LOCUS       NM_017582               3239 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens ubiquitin conjugating enzyme E2 Q1 (UBE2Q1), mRNA.
ACCESSION   NM_017582
VERSION     NM_017582.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3239)
  AUTHORS   Ghasemi,H., Seghatoleslam,A., Fahmideh Kar,M.A., Mahbudi,L.,
            Fard,B.G. and Jamshidi,M.
  TITLE     Analysis of the Interaction of UBE2Q1 with B4GALT1 and P53:
            Experimental and Molecular Modeling Study
  JOURNAL   Protein Pept Lett 30 (8), 668-678 (2023)
   PUBMED   37198983
  REMARK    GeneRIF: Analysis of the Interaction of UBE2Q1 with B4GALT1 and
            P53: Experimental and Molecular Modeling Study.
REFERENCE   2  (bases 1 to 3239)
  AUTHORS   Voth,K., Pasricha,S., Chung,I.Y.W., Wibawa,R.R., Zainudin,E.N.H.E.,
            Hartland,E.L. and Cygler,M.
  TITLE     Structural and Functional Characterization of
            Legionella&nbsp;pneumophila Effector MavL
  JOURNAL   Biomolecules 11 (12), 1802 (2021)
   PUBMED   34944446
  REMARK    GeneRIF: Structural and Functional Characterization of
            Legionella&nbsp;pneumophila Effector MavL.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3239)
  AUTHORS   Hu,N., Xie,X.C., Liu,L.L. and Lai,W.D.
  TITLE     Aberrant methylation of UBE2Q1 promoter is associated with poor
            prognosis of acute-on-chronic hepatitis B pre-liver failure
  JOURNAL   Medicine (Baltimore) 100 (21), e26066 (2021)
   PUBMED   34032735
  REMARK    GeneRIF: Aberrant methylation of UBE2Q1 promoter is associated with
            poor prognosis of acute-on-chronic hepatitis B pre-liver failure.
REFERENCE   4  (bases 1 to 3239)
  AUTHORS   Wang,J.C., Huang,Y., Zhang,R.X., Han,Z.J., Zhou,L.L., Sun,N.,
            Dong,W.Y. and Zhuang,G.S.
  TITLE     miR-338-3p inhibits autophagy in a rat model of allergic rhinitis
            after PM2.5 exposure through AKT/mTOR signaling by targeting UBE2Q1
  JOURNAL   Biochem Biophys Res Commun 554, 1-6 (2021)
   PUBMED   33770685
  REMARK    GeneRIF: miR-338-3p inhibits autophagy in a rat model of allergic
            rhinitis after PM2.5 exposure through AKT/mTOR signaling by
            targeting UBE2Q1.
REFERENCE   5  (bases 1 to 3239)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 3239)
  AUTHORS   Yoo,N.J., Park,S.W. and Lee,S.H.
  TITLE     Frameshift mutations of ubiquitination-related genes HERC2, HERC3,
            TRIP12, UBE2Q1 and UBE4B in gastric and colorectal carcinomas with
            microsatellite instability
  JOURNAL   Pathology 43 (7), 753-755 (2011)
   PUBMED   22124266
  REMARK    GeneRIF: we found somatic mutations of HERC2, HERC3, TRIP12, UBE2Q1
            and UBE4B genes in gastric carcinoma and colorectal carcinomas with
            microsatellite instability
REFERENCE   7  (bases 1 to 3239)
  AUTHORS   Wassler,M.J., Shur,B.D., Zhou,W. and Geng,Y.J.
  TITLE     Characterization of a novel ubiquitin-conjugating enzyme that
            regulates beta1,4-galactosyltransferase-1 in embryonic stem cells
  JOURNAL   Stem Cells 26 (8), 2006-2018 (2008)
   PUBMED   18511602
REFERENCE   8  (bases 1 to 3239)
  AUTHORS   Grelle,G., Kostka,S., Otto,A., Kersten,B., Genser,K.F.,
            Muller,E.C., Walter,S., Boddrich,A., Stelzl,U., Hanig,C.,
            Volkmer-Engert,R., Landgraf,C., Alberti,S., Hohfeld,J.,
            Strodicke,M. and Wanker,E.E.
