LOCUS       NM_032873               6865 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ubiquitin associated and SH3 domain containing B
            (UBASH3B), transcript variant 1, mRNA.
ACCESSION   NM_032873
VERSION     NM_032873.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6865)
  AUTHORS   Wang,J., Wang,C., Hu,A., Yu,K., Kuang,Y., Gajendran,B.,
            Zacksenhaus,E., Sample,K.M., Xiao,X., Liu,W. and Ben-David,Y.
  TITLE     FLI1 induces erythroleukemia through opposing effects on UBASH3A
            and UBASH3B expression
  JOURNAL   BMC Cancer 24 (1), 326 (2024)
   PUBMED   38461240
  REMARK    GeneRIF: FLI1 induces erythroleukemia through opposing effects on
            UBASH3A and UBASH3B expression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6865)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 6865)
  AUTHORS   Yao,Y., Liu,W., Gajendran,B., Wang,C., Zacksenhaus,E., Sample,K.M.,
            Varier,K.M., Hao,X. and Ben-David,Y.
  TITLE     Ubash3b promotes TPA-mediated suppression of leukemogenesis through
            accelerated downregulation of PKCdelta protein
  JOURNAL   Biochimie 184, 8-17 (2021)
   PUBMED   33556471
  REMARK    GeneRIF: Ubash3b promotes TPA-mediated suppression of
            leukemogenesis through accelerated downregulation of PKCdelta
            protein.
REFERENCE   4  (bases 1 to 6865)
  AUTHORS   Yin,Y., Frank,D., Zhou,W., Kaur,N., French,J.B. and Carpino,N.
  TITLE     An unexpected 2-histidine phosphoesterase activity of suppressor of
            T-cell receptor signaling protein 1 contributes to the suppression
            of cell signaling
  JOURNAL   J Biol Chem 295 (25), 8514-8523 (2020)
   PUBMED   32371395
  REMARK    GeneRIF: An unexpected 2-histidine phosphoesterase activity of
            suppressor of T-cell receptor signaling protein 1 contributes to
            the suppression of cell signaling.
REFERENCE   5  (bases 1 to 6865)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 6865)
  AUTHORS   Hoeller,D., Crosetto,N., Blagoev,B., Raiborg,C., Tikkanen,R.,
            Wagner,S., Kowanetz,K., Breitling,R., Mann,M., Stenmark,H. and
            Dikic,I.
  TITLE     Regulation of ubiquitin-binding proteins by monoubiquitination
  JOURNAL   Nat Cell Biol 8 (2), 163-169 (2006)
   PUBMED   16429130
REFERENCE   7  (bases 1 to 6865)
  AUTHORS   Guo,F., Sigua,C., Bali,P., George,P., Fiskus,W., Scuto,A.,
            Annavarapu,S., Mouttaki,A., Sondarva,G., Wei,S., Wu,J., Djeu,J. and
            Bhalla,K.
  TITLE     Mechanistic role of heat shock protein 70 in Bcr-Abl-mediated
            resistance to apoptosis in human acute leukemia cells
  JOURNAL   Blood 105 (3), 1246-1255 (2005)
   PUBMED   15388581
  REMARK    GeneRIF: hsp70 inhibits apoptosis upstream and downstream of the
            mitochondria and is a promising therapeutic target for reversing
            drug-resistance in chronic myeloid leukemia-blast crisis and acute
            myeloid leukemia cells.
REFERENCE   8  (bases 1 to 6865)
  AUTHORS   Kowanetz,K., Crosetto,N., Haglund,K., Schmidt,M.H.H., Heldin,C.H.
            and Dikic,I.
  TITLE     Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to
            Cbl and inhibit endocytosis of receptor tyrosine kinases
  JOURNAL   J Biol Chem 279 (31), 32786-32795 (2004)
   PUBMED   15159412
  REMARK    GeneRIF: Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of
            receptor tyrosine kinases
REFERENCE   9  (bases 1 to 6865)
  AUTHORS   Gevaert,K., Goethals,M., Martens,L., Van Damme,J., Staes,A.,
            Thomas,G.R. and Vandekerckhove,J.
