LOCUS       NM_173469               2968 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ubiquitin conjugating enzyme E2 Q2 (UBE2Q2),
            transcript variant 1, mRNA.
ACCESSION   NM_173469
VERSION     NM_173469.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2968)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2968)
  AUTHORS   Mokarram,P., Shakiba-Jam,F., Kavousipour,S., Sarabi,M.M. and
            Seghatoleslam,A.
  TITLE     Promoter Methylation Status of Two Novel Human Genes, UBE2Q1 and
            UBE2Q2, in Colorectal Cancer: a New Finding in Iranian Patients
  JOURNAL   Asian Pac J Cancer Prev 16 (18), 8247-8252 (2015)
   PUBMED   26745068
  REMARK    GeneRIF: UBE2Q1 hypomethylation is associated with Colorectal
            Cancer.
REFERENCE   3  (bases 1 to 2968)
  AUTHORS   Seghatoleslam,A., Monabati,A., Bozorg-Ghalati,F., Nikseresht,M.,
            Bordbar,M.R., Rahvar,M. and Owji,A.A.
  TITLE     Expression of UBE2Q2, a putative member of the
            ubiquitin-conjugating enzyme family in pediatric acute
            lymphoblastic leukemia
  JOURNAL   Arch Iran Med 15 (6), 352-355 (2012)
   PUBMED   22642244
  REMARK    GeneRIF: The newly characterized human gene, UBE2Q2, may have
            implications for the pathogenesis of acute lymphoblastic leukemia.
REFERENCE   4  (bases 1 to 2968)
  AUTHORS   David,Y., Ziv,T., Admon,A. and Navon,A.
  TITLE     The E2 ubiquitin-conjugating enzymes direct polyubiquitination to
            preferred lysines
  JOURNAL   J Biol Chem 285 (12), 8595-8604 (2010)
   PUBMED   20061386
REFERENCE   5  (bases 1 to 2968)
  AUTHORS   Nikseresht,M., Seghatoleslam,A., Monabati,A., Talei,A.,
            Ghalati,F.B. and Owji,A.A.
  TITLE     Overexpression of the novel human gene, UBE2Q2, in breast cancer
  JOURNAL   Cancer Genet Cytogenet 197 (2), 101-106 (2010)
   PUBMED   20193842
  REMARK    GeneRIF: In the 21 breast cancer cases investigated, a high
            increase in UBE2Q2 expression was found in 8 breast cancers
            (38.1%), a moderately increased UBE2Q2 expression was observed in 7
            cases (33.3%), and no sig. changes were detected in 6 cases
            (28.6%).
REFERENCE   6  (bases 1 to 2968)
  AUTHORS   Maeda,H., Miyajima,N., Kano,S., Tsukiyama,T., Okumura,F., Fukuda,S.
            and Hatakeyama,S.
  TITLE     Ubiquitin-conjugating enzyme UBE2Q2 suppresses cell proliferation
            and is down-regulated in recurrent head and neck cancer
  JOURNAL   Mol Cancer Res 7 (9), 1553-1562 (2009)
   PUBMED   19723876
  REMARK    GeneRIF: Found high expression levels of UBE2Q2 in human head and
            neck carcinoma cell lines and cancer tissues; found the level of
            UBE2Q2 is decreased in cell lines and cancer tissues that have
            resistance to CDDP or docetaxel.
REFERENCE   7  (bases 1 to 2968)
  AUTHORS   Banerjee,S., Brooks,W.S. and Crawford,D.F.
  TITLE     Inactivation of the ubiquitin conjugating enzyme UBE2Q2 causes a
            prophase arrest and enhanced apoptosis in response to microtubule
            inhibiting agents
  JOURNAL   Oncogene 26 (45), 6509-6517 (2007)
   PUBMED   17471241
  REMARK    GeneRIF: Inhibition of the UBE2Q2 protein causes cells to undergo a
            prolonged prophase arrest suggesting that UBE2Q2 normally functions
            to antagonize an early mitotic checkpoint.
REFERENCE   8  (bases 1 to 2968)
  AUTHORS   Seghatoleslam,A., Zambrano,A., Millon,R., Ganguli,G., Argentini,M.,
            Cromer,A., Abecassis,J. and Wasylyk,B.
  TITLE     Analysis of a novel human gene, LOC92912, over-expressed in
            hypopharyngeal tumours
  JOURNAL   Biochem Biophys Res Commun 339 (1), 422-429 (2006)
   PUBMED   16300736
  REMARK    GeneRIF: the novel LOC92912 gene is characterized. It is
            over-expressed in hypopharyngeal tumours. Its functions may be
            linked with the cytoskeleton; it may represent a new target for
            cancer therapeutics.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC019294.7 and AC027104.6.
