LOCUS       NM_014176                878 bp    mRNA    linear   PRI 06-OCT-2024
DEFINITION  Homo sapiens ubiquitin conjugating enzyme E2 T (UBE2T), transcript
            variant 1, mRNA.
ACCESSION   NM_014176
VERSION     NM_014176.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 878)
  AUTHORS   Pu,J., Wang,B., Zhang,D., Wang,K., Yang,Z., Zhu,P. and Song,Q.
  TITLE     UBE2T mediates SORBS3 ubiquitination to enhance IL-6/STAT3
            signaling and promote lung adenocarcinoma progression
  JOURNAL   J Biochem Mol Toxicol 38 (6), e23743 (2024)
   PUBMED   38816989
  REMARK    GeneRIF: UBE2T mediates SORBS3 ubiquitination to enhance IL-6/STAT3
            signaling and promote lung adenocarcinoma progression.
REFERENCE   2  (bases 1 to 878)
  AUTHORS   Pu,J., Zhang,D., Wang,B., Zhu,P., Yang,W., Wang,K., Yang,Z. and
            Song,Q.
  TITLE     FOXA1/UBE2T Inhibits CD8+T Cell Activity by Inducing Mediates
            Glycolysis in Lung Adenocarcinoma
  JOURNAL   Front Biosci (Landmark Ed) 29 (4), 134 (2024)
   PUBMED   38682180
  REMARK    GeneRIF: FOXA1/UBE2T Inhibits CD8[+]T Cell Activity by Inducing
            Mediates Glycolysis in Lung Adenocarcinoma.
REFERENCE   3  (bases 1 to 878)
  AUTHORS   de Carvalho,L.G.A., Komoto,T.T., Moreno,D.A., Goes,J.V.C., de
            Oliveira,R.T.G., de Lima Melo,M.M., Roa,M.E.G.V., Goncalves,P.G.,
            Montefusco-Pereira,C.V., Pinheiro,R.F. and Ribeiro Junior,H.L.
  TITLE     USP15-USP7 Axis and UBE2T Differential Expression May Predict
            Pathogenesis and Poor Prognosis in De Novo Myelodysplastic Neoplasm
  JOURNAL   Int J Mol Sci 24 (12), 10058 (2023)
   PUBMED   37373211
  REMARK    GeneRIF: USP15-USP7 Axis and UBE2T Differential Expression May
            Predict Pathogenesis and Poor Prognosis in De Novo Myelodysplastic
            Neoplasm.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 878)
  AUTHORS   Wang,Y., Gao,G., Wei,X., Zhang,Y. and Yu,J.
  TITLE     UBE2T Promotes Temozolomide Resistance of Glioblastoma Through
            Regulating the Wnt/beta-Catenin Signaling Pathway
  JOURNAL   Drug Des Devel Ther 17, 1357-1369 (2023)
   PUBMED   37181827
  REMARK    GeneRIF: UBE2T Promotes Temozolomide Resistance of Glioblastoma
            Through Regulating the Wnt/beta-Catenin Signaling Pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 878)
  AUTHORS   Ma,N., Li,Z., Yan,J., Liu,X., He,L., Xie,R. and Lu,X.
  TITLE     Diverse roles of UBE2T in cancer (Review)
  JOURNAL   Oncol Rep 49 (4) (2023)
   PUBMED   36825587
  REMARK    GeneRIF: Diverse roles of UBE2T in cancer (Review).
REFERENCE   6  (bases 1 to 878)
  AUTHORS   Hao,J., Xu,A., Xie,X., Hao,J., Tian,T., Gao,S., Xiao,X. and He,D.
  TITLE     Elevated expression of UBE2T in lung cancer tumors and cell lines
  JOURNAL   Tumour Biol 29 (3), 195-203 (2008)
   PUBMED   18667844
  REMARK    GeneRIF: UBE2T was significantly upregulated in lung cancer tissue
            and cell lines, suggesting involvement of UBE2T in the malignant
            cell phenotype.
REFERENCE   7  (bases 1 to 878)
  AUTHORS   Alpi,A., Langevin,F., Mosedale,G., Machida,Y.J., Dutta,A. and
            Patel,K.J.
  TITLE     UBE2T, the Fanconi anemia core complex, and FANCD2 are recruited
            independently to chromatin: a basis for the regulation of FANCD2
            monoubiquitination
  JOURNAL   Mol Cell Biol 27 (24), 8421-8430 (2007)
   PUBMED   17938197
REFERENCE   8  (bases 1 to 878)
  AUTHORS   Machida,Y.J., Machida,Y., Chen,Y., Gurtan,A.M., Kupfer,G.M.,
            D'Andrea,A.D. and Dutta,A.
  TITLE     UBE2T is the E2 in the Fanconi anemia pathway and undergoes
            negative autoregulation
  JOURNAL   Mol Cell 23 (4), 589-596 (2006)
   PUBMED   16916645
  REMARK    GeneRIF: UBE2T is the ubiquitin-conjugating enzyme (E2) in the
            Fanconi anemia pathway and has a self-inactivation mechanism that
            could be important for negative regulation of the Fanconi anemia
            pathway.
REFERENCE   9  (bases 1 to 878)
  AUTHORS   Hu,R.M., Han,Z.G., Song,H.D., Peng,Y.D., Huang,Q.H., Ren,S.X.,
            Gu,Y.J., Huang,C.H., Li,Y.B., Jiang,C.L., Fu,G., Zhang,Q.H.,
            Gu,B.W., Dai,M., Mao,Y.F., Gao,G.F., Rong,R., Ye,M., Zhou,J.,
            Xu,S.H., Gu,J., Shi,J.X., Jin,W.R., Zhang,C.K., Wu,T.M.,
            Huang,G.Y., Chen,Z., Chen,M.D. and Chen,J.L.
