LOCUS       NM_007019                777 bp    mRNA    linear   PRI 28-AUG-2024
DEFINITION  Homo sapiens ubiquitin conjugating enzyme E2 C (UBE2C), transcript
            variant 1, mRNA.
ACCESSION   NM_007019
VERSION     NM_007019.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 777)
  AUTHORS   Jiang,Y., Liu,B., Fu,L. and Li,F.
  TITLE     UBE2C regulates the KEAP1/NRF2 signaling pathway to promote the
            growth of gastric cancer by inhibiting autophagy
  JOURNAL   Int J Biol Macromol 276 (Pt 2), 134011 (2024)
   PUBMED   39032892
  REMARK    GeneRIF: UBE2C regulates the KEAP1/NRF2 signaling pathway to
            promote the growth of gastric cancer by inhibiting autophagy.
REFERENCE   2  (bases 1 to 777)
  AUTHORS   Li,W., Chen,C., Zheng,H., Lin,Y., An,M., Liu,D., Zhang,Y., Gao,M.,
            Lan,T. and He,W.
  TITLE     UBE2C-induced crosstalk between mono- and polyubiquitination of
            SNAT2 promotes lymphatic metastasis in bladder cancer
  JOURNAL   J Clin Invest 134 (13), e179122 (2024)
   PUBMED   38949026
  REMARK    GeneRIF: UBE2C-induced crosstalk between mono- and
            polyubiquitination of SNAT2 promotes lymphatic metastasis in
            bladder cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 777)
  AUTHORS   Wang,L., Zhao,S., Wang,Y., Liu,J. and Wang,X.
  TITLE     UBE2C promotes the proliferation of acute myeloid leukemia cells
            through PI3K/AKT activation
  JOURNAL   BMC Cancer 24 (1), 497 (2024)
   PUBMED   38637730
  REMARK    GeneRIF: UBE2C promotes the proliferation of acute myeloid leukemia
            cells through PI3K/AKT activation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 777)
  AUTHORS   Ong,K.H., Lai,H.Y., Sun,D.P., Chen,T.J., Huang,S.K., Tian,Y.F.,
            Chou,C.L., Shiue,Y.L., Chan,T.C., Li,C.F. and Kuo,Y.H.
  TITLE     Ubiquitin-conjugating enzyme E2C (UBE2C) is a prognostic indicator
            for cholangiocarcinoma
  JOURNAL   Eur J Med Res 28 (1), 593 (2023)
   PUBMED   38102624
  REMARK    GeneRIF: Ubiquitin-conjugating enzyme E2C (UBE2C) is a prognostic
            indicator for cholangiocarcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 777)
  AUTHORS   Luo,R., Bai,R., Guo,J., Xian,N. and Zheng,Y.
  TITLE     UBE2C promotes malignancy of cutaneous squamous cell carcinoma
  JOURNAL   Skin Res Technol 29 (11), e13526 (2023)
   PUBMED   38009019
  REMARK    GeneRIF: UBE2C promotes malignancy of cutaneous squamous cell
            carcinoma.
REFERENCE   6  (bases 1 to 777)
  AUTHORS   Okamoto,Y., Ozaki,T., Miyazaki,K., Aoyama,M., Miyazaki,M. and
            Nakagawara,A.
  TITLE     UbcH10 is the cancer-related E2 ubiquitin-conjugating enzyme
  JOURNAL   Cancer Res 63 (14), 4167-4173 (2003)
   PUBMED   12874022
  REMARK    GeneRIF: UbcH10 is highly expressed in various human primary tumors
            and UbcH10 has an ability to promote cell growth and malignant
            transformation.
REFERENCE   7  (bases 1 to 777)
  AUTHORS   Yurchenko,V., Xue,Z. and Sadofsky,M.
  TITLE     The RAG1 N-terminal domain is an E3 ubiquitin ligase
  JOURNAL   Genes Dev 17 (5), 581-585 (2003)
   PUBMED   12629039
REFERENCE   8  (bases 1 to 777)
  AUTHORS   Lin,Y., Hwang,W.C. and Basavappa,R.
  TITLE     Structural and functional analysis of the human mitotic-specific
            ubiquitin-conjugating enzyme, UbcH10
  JOURNAL   J Biol Chem 277 (24), 21913-21921 (2002)
   PUBMED   11927573
REFERENCE   9  (bases 1 to 777)
  AUTHORS   Tang,Z., Li,B., Bharadwaj,R., Zhu,H., Ozkan,E., Hakala,K.,
            Deisenhofer,J. and Yu,H.
  TITLE     APC2 Cullin protein and APC11 RING protein comprise the minimal
            ubiquitin ligase module of the anaphase-promoting complex
  JOURNAL   Mol Biol Cell 12 (12), 3839-3851 (2001)
   PUBMED   11739784
REFERENCE   10 (bases 1 to 777)
  AUTHORS   Townsley,F.M., Aristarkhov,A., Beck,S., Hershko,A. and
            Ruderman,J.V.
  TITLE     Dominant-negative cyclin-selective ubiquitin carrier protein
            E2-C/UbcH10 blocks cells in metaphase
  JOURNAL   Proc Natl Acad Sci U S A 94 (6), 2362-2367 (1997)
   PUBMED   9122200
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB062573.1 and BC007656.2.
