LOCUS       NM_003350               4342 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ubiquitin conjugating enzyme E2 V2 (UBE2V2), mRNA.
ACCESSION   NM_003350
VERSION     NM_003350.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4342)
  AUTHORS   Yang,Z., Wu,G., Zhao,J., Shi,G., Zhou,J. and Zhou,X.
  TITLE     UBE2V2 promotes metastasis by regulating EMT and predicts a poor
            prognosis in lung adenocarcinoma
  JOURNAL   Cancer Med 12 (19), 19850-19865 (2023)
   PUBMED   37755128
  REMARK    GeneRIF: UBE2V2 promotes metastasis by regulating EMT and predicts
            a poor prognosis in lung adenocarcinoma.
REFERENCE   2  (bases 1 to 4342)
  AUTHORS   Hua,Z.D., Liu,X.B., Sheng,J.H., Li,C., Li,P., Cai,X.Q. and Han,Z.Q.
  TITLE     UBE2V2 Positively Correlates With PD-L1 Expression and Confers Poor
            Patient Survival in Lung Adenocarcinoma
  JOURNAL   Appl Immunohistochem Mol Morphol 29 (8), 585-591 (2021)
   PUBMED   33734107
  REMARK    GeneRIF: UBE2V2 Positively Correlates With PD-L1 Expression and
            Confers Poor Patient Survival in Lung Adenocarcinoma.
REFERENCE   3  (bases 1 to 4342)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 4342)
  AUTHORS   Wu,Z., Andersen,P.L., Moraes,T., McKenna,S.A., Zhang,Y., Zhang,W.,
            Ellison,M.J. and Xiao,W.
  TITLE     Uev1A amino terminus stimulates poly-ubiquitin chain assembly and
            is required for NF-kappaB activation
  JOURNAL   Cell Signal 74, 109712 (2020)
   PUBMED   32659264
  REMARK    GeneRIF: Uev1A amino terminus stimulates poly-ubiquitin chain
            assembly and is required for NF-kappaB activation.
REFERENCE   5  (bases 1 to 4342)
  AUTHORS   Renz,C., Albanese,V., Troster,V., Albert,T.K., Santt,O.,
            Jacobs,S.C., Khmelinskii,A., Leon,S. and Ulrich,H.D.
  TITLE     Ubc13-Mms2 cooperates with a family of RING E3 proteins in budding
            yeast membrane protein sorting
  JOURNAL   J Cell Sci 133 (10) (2020)
   PUBMED   32265276
  REMARK    GeneRIF: Ubc13-Mms2 cooperates with a family of RING E3 proteins in
            budding yeast membrane protein sorting.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4342)
  AUTHORS   Chan,N.L. and Hill,C.P.
  TITLE     Defining polyubiquitin chain topology
  JOURNAL   Nat Struct Biol 8 (8), 650-652 (2001)
   PUBMED   11473244
REFERENCE   7  (bases 1 to 4342)
  AUTHORS   Hofmann,R.M. and Pickart,C.M.
  TITLE     Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in
            assembly of novel polyubiquitin chains for DNA repair
  JOURNAL   Cell 96 (5), 645-653 (1999)
   PUBMED   10089880
REFERENCE   8  (bases 1 to 4342)
  AUTHORS   Xiao,W., Lin,S.L., Broomfield,S., Chow,B.L. and Wei,Y.F.
  TITLE     The products of the yeast MMS2 and two human homologs (hMMS2 and
            CROC-1) define a structurally and functionally conserved Ubc-like
            protein family
  JOURNAL   Nucleic Acids Res 26 (17), 3908-3914 (1998)
   PUBMED   9705497
REFERENCE   9  (bases 1 to 4342)
  AUTHORS   Sancho,E., Vila,M.R., Sanchez-Pulido,L., Lozano,J.J., Paciucci,R.,
            Nadal,M., Fox,M., Harvey,C., Bercovich,B., Loukili,N.,
            Ciechanover,A., Lin,S.L., Sanz,F., Estivill,X., Valencia,A. and
            Thomson,T.M.
  TITLE     Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating
            enzymes, in in vitro differentiation and cell cycle behavior of
            HT-29-M6 intestinal mucosecretory cells
  JOURNAL   Mol Cell Biol 18 (1), 576-589 (1998)
   PUBMED   9418904
REFERENCE   10 (bases 1 to 4342)
  AUTHORS   Fritsche,J., Rehli,M., Krause,S.W., Andreesen,R. and Kreutz,M.