  TITLE     Exploring proteomes and analyzing protein processing by mass
            spectrometric identification of sorted N-terminal peptides
  JOURNAL   Nat Biotechnol 21 (5), 566-569 (2003)
   PUBMED   12665801
REFERENCE   10 (bases 1 to 6865)
  AUTHORS   Carpino,N., Kobayashi,R., Zang,H., Takahashi,Y., Jou,S.T., Feng,J.,
            Nakajima,H. and Ihle,J.N.
  TITLE     Identification, cDNA cloning, and targeted deletion of p70, a
            novel, ubiquitously expressed SH3 domain-containing protein
  JOURNAL   Mol Cell Biol 22 (21), 7491-7500 (2002)
   PUBMED   12370296
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK075203.1, BC007541.1, AP002762.4 and CR741636.1.
            
            On Nov 22, 2018 this sequence version replaced NM_032873.4.
            
            Summary: This gene encodes a protein that contains a ubiquitin
            associated domain at the N-terminus, an SH3 domain, and a
            C-terminal domain with similarities to the catalytic motif of
            phosphoglycerate mutase. The encoded protein was found to inhibit
            endocytosis of epidermal growth factor receptor (EGFR) and
            platelet-derived growth factor receptor. [provided by RefSeq, Jul
            2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075203.1, SRR1803617.165220.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000284273.6/ ENSP00000284273.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1335              AK075203.1         1-1335
            1336-2334           BC007541.1         1322-2320
            2335-6319           AP002762.4         161857-165841
            6320-6865           CR741636.1         1-546
FEATURES             Location/Qualifiers
     source          1..6865
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.1"
     gene            1..6865
                     /gene="UBASH3B"
                     /gene_synonym="p70; STS-1; STS1; TULA-2; TULA2"
                     /note="ubiquitin associated and SH3 domain containing B"
                     /db_xref="GeneID:84959"
                     /db_xref="HGNC:HGNC:29884"
                     /db_xref="MIM:609201"
     exon            1..489
                     /gene="UBASH3B"
                     /gene_synonym="p70; STS-1; STS1; TULA-2; TULA2"
                     /inference="alignment:Splign:2.1.0"
     CDS             329..2278
                     /gene="UBASH3B"
                     /gene_synonym="p70; STS-1; STS1; TULA-2; TULA2"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 is encoded by transcript variant 1; SH3
                     domain-containing 70 kDa protein, suppressor of T-cell
                     receptor signaling 1, nm23-phosphorylated unknown
                     substrate; Cbl-interacting protein Sts-1;
                     ubiquitin-associated and SH3 domain-containing protein B;
                     cbl-interacting protein p70; T-cell ubiquitin ligand 2;
                     tyrosine-protein phosphatase STS1/TULA2"
                     /codon_start=1
                     /product="ubiquitin-associated and SH3 domain-containing
                     protein B isoform 1"
                     /protein_id="NP_116262.2"
                     /db_xref="CCDS:CCDS31694.1"
                     /db_xref="GeneID:84959"
                     /db_xref="HGNC:HGNC:29884"
                     /db_xref="MIM:609201"
                     /translation="MAQYGHPSPLGMAAREELYSKVTPRRNRQQRPGTIKHGSALDVL
                     LSMGFPRARAQKALASTGGRSVQAACDWLFSHVGDPFLDDPLPREYVLYLRPTGPLAQ
                     KLSDFWQQSKQICGKNKAHNIFPHITLCQFFMCEDSKVDALGEALQTTVSRWKCKFSA
                     PLPLELYTSSNFIGLFVKEDSAEVLKKFAADFAAEAASKTEVHVEPHKKQLHVTLAYH
                     FQASHLPTLEKLAQNIDVKLGCDWVATIFSRDIRFANHETLQVIYPYTPQNDDELELV
