LOCUS       NM_001032288            2110 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens ubiquitin conjugating enzyme E2 V1 (UBE2V1),
            transcript variant 4, mRNA.
ACCESSION   NM_001032288
VERSION     NM_001032288.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2110)
  AUTHORS   Wang,X. and Zhu,Z.
  TITLE     Role of Ubiquitin-conjugating enzyme E2 (UBE2) in two
            immune-mediated inflammatory skin diseases: a mendelian
            randomization analysis
  JOURNAL   Arch Dermatol Res 316 (6), 249 (2024)
   PUBMED   38795139
  REMARK    GeneRIF: Role of Ubiquitin-conjugating enzyme E2 (UBE2) in two
            immune-mediated inflammatory skin diseases: a mendelian
            randomization analysis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2110)
  AUTHORS   Zhang,R., Wang,X., Ying,X., Huang,Y., Zhai,S., Shi,M., Tang,X.,
            Liu,J., Shi,Y., Li,F., Wang,W. and Deng,X.
  TITLE     Hypoxia-induced long non-coding RNA LINC00460 promotes p53 mediated
            proliferation and metastasis of pancreatic cancer by regulating the
            miR-4689/UBE2V1 axis and sequestering USP10
  JOURNAL   Int J Med Sci 20 (10), 1339-1357 (2023)
   PUBMED   37786443
  REMARK    GeneRIF: Hypoxia-induced long non-coding RNA LINC00460 promotes p53
            mediated proliferation and metastasis of pancreatic cancer by
            regulating the miR-4689/UBE2V1 axis and sequestering USP10.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2110)
  AUTHORS   Elangovan,M., Ka,J., Pak,B., Choi,W., Oh,S.R., Jin,S.W. and
            Yoo,Y.J.
  TITLE     Ubiquitin-conjugating enzyme V variant 1 enables cellular responses
            toward fibroblast growth factor signaling in endothelium
  JOURNAL   FASEB J 36 (1), e22103 (2022)
   PUBMED   34921695
  REMARK    GeneRIF: Ubiquitin-conjugating enzyme V variant 1 enables cellular
            responses toward fibroblast growth factor signaling in endothelium.
REFERENCE   4  (bases 1 to 2110)
  AUTHORS   Niu,T., Wu,Z. and Xiao,W.
  TITLE     Uev1A promotes breast cancer cell migration by up-regulating CT45A
            expression via the AKT pathway
  JOURNAL   BMC Cancer 21 (1), 1012 (2021)
   PUBMED   34503444
  REMARK    GeneRIF: Uev1A promotes breast cancer cell migration by
            up-regulating CT45A expression via the AKT pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2110)
  AUTHORS   Hofmann,R.M. and Pickart,C.M.
  TITLE     Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in
            assembly of novel polyubiquitin chains for DNA repair
  JOURNAL   Cell 96 (5), 645-653 (1999)
   PUBMED   10089880
REFERENCE   6  (bases 1 to 2110)
  AUTHORS   Ma,L., Broomfield,S., Lavery,C., Lin,S.L., Xiao,W. and Bacchetti,S.
  TITLE     Up-regulation of CIR1/CROC1 expression upon cell immortalization
            and in tumor-derived human cell lines
  JOURNAL   Oncogene 17 (10), 1321-1326 (1998)
   PUBMED   9771976
REFERENCE   7  (bases 1 to 2110)
  AUTHORS   Xiao,W., Lin,S.L., Broomfield,S., Chow,B.L. and Wei,Y.F.
  TITLE     The products of the yeast MMS2 and two human homologs (hMMS2 and
            CROC-1) define a structurally and functionally conserved Ubc-like
            protein family
  JOURNAL   Nucleic Acids Res 26 (17), 3908-3914 (1998)
   PUBMED   9705497
REFERENCE   8  (bases 1 to 2110)
  AUTHORS   Thomson,T.M., Khalid,H., Lozano,J.J., Sancho,E. and Arino,J.
  TITLE     Role of UEV-1A, a homologue of the tumor suppressor protein TSG101,
            in protection from DNA damage
  JOURNAL   FEBS Lett 423 (1), 49-52 (1998)
   PUBMED   9580084
REFERENCE   9  (bases 1 to 2110)
  AUTHORS   Sancho,E., Vila,M.R., Sanchez-Pulido,L., Lozano,J.J., Paciucci,R.,
            Nadal,M., Fox,M., Harvey,C., Bercovich,B., Loukili,N.,
            Ciechanover,A., Lin,S.L., Sanz,F., Estivill,X., Valencia,A. and
            Thomson,T.M.
