LOCUS       NM_016021               4164 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens ubiquitin conjugating enzyme E2 J1 (UBE2J1), mRNA.
ACCESSION   NM_016021 NM_016336
VERSION     NM_016021.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4164)
  AUTHORS   Rodriguez Tirado,C., Wang,C., Li,X., Deng,S., Gonzalez,J.,
            Johnson,N.A., Xu,Y., Metang,L.A., Sundar Rajan,M., Yang,Y., Yin,Y.,
            Hofstad,M., Raj,G.V., Zhang,S., Lemoff,A., He,W., Fan,J., Wang,Y.,
            Wang,T. and Mu,P.
  TITLE     UBE2J1 is the E2 ubiquitin-conjugating enzyme regulating androgen
            receptor degradation and antiandrogen resistance
  JOURNAL   Oncogene 43 (4), 265-280 (2024)
   PUBMED   38030789
  REMARK    GeneRIF: UBE2J1 is the E2 ubiquitin-conjugating enzyme regulating
            androgen receptor degradation and antiandrogen resistance.
REFERENCE   2  (bases 1 to 4164)
  AUTHORS   Wang,T., Jin,C., Yang,P., Chen,Z., Ji,J., Sun,Q., Yang,S., Feng,Y.,
            Tang,J. and Sun,Y.
  TITLE     UBE2J1 inhibits colorectal cancer progression by promoting
            ubiquitination and degradation of RPS3
  JOURNAL   Oncogene 42 (9), 651-664 (2023)
   PUBMED   36567344
  REMARK    GeneRIF: UBE2J1 inhibits colorectal cancer progression by promoting
            ubiquitination and degradation of RPS3.
REFERENCE   3  (bases 1 to 4164)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 4164)
  AUTHORS   Yang,D., Ma,X., Xu,J., Jia,K., Liu,X. and Zhang,P.
  TITLE     Zfx-induced upregulation of UBE2J1 facilitates endometrial cancer
            progression via PI3K/AKT pathway
  JOURNAL   Cancer Biol Ther 22 (3), 238-247 (2021)
   PUBMED   33632059
  REMARK    GeneRIF: Zfx-induced upregulation of UBE2J1 facilitates endometrial
            cancer progression via PI3K/AKT pathway.
REFERENCE   5  (bases 1 to 4164)
  AUTHORS   Cremer,T., Jongsma,M.L.M., Trulsson,F., Vertegaal,A.C.O.,
            Neefjes,J. and Berlin,I.
  TITLE     The ER-embedded UBE2J1/RNF26 ubiquitylation complex exerts
            spatiotemporal control over the endolysosomal pathway
  JOURNAL   Cell Rep 34 (3), 108659 (2021)
   PUBMED   33472082
REFERENCE   6  (bases 1 to 4164)
  AUTHORS   Wu,C.J., Conze,D.B., Li,X., Ying,S.X., Hanover,J.A. and
            Ashwell,J.D.
  TITLE     TNF-alpha induced c-IAP1/TRAF2 complex translocation to a
            Ubc6-containing compartment and TRAF2 ubiquitination
  JOURNAL   EMBO J 24 (10), 1886-1898 (2005)
   PUBMED   15861135
REFERENCE   7  (bases 1 to 4164)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   8  (bases 1 to 4164)
  AUTHORS   Lenk,U., Yu,H., Walter,J., Gelman,M.S., Hartmann,E., Kopito,R.R.
            and Sommer,T.
  TITLE     A role for mammalian Ubc6 homologues in ER-associated protein
            degradation
  JOURNAL   J Cell Sci 115 (Pt 14), 3007-3014 (2002)
   PUBMED   12082160
REFERENCE   9  (bases 1 to 4164)
  AUTHORS   Imai,Y., Soda,M., Inoue,H., Hattori,N., Mizuno,Y. and Takahashi,R.
