LOCUS       NM_004223               1219 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens ubiquitin conjugating enzyme E2 L6 (UBE2L6),
            transcript variant 1, mRNA.
ACCESSION   NM_004223
VERSION     NM_004223.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1219)
  AUTHORS   Shibahara,M., Kurita,T., Murakami,M., Harada,H., Koi,C., Izumi,H.
            and Yoshino,K.
  TITLE     Association of UBE2L6 and ABCB6 Expression With Platinum Resistance
            in Serous Ovarian Carcinoma
  JOURNAL   Anticancer Res 43 (8), 3787-3792 (2023)
   PUBMED   37500176
  REMARK    GeneRIF: Association of UBE2L6 and ABCB6 Expression With Platinum
            Resistance in Serous Ovarian Carcinoma.
REFERENCE   2  (bases 1 to 1219)
  AUTHORS   Gao,J., Li,C., Li,W., Chen,H., Fu,Y. and Yi,Z.
  TITLE     Increased UBE2L6 regulated by type 1 interferon as potential marker
            in TB
  JOURNAL   J Cell Mol Med 25 (24), 11232-11243 (2021)
   PUBMED   34773365
  REMARK    GeneRIF: Increased UBE2L6 regulated by type 1 interferon as
            potential marker in TB.
REFERENCE   3  (bases 1 to 1219)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1219)
  AUTHORS   Li,G., Wang,J., He,X., Zhang,L., Ran,Q., Xiong,A., Wu,D., Hu,L.,
            Song,Q. and Zhu,D.
  TITLE     An integrative analysis identifying transcriptional features and
            key genes involved in COVID-19
  JOURNAL   Epigenomics 12 (22), 1969-1981 (2020)
   PUBMED   33242255
  REMARK    GeneRIF: An integrative analysis identifying transcriptional
            features and key genes involved in COVID-19.
REFERENCE   5  (bases 1 to 1219)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 1219)
  AUTHORS   Nyman,T.A., Matikainen,S., Sareneva,T., Julkunen,I. and
            Kalkkinen,N.
  TITLE     Proteome analysis reveals ubiquitin-conjugating enzymes to be a new
            family of interferon-alpha-regulated genes
  JOURNAL   Eur J Biochem 267 (13), 4011-4019 (2000)
   PUBMED   10866800
REFERENCE   7  (bases 1 to 1219)
  AUTHORS   Huang,L., Kinnucan,E., Wang,G., Beaudenon,S., Howley,P.M.,
            Huibregtse,J.M. and Pavletich,N.P.
  TITLE     Structure of an E6AP-UbcH7 complex: insights into ubiquitination by
            the E2-E3 enzyme cascade
  JOURNAL   Science 286 (5443), 1321-1326 (1999)
   PUBMED   10558980
REFERENCE   8  (bases 1 to 1219)
  AUTHORS   Moynihan,T.P., Ardley,H.C., Nuber,U., Rose,S.A., Jones,P.F.,
            Markham,A.F., Scheffner,M. and Robinson,P.A.
  TITLE     The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with
            RING finger/IBR motif-containing domains of HHARI and H7-AP1
  JOURNAL   J Biol Chem 274 (43), 30963-30968 (1999)
   PUBMED   10521492
REFERENCE   9  (bases 1 to 1219)
  AUTHORS   Kang,H.Y., Yeh,S., Fujimoto,N. and Chang,C.
  TITLE     Cloning and characterization of human prostate coactivator ARA54, a
            novel protein that associates with the androgen receptor
  JOURNAL   J Biol Chem 274 (13), 8570-8576 (1999)
   PUBMED   10085091
REFERENCE   10 (bases 1 to 1219)
  AUTHORS   Kumar,S., Kao,W.H. and Howley,P.M.
  TITLE     Physical interaction between specific E2 and Hect E3 enzymes
            determines functional cooperativity
  JOURNAL   J Biol Chem 272 (21), 13548-13554 (1997)
   PUBMED   9153201
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC032491.1 and H17887.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004223.4.