  TITLE     Molecular cloning of a 1alpha,25-dihydroxyvitamin D3-inducible
            transcript (DDVit 1) in human blood monocytes
  JOURNAL   Biochem Biophys Res Commun 235 (2), 407-412 (1997)
   PUBMED   9199207
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC021236.10.
            
            On Aug 17, 2018 this sequence version replaced NM_003350.2.
            
            Summary: Ubiquitin-conjugating enzyme E2 variant proteins
            constitute a distinct subfamily within the E2 protein family. They
            have sequence similarity to other ubiquitin-conjugating enzymes but
            lack the conserved cysteine residue that is critical for the
            catalytic activity of E2s. The protein encoded by this gene also
            shares homology with ubiquitin-conjugating enzyme E2 variant 1 and
            yeast MMS2 gene product. It may be involved in the differentiation
            of monocytes and enterocytes. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7410570.427974.1,
                                           SRR1660805.19159.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000523111.7/ ENSP00000428209.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                AC021236.10        56908-56947         c
            41-189              AC021236.10        22197-22345         c
            190-315             AC021236.10        15400-15525         c
            316-4342            AC021236.10        670-4696            c
FEATURES             Location/Qualifiers
     source          1..4342
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q11.21"
     gene            1..4342
                     /gene="UBE2V2"
                     /gene_synonym="DDVit-1; DDVIT1; EDAF-1; EDPF-1; EDPF1;
                     MMS2; UEV-2; UEV2"
                     /note="ubiquitin conjugating enzyme E2 V2"
                     /db_xref="GeneID:7336"
                     /db_xref="HGNC:HGNC:12495"
                     /db_xref="MIM:603001"
     exon            1..40
                     /gene="UBE2V2"
                     /gene_synonym="DDVit-1; DDVIT1; EDAF-1; EDPF-1; EDPF1;
                     MMS2; UEV-2; UEV2"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..462
                     /gene="UBE2V2"
                     /gene_synonym="DDVit-1; DDVIT1; EDAF-1; EDPF-1; EDPF1;
                     MMS2; UEV-2; UEV2"
                     /note="methyl methanesulfonate sensitive 2, S. cerevisiae,
                     homolog of; 1 alpha,25-dihydroxyvitamin D3-inducible;
                     enterocyte differentiation promoting factor; DDVit 1;
                     vitamin D3-inducible protein; enterocyte
                     differentiation-associated factor EDAF-1; MMS2 homolog;
                     enterocyte differentiation-promoting factor 1; enterocyte
                     differentiation-associated factor 1"
                     /codon_start=1
                     /product="ubiquitin-conjugating enzyme E2 variant 2"
                     /protein_id="NP_003341.1"
                     /db_xref="CCDS:CCDS43738.1"
                     /db_xref="GeneID:7336"
                     /db_xref="HGNC:HGNC:12495"
                     /db_xref="MIM:603001"
                     /translation="MAVSTGVKVPRNFRLLEELEEGQKGVGDGTVSWGLEDDEDMTLT
                     RWTGMIIGPPRTNYENRIYSLKVECGPKYPEAPPSVRFVTKINMNGINNSSGMVDARS
                     IPVLAKWQNSYSIKVVLQELRRLMMSKENMKLPQPPEGQTYNN"
     exon            41..189
                     /gene="UBE2V2"
                     /gene_synonym="DDVit-1; DDVIT1; EDAF-1; EDPF-1; EDPF1;
                     MMS2; UEV-2; UEV2"
