggagca tctggggctt cgttcatcca
     1381 ttcatcccgt atcaggggcc aaggtacctt tacaggagca cctagagcga gggcctttgg
     1441 caaaaacaaa acaaccaaca cacctctcca cagggccagc tccttaggga taagtggaag
     1501 atggaaattg caattccaag agggagtgtg cccaaatgat ttatggggat acctggaagg
     1561 gagcttgggg tgggggctgt ctgtgacact taagcagtct gggtggttgt ctatttgtct
     1621 gtcttcagtc ttgaagcagg gcttcccaat gcccttttcc tccctgcctt ccttccccca
     1681 ttatttccca caggccagca taattttgtt tttcctaatt tatagtcact gttctagaca
     1741 gaccaaagag aaggaacagt ggtggagtct aggctgctga tcagtaagct ttacctagca
     1801 cctgagcacc tttctcccct cccctctttc ctcacccttt tctagatgta agacagaaag
     1861 taaatgtgac tgggacttaa ccaaggtctt ggtaaagcct gcatggcacc gtaagaagct
     1921 gaaaatactg tttgttcccg caatcactga tttgaaaagt tcccaacaca ggcagctgct
     1981 gtgtatatgg gattagagcc actacataga atagtctctt acagattttc ataaatacta
     2041 gtcacaataa gggtattttt cttgggggtg gagtaagggg gagactgatg ctagtccttg
     2101 ttgtattttg ttgggctgtc cttgtgtatt ttcaccccag cctgtagtcc tcctcacttc
     2161 aaccccaggg atttttgggg agcaagggta gccaatggca gagggggttg gggctgggac
     2221 tctggaggct cctccccttc tttctcttcc ttccgcctcc cccgtgcccc cagctgctct
     2281 tgtcactgtc tctgatgggt atttgcctgg ctttgttgct tctctatctg tatttagctg
     2341 cagtgatcct ttagctggtt ggctcagaaa aaaaaaaatg tgctttaggt gccctgtaat
     2401 cctgggcatc aagggaatcc atccttcccc tttttgatat gttctccccg tacttccaga
     2461 tttattgtta tggctcccag tgggtattgg cgattcttgt gatgcagggc ctcagtcagt
     2521 gtccagccat gcataaggga gaggatagtg tgtacctgcc ctgccctctg ctatgaaggt
     2581 ctctgccttg tggatcatgg gactcccctt ggaggatctg tgcaaagggg ggctgggcac
     2641 aaaggagaat gtcctatttg ggagggcagg aagcaaagga actggacagg gattggtggg
     2701 cttggggaac ggaagtttat cttggatacc cttgaagagg ctgggtctct tcacatgaag
     2761 atcgaaaagg gaccctgctt ccaatttccc tcttccattc ctcgagctac tccagggctt
     2821 agaagaatgc tcttggtctg tgggtccagt gttgtctgtc atccatttaa gtgttcccac
     2881 tttcaagtga caatcctctc cttggccctg ccatagggca gagcatgtct ggcatagcag
     2941 cctgactttt atgccctaat cttgagttga ggaaatatat gcacaggagt caaagagatg
     3001 tctttatatc tgactgtata taaatgaagt ttttttgttt tttttgtttt cctttttggt
     3061 gcaataaagt ttgttttggc agaa
//
