LOCUS       NM_001281720             864 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens ubiquitin B (UBB), transcript variant 6, mRNA.
ACCESSION   NM_001281720
VERSION     NM_001281720.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 864)
  AUTHORS   Wang,J., Zhao,E., Geng,B., Zhang,W., Li,Z., Liu,Q., Liu,W.,
            Zhang,W., Hou,W., Zhang,N., Liu,Z., You,B., Wu,P. and Li,X.
  TITLE     Downregulation of UBB potentiates SP1/VEGFA-dependent angiogenesis
            in clear cell renal cell carcinoma
  JOURNAL   Oncogene 43 (18), 1386-1396 (2024)
   PUBMED   38467852
  REMARK    GeneRIF: Downregulation of UBB potentiates SP1/VEGFA-dependent
            angiogenesis in clear cell renal cell carcinoma.
REFERENCE   2  (bases 1 to 864)
  AUTHORS   Chen,X., Munoz-Arellano,A.J. and Petranovic,D.
  TITLE     UBB+1 reduces amyloid-beta cytotoxicity by activation of autophagy
            in yeast
  JOURNAL   Aging (Albany NY) 13 (21), 23953-23980 (2021)
   PUBMED   34751669
  REMARK    GeneRIF: UBB(+1) reduces amyloid-beta cytotoxicity by activation of
            autophagy in yeast.
REFERENCE   3  (bases 1 to 864)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 864)
  AUTHORS   Xue,B., Li,S., Jin,X. and Liu,L.
  TITLE     Bioinformatics analysis of mRNA and miRNA microarray to identify
            the key miRNA-mRNA pairs in cisplatin-resistant ovarian cancer
  JOURNAL   BMC Cancer 21 (1), 452 (2021)
   PUBMED   33892654
  REMARK    GeneRIF: Bioinformatics analysis of mRNA and miRNA microarray to
            identify the key miRNA-mRNA pairs in cisplatin-resistant ovarian
            cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 864)
  AUTHORS   van Leeuwen,F.W., de Kleijn,D.P., van den Hurk,H.H., Neubauer,A.,
            Sonnemans,M.A., Sluijs,J.A., Koycu,S., Ramdjielal,R.D., Salehi,A.,
            Martens,G.J., Grosveld,F.G., Peter,J., Burbach,H. and Hol,E.M.
  TITLE     Frameshift mutants of beta amyloid precursor protein and
            ubiquitin-B in Alzheimer's and Down patients
  JOURNAL   Science 279 (5348), 242-247 (1998)
   PUBMED   9422699
REFERENCE   6  (bases 1 to 864)
  AUTHORS   Adams,S.M., Sharp,M.G., Walker,R.A., Brammar,W.J. and Varley,J.M.
  TITLE     Differential expression of translation-associated genes in benign
            and malignant human breast tumours
  JOURNAL   Br J Cancer 65 (1), 65-71 (1992)
   PUBMED   1370760
REFERENCE   7  (bases 1 to 864)
  AUTHORS   Pancre,V., Pierce,R.J., Fournier,F., Mehtali,M., Delanoye,A.,
            Capron,A. and Auriault,C.
  TITLE     Effect of ubiquitin on platelet functions: possible identity with
            platelet activity suppressive lymphokine (PASL)
  JOURNAL   Eur J Immunol 21 (11), 2735-2741 (1991)
   PUBMED   1657614
REFERENCE   8  (bases 1 to 864)
  AUTHORS   Vijay-Kumar,S., Bugg,C.E. and Cook,W.J.
  TITLE     Structure of ubiquitin refined at 1.8 A resolution
  JOURNAL   J Mol Biol 194 (3), 531-544 (1987)
   PUBMED   3041007
REFERENCE   9  (bases 1 to 864)
  AUTHORS   Baker,R.T. and Board,P.G.
  TITLE     The human ubiquitin gene family: structure of a gene and
            pseudogenes from the Ub B subfamily
  JOURNAL   Nucleic Acids Res 15 (2), 443-463 (1987)
   PUBMED   3029682
REFERENCE   10 (bases 1 to 864)
  AUTHORS   Lehman,W.
  TITLE     Hybrid troponin reconstituted from vertebrate and arthropod
            subunits
  JOURNAL   Nature 255 (5507), 424-426 (1975)
   PUBMED   124018
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC093484.2, BU661443.1,
            BT020104.1 and BM662083.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001281720.1.