  TITLE     Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating
            enzymes, in in vitro differentiation and cell cycle behavior of
            HT-29-M6 intestinal mucosecretory cells
  JOURNAL   Mol Cell Biol 18 (1), 576-589 (1998)
   PUBMED   9418904
REFERENCE   10 (bases 1 to 2110)
  AUTHORS   Rothofsky,M.L. and Lin,S.L.
  TITLE     CROC-1 encodes a protein which mediates transcriptional activation
            of the human FOS promoter
  JOURNAL   Gene 195 (2), 141-149 (1997)
   PUBMED   9305758
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BU934624.1, BC000468.2 and
            BX647511.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001032288.2.
            
            Summary: Ubiquitin-conjugating E2 enzyme variant proteins
            constitute a distinct subfamily within the E2 protein family. They
            have sequence similarity to other ubiquitin-conjugating enzymes but
            lack the conserved cysteine residue that is critical for the
            catalytic activity of E2s. The protein encoded by this gene is
            located in the nucleus and can cause transcriptional activation of
            the human FOS proto-oncogene. It is thought to be involved in the
            control of differentiation by altering cell cycle behavior.
            Alternatively spliced transcript variants encoding multiple
            isoforms have been described for this gene, and multiple
            pseudogenes of this gene have been identified. Co-transcription of
            this gene and the neighboring upstream gene generates a rare
            transcript (Kua-UEV), which encodes a fusion protein comprised of
            sequence sharing identity with each individual gene product.
            [provided by RefSeq, Apr 2012].
            
            Transcript Variant: This variant (4) differs in the 5' UTR and
            initiates translation at an alternate start codon, compared to
            variant 1. The encoded isoform (d) is shorter and has a distinct
            N-terminus, compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.238713.1,
                                           SRR1803617.128390.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371674.8/ ENSP00000360739.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                BU934624.1         19-30
            13-1864             BC000468.2         1-1852
            1865-2110           BX647511.1         1732-1977
FEATURES             Location/Qualifiers
     source          1..2110
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.13"
     gene            1..2110
                     /gene="UBE2V1"
                     /gene_synonym="CIR1; CROC-1; CROC1; UBE2V; UEV-1; UEV1;
                     UEV1A"
                     /note="ubiquitin conjugating enzyme E2 V1"
                     /db_xref="GeneID:7335"
                     /db_xref="HGNC:HGNC:12494"
                     /db_xref="MIM:602995"
     exon            1..44
                     /gene="UBE2V1"
                     /gene_synonym="CIR1; CROC-1; CROC1; UBE2V; UEV-1; UEV1;
                     UEV1A"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..466
                     /gene="UBE2V1"
                     /gene_synonym="CIR1; CROC-1; CROC1; UBE2V; UEV-1; UEV1;
                     UEV1A"
                     /note="isoform d is encoded by transcript variant 4;
                     DNA-binding protein; TRAF6-regulated IKK activator 1 beta
                     Uev1A"
                     /codon_start=1
                     /product="ubiquitin-conjugating enzyme E2 variant 1
                     isoform d"
                     /protein_id="NP_001027459.1"
                     /db_xref="CCDS:CCDS33483.1"
                     /db_xref="GeneID:7335"
                     /db_xref="HGNC:HGNC:12494"
                     /db_xref="MIM:602995"
                     /translation="MAATTGSGVKVPRNFRLLEELEEGQKGVGDGTVSWGLEDDEDMT
                     LTRWTGMIIGPPRTIYENRIYSLKIECGPKYPEAPPFVRFVTKINMNGVNSSNGVVDP
                     RAISVLAKWQNSYSIKVVLQELRRLMMSKENMKLPQPPEGQCYSN"
     exon            45..193