  TITLE     Identification of VCP/p97, carboxyl terminus of Hsp70-interacting
            protein (CHIP), and amphiphysin II interaction partners using
            membrane-based human proteome arrays
  JOURNAL   Mol Cell Proteomics 5 (2), 234-244 (2006)
   PUBMED   16275660
REFERENCE   9  (bases 1 to 3239)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Fariss,R.N., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human RPE/choroid for the
            NEIBank Project: over 6000 non-redundant transcripts, novel genes
            and splice variants
  JOURNAL   Mol Vis 8, 205-220 (2002)
   PUBMED   12107410
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 3239)
  AUTHORS   Marenholz,I., Zirra,M., Fischer,D.F., Backendorf,C., Ziegler,A. and
            Mischke,D.
  TITLE     Identification of human epidermal differentiation complex
            (EDC)-encoded genes by subtractive hybridization of entire YACs to
            a gridded keratinocyte cDNA library
  JOURNAL   Genome Res 11 (3), 341-355 (2001)
   PUBMED   11230159
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL592078.10, CA391436.1 and
            AY112698.1.
            
            On Nov 23, 2018 this sequence version replaced NM_017582.6.
            
            Summary: The modification of proteins with ubiquitin is an
            important cellular mechanism for targeting abnormal or short-lived
            proteins for degradation. Ubiquitination involves at least three
            classes of enzymes: ubiquitin-activating enzymes (E1s),
            ubiquitin-conjugating enzymes (E2s), and ubiquitin-protein ligases
            (E3s). This gene encodes a member of the E2 ubiquitin-conjugating
            enzyme family. The encoded protein is 98% identical to the mouse
            counterpart. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript from the same
            strain was available for the full length of the gene. The extent of
            this transcript is supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY112698.1, SRR14038191.607198.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000292211.5/ ENSP00000292211.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AL592078.10        27983-28000
            19-43               CA391436.1         2-26
            44-2043             AY112698.1         1-2000
            2044-3239           AL592078.10        36873-38068
FEATURES             Location/Qualifiers
     source          1..3239
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..3239
                     /gene="UBE2Q1"
                     /gene_synonym="GTAP; NICE-5; NICE5; PRO3094; UBE2Q"
                     /note="ubiquitin conjugating enzyme E2 Q1"
                     /db_xref="GeneID:55585"
                     /db_xref="HGNC:HGNC:15698"
                     /db_xref="MIM:617429"
     exon            1..436
                     /gene="UBE2Q1"
                     /gene_synonym="GTAP; NICE-5; NICE5; PRO3094; UBE2Q"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..1378
                     /gene="UBE2Q1"
                     /gene_synonym="GTAP; NICE-5; NICE5; PRO3094; UBE2Q"
                     /EC_number="2.3.2.23"
                     /note="ubiquitin-conjugating enzyme E2Q (putative) 1;
                     galactosyl transferase-associated protein; protein NICE-5;
                     ubiquitin-protein ligase Q1; ubiquitin carrier protein Q1;
                     E2 ubiquitin-conjugating enzyme Q1; ubiquitin conjugating
                     enzyme E2Q family member 1"
                     /codon_start=1
                     /product="ubiquitin-conjugating enzyme E2 Q1"
                     /protein_id="NP_060052.3"
                     /db_xref="CCDS:CCDS1069.1"
                     /db_xref="GeneID:55585"
                     /db_xref="HGNC:HGNC:15698"
