LOCUS       NM_001145161            5895 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens ubiquitin conjugating enzyme E2 QL1 (UBE2QL1), mRNA.
ACCESSION   NM_001145161 XR_040585 XR_040586
VERSION     NM_001145161.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5895)
  AUTHORS   Kravic,B., Behrends,C. and Meyer,H.
  TITLE     Regulation of lysosome integrity and lysophagy by the
            ubiquitin-conjugating enzyme UBE2QL1
  JOURNAL   Autophagy 16 (1), 179-180 (2020)
   PUBMED   31679434
  REMARK    Review article
REFERENCE   2  (bases 1 to 5895)
  AUTHORS   Koerver,L., Papadopoulos,C., Liu,B., Kravic,B., Rota,G., Brecht,L.,
            Veenendaal,T., Polajnar,M., Bluemke,A., Ehrmann,M., Klumperman,J.,
            Jaattela,M., Behrends,C. and Meyer,H.
  TITLE     The ubiquitin-conjugating enzyme UBE2QL1 coordinates lysophagy in
            response to endolysosomal damage
  JOURNAL   EMBO Rep 20 (10), e48014 (2019)
   PUBMED   31432621
  REMARK    GeneRIF: UBE2QL1 coordinates critical steps in the acute
            endolysosomal damage response and is essential for maintenance of
            lysosomal integrity.
REFERENCE   3  (bases 1 to 5895)
  AUTHORS   Wake,N.C., Ricketts,C.J., Morris,M.R., Prigmore,E., Gribble,S.M.,
            Skytte,A.B., Brown,M., Clarke,N., Banks,R.E., Hodgson,S.,
            Turnell,A.S., Maher,E.R. and Woodward,E.R.
  TITLE     UBE2QL1 is disrupted by a constitutional translocation associated
            with renal tumor predisposition and is a novel candidate renal
            tumor suppressor gene
  JOURNAL   Hum Mutat 34 (12), 1650-1661 (2013)
   PUBMED   24000165
  REMARK    GeneRIF: UBE2QL1 as a novel candidate renal tumor suppressor gene.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC127723.1 and AC093307.5.
            
            On Nov 22, 2018 this sequence version replaced NM_001145161.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK308577.1, SRR1803613.65511.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000399816.4/ ENSP00000382713.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-565               BC127723.1         2-566
            566-5895            AC093307.5         162998-168327
FEATURES             Location/Qualifiers
     source          1..5895
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p15.31"
     gene            1..5895
                     /gene="UBE2QL1"
                     /note="ubiquitin conjugating enzyme E2 QL1"
                     /db_xref="GeneID:134111"
                     /db_xref="HGNC:HGNC:37269"
                     /db_xref="MIM:615832"
     exon            1..389
                     /gene="UBE2QL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..521
                     /gene="UBE2QL1"
                     /EC_number="2.3.2.23"
                     /note="E2Q-like ubiquitin-conjugating enzyme 1;
                     ubiquitin-conjugating enzyme E2Q family-like 1; ubiquitin
