LOCUS       NM_018299               8379 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens ubiquitin conjugating enzyme E2 W (UBE2W), transcript
            variant 2, mRNA.
ACCESSION   NM_018299
VERSION     NM_018299.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8379)
  AUTHORS   Zang,J., Chen,Y., Liu,C., Hu,L., Zhao,H., Ding,W., Yuan,Y. and
            Lin,S.
  TITLE     Genetic code expansion reveals aminoacylated lysine ubiquitination
            mediated by UBE2W
  JOURNAL   Nat Struct Mol Biol 30 (1), 62-71 (2023)
   PUBMED   36593310
  REMARK    GeneRIF: Genetic code expansion reveals aminoacylated lysine
            ubiquitination mediated by UBE2W.
REFERENCE   2  (bases 1 to 8379)
  AUTHORS   Seo,S.U., Woo,S.M., Kim,M.W., Lee,E.W., Min,K.J. and Kwon,T.K.
  TITLE     Phosphorylation of OTUB1 at Tyr 26 stabilizes the mTORC1 component,
            Raptor
  JOURNAL   Cell Death Differ 30 (1), 82-93 (2023)
   PUBMED   35927303
REFERENCE   3  (bases 1 to 8379)
  AUTHORS   Luptak,J., Mallery,D.L., Jahun,A.S., Albecka,A., Clift,D.,
            Ather,O., Slodkowicz,G., Goodfellow,I. and James,L.C.
  TITLE     TRIM7 Restricts Coxsackievirus and Norovirus Infection by Detecting
            the C-Terminal Glutamine Generated by 3C Protease Processing
  JOURNAL   Viruses 14 (8), 1610 (2022)
   PUBMED   35893676
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8379)
  AUTHORS   Yuan,Y., Xiao,W.W., Xie,W.H., Li,R.Z. and Gao,Y.H.
  TITLE     Prognostic value of ubiquitin E2 UBE2W and its correlation with
            tumor-infiltrating immune cells in breast cancer
  JOURNAL   BMC Cancer 21 (1), 479 (2021)
   PUBMED   33931024
  REMARK    GeneRIF: Prognostic value of ubiquitin E2 UBE2W and its correlation
            with tumor-infiltrating immune cells in breast cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8379)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 8379)
  AUTHORS   David,Y., Ziv,T., Admon,A. and Navon,A.
  TITLE     The E2 ubiquitin-conjugating enzymes direct polyubiquitination to
            preferred lysines
  JOURNAL   J Biol Chem 285 (12), 8595-8604 (2010)
   PUBMED   20061386
REFERENCE   7  (bases 1 to 8379)
  AUTHORS   Ye,Y. and Rape,M.
  TITLE     Building ubiquitin chains: E2 enzymes at work
  JOURNAL   Nat Rev Mol Cell Biol 10 (11), 755-764 (2009)
   PUBMED   19851334
  REMARK    Review article
REFERENCE   8  (bases 1 to 8379)
  AUTHORS   Alpi,A.F., Pace,P.E., Babu,M.M. and Patel,K.J.
  TITLE     Mechanistic insight into site-restricted monoubiquitination of
            FANCD2 by Ube2t, FANCL, and FANCI
  JOURNAL   Mol Cell 32 (6), 767-777 (2008)
   PUBMED   19111657
REFERENCE   9  (bases 1 to 8379)
  AUTHORS   Christensen,D.E., Brzovic,P.S. and Klevit,R.E.
  TITLE     E2-BRCA1 RING interactions dictate synthesis of mono- or specific
            polyubiquitin chain linkages
  JOURNAL   Nat Struct Mol Biol 14 (10), 941-948 (2007)
   PUBMED   17873885
REFERENCE   10 (bases 1 to 8379)
  AUTHORS   Yin,G., Ji,C., Wu,T., Shen,Z., Xu,X., Xie,Y. and Mao,Y.
  TITLE     Cloning, characterization and subcellular localization of a gene
            encoding a human Ubiquitin-conjugating enzyme (E2) homologous to
            the Arabidopsis thaliana UBC-16 gene product
  JOURNAL   Front Biosci 11, 1500-1507 (2006)
   PUBMED   16368532
  REMARK    GeneRIF: human Ubiquitin-conjugating enzyme (E2) is homologous to
            the Arabidopsis thaliana UBC-16 gene product and contains 2 nuclear
            localization signals
            Publication Status: Online-Only
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK295792.1, BC016326.1,
            BX538145.1 and AC022826.12.