            
            Summary: This gene encodes ubiquitin, one of the most conserved
            proteins known. Ubiquitin has a major role in targeting cellular
            proteins for degradation by the 26S proteosome. It is also involved
            in the maintenance of chromatin structure, the regulation of gene
            expression, and the stress response. Ubiquitin is synthesized as a
            precursor protein consisting of either polyubiquitin chains or a
            single ubiquitin moiety fused to an unrelated protein. This gene
            consists of three direct repeats of the ubiquitin coding sequence
            with no spacer sequence. Consequently, the protein is expressed as
            a polyubiquitin precursor with a final amino acid after the last
            repeat. An aberrant form of this protein has been detected in
            patients with Alzheimer's disease and Down syndrome. Pseudogenes of
            this gene are located on chromosomes 1, 2, 13, and 17. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Aug 2013].
            
            Transcript Variant: This variant (6) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, 3, 4, 5, and 6 encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.3889241.1,
                                           SRR18074968.2386459.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AC093484.2         101880-101885
            7-351               BU661443.1         15-359
            352-720             BT020104.1         321-689
            721-864             BM662083.1         21-164              c
FEATURES             Location/Qualifiers
     source          1..864
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p11.2"
     gene            1..864
                     /gene="UBB"
                     /gene_synonym="HEL-S-50"
                     /note="ubiquitin B"
                     /db_xref="GeneID:7314"
                     /db_xref="HGNC:HGNC:12463"
                     /db_xref="MIM:191339"
     exon            1..25
                     /gene="UBB"
                     /gene_synonym="HEL-S-50"
                     /inference="alignment:Splign:2.1.0"
     exon            26..864
                     /gene="UBB"
                     /gene_synonym="HEL-S-50"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..721
                     /gene="UBB"
                     /gene_synonym="HEL-S-50"
                     /note="polyubiquitin B; epididymis secretory protein Li
                     50"
                     /codon_start=1
                     /product="polyubiquitin-B precursor"
                     /protein_id="NP_001268649.1"
                     /db_xref="CCDS:CCDS11177.1"
                     /db_xref="GeneID:7314"
                     /db_xref="HGNC:HGNC:12463"
                     /db_xref="MIM:191339"
                     /translation="MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLI
                     FAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENV
                     KAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTL
                     TGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKEST
                     LHLVLRLRGGC"
     regulatory      842..847
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBB"
                     /gene_synonym="HEL-S-50"
                     /note="hexamer: AATAAA"
     polyA_site      864
                     /gene="UBB"
                     /gene_synonym="HEL-S-50"
                     /note="major polyA site"
ORIGIN      
        1 atttaggggc ggttggcttt gttgggtcaa aatgcagatc ttcgtgaaaa cccttaccgg
       61 caagaccatc acccttgagg tggagcccag tgacaccatc gaaaatgtga aggccaagat
      121 ccaggataag gaaggcattc cccccgacca gcagaggctc atctttgcag gcaagcagct
      181 ggaagatggc cgtactcttt ctgactacaa catccagaag gagtcgaccc tgcacctggt
      241 cctgcgtctg agaggtggta tgcagatctt cgtgaagacc ctgaccggca agaccatcac
      301 cctggaagtg gagcccagtg acaccatcga aaatgtgaag gccaagatcc aggataaaga
      361 aggcatccct cccgaccagc agaggctcat ctttgcaggc aagcagctgg aagatggccg
      421 cactctttct gactacaaca tccagaagga gtcgaccctg cacctggtcc tgcgtctgag
      481 aggtggtatg cagatcttcg tgaagaccct gaccggcaag accatcactc tggaggtgga
      541 gcccagtgac accatcgaaa atgtgaaggc caagatccaa gataaagaag gcatcccccc
      601 cgaccagcag aggctcatct ttgcaggcaa gcagctggaa gatggccgca ctctttctga
      661 ctacaacatc cagaaagagt cgaccctgca cctggtcctg cgcctgaggg gtggctgtta
      721 attcttcagt catggcattc gcagtgccca gtgatggcat tactctgcac tatagccatt
      781 tgccccaact taagtttaga aattacaagt ttcagtaata gctgaacctg ttcaaaatgt
      841 taataaaggt ttcgttgcat ggta
//