                     conjugating enzyme E2 Q family like 1"
                     /codon_start=1
                     /product="ubiquitin-conjugating enzyme E2Q-like protein 1"
                     /protein_id="NP_001138633.1"
                     /db_xref="CCDS:CCDS47189.1"
                     /db_xref="GeneID:134111"
                     /db_xref="HGNC:HGNC:37269"
                     /db_xref="MIM:615832"
                     /translation="MKELQDIARLSDRFISVELVDESLFDWNVKLHQVDKDSVLWQDM
                     KETNTEFILLNLTFPDNFPFSPPFMRVLSPRLENGYVLDGGAICMELLTPRGWSSAYT
                     VEAVMRQFAASLVKGQGRICRKAGKSKKSFSRKEAEATFKSLVKTHEKYGWVTPPVSD
                     G"
     exon            390..5895
                     /gene="UBE2QL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1745..1750
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBE2QL1"
                     /note="hexamer: AATAAA"
     polyA_site      1765
                     /gene="UBE2QL1"
                     /note="major polyA site"
     regulatory      5858..5863
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBE2QL1"
                     /note="hexamer: AATAAA"
     regulatory      5875..5880
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBE2QL1"
                     /note="hexamer: AATAAA"
     polyA_site      5876
                     /gene="UBE2QL1"
     polyA_site      5895
                     /gene="UBE2QL1"
ORIGIN      
        1 agcaacactg cacgcaggtg cgcagccggc ggctcatgaa ggagctgcag gacatcgcgc
       61 gccttagcga ccgcttcatc tccgtggagc tggtggacga gagcctgttc gactggaacg
      121 tgaagctgca ccaggtggac aaggactcgg tgctgtggca ggacatgaag gagaccaaca
      181 ccgagttcat cctgctcaac ctcaccttcc ccgacaactt ccccttctcg ccgcccttca
      241 tgcgggtgct cagcccgcgc ctggagaacg gctacgtgct ggacggcggc gccatctgca
      301 tggagctgct cacgccgcgc ggctggtcca gcgcctacac cgtggaggcc gtcatgcgcc
      361 agttcgcagc cagcctggtc aagggccagg gacggatctg tagaaaagct ggcaaatcaa
      421 aaaagtcctt cagtcgcaag gaagctgaag ctacctttaa gagtttggtg aagacgcatg
      481 aaaaatatgg ttgggtcacc ccgcccgtgt ccgacggctg atgtctgcca cgtgcagtag
      541 acgctcgagc gcctgtccac acacacacca gtaccctgac atctcctcaa tgctgtgcat
      601 cctccacccg tttttactcc agccagaact gcatcctgaa tgcccaggag acgtttaagt
      661 tatttatgaa aagatgtgtg tacagagagg aagagggagc aaatgccgtt cggattatgt
      721 ttcgattata aatgaatgat cacctcgaag tcactttaga acacatgttg agatggtgac
      781 atttcccagc ctgcctgccc ctctgcccac cccggtcaca ttgccctgag cttctttcca
      841 tgacagcagc tccgacgagc cggcaggaaa ctcaatgccc ctgctggctc catttccatg
      901 taaatggcgc cgttcatatt tcacagggac gccgtgcatc tccgccgtgc gtccccggca
      961 cgtgtttgct gtgctctgta tctctgtttt tcttcctgga aggtcaacat aacttgaaaa
     1021 tgtgtctttc tgtggcccat ggtccgctgt gatgacattt agacctcatt tgtgctatga
     1081 cctttggctc atgaaaacac aaatttaaca ttgccaggtt ctagtgattt aaaaccacaa
     1141 ctgcccactt ggtgaaaacg tgctctcgat gctgatttgt ggtgtgctgc tgtccacaga