            
            On May 17, 2019 this sequence version replaced NM_018299.5.
            
            Summary: This gene encodes a nuclear-localized
            ubiquitin-conjugating enzyme (E2) that, along with
            ubiquitin-activating (E1) and ligating (E3) enzymes, coordinates
            the addition of a ubiquitin moiety to existing proteins. The
            encoded protein promotes the ubiquitination of Fanconi anemia
            complementation group proteins and may be important in the repair
            of DNA damage. There is a pseudogene for this gene on chromosome 1.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Aug 2012].
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the coding region, compared to variant 1. The encoded
            isoform (2) is shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.154025.1,
                                           SRR1660805.129361.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000602593.6/ ENSP00000473561.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AK295792.1         49-50
            3-713               BC016326.1         5-715
            714-3986            BX538145.1         582-3854
            3987-8379           AC022826.12        89711-94103         c
FEATURES             Location/Qualifiers
     source          1..8379
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.11"
     gene            1..8379
                     /gene="UBE2W"
                     /gene_synonym="UBC-16; UBC16"
                     /note="ubiquitin conjugating enzyme E2 W"
                     /db_xref="GeneID:55284"
                     /db_xref="HGNC:HGNC:25616"
                     /db_xref="MIM:614277"
     exon            1..55
                     /gene="UBE2W"
                     /gene_synonym="UBC-16; UBC16"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..496
                     /gene="UBE2W"
                     /gene_synonym="UBC-16; UBC16"
                     /EC_number="2.3.2.23"
                     /EC_number="2.3.2.25"
                     /note="isoform 2 is encoded by transcript variant 2;
                     ubiquitin-conjugating enzyme 16; ubiquitin-protein ligase
                     W; ubiquitin conjugating enzyme E2 W (putative); ubiquitin
                     carrier protein W; ubiquitin-conjugating enzyme 2W;
                     N-terminus-conjugating E2; E2 ubiquitin-conjugating enzyme
                     W; N-terminal E2 ubiquitin-conjugating enzyme; ubiquitin
                     conjugating enzyme E2W (putative)"
                     /codon_start=1
                     /product="ubiquitin-conjugating enzyme E2 W isoform 2"
                     /protein_id="NP_060769.5"
                     /db_xref="CCDS:CCDS47874.3"
                     /db_xref="GeneID:55284"
                     /db_xref="HGNC:HGNC:25616"
                     /db_xref="MIM:614277"
                     /translation="MASMQKRLQKELLALQNDPPPGMTLNEKSVQNSITQWIVDMEGA
                     PGTLYEGEKFQLLFKFSSRYPFDSPQVMFTGENIPVHPHVYSNGHICLSILTEDWSPA
                     LSVQSVCLSIISMLSSCKEKRRPPDNSFYVRTCNKNPKKTKWWYHDDTC"
     exon            56..147
                     /gene="UBE2W"