  TITLE     An unfolded putative transmembrane polypeptide, which can lead to
            endoplasmic reticulum stress, is a substrate of Parkin
  JOURNAL   Cell 105 (7), 891-902 (2001)
   PUBMED   11439185
REFERENCE   10 (bases 1 to 4164)
  AUTHORS   Lester,D., Farquharson,C., Russell,G. and Houston,B.
  TITLE     Identification of a family of noncanonical ubiquitin-conjugating
            enzymes structurally related to yeast UBC6
  JOURNAL   Biochem Biophys Res Commun 269 (2), 474-480 (2000)
   PUBMED   10708578
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC013973.1, AF151834.1,
            AJ420578.1 and AJ420522.1.
            
            On Nov 22, 2018 this sequence version replaced NM_016021.2.
            
            Summary: The modification of proteins with ubiquitin is an
            important cellular mechanism for targeting abnormal or short-lived
            proteins for degradation. Ubiquitination involves at least three
            classes of enzymes: ubiquitin-activating enzymes, or E1s,
            ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein
            ligases, or E3s. This gene encodes a member of the E2
            ubiquitin-conjugating enzyme family. This enzyme is located in the
            membrane of the endoplasmic reticulum (ER) and may contribute to
            quality control ER-associated degradation by the
            ubiquitin-proteasome system. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.283037.1,
                                           SRR1660807.27293.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000435041.3/ ENSP00000451261.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-831               BC013973.1         141-971
            832-1801            AF151834.1         817-1786
            1802-2539           AJ420578.1         1630-2367
            2540-4164           AJ420522.1         672-2296
FEATURES             Location/Qualifiers
     source          1..4164
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q15"
     gene            1..4164
                     /gene="UBE2J1"
                     /gene_synonym="CGI-76; HSPC153; HSPC205; HSU93243;
                     NCUBE-1; NCUBE1; UBC6; UBC6E; Ubc6p"
                     /note="ubiquitin conjugating enzyme E2 J1"
                     /db_xref="GeneID:51465"
                     /db_xref="HGNC:HGNC:17598"
                     /db_xref="MIM:616175"
     exon            1..184
                     /gene="UBE2J1"
                     /gene_synonym="CGI-76; HSPC153; HSPC205; HSU93243;
                     NCUBE-1; NCUBE1; UBC6; UBC6E; Ubc6p"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..1110
                     /gene="UBE2J1"
                     /gene_synonym="CGI-76; HSPC153; HSPC205; HSU93243;
                     NCUBE-1; NCUBE1; UBC6; UBC6E; Ubc6p"
                     /EC_number="2.3.2.23"
                     /note="ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog,
                     yeast); HSUBC6e; non-canonical ubiquitin-conjugating
                     enzyme 1; yeast ubiquitin-conjugating enzyme UBC6 homolog
                     E; ubiquitin-conjugating enzyme E2, J1, U; E2
                     ubiquitin-conjugating enzyme J1"