  TITLE     Gene expression profiling in the human
            hypothalamus-pituitary-adrenal axis and full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 97 (17), 9543-9548 (2000)
   PUBMED   10931946
REFERENCE   10 (bases 1 to 878)
  AUTHORS   Mehta,P.A. and Ebens,C.
  TITLE     Fanconi Anemia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301575
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG776416.1 and AK000504.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 11, 2018 this sequence version replaced NM_014176.3.
            
            Summary: The protein encoded by this gene catalyzes the covalent
            attachment of ubiquitin to protein substrates. Defects in this gene
            have been associated with Fanconi anemia of complementation group
            T. Two transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Jul 2015].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF161499.1, SRR5189652.22045.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267760 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000646651.1/ ENSP00000494957.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                BG776416.1         32-46
            16-878              AK000504.1         1-863
FEATURES             Location/Qualifiers
     source          1..878
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..878
                     /gene="UBE2T"
                     /gene_synonym="FANCT; HSPC150; PIG50"
                     /note="ubiquitin conjugating enzyme E2 T"
                     /db_xref="GeneID:29089"
                     /db_xref="HGNC:HGNC:25009"
                     /db_xref="MIM:610538"
     exon            1..42
                     /gene="UBE2T"
                     /gene_synonym="FANCT; HSPC150; PIG50"
                     /inference="alignment:Splign:2.1.0"
     exon            43..215
                     /gene="UBE2T"
                     /gene_synonym="FANCT; HSPC150; PIG50"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..700
                     /gene="UBE2T"
                     /gene_synonym="FANCT; HSPC150; PIG50"
                     /EC_number="2.3.2.23"
                     /note="isoform 1 is encoded by transcript variant 1;
                     HSPC150 protein similar to ubiquitin-conjugating enzyme;
                     ubiquitin-protein ligase T; ubiquitin carrier protein T;
                     cell proliferation-inducing gene 50 protein; ubiquitin
                     conjugating enzyme E2T; ubiquitin-conjugating enzyme E2T
                     (putative); E2 ubiquitin-conjugating enzyme T"
                     /codon_start=1
                     /product="ubiquitin-conjugating enzyme E2 T isoform 1"
                     /protein_id="NP_054895.1"
                     /db_xref="CCDS:CCDS1425.1"
                     /db_xref="GeneID:29089"
                     /db_xref="HGNC:HGNC:25009"
                     /db_xref="MIM:610538"
                     /translation="MQRASRLKRELHMLATEPPPGITCWQDKDQMDDLRAQILGGANT
                     PYEKGVFKLEVIIPERYPFEPPQIRFLTPIYHPNIDSAGRICLDVLKLPPKGAWRPSL
                     NIATVLTSIQLLMSEPNPDDPLMADISSEFKYNKPAFLKNARQWTEKHARQKQKADEE
                     EMLDNLPEAGDSRVHNSTQKRKASQLVGIEKKFHPDV"
     exon            216..285
                     /gene="UBE2T"
                     /gene_synonym="FANCT; HSPC150; PIG50"
                     /inference="alignment:Splign:2.1.0"
     exon            286..391
                     /gene="UBE2T"
                     /gene_synonym="FANCT; HSPC150; PIG50"
                     /inference="alignment:Splign:2.1.0"
     exon            392..490
                     /gene="UBE2T"
                     /gene_synonym="FANCT; HSPC150; PIG50"
                     /inference="alignment:Splign:2.1.0"
     exon            491..574
                     /gene="UBE2T"
                     /gene_synonym="FANCT; HSPC150; PIG50"
                     /inference="alignment:Splign:2.1.0"
     exon            575..878
                     /gene="UBE2T"
                     /gene_synonym="FANCT; HSPC150; PIG50"
                     /inference="alignment:Splign:2.1.0"
     regulatory      856..861
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBE2T"
                     /gene_synonym="FANCT; HSPC150; PIG50"
                     /note="hexamer: AATAAA"
     polyA_site      878
                     /gene="UBE2T"
                     /gene_synonym="FANCT; HSPC150; PIG50"
                     /note="major polyA site"
ORIGIN      
        1 gttggtccgc gcgttgctgc gttgtgaggg gtgtcagctc agtgcatccc aggcagctct
       61 tagtgtggag cagtgaactg tgtgtggttc cttctacttg gggatcatgc agagagcttc
      121 acgtctgaag agagagctgc acatgttagc cacagagcca cccccaggca tcacatgttg
      181 gcaagataaa gaccaaatgg atgacctgcg agctcaaata ttaggtggag ccaacacacc
      241 ttatgagaaa ggtgttttta agctagaagt tatcattcct gagaggtacc catttgaacc
      301 tcctcagatc cgatttctca ctccaattta tcatccaaac attgattctg ctggaaggat
      361 ttgtctggat gttctcaaat tgccaccaaa aggtgcttgg agaccatccc tcaacatcgc
      421 aactgtgttg acctctattc agctgctcat gtcagaaccc aaccctgatg acccgctcat
      481 ggctgacata tcctcagaat ttaaatataa taagccagcc ttcctcaaga atgccagaca
      541 gtggacagag aagcatgcaa gacagaaaca aaaggctgat gaggaagaga tgcttgataa
      601 tctaccagag gctggtgact ccagagtaca caactcaaca cagaaaagga aggccagtca
      661 gctagtaggc atagaaaaga aatttcatcc tgatgtttag gggacttgtc ctggttcatc
      721 ttagttaatg tgttctttgc caaggtgatc taagttgcct accttgaatt tttttttaaa
      781 tatatttgat gacataattt ttgtgtagtt tatttatctt gtacatatgt attttgaaat
      841 cttttaaacc tgaaaaataa atagtcattt aatgttga
//