            
            On May 17, 2019 this sequence version replaced NM_173469.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.45220.1,
                                           SRR1803613.203109.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000267938.9/ ENSP00000267938.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-400               AC019294.7         26090-26489         c
            401-502             AC019294.7         15449-15550         c
            503-607             AC019294.7         9954-10058          c
            608-667             AC019294.7         926-985             c
            668-808             AC027104.6         84148-84288         c
            809-893             AC027104.6         81445-81529         c
            894-954             AC027104.6         79695-79755         c
            955-1045            AC027104.6         78528-78618         c
            1046-1104           AC027104.6         74292-74350         c
            1105-1153           AC027104.6         67233-67281         c
            1154-1249           AC027104.6         66702-66797         c
            1250-1316           AC027104.6         60655-60721         c
            1317-2968           AC027104.6         56638-58289         c
FEATURES             Location/Qualifiers
     source          1..2968
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q24.2"
     gene            1..2968
                     /gene="UBE2Q2"
                     /note="ubiquitin conjugating enzyme E2 Q2"
                     /db_xref="GeneID:92912"
                     /db_xref="HGNC:HGNC:19248"
                     /db_xref="MIM:612501"
     exon            1..400
                     /gene="UBE2Q2"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..1348
                     /gene="UBE2Q2"
                     /EC_number="2.3.2.23"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ubiquitin-protein ligase Q2; ubiquitin carrier protein Q2;
                     E2 ubiquitin-conjugating enzyme Q2; ubiquitin conjugating
                     enzyme E2Q family member 2"
                     /codon_start=1
                     /product="ubiquitin-conjugating enzyme E2 Q2 isoform 1"
                     /protein_id="NP_775740.1"
                     /db_xref="CCDS:CCDS10286.1"
                     /db_xref="GeneID:92912"
                     /db_xref="HGNC:HGNC:19248"
                     /db_xref="MIM:612501"
                     /translation="MSVSGLKAELKFLASIFDKNHERFRIVSWKLDELHCQFLVPQQG
                     SPHSLPPPLTLHCNITESYPSSSPIWFVDSEDPNLTSVLERLEDTKNNNLLRQQLKWL
                     ICELCSLYNLPKHLDVEMLDQPLPTGQNGTTEEVTSEEEEEEEEMAEDIEDLDHYEMK
                     EEEPISGKKSEDEGIEKENLAILEKIRKTQRQDHLNGAVSGSVQASDRLMKELRDIYR
                     SQSYKTGIYSVELINDSLYDWHVKLQKVDPDSPLHSDLQILKEKEGIEYILLNFSFKD
                     NFPFDPPFVRVVLPVLSGGYVLGGGALCMELLTKQGWSSAYSIESVIMQINATLVKGK
                     ARVQFGANKNQYNLARAQQSYNSIVQIHEKNGWYTPPKEDG"
     exon            401..502
                     /gene="UBE2Q2"
                     /inference="alignment:Splign:2.1.0"
     exon            503..607
                     /gene="UBE2Q2"
                     /inference="alignment:Splign:2.1.0"
     exon            608..667
                     /gene="UBE2Q2"
                     /inference="alignment:Splign:2.1.0"
     exon            668..808
                     /gene="UBE2Q2"
                     /inference="alignment:Splign:2.1.0"
     exon            809..893
                     /gene="UBE2Q2"
                     /inference="alignment:Splign:2.1.0"
     exon            894..954
                     /gene="UBE2Q2"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1045
                     /gene="UBE2Q2"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1104
                     /gene="UBE2Q2"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1153
                     /gene="UBE2Q2"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1249
                     /gene="UBE2Q2"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1316
