LOCUS       NM_021009               2193 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens ubiquitin C (UBC), mRNA.
ACCESSION   NM_021009 XM_942709 XM_946288-XM_946327
VERSION     NM_021009.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2193)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 2193)
  AUTHORS   Stuber,K., Schneider,T., Werner,J., Kovermann,M., Marx,A. and
            Scheffner,M.
  TITLE     Structural and functional consequences of NEDD8 phosphorylation
  JOURNAL   Nat Commun 12 (1), 5939 (2021)
   PUBMED   34642328
  REMARK    GeneRIF: Structural and functional consequences of NEDD8
            phosphorylation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2193)
  AUTHORS   Al Mamun,A., Rahman,M.M., Zaman,S., Munira,M.S., Uddin,M.S.,
            Rauf,A., Banu,N. and Ashraf,G.M.
  TITLE     Molecular Insight into the Crosstalk of UPS Components and
            Alzheimer's Disease
  JOURNAL   Curr Protein Pept Sci 21 (12), 1193-1201 (2020)
   PUBMED   32964822
  REMARK    GeneRIF: Molecular Insight into the Crosstalk of UPS Components and
            Alzheimer's Disease.
            Review article
REFERENCE   4  (bases 1 to 2193)
  AUTHORS   Bianchi,M., Crinelli,R., Giacomini,E., Carloni,E. and Magnani,M.
  TITLE     A potent enhancer element in the 5'-UTR intron is crucial for
            transcriptional regulation of the human ubiquitin C gene
  JOURNAL   Gene 448 (1), 88-101 (2009)
   PUBMED   19733223
  REMARK    GeneRIF: provide insights into the pivotal role of Sp1/Sp3 binding
            to the intronic enhancer in the regulation of UbC transcription.
REFERENCE   5  (bases 1 to 2193)
  AUTHORS   Board,P.G., Coggan,M., Baker,R.T., Vuust,J. and Webb,G.C.
  TITLE     Localization of the human UBC polyubiquitin gene to chromosome band
            12q24.3
  JOURNAL   Genomics 12 (4), 639-642 (1992)
   PUBMED   1315303
REFERENCE   6  (bases 1 to 2193)
  AUTHORS   Kanayama,H., Tanaka,K., Aki,M., Kagawa,S., Miyaji,H., Satoh,M.,
            Okada,F., Sato,S., Shimbara,N. and Ichihara,A.
  TITLE     Changes in expressions of proteasome and ubiquitin genes in human
            renal cancer cells
  JOURNAL   Cancer Res 51 (24), 6677-6685 (1991)
   PUBMED   1660345
REFERENCE   7  (bases 1 to 2193)
  AUTHORS   Baker,R.T. and Board,P.G.
  TITLE     Unequal crossover generates variation in ubiquitin coding unit
            number at the human UbC polyubiquitin locus
  JOURNAL   Am J Hum Genet 44 (4), 534-542 (1989)
   PUBMED   2564731
REFERENCE   8  (bases 1 to 2193)
  AUTHORS   Einspanier,R., Sharma,H.S. and Scheit,K.H.
  TITLE     Cloning and sequence analysis of a cDNA encoding poly-ubiquitin in
            human ovarian granulosa cells
  JOURNAL   Biochem Biophys Res Commun 147 (2), 581-587 (1987)
   PUBMED   2820408
REFERENCE   9  (bases 1 to 2193)
  AUTHORS   Wiborg,O., Pedersen,M.S., Wind,A., Berglund,L.E., Marcker,K.A. and
            Vuust,J.
  TITLE     The human ubiquitin multigene family: some genes contain multiple
            directly repeated ubiquitin coding sequences
  JOURNAL   EMBO J 4 (3), 755-759 (1985)
   PUBMED   2988935
REFERENCE   10 (bases 1 to 2193)
  AUTHORS   Lehman,W.
  TITLE     Hybrid troponin reconstituted from vertebrate and arthropod
            subunits
  JOURNAL   Nature 255 (5507), 424-426 (1975)
   PUBMED   124018
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK129749.1 and BC093445.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_021009.6.
            
            Summary: This gene represents a ubiquitin gene, ubiquitin C. The
            encoded protein is a polyubiquitin precursor. Conjugation of
            ubiquitin monomers or polymers can lead to various effects within a
            cell, depending on the residues to which ubiquitin is conjugated.
