LOCUS       NM_014501               2559 bp    mRNA    linear   PRI 02-MAY-2024
DEFINITION  Homo sapiens ubiquitin conjugating enzyme E2 S (UBE2S), mRNA.
ACCESSION   NM_014501
VERSION     NM_014501.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2559)
  AUTHORS   Chen,H., Li,Z., Wang,M., Lu,L., Tang,Q. and Luo,L.
  TITLE     [High expression of UBE2S promotes progression of hepatocellular
            carcinoma by increasing cancer cell stemness]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 44 (3), 455-464 (2024)
   PUBMED   38597436
  REMARK    GeneRIF: [High expression of UBE2S promotes progression of
            hepatocellular carcinoma by increasing cancer cell stemness].
REFERENCE   2  (bases 1 to 2559)
  AUTHORS   Yue,H., Wang,J., Hou,S. and Zhang,M.
  TITLE     As a potential predictor of pan-cancer, UBE2S is related to
            tumor-associated macrophage infiltration
  JOURNAL   Future Oncol 19 (29), 1973-1990 (2023)
   PUBMED   37791471
  REMARK    GeneRIF: As a potential predictor of pan-cancer, UBE2S is related
            to tumor-associated macrophage infiltration.
REFERENCE   3  (bases 1 to 2559)
  AUTHORS   Xiao,K., Peng,S., Lu,J., Zhou,T., Hong,X., Chen,S., Liu,G., Li,H.,
            Huang,J., Chen,X. and Lin,T.
  TITLE     UBE2S interacting with TRIM21 mediates the K11-linked
            ubiquitination of LPP to promote the lymphatic metastasis of
            bladder cancer
  JOURNAL   Cell Death Dis 14 (7), 408 (2023)
   PUBMED   37422473
  REMARK    GeneRIF: UBE2S interacting with TRIM21 mediates the K11-linked
            ubiquitination of LPP to promote the lymphatic metastasis of
            bladder cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2559)
  AUTHORS   Zhao,R., Yu,Z., Mao,X., Zheng,Y., Wang,Y. and Zhou,Y.
  TITLE     Knockout of UBE2S inhibits the proliferation of gastric cancer
            cells and induces apoptosis by FAS-mediated death receptor pathway
  JOURNAL   Exp Cell Res 419 (1), 113293 (2022)
   PUBMED   35863455
  REMARK    GeneRIF: Knockout of UBE2S inhibits the proliferation of gastric
            cancer cells and induces apoptosis by FAS-mediated death receptor
            pathway.
REFERENCE   5  (bases 1 to 2559)
  AUTHORS   Zhang,M., Liu,Y., Yin,Y., Sun,Z., Wang,Y., Zhang,Z., Li,F. and
            Chen,X.
  TITLE     UBE2S promotes the development of ovarian cancer by promoting
            PI3K/AKT/mTOR signaling pathway to regulate cell cycle and
            apoptosis
  JOURNAL   Mol Med 28 (1), 62 (2022)
   PUBMED   35658829
  REMARK    GeneRIF: UBE2S promotes the development of ovarian cancer by
            promoting PI3K/AKT/mTOR signaling pathway to regulate cell cycle
            and apoptosis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2559)
  AUTHORS   Garnett,M.J., Mansfeld,J., Godwin,C., Matsusaka,T., Wu,J.,
            Russell,P., Pines,J. and Venkitaraman,A.R.
  TITLE     UBE2S elongates ubiquitin chains on APC/C substrates to promote
            mitotic exit
  JOURNAL   Nat Cell Biol 11 (11), 1363-1369 (2009)
   PUBMED   19820702
  REMARK    GeneRIF: UBE2S functions with the APC/C in a two-step mechanism to
            control substrate ubiquitylation that is essential for mitotic exit
            after prolonged SAC activation, providing a new model for APC/C
            function in human cells
REFERENCE   7  (bases 1 to 2559)
  AUTHORS   Chen,M.F., Lee,K.D., Lu,M.S., Chen,C.C., Hsieh,M.J., Liu,Y.H.,
            Lin,P.Y. and Chen,W.C.
  TITLE     The predictive role of E2-EPF ubiquitin carrier protein in
            esophageal squamous cell carcinoma
  JOURNAL   J Mol Med (Berl) 87 (3), 307-320 (2009)
   PUBMED   19083192
  REMARK    GeneRIF: Results suggest that UCP was significantly associated with
            poor prognosis of esophageal cancer and may be a new molecular
            target for therapeutic intervention for esophageal squamous cell
            carcinoma.
REFERENCE   8  (bases 1 to 2559)
  AUTHORS   Lim,J.H., Jung,C.R., Lee,C.H. and Im,D.S.