            
            Summary: The modification of proteins with ubiquitin is an
            important cellular mechanism for targeting abnormal or short-lived
            proteins for degradation. Ubiquitination involves at least three
            classes of enzymes: ubiquitin-activating enzymes (E1s),
            ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases
            (E3s). This gene encodes a member of the E2 ubiquitin-conjugating
            enzyme family. This enzyme is highly similar in primary structure
            to the enzyme encoded by the UBE2L3 gene. Two alternatively spliced
            transcript variants encoding distinct isoforms have been found for
            this gene. [provided by RefSeq, May 2011].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032491.1, SRR3476690.293196.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000287156.9/ ENSP00000287156.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1014              BC032491.1         36-1049
            1015-1219           H17887.1           30-234              c
FEATURES             Location/Qualifiers
     source          1..1219
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.1"
     gene            1..1219
                     /gene="UBE2L6"
                     /gene_synonym="RIG-B; UBCH8"
                     /note="ubiquitin conjugating enzyme E2 L6"
                     /db_xref="GeneID:9246"
                     /db_xref="HGNC:HGNC:12490"
                     /db_xref="MIM:603890"
     exon            1..88
                     /gene="UBE2L6"
                     /gene_synonym="RIG-B; UBCH8"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..523
                     /gene="UBE2L6"
                     /gene_synonym="RIG-B; UBCH8"
                     /EC_number="2.3.2.23"
                     /note="isoform 1 is encoded by transcript variant 1;
                     retinoic acid induced gene B protein;
                     ubiquitin/ISG15-conjugating enzyme E2 L6; ubiquitin
                     conjugating enzyme E2L 6; ubiquitin-protein ligase L6;
                     ubiquitin carrier protein L6; E2 ubiquitin-conjugating
                     enzyme L6"
                     /codon_start=1
                     /product="ubiquitin/ISG15-conjugating enzyme E2 L6 isoform
                     1"
                     /protein_id="NP_004214.1"
                     /db_xref="CCDS:CCDS7960.1"
                     /db_xref="GeneID:9246"
                     /db_xref="HGNC:HGNC:12490"
                     /db_xref="MIM:603890"
                     /translation="MMASMRVVKELEDLQKKPPPYLRNLSSDDANVLVWHALLLPDQP
                     PYHLKAFNLRISFPPEYPFKPPMIKFTTKIYHPNVDENGQICLPIISSENWKPCTKTC
                     QVLEALNVLVNRPNIREPLRMDLADLLTQNPELFRKNAEEFTLRFGVDRPS"
     exon            89..184
                     /gene="UBE2L6"
                     /gene_synonym="RIG-B; UBCH8"
                     /inference="alignment:Splign:2.1.0"
     exon            185..371
                     /gene="UBE2L6"
                     /gene_synonym="RIG-B; UBCH8"
                     /inference="alignment:Splign:2.1.0"
     exon            372..1219
                     /gene="UBE2L6"
                     /gene_synonym="RIG-B; UBCH8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1202..1207
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBE2L6"
                     /gene_synonym="RIG-B; UBCH8"
                     /note="hexamer: ATTAAA"
     polyA_site      1219
                     /gene="UBE2L6"
                     /gene_synonym="RIG-B; UBCH8"
                     /note="major polyA site"
ORIGIN      
        1 gtgtcgcggg tcggagctcg gtcctgctgg aggccacggg tgccacacac tcggtcccga
       61 catgatggcg agcatgcgag tggtgaagga gctggaggat cttcagaaga agcctccccc
      121 atacctgcgg aacctgtcca gcgatgatgc caatgtcctg gtgtggcacg ctctcctcct
      181 acccgaccaa cctccctacc acctgaaagc cttcaacctg cgcatcagct tcccgccgga
      241 gtatccgttc aagcctccca tgatcaaatt cacaaccaag atctaccacc ccaacgtgga
      301 cgagaacgga cagatttgcc tgcccatcat cagcagtgag aactggaagc cttgcaccaa
      361 gacttgccaa gtcctggagg ccctcaatgt gctggtgaat agaccgaata tcagggagcc
      421 cctgcggatg gacctcgctg acctgctgac acagaatccg gagctgttca gaaagaatgc
      481 cgaagagttc accctccgat tcggagtgga ccggccctcc taactcatgt tctgaccctc
      541 tgtgcactgg atcctcggca tagcggacgg acacacctca tggactgagg ccagagcccc
      601 ctgtggccca ttccccattc atttttccct tcttaggttg ttagtcatta gtttgtgtgt
      661 gtgtgtggtg gagggaaggg agctatgagt gtgtgtgttg tgtatggact cactcccagg
      721 ttcacctggc cacaggtgca cccttcccac accctttaca ttccccagag ccaagggagt
      781 ttaagtttgc agttacaggc cagttctcca gctctccatc ttagagagac aggtcacctt
      841 gcaggcctgc ttgcaggaaa tgaatccagc agccaactcg aatcccccta gggctcaggc
      901 actgagggcc tggggacagt ggagcatatg ggtgggagac agatggaggg taccctattt
      961 acaactgagt cagccaagcc actgatggga atatacagat ttaggtgcta aaccatttat
     1021 tttccacgga tgagtcacaa tctgaagaat caaacttcca tcctgaaaat ctatatgttt
     1081 caaaaccact tgccatcctg ttagattgcc agttcctggg accaggcctc agactgtgaa
     1141 gtatatatcc tccagcattc agtccagggg gagccacgga aaccatgttc ttgcttaagc
     1201 cattaaagtc agagatgaa
//