                     PGDFIFMSPMEQTSTSEGWIYGTSLTTGCSGLLPENYITKADECSTWIFHGSYSILNT
                     SSSNSLTFGDGVLERRPYEDQGLGETTPLTIICQPMQPLRVNSQPGPQKRCLFVCRHG
                     ERMDVVFGKYWLSQCFDAKGRYIRTNLNMPHSLPQRSGGFRDYEKDAPITVFGCMQAR
                     LVGEALLESNTIIDHVYCSPSLRCVQTAHNILKGLQQENHLKIRVEPGLFEWTKWVAG
                     STLPAWIPPSELAAANLSVDTTYRPHIPISKLVVSESYDTYISRSFQVTKEIISECKS
                     KGNNILIVAHASSLEACTCQLQGLSPQNSKDFVQMVRKIPYLGFCSCEELGETGIWQL
                     TDPPILPLTHGPTGGFNWRETLLQE"
     exon            490..543
                     /gene="UBASH3B"
                     /gene_synonym="p70; STS-1; STS1; TULA-2; TULA2"
                     /inference="alignment:Splign:2.1.0"
     exon            544..730
                     /gene="UBASH3B"
                     /gene_synonym="p70; STS-1; STS1; TULA-2; TULA2"
                     /inference="alignment:Splign:2.1.0"
     exon            731..929
                     /gene="UBASH3B"
                     /gene_synonym="p70; STS-1; STS1; TULA-2; TULA2"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1099
                     /gene="UBASH3B"
                     /gene_synonym="p70; STS-1; STS1; TULA-2; TULA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1308
                     /gene="UBASH3B"
                     /gene_synonym="p70; STS-1; STS1; TULA-2; TULA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1441
                     /gene="UBASH3B"
                     /gene_synonym="p70; STS-1; STS1; TULA-2; TULA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1562
                     /gene="UBASH3B"
                     /gene_synonym="p70; STS-1; STS1; TULA-2; TULA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1685
                     /gene="UBASH3B"
                     /gene_synonym="p70; STS-1; STS1; TULA-2; TULA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1778
                     /gene="UBASH3B"
                     /gene_synonym="p70; STS-1; STS1; TULA-2; TULA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1923
                     /gene="UBASH3B"
                     /gene_synonym="p70; STS-1; STS1; TULA-2; TULA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1924..2030
                     /gene="UBASH3B"
                     /gene_synonym="p70; STS-1; STS1; TULA-2; TULA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..2140
                     /gene="UBASH3B"
                     /gene_synonym="p70; STS-1; STS1; TULA-2; TULA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2141..6865
                     /gene="UBASH3B"
                     /gene_synonym="p70; STS-1; STS1; TULA-2; TULA2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3537..3542
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBASH3B"
                     /gene_synonym="p70; STS-1; STS1; TULA-2; TULA2"
                     /note="hexamer: AATAAA"
     polyA_site      3558
                     /gene="UBASH3B"
                     /gene_synonym="p70; STS-1; STS1; TULA-2; TULA2"
                     /note="major polyA site"
     regulatory      4190..4195
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBASH3B"
                     /gene_synonym="p70; STS-1; STS1; TULA-2; TULA2"
                     /note="hexamer: AATAAA"
     polyA_site      4210
                     /gene="UBASH3B"
                     /gene_synonym="p70; STS-1; STS1; TULA-2; TULA2"
     regulatory      6842..6847
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBASH3B"
                     /gene_synonym="p70; STS-1; STS1; TULA-2; TULA2"
                     /note="hexamer: AATAAA"
     polyA_site      6865
                     /gene="UBASH3B"
                     /gene_synonym="p70; STS-1; STS1; TULA-2; TULA2"
ORIGIN      