            Ubiquitination has been associated with protein degradation, DNA
            repair, cell cycle regulation, kinase modification, endocytosis,
            and regulation of other cell signaling pathways. [provided by
            RefSeq, Aug 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC093445.1, BC039193.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000339647.6/ ENSP00000344818.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1752              AK129749.1         1-1752
            1753-2193           BC093445.1         1753-2193
FEATURES             Location/Qualifiers
     source          1..2193
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.31"
     gene            1..2193
                     /gene="UBC"
                     /gene_synonym="HMG20"
                     /note="ubiquitin C"
                     /db_xref="GeneID:7316"
                     /db_xref="HGNC:HGNC:12468"
                     /db_xref="MIM:191340"
     exon            1..64
                     /gene="UBC"
                     /gene_synonym="HMG20"
                     /inference="alignment:Splign:2.1.0"
     exon            65..2193
                     /gene="UBC"
                     /gene_synonym="HMG20"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..2125
                     /gene="UBC"
                     /gene_synonym="HMG20"
                     /codon_start=1
                     /product="polyubiquitin-C"
                     /protein_id="NP_066289.3"
                     /db_xref="CCDS:CCDS9260.1"
                     /db_xref="GeneID:7316"
                     /db_xref="HGNC:HGNC:12468"
                     /db_xref="MIM:191340"
                     /translation="MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLI
                     FAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENV
                     KAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTL
                     TGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKEST
                     LHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGK
                     QLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKI
                     QDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKT
                     ITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLV
                     LRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLED
                     GRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKE
                     GIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLE
                     VEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLR
                     GGV"
     regulatory      2172..2177
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBC"
                     /gene_synonym="HMG20"
                     /note="hexamer: AATAAA"
     polyA_site      2193
                     /gene="UBC"
                     /gene_synonym="HMG20"
                     /note="major polyA site"
ORIGIN      
        1 agttccgtcg cagccgggat ttgggtcgca gttcttgttt gtggatcgct gtgatcgtca
       61 cttgacaatg cagatcttcg tgaagactct gactggtaag accatcaccc tcgaggttga
      121 gcccagtgac accatcgaga atgtcaaggc aaagatccaa gataaggaag gcatccctcc
      181 tgaccagcag aggctgatct ttgctggaaa acagctggaa gatgggcgca ccctgtctga
      241 ctacaacatc cagaaagagt ccaccctgca cctggtgctc cgtctcagag gtgggatgca
      301 aatcttcgtg aagacactca ctggcaagac catcaccctt gaggtcgagc ccagtgacac
      361 catcgagaac gtcaaagcaa agatccagga caaggaaggc attcctcctg accagcagag
      421 gttgatcttt gccggaaagc agctggaaga tgggcgcacc ctgtctgact acaacatcca
      481 gaaagagtct accctgcacc tggtgctccg tctcagaggt gggatgcaga tcttcgtgaa
      541 gaccctgact ggtaagacca tcaccctcga ggtggagccc agtgacacca tcgagaatgt
      601 caaggcaaag atccaagata aggaaggcat tcctcctgat cagcagaggt tgatctttgc
      661 cggaaaacag ctggaagatg gtcgtaccct gtctgactac aacatccaga aagagtccac
      721 cttgcacctg gtactccgtc tcagaggtgg gatgcaaatc ttcgtgaaga cactcactgg
      781 caagaccatc acccttgagg tcgagcccag tgacactatc gagaacgtca aagcaaagat
      841 ccaagacaag gaaggcattc ctcctgacca gcagaggttg atctttgccg gaaagcagct
      901 ggaagatggg cgcaccctgt ctgactacaa catccagaaa gagtctaccc tgcacctggt
      961 gctccgtctc agaggtggga tgcagatctt cgtgaagacc ctgactggta agaccatcac
     1021 tctcgaagtg gagccgagtg acaccattga gaatgtcaag gcaaagatcc aagacaagga
     1081 aggcatccct cctgaccagc agaggttgat ctttgccgga aaacagctgg aagatggtcg
     1141 taccctgtct gactacaaca tccagaaaga gtccaccttg cacctggtgc tccgtctcag
     1201 aggtgggatg cagatcttcg tgaagaccct gactggtaag accatcactc tcgaggtgga
     1261 gccgagtgac accattgaga atgtcaaggc aaagatccaa gacaaggaag gcatccctcc
     1321 tgaccagcag aggttgatct ttgctgggaa acagctggaa gatggacgca ccctgtctga
     1381 ctacaacatc cagaaagagt ccaccctgca cctggtgctc cgtcttagag gtgggatgca
     1441 gatcttcgtg aagaccctga ctggtaagac catcactctc gaagtggagc cgagtgacac
     1501 cattgagaat gtcaaggcaa agatccaaga caaggaaggc atccctcctg accagcagag
     1561 gttgatcttt gctgggaaac agctggaaga tggacgcacc ctgtctgact acaacatcca
     1621 gaaagagtcc accctgcacc tggtgctccg tcttagaggt gggatgcaga tcttcgtgaa
     1681 gaccctgact ggtaagacca tcactctcga agtggagccg agtgacacca ttgagaatgt
     1741 caaggcaaag atccaagaca aggaaggcat ccctcctgac cagcagaggt tgatctttgc
     1801 tgggaaacag ctggaagatg gacgcaccct gtctgactac aacatccaga aagagtccac
     1861 cctgcacctg gtgctccgtc tcagaggtgg gatgcaaatc ttcgtgaaga ccctgactgg
     1921 taagaccatc accctcgagg tggagcccag tgacaccatc gagaatgtca aggcaaagat
     1981 ccaagataag gaaggcatcc ctcctgatca gcagaggttg atctttgctg ggaaacagct
     2041 ggaagatgga cgcaccctgt ctgactacaa catccagaaa gagtccactc tgcacttggt
     2101 cctgcgcttg agggggggtg tctaagtttc cccttttaag gtttcaacaa atttcattgc
     2161 actttccttt caataaagtt gttgcattcc caa
//