                     /gene_synonym="UBC-16; UBC16"
                     /inference="alignment:Splign:2.1.0"
     exon            148..250
                     /gene="UBE2W"
                     /gene_synonym="UBC-16; UBC16"
                     /inference="alignment:Splign:2.1.0"
     exon            251..406
                     /gene="UBE2W"
                     /gene_synonym="UBC-16; UBC16"
                     /inference="alignment:Splign:2.1.0"
     exon            407..482
                     /gene="UBE2W"
                     /gene_synonym="UBC-16; UBC16"
                     /inference="alignment:Splign:2.1.0"
     exon            483..8379
                     /gene="UBE2W"
                     /gene_synonym="UBC-16; UBC16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3965..3970
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBE2W"
                     /gene_synonym="UBC-16; UBC16"
                     /note="hexamer: AATAAA"
     polyA_site      3986
                     /gene="UBE2W"
                     /gene_synonym="UBC-16; UBC16"
                     /note="major polyA site"
     regulatory      6450..6455
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBE2W"
                     /gene_synonym="UBC-16; UBC16"
                     /note="hexamer: AATAAA"
     polyA_site      6470
                     /gene="UBE2W"
                     /gene_synonym="UBC-16; UBC16"
                     /note="major polyA site"
     regulatory      7127..7132
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBE2W"
                     /gene_synonym="UBC-16; UBC16"
                     /note="hexamer: AATATA"
     polyA_site      7148
                     /gene="UBE2W"
                     /gene_synonym="UBC-16; UBC16"
     regulatory      7672..7677
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBE2W"
                     /gene_synonym="UBC-16; UBC16"
                     /note="hexamer: ATTAAA"
     polyA_site      7699
                     /gene="UBE2W"
                     /gene_synonym="UBC-16; UBC16"
     regulatory      8357..8362
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBE2W"
                     /gene_synonym="UBC-16; UBC16"
                     /note="hexamer: AATAAA"
     polyA_site      8379
                     /gene="UBE2W"
                     /gene_synonym="UBC-16; UBC16"
ORIGIN      
        1 gcgtctctgg cctcgccggt cttgggggga tggttccatc atggcgtcaa tgcagaaacg
       61 actacagaaa gaactgttgg ctttgcaaaa tgacccacct cctggaatga ccttaaatga
      121 gaagagtgtt caaaattcaa ttacacagtg gattgtagac atggaaggtg caccaggtac
      181 cttatatgaa ggggaaaaat ttcaacttct atttaaattt agtagtcgat atccttttga
      241 ctctcctcag gtcatgttta ctggtgaaaa tattcctgtt catcctcatg tttatagcaa
      301 tggtcatatc tgtttatcca ttctaacaga agactggtcc ccagcgctct cagtccaatc
      361 agtttgtctt agcattatta gcatgctttc cagctgcaag gaaaagagac gaccaccgga
      421 taattctttt tatgtgcgaa catgtaacaa gaatccaaag aaaacaaaat ggtggtatca
      481 tgatgatact tgttgatgcc actgttatca tcctcctagc agaagatagt cctactgaga
      541 aaatgagcac tttgatcatt cagtctttga actttaacct ttgactggaa gtgacctata
      601 ggcaatgaag actacttcct tttactgcat ttttactcgt gtgcattctg ggcgcatgtt
      661 gatcgctggt tcagtccagg caactgacat gcttttatta gtcatacagt attaatgcag