                     /db_xref="MIM:617429"
                     /translation="MQQPQPQGQQQPGPGQQLGGQGAAPGAGGGPGGGPGPGPCLRRE
                     LKLLESIFHRGHERFRIASACLDELSCEFLLAGAGGAGAGAAPGPHLPPRGSVPGDPV
                     RIHCNITESYPAVPPIWSVESDDPNLAAVLERLVDIKKGNTLLLQHLKRIISDLCKLY
                     NLPQHPDVEMLDQPLPAEQCTQEDVSSEDEDEEMPEDTEDLDHYEMKEEEPAEGKKSE
                     DDGIGKENLAILEKIKKNQRQDYLNGAVSGSVQATDRLMKELRDIYRSQSFKGGNYAV
                     ELVNDSLYDWNVKLLKVDQDSALHNDLQILKEKEGADFILLNFSFKDNFPFDPPFVRV
                     VSPVLSGGYVLGGGAICMELLTKQGWSSAYSIESVIMQISATLVKGKARVQFGANKSQ
                     YSLTRAQQSYKSLVQIHEKNGWYTPPKEDG"
     exon            437..541
                     /gene="UBE2Q1"
                     /gene_synonym="GTAP; NICE-5; NICE5; PRO3094; UBE2Q"
                     /inference="alignment:Splign:2.1.0"
     exon            542..646
                     /gene="UBE2Q1"
                     /gene_synonym="GTAP; NICE-5; NICE5; PRO3094; UBE2Q"
                     /inference="alignment:Splign:2.1.0"
     exon            647..697
                     /gene="UBE2Q1"
                     /gene_synonym="GTAP; NICE-5; NICE5; PRO3094; UBE2Q"
                     /inference="alignment:Splign:2.1.0"
     exon            698..838
                     /gene="UBE2Q1"
                     /gene_synonym="GTAP; NICE-5; NICE5; PRO3094; UBE2Q"
                     /inference="alignment:Splign:2.1.0"
     exon            839..923
                     /gene="UBE2Q1"
                     /gene_synonym="GTAP; NICE-5; NICE5; PRO3094; UBE2Q"
                     /inference="alignment:Splign:2.1.0"
     exon            924..984
                     /gene="UBE2Q1"
                     /gene_synonym="GTAP; NICE-5; NICE5; PRO3094; UBE2Q"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1075
                     /gene="UBE2Q1"
                     /gene_synonym="GTAP; NICE-5; NICE5; PRO3094; UBE2Q"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1134
                     /gene="UBE2Q1"
                     /gene_synonym="GTAP; NICE-5; NICE5; PRO3094; UBE2Q"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1183
                     /gene="UBE2Q1"
                     /gene_synonym="GTAP; NICE-5; NICE5; PRO3094; UBE2Q"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1279
                     /gene="UBE2Q1"
                     /gene_synonym="GTAP; NICE-5; NICE5; PRO3094; UBE2Q"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1346
                     /gene="UBE2Q1"
                     /gene_synonym="GTAP; NICE-5; NICE5; PRO3094; UBE2Q"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..3239
                     /gene="UBE2Q1"
                     /gene_synonym="GTAP; NICE-5; NICE5; PRO3094; UBE2Q"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1813..1818
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBE2Q1"
                     /gene_synonym="GTAP; NICE-5; NICE5; PRO3094; UBE2Q"
                     /note="hexamer: ATTACA"
     polyA_site      1833
                     /gene="UBE2Q1"
                     /gene_synonym="GTAP; NICE-5; NICE5; PRO3094; UBE2Q"
                     /note="major polyA site"
     regulatory      3222..3227
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBE2Q1"
                     /gene_synonym="GTAP; NICE-5; NICE5; PRO3094; UBE2Q"
                     /note="hexamer: AATAAA"
     polyA_site      3239
                     /gene="UBE2Q1"
                     /gene_synonym="GTAP; NICE-5; NICE5; PRO3094; UBE2Q"
ORIGIN      
        1 aggaagtgcg gaccgcggcg gcggcggcgg cggcggcggc ggcggcggag cccggagcgc
       61 aggccggagg ctcccggccc gccggccccg gagcggagcg gagcggagga tgcagcagcc
      121 gcagccgcag gggcagcagc agccggggcc ggggcagcag ctggggggcc agggggcggc
      181 gccgggggcc gggggcggcc cagggggggg cccggggccg gggccctgcc tgaggcgaga