  TITLE     Egr-1 and serum response factor are involved in growth factors- and
            serum-mediated induction of E2-EPF UCP expression that regulates
            the VHL-HIF pathway
  JOURNAL   J Cell Biochem 105 (4), 1117-1127 (2008)
   PUBMED   18780286
  REMARK    GeneRIF: E2-EPF UCP expression induced by growth factors or serum
            increased HIF-1alpha protein level under non-hypoxic conditions,
            suggesting that the Egr-1/SRF-UCP-VHL pathway is in part
            responsible for the increased HIF-1alpha protein level
REFERENCE   9  (bases 1 to 2559)
  AUTHORS   Marques,A.C., Dupanloup,I., Vinckenbosch,N., Reymond,A. and
            Kaessmann,H.
  TITLE     Emergence of young human genes after a burst of retroposition in
            primates
  JOURNAL   PLoS Biol 3 (11), e357 (2005)
   PUBMED   16201836
REFERENCE   10 (bases 1 to 2559)
  AUTHORS   Liu,Z., Diaz,L.A., Haas,A.L. and Giudice,G.J.
  TITLE     cDNA cloning of a novel human ubiquitin carrier protein. An
            antigenic domain specifically recognized by endemic pemphigus
            foliaceus autoantibodies is encoded in a secondary reading frame of
            this human epidermal transcript
  JOURNAL   J Biol Chem 267 (22), 15829-15835 (1992)
   PUBMED   1379239
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CN305224.1, BC065364.1,
            CA421746.1 and AC020922.9.
            
            On Nov 22, 2018 this sequence version replaced NM_014501.2.
            
            Summary: This gene encodes a member of the ubiquitin-conjugating
            enzyme family. The encoded protein is able to form a thiol ester
            linkage with ubiquitin in a ubiquitin activating enzyme-dependent
            manner, a characteristic property of ubiquitin carrier proteins.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC065364.1, AB062397.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA2149004 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264552.14/ ENSP00000264552.8
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                CN305224.1         170-180
            12-1021             BC065364.1         1-1010
            1022-1022           CA421746.1         17-17               c
            1023-2559           AC020922.9         108028-109564       c
FEATURES             Location/Qualifiers
     source          1..2559
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..2559
                     /gene="UBE2S"
                     /gene_synonym="E2-EPF; E2EPF; EPF5"
                     /note="ubiquitin conjugating enzyme E2 S"
                     /db_xref="GeneID:27338"
                     /db_xref="HGNC:HGNC:17895"
                     /db_xref="MIM:610309"
     exon            1..202
                     /gene="UBE2S"
                     /gene_synonym="E2-EPF; E2EPF; EPF5"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..868
                     /gene="UBE2S"
                     /gene_synonym="E2-EPF; E2EPF; EPF5"
                     /EC_number="2.3.2.23"
                     /note="ubiquitin-protein ligase S; ubiquitin carrier
                     protein S; E2-EPF5; ubiquitin-conjugating enzyme E2-24
                     kDa; ubiquitin-conjugating enzyme E2-EPF5; E2
                     ubiquitin-conjugating enzyme S; ubiquitin conjugating
                     enzyme E2S"
                     /codon_start=1
                     /product="ubiquitin-conjugating enzyme E2 S"
                     /protein_id="NP_055316.2"
                     /db_xref="CCDS:CCDS33114.1"
                     /db_xref="GeneID:27338"
                     /db_xref="HGNC:HGNC:17895"
                     /db_xref="MIM:610309"
                     /translation="MNSNVENLPPHIIRLVYKEVTTLTADPPDGIKVFPNEEDLTDLQ
                     VTIEGPEGTPYAGGLFRMKLLLGKDFPASPPKGYFLTKIFHPNVGANGEICVNVLKRD
                     WTAELGIRHVLLTIKCLLIHPNPESALNEEAGRLLLENYEEYAARARLLTEIHGGAGG
                     PSGRAEAGRALASGTEASSTDPGAPGGPGGAEGPMAKKHAGERDKKLAAKKKTDKKRA
                     LRRL"
     exon            203..350
                     /gene="UBE2S"
                     /gene_synonym="E2-EPF; E2EPF; EPF5"
                     /inference="alignment:Splign:2.1.0"
     exon            351..541
                     /gene="UBE2S"
                     /gene_synonym="E2-EPF; E2EPF; EPF5"
                     /inference="alignment:Splign:2.1.0"