      721 gtgtcaggaa atgtcaaata taattccatt ttttattttt atttttttaa gcttttggaa
      781 aagctccagg tcctcatgta ttgtgcaata acaatgactt ccttggcggt tttggtacgt
      841 tcattgccgg caatgggcgt tgtaacagga aaagttttca ttaactcctg ccattcaatg
      901 attaatgcat gatagggcct atgaaatgaa cttactggtt atagtgggaa tataaataaa
      961 gtgagggatc caacattact ttaaaagtca ccccaactgt ttatatttgg attctatgca
     1021 ctgtgatcct aaggttaaca gcatgaatta acatgcgtct ttaaaggact gtaatgaaag
     1081 atcattgcat atttattgaa ttgtttatat ctactgtcaa gttgttttga catggaagat
     1141 tttcaagtaa cattggcaga gaggtacagt atgttatccc tatggtgaaa ataaattaat
     1201 ttgttgtata tagttcctca atctctgaag taaaggtatg agtaatatag ggtatgaatg
     1261 gtttaatcaa ggctttattt tggaagtaag aaaaatggca gtgatgatta aattgctgca
     1321 gtccataatt tgggcttgtt atttgtacat taaagatttt ttccaagtaa gttacactct
     1381 gttaacttcc tgctagccat cagcatgagc cctactgcct aaacactatt tcatttattt
     1441 atgtttggaa accccgtaaa catttttgtt tgcaatcttg tttcttttgt tataagtcaa
     1501 gtttgaatgt tacaatactt ttattgaaac ttttgttaag ttttttcttg taaattttct
     1561 ttacttgtga gtatcatctt gtcctttaat cctgtaccct aaaataagaa atacattttt
     1621 gacagaggct taatgtttta acaaaagagt gtggacattt ttattttaaa atttaggcaa
     1681 aagtcactat caaatggttg cttatttgtc tcacacagcc atatagtttt tcctggaggg
     1741 ttttgttttg ttgttgttga aaagactttg cttacagcta gatgaaactt tctatagaaa
     1801 aaaaaaattg ttgaaaggtc cagttctcag taccatgtga gttaatgata ctacaactaa
     1861 gttcttttta aaaagtgatt aatgtatttt ataaattacc ttttcacata tgcaaaatct
     1921 gtttctacta caatgttatt tttactaatg ccttattgtt gcactctttt tgaaatatcc
     1981 tgcagtgaat atatgaatca atttgggctt aaaactgaaa gccagttggc tgaaaggttt
     2041 gaaatacgta ccccagtaaa accattcaat caataattgg taaataatat tttaaaattg
     2101 tttttaatct gtatagatga cattttgtag ctttgtacat gttgttaatt aagggcatat
     2161 aattttacac tcaaagtata attgctgaac tcaggggtgg gtagacttca aaaatatgtc
     2221 tgctatagaa ataacttgaa aaaaaaaatt aaaaccgtgg ccagccacca aattgtggac
     2281 actgtttata tactgctagt taacaattac cacttttaaa aaattataac cgtttttgtt
     2341 ctatcttgac tagataaatt ctcacaatga tctctgtcag ttttattagt tggcctgttt
     2401 aaccaagaca gaaagtcttt gaattactca tagttttaaa ctgcttttaa tatgaaaatt
     2461 gcagctgtaa attatgtatt ttcatatttt gcgtaactgc tctacactac tgtttgactt
     2521 gatcttcttc tgggggttag ggagaaatct gtctccatat tgctggttct cttaccaaaa
     2581 tgcttttata aagaaatgac cggtgacatt tattcaccaa aggaattaat atactgagtc
     2641 aaagattaac aatgctatac tatagagtaa taggtcatat atagcctcaa ttgagttttt
     2701 tatgacaata ttttaacata cctctctctc tacatataaa taccataaag taaactaaaa
     2761 tgacacagag gaaagtagag gaaaatgaaa taatttcggt acatcttatg gtttaaagag
     2821 tagaaaataa gatgaaatat cctaaaatat aggagcacag acatttaaaa ttcataatca
     2881 ggctaacaac actctcttga atttaggaat cattgaaaac tccttgcact tagatttaat
     2941 ttatatgtta gttacattat taaaagtcat aaggcattta tctgagtcat tgctctacag
     3001 agagcaatta atggcttgta ataataaaaa gaatatttct ctgtaatgca ttgttgaaag
     3061 acaaccagaa tatcaagaaa atgtatatag gaatatgcta cttgcctcct ccctgcattt
     3121 cctcgtgggg cactatttgc gacataggcc tacagaatta gactttcata cttagaagat
     3181 aaggtacact cttcttcttt tatttattta tttatttatt tttaggccat tcttctggtt