      241 gctgaagctg ctcgagtcca tcttccaccg cggccacgag cgcttccgca ttgccagcgc
      301 ctgcctggac gagctgagct gcgagttcct gctggctggg gccggagggg ccggggcggg
      361 ggccgcgccc ggaccgcatc tccccccacg ggggtcggtg cctggggatc ctgtccgcat
      421 ccactgcaac atcacggagt cataccctgc tgtgcccccc atctggtcgg tggagtctga
      481 tgaccctaac ttggctgctg tcttggagag gctggtggac ataaagaaag ggaatactct
      541 gctattgcag catctgaaga ggatcatctc cgacctgtgt aaactctata acctccctca
      601 gcatccagat gtggagatgc tggatcaacc cttgccagca gagcagtgca cacaggaaga
      661 cgtgtcttca gaagatgaag atgaggagat gcctgaggac acagaagact tagatcacta
      721 tgaaatgaaa gaggaagagc cagctgaggg caagaaatct gaagatgatg gcattggaaa
      781 agaaaacttg gccatcctag agaaaattaa aaagaaccag aggcaagatt acttaaatgg
      841 tgcagtgtct ggctcggtgc aggccactga ccggctgatg aaggagctca gggatatata
      901 ccgatcacag agtttcaaag gcggaaacta tgcagtcgaa ctcgtgaatg acagtctgta
      961 tgattggaat gtcaaactcc tcaaagttga ccaggacagc gctttgcaca acgatctcca
     1021 gatcctcaaa gagaaagaag gagccgactt cattctactt aacttttcct ttaaagataa
     1081 ctttcccttt gacccaccat ttgtcagggt tgtgtctcca gtcctctctg gagggtatgt
     1141 tctgggcgga ggggccatct gcatggaact tctcaccaaa cagggctgga gcagtgccta
     1201 ctccatagag tcagtgatca tgcagatcag tgccacactg gtgaagggga aagcacgagt
     1261 gcagtttgga gccaacaaat ctcaatacag tctgacaaga gcacagcagt cctacaagtc
     1321 cttggtgcag atccacgaaa aaaacggctg gtacacaccc ccaaaagaag acggctaacc
     1381 ctggagtatc acccttcctc cctccccagg caccactgga ccaattacct ttgaatgctg
     1441 tatttggatc tcacgctgcc tctgtggttc cctccctcat ttttcctgga cgtgatagct
     1501 ctgcctattg caggacaatg atggctattc taaacgctaa ggaaaaaaaa caaacacaga
     1561 actgtttcaa gtactcaaga ctgacttaca gaccaaccaa ccaccttgct ggaacccttg
     1621 ctagcaggca ttcttataaa agaaactttc gagcctcctt atattgctgg aaactcagct
     1681 gtgctccaga ctagagcctc cttacctatg ctatggattt ttaatttatt ttctcttatt
     1741 tcatgtacac tgcttttttt ggttacagtg tatgatggat gtgtatgaaa aaaatgtatc
     1801 tttgggaaaa caattacagt ttgttaattt gaagatgctg gtcttgactc atctttattt
     1861 ttattcgcac atcccacccc atcccctgaa ctacttggga ggtggggagg ggtacgagtc
     1921 cactgttgct ttggtagaga tgagaggccg cattttgctg ctaaagcaag agaaacttgg
     1981 agctgaagca cacacctggt ctgcccctag atttctcctc aaggcctctg gagcaaccag
     2041 cacttgcccc cttggaatgc agagcctggc ctgccaaact acaatgtggt aggctgaaac
     2101 gatggtgtta attcttagga ctacttttct agtcacagat gttttcaaat ttctaagaaa
     2161 aagaaaatga ggctcaagag gctgcttcgt agaattcctt ttgaatgaat tgagtgggga
     2221 tggggacaca gtctccaagt gtgtatgtgg tcttttctga tctcagctgt gtggctgcaa
     2281 ctcttcgctg ttcattggtt cctctcctgg aaagtggctt ctaaccagca ctggatggtg
     2341 atcattggta agctttgctc acctccctct ctcttgcttc atttggcttt atcaaaaaga
     2401 acagacctag ctctgaattt gtttggcttg ggaaattatg gattctttca agccactccc
     2461 acaaggtggg tcctactaga aagggttagc attttaaggg gggttgttct atacacctgt
     2521 gtccttaccc caggctcagg aactgccagg gagggaagat gaggtgggga gtctgtactg
     2581 agatggaact gtcagtgctg tgttgtatgt acttgctgtt gtaaaagttt gggcatgact
     2641 ttgcatctag cgggtgctgc ctgcatctct ttgtctgtaa gcttgctctg ggactcagcc
     2701 tcttaggacc tacgatgcca gcagctctca ttaacagtga aatgacagag gccaaagatg
     2761 gccaagtgaa gacccaagtc tcagaaaacc cagacttggg acaactgcct gggaactagg
     2821 atgctagagc agttctgtaa tgctttgaga cacagcaatt ttcacattgg ccattctttc
     2881 ccctccccta ccccttttct tttgagggac ttttaatgtt tgctgcttta ggtggatgga
     2941 gagtccacca gtcccactca atgctgctct aactctaccc acacccacct aattaggggt
     3001 gctaataaaa catgctgagg ttgagataaa gacgggacat aaggggaaaa ttcattccat
     3061 agagctgaaa tctggttttc aaggcctctg tggctttctt ctgaacttac caccagccct
     3121 ggctggaatg tagattgtgt ttttagtaat gtgtactgtg agctgtcttc tgtataatgt
     3181 attttgtaat gtatttttct catctaccaa aggatgaaac aaataaaatt atttaaata
//