                     /codon_start=1
                     /product="ubiquitin-conjugating enzyme E2 J1"
                     /protein_id="NP_057105.2"
                     /db_xref="CCDS:CCDS5021.1"
                     /db_xref="GeneID:51465"
                     /db_xref="HGNC:HGNC:17598"
                     /db_xref="MIM:616175"
                     /translation="METRYNLKSPAVKRLMKEAAELKDPTDHYHAQPLEDNLFEWHFT
                     VRGPPDSDFDGGVYHGRIVLPPEYPMKPPSIILLTANGRFEVGKKICLSISGHHPETW
                     QPSWSIRTALLAIIGFMPTKGEGAIGSLDYTPEERRALAKKSQDFCCEGCGSAMKDVL
                     LPLKSGSDSSQADQEAKELARQISFKAEVNSSGKTISESDLNHSFSLTDLQDDIPTTF
                     QGATASTSYGLQNSSAASFHQPTQPVAKNTSMSPRQRRAQQQSQRRLSTSPDVIQGHQ
                     PRDNHTDHGGSAVLIVILTLALAALIFRRIYLANEYIFDFEL"
     exon            185..258
                     /gene="UBE2J1"
                     /gene_synonym="CGI-76; HSPC153; HSPC205; HSU93243;
                     NCUBE-1; NCUBE1; UBC6; UBC6E; Ubc6p"
                     /inference="alignment:Splign:2.1.0"
     exon            259..390
                     /gene="UBE2J1"
                     /gene_synonym="CGI-76; HSPC153; HSPC205; HSU93243;
                     NCUBE-1; NCUBE1; UBC6; UBC6E; Ubc6p"
                     /inference="alignment:Splign:2.1.0"
     exon            391..475
                     /gene="UBE2J1"
                     /gene_synonym="CGI-76; HSPC153; HSPC205; HSU93243;
                     NCUBE-1; NCUBE1; UBC6; UBC6E; Ubc6p"
                     /inference="alignment:Splign:2.1.0"
     exon            476..581
                     /gene="UBE2J1"
                     /gene_synonym="CGI-76; HSPC153; HSPC205; HSU93243;
                     NCUBE-1; NCUBE1; UBC6; UBC6E; Ubc6p"
                     /inference="alignment:Splign:2.1.0"
     exon            582..711
                     /gene="UBE2J1"
                     /gene_synonym="CGI-76; HSPC153; HSPC205; HSU93243;
                     NCUBE-1; NCUBE1; UBC6; UBC6E; Ubc6p"
                     /inference="alignment:Splign:2.1.0"
     exon            712..831
                     /gene="UBE2J1"
                     /gene_synonym="CGI-76; HSPC153; HSPC205; HSU93243;
                     NCUBE-1; NCUBE1; UBC6; UBC6E; Ubc6p"
                     /inference="alignment:Splign:2.1.0"
     exon            832..4164
                     /gene="UBE2J1"
                     /gene_synonym="CGI-76; HSPC153; HSPC205; HSU93243;
                     NCUBE-1; NCUBE1; UBC6; UBC6E; Ubc6p"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1150..1155
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBE2J1"
                     /gene_synonym="CGI-76; HSPC153; HSPC205; HSU93243;
                     NCUBE-1; NCUBE1; UBC6; UBC6E; Ubc6p"
                     /note="hexamer: ATTAAA"
     polyA_site      1179
                     /gene="UBE2J1"
                     /gene_synonym="CGI-76; HSPC153; HSPC205; HSU93243;
                     NCUBE-1; NCUBE1; UBC6; UBC6E; Ubc6p"
                     /note="major polyA site"
     regulatory      2696..2701
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBE2J1"
                     /gene_synonym="CGI-76; HSPC153; HSPC205; HSU93243;
                     NCUBE-1; NCUBE1; UBC6; UBC6E; Ubc6p"