                     /inference="alignment:Splign:2.1.0"
     exon            190..315
                     /gene="UBE2V2"
                     /gene_synonym="DDVit-1; DDVIT1; EDAF-1; EDPF-1; EDPF1;
                     MMS2; UEV-2; UEV2"
                     /inference="alignment:Splign:2.1.0"
     exon            316..4342
                     /gene="UBE2V2"
                     /gene_synonym="DDVit-1; DDVIT1; EDAF-1; EDPF-1; EDPF1;
                     MMS2; UEV-2; UEV2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1180..1185
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBE2V2"
                     /gene_synonym="DDVit-1; DDVIT1; EDAF-1; EDPF-1; EDPF1;
                     MMS2; UEV-2; UEV2"
                     /note="hexamer: AATAAA"
     polyA_site      1205
                     /gene="UBE2V2"
                     /gene_synonym="DDVit-1; DDVIT1; EDAF-1; EDPF-1; EDPF1;
                     MMS2; UEV-2; UEV2"
                     /note="major polyA site"
     regulatory      3156..3161
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBE2V2"
                     /gene_synonym="DDVit-1; DDVIT1; EDAF-1; EDPF-1; EDPF1;
                     MMS2; UEV-2; UEV2"
                     /note="hexamer: AATAAA"
     polyA_site      3176
                     /gene="UBE2V2"
                     /gene_synonym="DDVit-1; DDVIT1; EDAF-1; EDPF-1; EDPF1;
                     MMS2; UEV-2; UEV2"
     regulatory      4319..4324
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBE2V2"
                     /gene_synonym="DDVit-1; DDVIT1; EDAF-1; EDPF-1; EDPF1;
                     MMS2; UEV-2; UEV2"
                     /note="hexamer: AATAAA"
     polyA_site      4342
                     /gene="UBE2V2"
                     /gene_synonym="DDVit-1; DDVIT1; EDAF-1; EDPF-1; EDPF1;
                     MMS2; UEV-2; UEV2"
ORIGIN      
        1 ggctgcgtcg ggctgcagga gaagatggcg gtctccacag gagttaaagt tcctcgtaat
       61 tttcgcttgt tggaagaact tgaagaagga caaaaaggag taggcgacgg tacagttagc
      121 tggggccttg aagatgatga agatatgaca cttacaaggt ggacaggcat gattattggg
      181 ccaccaagga caaattatga aaacagaata tatagcctga aagtagaatg tggacctaaa
      241 tacccagaag ctcctccgtc agttagattt gtaacaaaaa ttaatatgaa cggaataaat
      301 aattccagtg ggatggtgga tgcccggagc ataccagtgt tagcaaaatg gcaaaattca
      361 tatagcatta aagttgtact tcaagagcta agacgtctaa tgatgtccaa agaaaatatg
      421 aagcttccac agccaccaga aggacaaaca tacaacaatt aattttagtg gatctcaaac
      481 ttgtcttaaa tcaacaacct tctactcatg ttaatgtctt gattaaatat cacaatgcaa
      541 aatacacatt aagtaaaaga attccagctg gtaaacatga cctggacatt tgtaagaata
      601 tatttaatat atgtacaccc attatgtttt caggtaacag gaggaaaaat gcagcacaat
      661 tttttttctc ttgaaaggca ctgtcattta aacataaacc tggagtactc gaaatagaat
      721 tcaggtttac aagatgaaag cgtgtggaga agtgtcagat ggcagtggaa gcatgtgtgt
      781 ttctaaaaag taaaaatctc aagaaaacag aaatggcatg ctttacccat cttacttagt
      841 gaaagagagc tgcagttgaa attgtttaaa aagtagcagg tacaatgaat attgtcacag
      901 atgtgttaat ttttgaagca atgtgggtgc tgactactag tagtatcaaa aatatgttca
      961 ggattgtttt gatacctgta tttataataa aaaatgttgg ggggagttga tgaattcctg
     1021 ttaaaagctg ttcttgtgtg ttacatgtaa cagacatggt aaatatttgt ttacagtctt
     1081 tgtttaacaa accatgcatt taagtttaag tgaagtcaac aaaaaggaaa taggtgtatg
     1141 gatatgtgat tttgagatta aagttagtct taaaatgtaa ataaaatgtg aaacgtgtcc
     1201 tcagagactg tgccatttct attatgttga tgtatatgta cagtaccttg ccagggaagc
     1261 aaaaattgga attattgtag cttttcatgt atacacactt ttatttaccc tattttgtgt
     1321 acttcttgtg aattataatt tgcagactat ttcagaaaag aaattatcta gtttaatttc
     1381 ttctttggac aaggagtcct aggtattata ttttgagttt gatttcacca gaaataataa