     3241 tgccaaattc tattaagaca gtgatacatt tgcttcctta tttatgcatg cttagatcat
     3301 gaacatgatg cccttctttt tttttttttt ctttggtcaa gtagggatta atgccatagg
     3361 tttagagaga aggattgttt tcagttttta agagaatttt ttaaaaatac attttatggt
     3421 tctcttaagg aattaatatt cacttctgaa ggacttactt gtaatatata atttatcatt
     3481 ttagccagca gggaaataaa tcatttttaa tccccagaag aaagtgctgg aaatagcttc
     3541 tatatagtca gcagttcacc tggagaaaga tcttaattcc ttgttgtttt gactaggaat
     3601 atcaatattt ggtataaaat aactagaata gtttattacc ttttccctca tgaaatttta
     3661 aatatatgca aatatatata tcattagatt cctgtggtgg ataataattt cttcagattc
     3721 taaaacaggt gtctagtgac tgcttaattg tttccaagtt gcatcaaaga tgaattggta
     3781 aataatggaa atgagtagtg atatgaaaat ggttatgtaa ctacatatta cttgtttctg
     3841 gtaatcaagt cttatttttt aaaagcctat tgtttttcag aattgagata tttaaaactt
     3901 gttataactt cttcctaaaa atagaagaga agaggaggta ctgtgtgtta caaaaatttt
     3961 tttaaataaa gaattcagtg tcactagttc taagccttta tggttactgc tgcttatatt
     4021 tcttgatctc actttcatta atttttttgt acatatctta gctgaatgct taaaatttac
     4081 aattatttgt aattgtgtat gtaaattgct tttcaaaaag aactgaagct taaccatatt
     4141 cttcttttct gaggattcat tatcagaatc agctactata ctgttctgtg ttatagtaat
     4201 gccgttactg cctgtgcatg attgaggtct gtgaagaagg tgtcttttaa tctgcaccaa
     4261 ctggccccaa tcctctttgt agtccttttt aaattgtttt aaatctgtcc tttatttttc
     4321 ttcctatttt tctgcctctt cccactgatg tccaatgtgt cagtcttccg cagtttcctt
     4381 ttctcacttc taatttattc tctctttttt ttttctgagg ttagggattc tacagaagga
     4441 cgattattaa aattatgcca tgaatttttg aaaaatttaa aatgctctcc tacaaataaa
     4501 atacatggag tttctgatac taatttcagt ttgtcagtag atggctaaat ttgttgaata
     4561 attgactact tggtaaatga gctgttagct gtaattagtt ctttagtact aatattaagg
     4621 aaattttgtt attttcggat gaggactctc ccaaagccaa attattgtcc aagcaaatta
     4681 tttatttttt ccatttaaat ttctaagtca ttttgagatg tggaatgatt atttttatta
     4741 tttatttatt tatttatttt tgagacggag tcttgctctg tcacccgggc tttagtgcag
     4801 tgcacgatct tggctcattt caatctccac ctcctgggtc taagcgattc tcctgcctca
     4861 gcctcttgag tagctgggat tacaggcatg tgctgccaca cctgactaat ttttagtaga
     4921 gacaaggttt caccgtgttg gccaggctgg tgttgaactc ctgacttcaa gtgatctgcc
     4981 cacctcagcc tcccaaagtg ctgcgattac aggcatgacc caccacaccc agcctggaat
     5041 cattttttaa aaataatttg tgggagactt gctttctcaa cataaattgt gtgtgggttg
     5101 ttttttgttt tttgagacgg tcttcctctg ttgcccaggc tggagtgtgc agtggaacag
     5161 tcattgcagc cttgaccacc ttggctcaag caatcctcct gcctcccggg tagctgagtc
     5221 tacaggtgtg tgccaccatg cctggatgga tagaattttt tttttttttt tttttttttt
     5281 tttttttttt aaagacacga ggtctcacca tgttgcccag gctgatcttg aattcctggg
     5341 ctcaagcatt cctcctgcct cagcctccca aaatgctggg attacaggtg caagccacca
     5401 tgcctcgtct gtttgccgat ttaagacagg tttatgtaca tcattatcat tagaggcaca
     5461 tagaatctag acatgtactt gaaacttagc tctctatcct gaaagttgaa gttagggttc
     5521 tttgatcctg gtgagatgtt aattgtaatt ttaattttca tatgttaata ttgtgacttg
     5581 tattttgtga tgagtctcta gaatgattaa atgactattt ttttatgaaa aattttttgt
     5641 taataaaata tctgagggta ttttgagtat gtggaaggaa tgcctgaata gaagctgatc
     5701 tatcttaaca tacctcaaga actccagttt taatatggtg agtgaggagt tgactgggaa
     5761 aaggagagat ccaattcttg ttctagtcct tggcacatac actctctggg ttttgagaaa