     exon            542..2559
                     /gene="UBE2S"
                     /gene_synonym="E2-EPF; E2EPF; EPF5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1004..1009
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBE2S"
                     /gene_synonym="E2-EPF; E2EPF; EPF5"
                     /note="hexamer: AATAAA"
     polyA_site      1023
                     /gene="UBE2S"
                     /gene_synonym="E2-EPF; E2EPF; EPF5"
                     /note="major polyA site"
     regulatory      2119..2124
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBE2S"
                     /gene_synonym="E2-EPF; E2EPF; EPF5"
                     /note="hexamer: AATAAA"
     polyA_site      2144
                     /gene="UBE2S"
                     /gene_synonym="E2-EPF; E2EPF; EPF5"
     regulatory      2537..2542
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBE2S"
                     /gene_synonym="E2-EPF; E2EPF; EPF5"
                     /note="hexamer: AATAAA"
     polyA_site      2559
                     /gene="UBE2S"
                     /gene_synonym="E2-EPF; E2EPF; EPF5"
ORIGIN      
        1 ggctcagtgc tgccgggcac cggggcggcg ggttggtcta cgctgtgcgc ggcggacgtc
       61 ggaggcagcg gggagcggag cggggccgcc ggggcctctc cagggccgca gcggcagcag
      121 ttgggccccc cgccccggcc ggcggaccga agaacgcagg aagggggccg gggggacccg
      181 cccccggccg gccgcagcca tgaactccaa cgtggagaac ctacccccgc acatcatccg
      241 cctggtgtac aaggaggtga cgacactgac cgcagaccca cccgatggca tcaaggtctt
      301 tcccaacgag gaggacctca ccgacctcca ggtcaccatc gagggccctg aggggacccc
      361 atatgctgga ggtctgttcc gcatgaaact cctgctgggg aaggacttcc ctgcctcccc
      421 acccaagggc tacttcctga ccaagatctt ccacccgaac gtgggcgcca atggcgagat
      481 ctgcgtcaac gtgctcaaga gggactggac ggctgagctg ggcatccgac acgtactgct
      541 gaccatcaag tgcctgctga tccaccctaa ccccgagtct gcactcaacg aggaggcggg
      601 ccgcctgctc ttggagaact acgaggagta tgcggctcgg gcccgtctgc tcacagagat
      661 ccacgggggc gccggcgggc ccagcggcag ggccgaagcc ggtcgggccc tggccagtgg
      721 cactgaagct tcctccaccg accctggggc cccagggggc ccgggagggg ctgagggtcc
      781 catggccaag aagcatgctg gcgagcgcga taagaagctg gcggccaaga aaaagacgga
      841 caagaagcgg gcgctgcggc ggctgtagtg ggctctcttc ctccttccac cgtgacccca
      901 acctctcctg tcccctccct ccaactctgt ctctaagtta tttaaattat ggctggggtc
      961 ggggagggta cagggggcac tgggacctgg atttgttttt ctaaataaag ttggaaaagc
     1021 agcttctgtg tctcacagat gccccaggac cgctgcatgg tgccatgtgg ctctgggagt
     1081 ttggctcccc tgcacaggcc ctgggtcctt gtaaagcctc atggactgca gcagtgggtc
     1141 catctagctc accagccttg ctgtttgagg tttgggtcca cctctttgtt ctgtggaggt
     1201 agagcggtca caacccctct ttggagtcag atttccaatc taaaatgggg cgaggacctg
     1261 gagctgctcc tggtggcctg agcggcactg ccctatactt ctccctctag aataatggcc
     1321 acgttggtgt ggcagtggtg ttcctgctca ggacggccag gtgccagcag tctggcatga
     1381 ggctcgcctc gtctgtctgg ttctggactg ggccaaggtt cggtcccctt gaatcatctg
     1441 atcctgcttt gtgctaaaga ttggtttttc ccttgtgggc agcaaagcct gttcccacat
     1501 gtatttctgc acaacagatc acaaagccag cggcttaaaa caacacccac ttcagacttt
     1561 gtgttggaag tctggacacg gctgagctag tctctgctca gtgctttgca ggctaaaatt
     1621 gaggtattgg ttgttggtgt tccttagtct gggtcctctt ccatgctcat ggttgttggc
     1681 tgatttcagt cctcgtagaa ctagggtctt agctccaaga agctgcccct ccttgggccc
     1741 tggcaggtct gatttaaggg cccattccct ttgaggtgct caccggatta ggtcaggccc
     1801 atccagatac ttaagtgata atgactaaat cacaggggta agatcccagc ttagtcttag
     1861 tttctgccct caaggggaag ggattaacct gggtgtgcac accagggggt ggggaaactt
     1921 cccattctat taatgcgttt aggttattta gaccaatgtc tcattaattt taaaaaaatt
     1981 aaaaataggc caggcgcaat ggctcacgcc tgtaatccca actttaggag gtgaaaggat
     2041 cacttgaggc caggagttaa agacgaacgt gggcaacaca gtgagatccc atctctacaa
     2101 aaagtaaaat acatttacaa taaaaatcta caagttctga cccataggag agtggaaaac
     2161 tcaaaggctg cttttgtcct gaaagaattt gcctattcta ataaaacagc tgaggttgaa
     2221 acggctcagc ctctgaaagg ggtctgaccc ttccttgagc ccttgcctcc agtgacaatc
     2281 tcccaagcta agggagaaaa ggaaccaaaa gtctgcactc ctctctacct ctagcagtgc
     2341 agggagcgaa ggaaagacaa gggaagaaac ccttcagatt ttcagatcaa attcacatca
     2401 ctggccatcc aagaaatctt aagctctgcg tttatcgtca accatttctg catgagggaa
     2461 gcaaacagtc cttgctgaag gaaggtgcct gcatcctggg cctcggaacc cactgaaata
     2521 atttagcgaa gtgcataata aaaataatat ttgccctta
//