     1441 tattaaaaag atctttgcat tctggcagtt cttttaggat tataggttgc aaattatcca
     1501 aatatatatc ccatttttta aagcataata tcttttttag ttgtttttct gtgaagcttt
     1561 tggttaataa atagggtcaa ctaattggag acttttctct tccaattagg gcttttaata
     1621 ctaacaagga taactttatt cattcctcgt attctctact ctaacaaata tgaactctga
     1681 agttgaaaag tcatttatgt tccgctttca ccaaagtgac gtgaggcttt aggtcactgt
     1741 ttcacttcaa agtactggat ccaaagcttt gttgaaaatg ctgtttgatg aattcactga
     1801 agaatataga aaggtggtca ggtaaagtct acttttattt tgtcaagctt aataatttgt
     1861 gtcatacttt accccagtat atataggcaa accaaaacct tatcaaatat taaattagtt
     1921 gtttaaactt tgcttataaa gtattggcca tgtggtggct catgccgcta atcccagcac
     1981 tttgggaggc tgagacgggc agatcacttg aggtcaggag cttgagacca gcctggccaa
     2041 catgatgaaa ccctgtctct actaaaaata caaaaaatta gccaggtgtg gtggtgggta
     2101 cttgtagtcc cagctactcg ggaggctggg caggagaact acttgaaact ggcagacaga
     2161 ggttgcagtg ccgagagcgc accactgctc cagcctgggc aacagagcaa gactccatct
     2221 caaaaaaaaa aaaaaaaaga aaaatattaa taattgacct tggctgtata ttaaaatagt
     2281 tacttttata gtagagcaca tttctcaaac atgccctgaa aggcttttat caagctcata
     2341 taaagttaaa gctttgagct accttttctt ggccaataaa gtcactgaca gtttatgtaa
     2401 acattaattt caacatggct gttgcatttt aattatcaaa aatgtttaaa atgctttaag
     2461 atgacacata gagaacatac acatacatac aaattagtgc atttgtaatt tgttaaattt
     2521 gaaatgaact attaccttga aatatagtct ttaaaaattt ttaatggtta aagattaaat
     2581 tgaatgaaac tgtagtctaa tggtaactga tgatctgaat ccgtctctct gataacctcc
     2641 tttccatttt gaaaatgtgt cttattatac atggaagcta gtaactacgt gaatgctgtt
     2701 ggcaggatga gggtctgggt acctcagtct cttgtcctgt ttccttcccc caaatccacc
     2761 attgtgaagt tgccaacccc ctgccgcctt cccctgccaa gtacatgttg tcagagtcag
     2821 ccctataatg ttcatttccc ctcttgtttg tgggattatg gatctctgca gaaatctgca
     2881 tgccaattaa cccatttcta aagcagaatc cattttgcat gtcacaatca agatgtactt
     2941 ggcaatctaa gacacactgg gagactgtaa gaggaattaa tatagaaaag ctcttaatta
     3001 taataacatt tggaagaaat ttttcctttg ttttgtaaag tggctaaggt tgtaggagtg
     3061 tgtggtattt attacctttt aaatgaactg taaatttgcc ttagaaattt gtttaaaagg
     3121 ctagcaagtg agacccttga ggatgatcat atactaataa agattaccaa aagaaacttc
     3181 ttgtcctgtt aggtcagtgt tatgatttaa tggttttaat tacttaacca attttaagaa
     3241 ttgacaattt ttaaaaatat ttttttctac cattctaaag taatgtcttt tgttgtgggt
     3301 ttatgtgtaa ctacaggatt ttggaacata aacattttga aggatagtca atggtattta
     3361 gtcttggata taaaaataga gaaaatttat agctttatgt tattaaaata atttatcaca
     3421 cagagtgatt tgaggttttc gcagagtaga tttgtttgac tcatggttta ttagtctgga
     3481 ttacttaaga acaatatgtt gattttaatg ttaattccca ctaaatatat aatattgata
     3541 aatacatgtg aaattaatat tgtttggaaa atgtagagga cacagctggg aattatgaat
     3601 gcttttttct taataggttt ggtgtgtgtg gctttgaatg gttctgctga tgcatcatgg
     3661 aaagacagca gggaactgta gcctgccatc aaaactgtat caactctttt aatgagcatg
     3721 tgactgtatt aggtacattt tgaagaatat aagtactgat gataaagtct agtatgcata
     3781 ataggatttt ggaggcattt caggaatttt ccttttatag tatgcttttt aggcatctgt
     3841 atgtgtaata tcatagtatc atttattgct gggatggatc gaaaagcact gcttttactt
     3901 ttctgataag tatcaaaatg attttccagt accaacttga ctggctttta attattgtca
     3961 cacacacaca aaattcaact cctcaaggtt tgggaaaatt gtgtattttt ttgtatacaa
     4021 gataaaagtg tcataaaaag gaatggatga attgttgata ggaacattag cagttaattt
     4081 ttacctgata ctgagtttac tgtaaaatag gaaatgcata ggaaggaata cctcctaaat
     4141 aatatgcctt atagaatgat gaaatcttac catagttcat actgaaaatg ttgtttattt
     4201 aaaagtattg tggagtgttg aaaataaaga tacacaataa gtattttctg aagagaaaat
     4261 taatgaaggt atttaatgat ataggaaata agtgacaagt taaagtccat tttgtttcaa
     4321 taaaggagtt gtgcaaactc aa
//
