LOCUS       NM_006398                894 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens ubiquitin D (UBD), mRNA.
ACCESSION   NM_006398
VERSION     NM_006398.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 894)
  AUTHORS   Wang,Q., Tan,W., Zhang,Z., Chen,Q., Xie,Z., Yang,L., Tang,C.,
            Zhuang,H., Wang,B., Jiang,J., Ma,X., Wang,W., Hua,Y., Shang,C. and
            Chen,Y.
  TITLE     FAT10 induces immune suppression by upregulating PD-L1 expression
            in hepatocellular carcinoma
  JOURNAL   Apoptosis 29 (9-10), 1529-1545 (2024)
   PUBMED   38824477
  REMARK    GeneRIF: FAT10 induces immune suppression by upregulating PD-L1
            expression in hepatocellular carcinoma.
REFERENCE   2  (bases 1 to 894)
  AUTHORS   Chen,X., Wu,W., Jeong,J.H., Rokavec,M., Wei,R., Feng,S.,
            Schroth,W., Brauch,H., Zhong,S. and Luo,J.L.
  TITLE     Cytokines-activated nuclear IKKalpha-FAT10 pathway induces breast
            cancer tamoxifen-resistance
  JOURNAL   Sci China Life Sci 67 (7), 1413-1426 (2024)
   PUBMED   38565741
  REMARK    GeneRIF: Cytokines-activated nuclear IKKalpha-FAT10 pathway induces
            breast cancer tamoxifen-resistance.
REFERENCE   3  (bases 1 to 894)
  AUTHORS   Hong,F., Gong,Z., Chen,C., Hua,T., Huang,Q., Liu,Y., Ma,P.,
            Zhang,X., Wang,H. and Chen,J.
  TITLE     UBDP1 pseudogene and UBD network competitively bind miR-6072 to
            promote glioma progression
  JOURNAL   Int J Oncol 64 (3) (2024)
   PUBMED   38275102
  REMARK    GeneRIF: UBDP1 pseudogene and UBD network competitively bind
            miR-6072 to promote glioma progression.
REFERENCE   4  (bases 1 to 894)
  AUTHORS   Clavreul,L., Bernard,L., Cotte,A.K., Hennuyer,N., Bourouh,C.,
            Devos,C., Helleboid,A., Haas,J.T., Verrijken,A., Gheeraert,C.,
            Derudas,B., Guille,L., Chevalier,J., Eeckhoute,J., Vallez,E.,
            Dorchies,E., Van Gaal,L., Lassailly,G., Francque,S., Staels,B. and
            Paumelle,R.
  TITLE     The ubiquitin-like modifier FAT10 is induced in MASLD and impairs
            the lipid-regulatory activity of PPARalpha
  JOURNAL   Metabolism 151, 155720 (2024)
   PUBMED   37926201
  REMARK    GeneRIF: The ubiquitin-like modifier FAT10 is induced in MASLD and
            impairs the lipid-regulatory activity of PPARalpha.
REFERENCE   5  (bases 1 to 894)
  AUTHORS   Aichem,A. and Groettrup,M.
  TITLE     The ubiquitin-like modifier FAT10 in cancer development
  JOURNAL   Int J Biochem Cell Biol 79, 451-461 (2016)
   PUBMED   27393295
  REMARK    Review article
REFERENCE   6  (bases 1 to 894)
  AUTHORS   Schmidtke,G., Aichem,A. and Groettrup,M.
  TITLE     FAT10ylation as a signal for proteasomal degradation
  JOURNAL   Biochim Biophys Acta 1843 (1), 97-102 (2014)
   PUBMED   23333871
  REMARK    Review article
REFERENCE   7  (bases 1 to 894)
  AUTHORS   Liu,Y.C., Pan,J., Zhang,C., Fan,W., Collinge,M., Bender,J.R. and
            Weissman,S.M.
  TITLE     A MHC-encoded ubiquitin-like protein (FAT10) binds noncovalently to
            the spindle assembly checkpoint protein MAD2
  JOURNAL   Proc Natl Acad Sci U S A 96 (8), 4313-4318 (1999)
   PUBMED   10200259
REFERENCE   8  (bases 1 to 894)
  AUTHORS   Ott,D.E., Coren,L.V., Copeland,T.D., Kane,B.P., Johnson,D.G.,
            Sowder,R.C. 2nd, Yoshinaka,Y., Oroszlan,S., Arthur,L.O. and
            Henderson,L.E.
  TITLE     Ubiquitin is covalently attached to the p6Gag proteins of human
            immunodeficiency virus type 1 and simian immunodeficiency virus and
            to the p12Gag protein of Moloney murine leukemia virus
  JOURNAL   J Virol 72 (4), 2962-2968 (1998)
   PUBMED   9525617
REFERENCE   9  (bases 1 to 894)
  AUTHORS   Bates,E.E., Ravel,O., Dieu,M.C., Ho,S., Guret,C., Bridon,J.M.,
            Ait-Yahia,S., Briere,F., Caux,C., Banchereau,J. and Lebecque,S.