     1201 taaaccagtg ccattagatg gaaggcagag gatactgcga ccacccctgg cagacggtgg
     1261 cgtagacacc aggtgcgccc tctggggctc agagcaacgg atggtcagct gcgaacagtc
     1321 tcgtccgatg ttaggaaatg gtcctacggc cgcgcctttg tgttcctgtc ttctctccac
     1381 caccaaaagc aaaagatgat ttcccattca ctgcagtcat ctgactcatt ttaatatctg
     1441 tgctagtgac aatgaatgtc agaactgcca aaggatacca agtgatcata cgatgatttg
     1501 catgatcggg tctatttcac ccaatagtca cttgtgtgtc ccccgaaatt gggatgggtg
     1561 agcacccttg ctgtggtgta aacttcctgt tatttaatct cccccacggt ttcatttttc
     1621 tcttctgtta atacttagaa ctttctaaga aactccatga aatgaggaaa tactgtttct
     1681 aataatatga ggaaagaagt aaaaatgttc attccaagtg gcaagtctta ttggacacat
     1741 tttaaataaa atcatgcata cctgatacac tgcctcaagg atccagtcat tgtgggctat
     1801 ccttccattt aaaatatttc agatattctt aaatttttta aatattgcaa atactacaac
     1861 atgtaattcc agagcagcgt tctaagtcag gtaccagaaa tgagtcttag gaacccatag
     1921 tctttgcaaa aattcagtag attgaaatag tccccagaag cagccaagga gctgaaggga
     1981 tgattcgatc aagttcagat gttgccaatt gtatcttact gctgtgaagg aggaaaagtc
     2041 ttccgggata atgtattcaa ttcttcaggc agttttgtct acttggggac ctgcccattg
     2101 gttcaaggtt ttcagagatc caagaggcct tgcctcaaag aacaaggatt ggcgcctttc
     2161 agcagggctg cccattcacc aaacttattg ttacttttgt ttttctttac cactttctta
     2221 tttgccccca agtgcacaca ggcagctctg ccagaccaaa atgacagtgt attaagaatg
     2281 cagggcctgc tcagcttccc tgtgagtcat aatagtcgtg aaacttgatg acagtgaact
     2341 tacgatgttc attcatccaa ccctctatgg tggcattctc catcctggaa acctgacatt
     2401 tggctgacgg tctttggacc ctggagctag tggtcatcat ggaattacac tgtggagatg
     2461 aaagacctag gacagaaaca tcttgctagg gaaagcacct gagtttattc ctttctaaat
     2521 attttcctct tctaatgaaa actaaaagca gctttacttt agggggaaaa atatatccaa
     2581 aggcaggtca tttcagtagt gtttattagc tgattgaaaa acaggttcac ggtgctctct
     2641 gagaactgca ccaaggggtg cagccaagag actggtctga ccccgggttg ggctgggtgg
     2701 cagccggcga cagagcagag agacactcag ctcagtgtcg ctccttccat acactcagag
     2761 tttgattttt cttgcatggc atttccatta ggtttgttag aaacttatag aagaaatcaa
     2821 ttctttagtg aacgaaatac catttttcac tcaattggta agaatttttc attttaaaag
     2881 cagtaggaag tgatgtaaaa ctctaccatt gcttggactg ttaggagtgc ggactccctt
     2941 tctggtagac tcccttcgta ggcaagcacg gtggtgccca gccatggagg cacccttagg
     3001 acactgagca caggcctggc tgcctgtgcc ttggccacag cctccttcca ccccactgaa
     3061 gtggacacct gcctctggag cccagggtga gaaggagagg cctgaagcct ggggccacgt
     3121 tcccacacaa gccaaggaac ctattcctct ttggacagac agcgagggaa taatcagaca
     3181 gtgggtgcaa atgttcatgt cccgatagct ccacacaccc atgtatctgt gggaactcaa
     3241 accaagccag agcccacaga gccaaacaaa cagaaaatca caaacccatc tgtcctcttc
     3301 tcaatgcaga actccttccc gtccaataat tttcctgaac caatcaccct tgttattggg
     3361 tatcttctcc actgctgggt aaggcctgca catggtctgt ctgtaacttt ctagaagact
     3421 gagaactgct tatgccttag ggagttctat gtgagcagca aggttattcc ccctagttac
     3481 acacacacgc acatgtgcca atactcctgc aaagacttgc tgtttctaaa atccactact