                     /gene="UBE2V1"
                     /gene_synonym="CIR1; CROC-1; CROC1; UBE2V; UEV-1; UEV1;
                     UEV1A"
                     /inference="alignment:Splign:2.1.0"
     exon            194..319
                     /gene="UBE2V1"
                     /gene_synonym="CIR1; CROC-1; CROC1; UBE2V; UEV-1; UEV1;
                     UEV1A"
                     /inference="alignment:Splign:2.1.0"
     exon            320..2110
                     /gene="UBE2V1"
                     /gene_synonym="CIR1; CROC-1; CROC1; UBE2V; UEV-1; UEV1;
                     UEV1A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1843..1848
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBE2V1"
                     /gene_synonym="CIR1; CROC-1; CROC1; UBE2V; UEV-1; UEV1;
                     UEV1A"
                     /note="hexamer: AATAAA"
     polyA_site      1869
                     /gene="UBE2V1"
                     /gene_synonym="CIR1; CROC-1; CROC1; UBE2V; UEV-1; UEV1;
                     UEV1A"
                     /note="major polyA site"
     regulatory      2081..2086
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBE2V1"
                     /gene_synonym="CIR1; CROC-1; CROC1; UBE2V; UEV-1; UEV1;
                     UEV1A"
                     /note="hexamer: AATAAA"
     polyA_site      2110
                     /gene="UBE2V1"
                     /gene_synonym="CIR1; CROC-1; CROC1; UBE2V; UEV-1; UEV1;
                     UEV1A"
ORIGIN      
        1 cttcaagcaa gagcgacgca agatggcagc caccacgggc tcgggagtaa aagtccctcg
       61 caatttccga ctgttggaag aactcgaaga aggccagaaa ggagtaggag atggcacagt
      121 tagctggggt ctagaagatg acgaagacat gacacttaca agatggacag ggatgataat
      181 tgggcctcca agaacaattt atgaaaaccg aatatacagc cttaaaatag aatgtggacc
      241 taaataccca gaagcacccc cctttgtaag atttgtaaca aaaattaata tgaatggagt
      301 aaatagttct aatggagtgg tggacccaag agccatatca gtgctagcaa aatggcagaa
      361 ttcatatagc atcaaagttg tcctgcaaga gcttcggcgc ctaatgatgt ctaaagaaaa
      421 tatgaaactc cctcagccgc ccgaaggaca gtgttacagc aattaatcaa aaagaaaaac
      481 cacaggccct tccccttccc cccaattcga tttaatcagt cttcattttc cacagtagta
      541 aattttctag atacgtcttg tagacctcaa agtaccggaa aggaagctcc cattcaaagg
      601 aaatttatct taagatactg taaatgatac taattttttg tccatttgaa atatataagt
      661 tgtgctataa caaatcatcc tgtcaagtgt aaccactgtc cacgtagttg aacttctggg
      721 atcaagaaag tctatttaaa ttgattccca tcataactgg tggggcacat ctaactcaac
      781 tgtgaaaaga cacatcacac aatcaccttg ctgctgatta cacggcctgg ggtctctgcc
      841 ttctcccctt accctcccgc ctcccaccct ccctgcaaca acagccctct agcctggggg
      901 gcttgttaga gtagatgtga aggtttcagg tcgcagcctg tgggactact gctaggtgtg
      961 tggggtgttt cgcctgcacc cctggtttct ttaagtctta agtgatgccc cttccaaacc
     1021 atcatcctgt ccccacgctc ctccactccc gcccttggcc gaagcataga ttgtaacccc
     1081 tccactcccc tctgagattg gccttcggtg aggaattcag ggctttcccc atatcttctc
     1141 tcccccacct ttatcgaggg gtgctgcttt ttctccctcc tcctcaagtt cctttttgca
     1201 ccgtcaccac ccaacacctt ccatgacact tccttgcttt ggccagaagc catcaggtaa
     1261 ggttggaaag agcctctgac ctcccttgtt tagttttgga accatactca ctcactctcc
     1321 accagcctgg gaaatgaata ttgggtcctc agccctgcca ccctctgctg tcatcagctg
     1381 atgcattgtt tttagctcag gttttgataa ggtgaaaaga atagtcacca gggttactca
     1441 gacctgccag ctctcggagt ccttggtggt tgaacttgga gaaagaccgc atgaagatac
     1501 ttgtaagcac acatgatccc tctgaattgt tttactttcc tgtaactgct tttgctttta
     1561 aaaattgaag aagttttaaa cagggctttc atttggtcat ccttgcaatc cattggggtc
     1621 tagtttggaa tctgacaact ggaacaaaaa gaaccttgaa tccggtgcat gccttggttt
     1681 tggtgctgct gctgcttccc aagatcctca gcagggatta agaaggaacc cggtgtgcac
     1741 agcagatccc cgaaattggt gggcttgacc tcctggcaaa ttgctgcgtc tttccacttg
     1801 ctgttcagga ccactaaatg ctgaaatgtg gatgcatacc gaaataaaag caattcattg
     1861 tgtactaaag gttttttttt tttttttaat ttagtatttg tgtaaaacca ccttttgaag
     1921 cagcaactat caagtctgaa aagcaattga tgtttccatt aatctttttc tggggggaaa
     1981 accttagttc taaggattta acatcctgta agtgaagttt aacataacag tattccataa
     2041 gcagcctttt tattgtcaga ccattgcctg attttaatat aataaaaaaa aagtgtgcgt
     2101 taatatttaa
//