  TITLE     Identification and analysis of a novel member of the ubiquitin
            family expressed in dendritic cells and mature B cells
  JOURNAL   Eur J Immunol 27 (10), 2471-2477 (1997)
   PUBMED   9368598
REFERENCE   10 (bases 1 to 894)
  AUTHORS   Fan,W., Cai,W., Parimoo,S., Schwarz,D.C., Lennon,G.G. and
            Weissman,S.M.
  TITLE     Identification of seven new human MHC class I region genes around
            the HLA-F locus
  JOURNAL   Immunogenetics 44 (2), 97-103 (1996)
   PUBMED   8662070
  REMARK    Erratum:[Immunogenetics 1997;46(2):169]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB181897.1, AA878968.1,
            CB111380.1 and AL645936.5.
            
            On May 17, 2019 this sequence version replaced NM_006398.3.
            
            Summary: This gene encodes a protein which contains two
            ubiquitin-like domains and appears to have similar function to
            ubiquitin. Through covalent attachment, the encoded protein targets
            other proteins for 26S proteasome degradation. This protein has
            been implicated to function in many cellular processes, including
            caspase-dependent apoptosis, formation of aggresomes, mitotic
            regulation, and dendritic cell maturation. Upregulation of this
            gene may promote inflammation in chronic kidney disease and has
            been observed in many cancer types. [provided by RefSeq, Aug 2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BI760949.1, AK311914.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377050.5/ ENSP00000366249.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-450               DB181897.1         105-554
            451-786             AA878968.1         1-336               c
            787-797             CB111380.1         118-128
            798-894             AL645936.5         6501-6597           c
FEATURES             Location/Qualifiers
     source          1..894
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.1"
     gene            1..894
                     /gene="UBD"
                     /gene_synonym="FAT10; UBD-3"
                     /note="ubiquitin D"
                     /db_xref="GeneID:10537"
                     /db_xref="HGNC:HGNC:18795"
                     /db_xref="MIM:606050"
     exon            1..58
                     /gene="UBD"
                     /gene_synonym="FAT10; UBD-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..529
                     /gene="UBD"
                     /gene_synonym="FAT10; UBD-3"
                     /note="diubiquitin; ubiquitin-like protein FAT10"
                     /codon_start=1
                     /product="ubiquitin D"
                     /protein_id="NP_006389.2"
                     /db_xref="CCDS:CCDS4662.1"
                     /db_xref="GeneID:10537"
                     /db_xref="HGNC:HGNC:18795"
                     /db_xref="MIM:606050"
                     /translation="MAPNASCLCVHVRSEEWDLMTFDANPYDSVKKIKEHVRSKTKVP
                     VQDQVLLLGSKILKPRRSLSSYGIDKEKTIHLTLKVVKPSDEELPLFLVESGDEAKRH
                     LLQVRRSSSVAQVKAMIETKTGIIPETQIVTCNGKRLEDGKMMADYGIRKGNLLFLAC
                     YCIGG"
     exon            59..894
                     /gene="UBD"
                     /gene_synonym="FAT10; UBD-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      761..766
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBD"
                     /gene_synonym="FAT10; UBD-3"
                     /note="hexamer: AATAAA"
     regulatory      779..784
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBD"
                     /gene_synonym="FAT10; UBD-3"
                     /note="hexamer: AATAGA"
     polyA_site      784
                     /gene="UBD"
                     /gene_synonym="FAT10; UBD-3"
                     /note="major polyA site"
     polyA_site      810
                     /gene="UBD"
                     /gene_synonym="FAT10; UBD-3"
ORIGIN      
        1 gtctctggtt tctggcccct tgtctgcaga gatggctccc aatgcttcct gcctctgtgt
       61 gcatgtccgt tccgaggaat gggatttaat gacctttgat gccaacccat atgacagcgt
      121 gaaaaaaatc aaagaacatg tccggtctaa gaccaaggtt cctgtgcagg accaggttct
      181 tttgctgggc tccaagatct taaagccacg gagaagcctc tcatcttatg gcattgacaa
      241 agagaagacc atccacctta ccctgaaagt ggtgaagccc agtgatgagg agctgccctt
      301 gtttcttgtg gagtcaggtg atgaggcaaa gaggcacctc ctccaggtgc gaaggtccag
      361 ctcagtggca caagtgaaag caatgatcga gactaagacg ggtataatcc ctgagaccca
      421 gattgtgact tgcaatggaa agagactgga agatgggaag atgatggcag attacggcat
      481 cagaaagggc aacttactct tcctggcatg ttattgtatt ggagggtgac caccctgggc
      541 atggggtgtt ggcaggggtc aaaaagctta tttcttttaa tctcttactc aacgaacaca
      601 tcttctgatg atttcccaaa attaatgaga atgagatgag tagagtaaga tttgggtggg
      661 atgggtagga tgaagtatat tgcccaactc tatgtttctt tgattctaac acaattaatt
      721 aagtgacatg atttttacta atgtattact gagactagta aataaatttt taaggcaaaa
      781 tagagcattc aaagccagct tggaatttaa ttctgtcttg ataccttgtt atttatgcaa
      841 aaactcctat ctcctttcct ttatgacaag agagtaagtt ttaggttggg atcc
//