     5821 aggatggtcc tacaacgatt ctaagttgtt ttctcattgg tcctacaaca attctaagtt
     5881 gttttctcaa aggcaaaagc atgatttcaa aatgacatca cttgtcagat tttctggtgt
     5941 atggaaagat ttaataatcc tgcctctttt gaagcctgaa acttacaatt taaagcctga
     6001 aatctaccat aaggaacttg gtaaattgtg tcagatacca tgaaaatgca tcttttcata
     6061 gttaaccaca gattgtttat gtaaaggcaa attggtggtc aggttcaagg taaaatggat
     6121 tattgggttg attagtagcc aaaaactaaa tgcatgttca ggtcaaaatg aatttgtttg
     6181 ttttagttgg tgccattttc cttttattat tcagaactac agagtgtgca ttttattaat
     6241 aggaatgaaa gctcatgctt gaggatttga atagggtgga tgtatatatt ttataaactc
     6301 aagttgcaaa atatgtaaag tcactacttt ttaaatagaa tataaatgtt aaaacagaca
     6361 aatctatgtt atatattttt taatacatgt atcagacttg ttagttgaat gcagattact
     6421 ttgctttatg gaatttcata acttttaata ataaagcagt tgttattgga ttttttctgt
     6481 agacttgaat actaaatggg atagatacca gacctctttt tggtttatga cgtaaaagta
     6541 tttgtacagt agtttctctt cacaaaagac tgaattttaa aggattatag aaacaggaac
     6601 atgtccattt ccaaaatgag tgcaacagaa tgaagatagt cacttaaacc atctatttaa
     6661 cacatcacct ttatgtaata tgtagctagt tttagtgttt taataagtcc caactaaaga
     6721 ctgagtgttt tcagtgaaga tggaaatgga gacccaggca cttgcttaga gttatcgtga
     6781 gtccgatgtt cctgaacttc aagttgtaca attaagggca tactctaaga acttctggat
     6841 gctttctgga gtatacaaac agatcaacta atgacttaaa tgagtgactc ttgaagctgc
     6901 aagaagagga aagaaataac cacaagaagg ggctatctca gcatctgtta ttcctgacag
     6961 gaggaattaa atatgctctg ctggtaattc taagcttttc tgcaggggat ctgcttgccc
     7021 caggagcacc ttagtcctca ttgaggcagc cattctgcca taaaaacgat catgtctcaa
     7081 gctgttcctg ccgtcctaca caactatgtt agtagatggt tagataaata tatgaaccat
     7141 cttttgtact ttgatgatgc ccttttcctt tattataatc cttaatttct actttccata
     7201 gtaggatttg acttttctcc attagtttaa gctaccctgg ataagtgact ctgtttatgt
     7261 cctccctata tttcttactc attttcacac taacataaca cgtaacaaaa ttaaacataa
     7321 gctaaattga agaagcaagt gagacagcta agagttttgt gtacttggac aacaaagctc
     7381 aaagccactg tggttatctg tcctgttggg agcccctttc aaccattttt ttagttgcct
     7441 gtaagattta tttttaatgt ttgcctgcat aatgcaaaat acataagtgg gaatccctac
     7501 gccctttaca gttaagtgga ttatggaaat aataaggaaa gtttatcaac taaggtagga
     7561 aatatcttct catgtctgta tctggccttc agggacttaa tgtgggtgaa tatatgtcat
     7621 tagacaagat cctaatatag atggctgtat cctgcagata gccaattcaa cattaaaatt
     7681 ttatgtttcc atacctcaat gaaaacatat ttcttttatc ctgttataat ttaatgacat
     7741 tcccatccaa cttaatcaag caatgatact cagtagtcct ctccttgcat ttttcaagtc
     7801 ctgttgagtg taactttaaa atgtctctga gatttctacc ttctctccag tctccttacc
     7861 attagggcct ttcactacct ggccttggtg tccctaggct gctcttcagc tgtccacaaa
     7921 ccttgtttca taagcagtag caatgcaagc ttccactgcc gtctgctaat gttcttccct
     7981 cctagaatgt tcatgatctg cgtttctacc tgaaaggtct agttcaaagg tagctgaaag
     8041 gttatcatcc ttgtcctttc ttctctccct accagtcatc tatcctgaac tttttaacag
     8101 tagggacagt gttgcaattg tgtttgtgtc cccagcacgt agcacacagt acctagtata
     8161 cagtacctgt agcacatagg catttaataa gtgtgtattg aattaacttg gttatgcttg
     8221 tatttttatc ctagctttct caaagaaact taggtgctag ctattttgaa acatatatcc
     8281 agaaccacca cctgagtaaa atgtataaca ggaccctgct ctttctatcc cagagagttt
     8341 gagaaaacta cttttaaata aatcattaat cattcttca
//