                     /gene="UBE2Q2"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..2968
                     /gene="UBE2Q2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2915..2920
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBE2Q2"
                     /note="hexamer: AATAAA"
     polyA_site      2934
                     /gene="UBE2Q2"
                     /note="major polyA site"
ORIGIN      
        1 gctggagtcg gttacaaagg aagcgccacc caggccgcca cacgccgagg cttccgcgcc
       61 cctcgccatt ttccagcagc gctcgacgag gcggagccgc gagagcgcgg cccaggccgg
      121 ccccgcgggg cggtcgcggc cgtgacggcg gctccgggcc cggctcccct tccgcgcccg
      181 gctccccttc cgcgcccctc ccgccggaga tgaggggaag atgtccgtgt cagggctcaa
      241 ggccgagctg aagttcctgg cgtccatctt cgacaagaac cacgagcgat tccgcatcgt
      301 cagttggaag ctggacgagc tgcactgcca gttcctggtg ccgcagcagg gcagcccgca
      361 ctcgctgccg ccgccactca cgctccactg caacatcacg gaatcctatc catcttcttc
      421 accgatatgg tttgtggatt ctgaagaccc aaatctgaca tcagttctgg aacgtctaga
      481 agatactaag aacaacaatt tgcttcgtca gcaattgaag tggttgatat gtgaactctg
      541 cagtttatat aaccttccta agcacctgga tgttgagatg ctagatcaac cactacccac
      601 gggtcagaat gggacaacag aagaagtgac ttcagaagaa gaggaagaag aagaagagat
      661 ggctgaagat atagaagact tagatcacta tgagatgaag gaagaagagc ctattagtgg
      721 gaaaaagtca gaggatgaag gaattgaaaa agaaaatttg gcaatattag agaaaattag
      781 gaagactcaa aggcaagacc atttaaatgg tgcagtgtct gggtcagtgc aagcttcaga
      841 tagacttatg aaagagctca gggacatata cagatcacag agttataaaa cagggattta
      901 ttcagtggaa ctcataaatg acagtttata tgactggcat gttaaactgc agaaggttga
      961 ccctgatagt cctttgcaca gtgatcttca gatcttaaaa gaaaaagaag gcatagaata
     1021 tattttgctt aacttctctt ttaaggataa ctttccattt gatcctccat ttgttcgagt
     1081 ggtgttacct gttctctcag gagggtatgt attgggtgga ggagcattat gtatggaact
     1141 tctcacaaaa cagggctgga gcagtgccta ctcaatagaa tcggtcatca tgcaaataaa
     1201 tgccacctta gtcaaaggca aagccagagt gcagtttgga gcaaataaga atcaatataa
     1261 tctagcaaga gcccaacaat cctataattc cattgtacag atacatgaga aaaatggctg
     1321 gtacacccct ccaaaggaag atggctaaat gtgttgactg ttgtatgttt ggactaatgt
     1381 tgctttaaag aaaatctttc taacatgcag acaaaagctt tgagtgcccc tattacagca
     1441 gtaccgaaga tgttagttaa tagatatttt agtggataat ctgtcatctg acatccagta
     1501 taagttacag cctttgcatt ttgctcattt tagatatctt ggactgagca gtggggcctt
     1561 tactgtattt ttcctgataa atacacatac tggccactcc ttatctcttt ttcttgaaaa
     1621 gtgaactttt taaagcagcc aagtcaacat caggctactg aagttgaggc tttagggtaa
     1681 ctttcctata ttgagcccat gggttacaag gatttgcaat atattgttcc atttacagcc
     1741 aatacaggtt taatcgatgt tcaatattgg tttaggaaat ttaaggcctt ctaaatcata
     1801 atagctcttt catgtctaaa accattttat gatattgcca aaatgtgata ggaaacctac
     1861 tcattaaatt gttaaacttt ttaatgacta tgtgaagata tgaattgttt cctgaagata
     1921 atactcttaa ttgagttgta ttgtacttct taggcaaagc agtgtaaaac tgtatcaatt
     1981 aaggcttgtg agtagtgatt tccactgggg catcagagtc ttggctgggc tgaatctgct
     2041 gcttgttggt tcagtgtttc ttatgaacaa gagccacagt acagagcttc aagttattta
     2101 aaatactaag tcatcttacg tttccatttt attaacggga tgttgcaatc gtttgtaaac
     2161 taataaactt ataaagtgat tggcacaaag actccttgag caaaagctgt gcagttaagt
     2221 acaaaaagat acttaatttg gagactctta cagtaatttt tgccatgtca aaacaatggc
     2281 ttttacattg aaagattaat agaaactcta catatgttaa tttttttata gaacctgact
     2341 caaatcaagg tactctccat tttattgcct tacctgaatc agtccttttt ggttggtaat
     2401 agattttttt atacacccac gtttgattta aaagtaaatt ctagttctta agcactttta
     2461 acaaatccag aagcacattt ttctgcacaa acaagttaca aagttcaaaa gtgtttcttg
     2521 tgcattagct ttgagattca gtttttaact ttgtaaacca catctgagag acttgtcatt
     2581 tctacattgt gtgtgtttaa tttcttttga ttccattttg gttaagagag cagtaaatag
     2641 attttctggt attcttgttc acttgattac atttgtataa agttctgatt gccagttgct
     2701 cagataacaa gtgacaaggc agaattcttt aaatcagtaa agttccttaa gcctaaggct
     2761 aaatcttgaa tacattgttg aattctttaa tatcctgatg gcaagcagac tgatagctgc
     2821 acatttggca tgctttgttt aatggatttt atttttaatt gcagatttat ttggcaatgt
     2881 acagtaaatt ttgtaaactt gcatcaagtt tatgaataaa gaaccattta aaaattttgt
     2941 ttgtgctgat catggcaagc aaaaaaaa
//