            
            On Nov 23, 2018 this sequence version replaced NM_007019.3.
            
            Summary: The modification of proteins with ubiquitin is an
            important cellular mechanism for targeting abnormal or short-lived
            proteins for degradation. Ubiquitination involves at least three
            classes of enzymes: ubiquitin-activating enzymes,
            ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This
            gene encodes a member of the E2 ubiquitin-conjugating enzyme
            family. The encoded protein is required for the destruction of
            mitotic cyclins and for cell cycle progression, and may be involved
            in cancer progression. Multiple transcript variants encoding
            different isoforms have been found for this gene. Pseudogenes of
            this gene have been defined on chromosomes 4, 14, 15, 18, and 19.
            [provided by RefSeq, Aug 2013].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050736.1, SRR1163655.9267.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356455.9/ ENSP00000348838.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 DB062573.1         69-77
            10-777              BC007656.2         1-768
FEATURES             Location/Qualifiers
     source          1..777
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.12"
     gene            1..777
                     /gene="UBE2C"
                     /gene_synonym="dJ447F3.2; UBCH10"
                     /note="ubiquitin conjugating enzyme E2 C"
                     /db_xref="GeneID:11065"
                     /db_xref="HGNC:HGNC:15937"
                     /db_xref="MIM:605574"
     exon            1..153
                     /gene="UBE2C"
                     /gene_synonym="dJ447F3.2; UBCH10"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..592
                     /gene="UBE2C"
                     /gene_synonym="dJ447F3.2; UBCH10"
                     /EC_number="2.3.2.23"
                     /EC_number="2.3.2.24"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ubiquitin-protein ligase C; cyclin-selective ubiquitin
                     carrier protein; mitotic-specific ubiquitin-conjugating
                     enzyme; E2 ubiquitin-conjugating enzyme C;
                     (E3-independent) E2 ubiquitin-conjugating enzyme C;
                     ubiquitin conjugating enzyme E2C"
                     /codon_start=1
                     /product="ubiquitin-conjugating enzyme E2 C isoform 1"
                     /protein_id="NP_008950.1"
                     /db_xref="CCDS:CCDS13370.1"
                     /db_xref="GeneID:11065"
                     /db_xref="HGNC:HGNC:15937"
                     /db_xref="MIM:605574"
                     /translation="MASQNRDPAATSVAAARKGAEPSGGAARGPVGKRLQQELMTLMM
                     SGDKGISAFPESDNLFKWVGTIHGAAGTVYEDLRYKLSLEFPSGYPYNAPTVKFLTPC
                     YHPNVDTQGNICLDILKEKWSALYDVRTILLSIQSLLGEPNIDSPLNTHAAELWKNPT
                     AFKKYLQETYSKQVTSQEP"
     exon            154..181
                     /gene="UBE2C"
                     /gene_synonym="dJ447F3.2; UBCH10"
                     /inference="alignment:Splign:2.1.0"
     exon            182..268
                     /gene="UBE2C"
                     /gene_synonym="dJ447F3.2; UBCH10"
                     /inference="alignment:Splign:2.1.0"
     exon            269..473
                     /gene="UBE2C"
                     /gene_synonym="dJ447F3.2; UBCH10"
                     /inference="alignment:Splign:2.1.0"
     exon            474..533
                     /gene="UBE2C"
                     /gene_synonym="dJ447F3.2; UBCH10"
                     /inference="alignment:Splign:2.1.0"
     exon            534..777
                     /gene="UBE2C"
                     /gene_synonym="dJ447F3.2; UBCH10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      752..757
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBE2C"
                     /gene_synonym="dJ447F3.2; UBCH10"
                     /note="hexamer: AATAAA"
     polyA_site      777
                     /gene="UBE2C"
                     /gene_synonym="dJ447F3.2; UBCH10"
                     /note="major polyA site"
ORIGIN      
        1 gcagttgcag tcgtgttctc cgagttcctg tctctctgcc aacgccgccc ggatggcttc
       61 ccaaaaccgc gacccagccg ccactagcgt cgccgccgcc cgtaaaggag ctgagccgag
      121 cgggggcgcc gcccggggtc cggtgggcaa aaggctacag caggagctga tgaccctcat
      181 gatgtctggc gataaaggga tttctgcctt ccctgaatca gacaaccttt tcaaatgggt
      241 agggaccatc catggagcag ctggaacagt atatgaagac ctgaggtata agctctcgct
      301 agagttcccc agtggctacc cttacaatgc gcccacagtg aagttcctca cgccctgcta
      361 tcaccccaac gtggacaccc agggtaacat atgcctggac atcctgaagg aaaagtggtc
      421 tgccctgtat gatgtcagga ccattctgct ctccatccag agccttctag gagaacccaa
      481 cattgatagt cccttgaaca cacatgctgc cgagctctgg aaaaacccca cagcttttaa
      541 gaagtacctg caagaaacct actcaaagca ggtcaccagc caggagccct gacccaggct
      601 gcccagcctg tccttgtgtc gtctttttaa tttttcctta gatggtctgt cctttttgtg
      661 atttctgtat aggactcttt atcttgagct gtggtatttt tgttttgttt ttgtctttta
      721 aattaagcct cggttgagcc cttgtatatt aaataaatgc atttttgtcc tttttta
//