                     /note="hexamer: AATAAA"
     polyA_site      2718
                     /gene="UBE2J1"
                     /gene_synonym="CGI-76; HSPC153; HSPC205; HSU93243;
                     NCUBE-1; NCUBE1; UBC6; UBC6E; Ubc6p"
                     /note="major polyA site"
     regulatory      3630..3635
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBE2J1"
                     /gene_synonym="CGI-76; HSPC153; HSPC205; HSU93243;
                     NCUBE-1; NCUBE1; UBC6; UBC6E; Ubc6p"
                     /note="hexamer: AATAAA"
     polyA_site      3649
                     /gene="UBE2J1"
                     /gene_synonym="CGI-76; HSPC153; HSPC205; HSU93243;
                     NCUBE-1; NCUBE1; UBC6; UBC6E; Ubc6p"
     regulatory      4140..4145
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBE2J1"
                     /gene_synonym="CGI-76; HSPC153; HSPC205; HSU93243;
                     NCUBE-1; NCUBE1; UBC6; UBC6E; Ubc6p"
                     /note="hexamer: AATAAA"
     polyA_site      4164
                     /gene="UBE2J1"
                     /gene_synonym="CGI-76; HSPC153; HSPC205; HSU93243;
                     NCUBE-1; NCUBE1; UBC6; UBC6E; Ubc6p"
                     /note="major polyA site"
ORIGIN      
        1 accccgcccg cagtccaggc tggactgggc ggcatttgcc gaggctcctc ggccaggccc
       61 cgtccgcccg agccgcgctg agacccgggc agcggccgcg tggagaggag gtggcagcgg
      121 cccgggaggc cggagccaag ccagcgaccc accatggaga cccgctacaa cctgaagagt
      181 ccggctgtta aacgtttaat gaaagaagcg gcagaattga aagatccaac agatcattac
      241 catgcgcagc ctttagagga taaccttttt gaatggcact tcacggttag agggccccca
      301 gactccgatt ttgatggagg agtttatcac gggcggatag tactgccacc agagtatccc
      361 atgaaaccac caagcattat tctcctaacg gctaatggtc gatttgaagt gggcaagaaa
      421 atctgtttga gcatctcagg ccatcatcct gaaacttggc agccttcgtg gagtataagg
      481 acagcattat tagccatcat tgggtttatg ccaacaaaag gagagggagc cataggttct
      541 ctagattaca ctcctgagga aagaagagca cttgccaaaa aatcacaaga tttctgttgt
      601 gaaggatgtg gctctgccat gaaggatgtc ctgttgcctt taaaatctgg aagcgattca
      661 agccaagctg accaagaagc caaagaactg gctaggcaaa taagctttaa ggcagaagtc
      721 aattcatctg gaaagactat ctctgagtca gacttaaacc actctttttc actaactgat
      781 ttacaagatg atatacctac aacattccag ggtgctacgg ccagtacatc gtacggactc
      841 cagaattcct cagcagcatc ctttcatcaa cctacccaac ctgtagctaa gaatacctcc
      901 atgagccctc gacagcgccg ggcccagcag cagagtcaga gaaggttgtc tacttcacca
      961 gatgtaatcc agggccacca gccaagagac aaccacactg atcatggtgg gtcagctgta
     1021 ctgattgtca tcctgacttt ggcattggca gctcttatat tccgacgaat atatctggca
     1081 aacgaataca tatttgactt tgagttataa tatggttttg tgacttatga gctgtgactc
     1141 aactgcttca ttaaacattc tgcattgggt ataatctaag aattgtttac aaaaagatta
     1201 ttttgtattt acccttcatt cctttttttg atccttgtaa gtttagtata aatatatcta
     1261 gacattcaga ctgtgtctag cagttacgtc ctgcttaaag ggactagaag tcaaagttcc
     1321 ttgtctcact atttgatctg ctttgcaggg aaataacttg ttttttctca tgtttcatct
     1381 tctttttatg taaatttgta atactttcct atattgccct ttgaaatttt tggataaaag
     1441 atgatgtttt aagttccaat gagtattact agttactcaa taccacttat tgagtactct
     1501 gtttctacgt atgtagaatg tatagggata gaagagttga aaagggaaag caaaactcct
     1561 caagtagctt ccttaaaatg tcattcatag gagatgtact ggaattgctc attctgtgac