     3541 cagaaaaacc agggtgtcgg cttaaagttt tcagctccat ctatcaaaat ttgacctttt
     3601 tttaagagaa aaatatgtag atgagtgaaa aagacctagg attgaaagac aaaaagccat
     3661 gtgtccatgt aaccctggcc agtcactcca cctgcctgag ccttggtttc ctcagctgtg
     3721 agctcctacc aggtcagtgt gggaattggc caaaatgacg cagcagaagt gctttggaga
     3781 ctaaagattg tcaacgaaat gtaagtgtca ttttcgtagt attaggacgt ttacattaca
     3841 gcaggcttta attagaaccc acttagatat cgactcagaa tgatcaatta cagtggttaa
     3901 aatacacata cctggtaatc atatacttgc tttctgtccc cagttcttac attaagtcaa
     3961 ccaactgacc caaaaatcaa ccaataacta actggccatc tctccactca ctcagcattc
     4021 tcctcttaaa tgcagggcat gcagaagatt aaggtacagc cccttccctg gataggaact
     4081 caaaagatag gaatagcgca caggcaccag caccaagcaa ggcaagtgcc aaattgcact
     4141 gcagaaatta aagacatgtg caagtccaga gattttctga ctgaaaacca gaaagatttc
     4201 atggagtaaa tcaggtttga gccatggctg ggcaaaggga aggagaaggg caggtgtagc
     4261 aggtgtagaa atgggagggg ctgagggcac cttgaaaggg agcgtggact ctgtcctcac
     4321 tggccctgaa cgggagaact ggagtcccct tgccacctct cacctgcaga gtccctattc
     4381 atggagctga tttcaggaag caggacacgg tcccacctga cagcctagcc tggcgtgtgg
     4441 agcttgccct gtgtgtagca attatatttc agtgtaccca tccaatagca tgcgaaattt
     4501 taatggaatt tgctttctaa aggggcagag cttacttcct gactgtagtg agggtagagc
     4561 cactgaatct ggaagaccac ttagcctaat tttacaccct ctgcagtgaa ggaggcgagc
     4621 ccagagactt tgaggggctt gtccacagta ggacaggagc cacaaggcca ctgccttact
     4681 gtggctttct gatcctttat gttgcttcat gagactatta ggcaattcat gtggccctca
     4741 ccaaacacac actcttcacc ccatcattga atcagtacag ttgcaagtct tccaagccag
     4801 ctgagaaaca cccacaggat ccattctgtg cccaaagcaa attggagcaa agggcagaaa
     4861 ttccctccaa ctgttttggg aagcttctgt aaggggcttg gagctcagcc tatgggactg
     4921 tagtcagaac tttgtaattt ttttctccaa agacagtgaa atcatgtaca gctctgttct
     4981 tagttttctg ctaggttcta cttatccttc taatttttgc agcctctagt tcccatagta
     5041 ttaaatatca tttttaagcc cagggcctgt ctgatccaca gaatgtggtc aataatctgg
     5101 aaaggcaaac aaactctgtt gacattcggg aaagcaataa gtaatgttag tttggttcca
     5161 gaagaaacac gggagcaaag tgtgctggcc aaacagcaac aatcaaagca gaggggagca
     5221 agattttctt tcaaggtcat gataaggcta gacaaataga gtgcaatgag ggggtcaggt
     5281 gcgaggccgt cctcccaggt cagtaaggcc gcatggaggg ataaagagat ccctgcactg
     5341 cccccaaccg ccaattcacc ctgtgtctct cgcagaatta aagccaggag gtggctttct
     5401 ctttccttct actggtggta aattaagtga ctgtcctact ttgtagacat gcaatcgttt
     5461 tgtacctcta gaccttgggc agtcactggt gatgacacta attgaactaa cacagaaact
     5521 gctgtcacct gatgtgcttg gtttcattcc tgcctgcctt ctctacaacg tgacttcatt
     5581 tcatgaatgt ggttgccatt atgacagtgc taggatgctg atctgtacac catgagtgac
     5641 tgcgaacttt cagactctca ccgcaattca tggggagact ttggtgtatc ctgtttccag
     5701 agttgtcctc ttctgtgatc ctcaaaagaa gagaaaaaaa cgcatgtggc ataaatcaac
     5761 aggaaagaaa tgtttaccac tggaagatgg tgagtgcatg agtcaaataa tctagaggca
     5821 ctgccctaat gagaaaaaaa aaacaatgat tctagaaaat aaaactttaa aaccaataaa
     5881 cgtctttaca cggaa
//