     1621 tttatttgtg tcctaaacat tcttcagtga aaataatttt atttcagtca aacatttatg
     1681 aggaaatgag atcacatctt tgtcactgga tgctacttga agagggagta ctttgtaacc
     1741 actttgatat gctgttatca ccaccccctg ccctctgctg ccataatcac acaaatttaa
     1801 aaagaaagaa aacagtcttc catagatttt taaggaagaa agggcccaag ccaggagatc
     1861 gcttggtttt cttccagaag ttaaatgggg ggatctgaag atttgaatgt ttggtctgct
     1921 ttgaaatgta tgtcttttgg gatgtattat atgcctagct ttataatcag tataaatttt
     1981 aattattcca ggaatatgca taatattgaa atatttcatg tcctatttta atagaaaacc
     2041 tcagggccca agtaacagtg atagaagtta gaaaaacctt tacttagaat tgtccaccta
     2101 gtcagagccc aagaaagaat tttcagtgga aaaatcaata tataacttag tgctagctag
     2161 cgccacagac tctagtagat aatattatca tcataatggc tggtgaaacc atataatcac
     2221 agaaaaacat tgccttcagc atgttcagtt cgcagcactg agggcactct tgagggtgtt
     2281 gttaatgaag atttaatttt taaatacagg tggttccaag ctttcaaata ggttatgctc
     2341 caaaagtgtt atttgtaagt taattttttt acaagtcaaa caatgttgga agtggtattt
     2401 aggttctaga tcggtccacg aaagttagcc catatgtata tcttgaatag tataggggag
     2461 ggtattcata aagtccttat gtggttttaa ctaagtgaaa ttatggacaa gagaaataat
     2521 tgtaaaatcg tcttaaagga aaatttaatt tttactcctg tttatgggac attcgttcta
     2581 ttaactgtca gacacaattt ctgttttcat ctgagagcca gttttccttt atttctacat
     2641 ctaaaataag aacatattgt acactattat ataatacaga attgtcttaa actttaataa
     2701 attcgcattt taaaggtgtt tacagattat tttttatatc tgtagctgaa tttgttaaag
     2761 tctaaaaagc tcaaggactt tatgaagatc tcattatatg aggaaaatca taggttacca
     2821 ttttataact ctattgccat aagaaaatac actctaaaat cttgatttga aacatattag
     2881 aaaccttgat tcagtgctca gtggtctcct agtaagaagt caccgacggt agcgtcatat
     2941 gagaagaaag aaatccccac cacctcaacc tctgctgaga ttgtgtgcta ggaacagcct
     3001 tccctccgtt tcccctcagt caaacttgag ccagcctctg gatcgatgtg atcttattgc
     3061 atgtttccat ggggtgtacc tatactttaa gccaatcctg ctgcattcac tgctaagtta
     3121 aataaaaagc caagaagatt ttgcactgtg cagatccttt gctatctgac ttgcatctct
     3181 tcccccacct gtcagctagc cacctgcttg tttgtgttgg gatatttttt agcacctgaa
     3241 gcaccatctg aaaggggcac cattttcttc ttccctttga tctcacatat gctccctaaa
     3301 aatccttaag ttgtcaatct gatccccagt gtgaggttaa tgagcaaaat tggtctttgg
     3361 ggcccttttt gtccaagccc cactgaaagg cctcttcaga aaactattat ctttaaagcc
     3421 ctactttaac tccttaattc cagcatacag ctaaaactgg atgtatattc tggcaagtaa
     3481 aggctgagga ctcctcttta atcctcagat ctagataact catgacattt tatttgacca
     3541 acatagcaca tgatgagata tcaaggtaat taaaatagca tgcttgaaaa aaaaatacgt
     3601 aatctgtttc acctgtaact gtttaagcca ataaactttt caaaatttat gtaatgtggg
     3661 gcttttatgt agcactttac gttttcatgc tgcttattgt tttattctac tgaaaaaaat
     3721 gaatttcaag attctcaact tttttaattt caaaaattgt ttattgtttt gactatagga
     3781 atacaaaatt tcctattttg ggagaataag aactcttttt gtcatttttg gctatgaata
     3841 aactttctgg tcttttgaga ccacccattt ttatagatca gaatcagaaa acaggtaaac
     3901 ctcactcaca catttggact catttgaaca aaaatctagg ccaaaatact gaaaagccta
     3961 tgtgtttttt taattggaag tatatgtaag gttaatgcat ttagtgaacg tgactaacaa
     4021 agactaatgt gcacattaac agatgtactt tttaaggttt tatgggaggc tgtgcattgc
     4081 tcaaaagctg ttgggaacgc cttctgaaca gttgccttca gaactagttt gagctgctca
     4141 ataaaaccag tgactttact cata
//