        1 attgcaaatt cccggactgc taggcgagga gagggaaggg ggcggaggag acagggctac
       61 tgcaggcgca gagctggggg cagccggggg cccgagtggc tgaggctggt cccgcagcgg
      121 ccgcttgccg gcgttctggc tcctgtggcc tcaccaggaa gcgtcagagt cccgacactg
      181 gggaagctcg gagcgccgcc tccgctgccg ccgcctcctg cctggctctg ggtccccgag
      241 ccccctcccc tggcccagcc cgactccctc ctccttcccg aaccatccgg ctcgggctcc
      301 ttccctggcg atggctggcc gctgagccat ggctcagtac ggccacccca gtccgctcgg
      361 catggctgcg agagaggagc tgtacagcaa agtcaccccc cggaggaacc gccaacagcg
      421 ccccggcacc atcaagcatg gatcggcgct ggacgtgctc ctctccatgg ggttccccag
      481 agcccgcgca caaaaagcct tggcatccac gggaggaaga agtgttcagg cagcatgtga
      541 ctggttattc tcccatgtcg gtgacccctt cctggatgac cccctgcccc gggagtacgt
      601 cctctacctc cgtcccaccg gccccttagc acagaagctt tccgactttt ggcagcagtc
      661 gaagcagatc tgcgggaaga acaaggcaca caacatcttc ccccacatca cactctgcca
      721 gttctttatg tgcgaggaca gcaaggtgga tgccctgggg gaagccctgc agaccacggt
      781 cagtcgctgg aaatgtaagt tctcggcccc gctgcccctg gagctctata cgtcgtccaa
      841 cttcatcggc ctctttgtaa aggaagacag tgcggaggtc ctcaagaagt ttgctgctga
      901 ctttgctgca gaggctgcat ccaaaaccga agtgcatgtg gaacctcata agaagcagct
      961 acatgtgacc ctggcttacc acttccaagc cagccaccta cccaccctag agaaactggc
     1021 ccagaacatt gacgtcaagc tagggtgtga ctgggtggct accatatttt ctcgggatat
     1081 ccgatttgct aaccatgaga cattacaggt catctacccc tataccccac aaaatgacga
     1141 tgagctggag ctggtccccg gggacttcat cttcatgtct ccaatggagc agaccagcac
     1201 cagcgagggt tggatctatg gcacgtcctt aaccaccggc tgctctggac tcctgcctga
     1261 gaattacatt accaaggctg atgaatgcag cacctggata tttcatggtt cttattcaat
     1321 cttaaataca tcgtcatcca actctctcac gtttggggat ggagtattgg agaggcggcc
     1381 ttatgaggac caggggctcg gggagacgac tcctcttact atcatctgcc agcccatgca
     1441 gccgctgagg gtcaacagcc agcccggccc ccagaagcga tgcctttttg tgtgtcggca
     1501 tggtgagagg atggatgttg tgtttgggaa gtactggctg tcccagtgct tcgatgccaa
     1561 aggccgctac atacgcacca acctgaacat gcctcatagt ttacctcagc ggagtggtgg
     1621 tttccgagat tacgagaaag atgctcccat cactgtgttt ggatgcatgc aagcaagact
     1681 agtgggtgaa gccttattag agagcaatac cattatcgat catgtctatt gctccccgtc
     1741 ccttcgctgc gttcagactg cacacaatat cttgaaaggt ttacaacaag aaaatcactt
     1801 gaagatccgt gtagagcccg gcttatttga gtggacaaaa tgggttgctg ggagcacatt
     1861 acctgcatgg atacctccat cagagttagc tgcagccaac ctgagtgttg atacaaccta
     1921 cagacctcac attccaatca gcaaattagt tgtttcagaa tcctatgata cttatatcag
     1981 tagaagtttc caagtaacaa aagaaataat aagtgaatgt aaaagtaaag gaaataacat
     2041 cctgattgtg gcccacgcat cttcccttga agcgtgtacc tgccaacttc agggcctgtc
     2101 acctcagaac tccaaggact tcgtacaaat ggtccgaaag atcccatatc tgggattttg
     2161 ttcctgtgaa gaattaggag aaactggaat atggcagctg acagatccac caatccttcc
     2221 tcttacccat ggaccaactg ggggcttcaa ctggagagag accttgcttc aagaataaac
     2281 cacaccagtg aacaagaagg aaaggccttt tggagtgtgt ctttctgtgt gtttaaaaac
     2341 agtgggaaaa tccacaccac actctaagtg gacagctcag aataatttag catatttcct
     2401 ttcacactta aagttcttaa gatgagactg tgtaaatgag agaaagactt gattcagagg
     2461 aaaaaaatgt gttctctctg gactcttgcc tagctcacaa ggctttggag aattgtcttc
     2521 ctaaatcggg gcacctgcta cagaagagaa tgtttcgttc cctctgggta tgcacagcta
     2581 aggggcctca tttctcccag agggagctgc tggcccgctc taaggggtgc aagaggaagg
     2641 agtgtgccca gaccagctgg gggagcattg aaaggacagc ttggggatgg aatttttttt
     2701 tttttatctc cattttccag ttaggtagag ccaagctgag gaatcctttt aagattatta
     2761 gaaaacatgc cctgaagaga gttgttctta ggttacacat gaaatcctac cgtcactagc
     2821 ccccatacac cagtgttgct ggctgaagat acccgcttaa ggatgctaac atttaccctg
     2881 gtactgccac attttctcta gagcagctgg cccttcttgc tacagcccta tcccccctcc
     2941 ttgcttctgt gaaatgggga gacaaagcac ttttgctctc caaagcactt ttggatactc
     3001 aggaggaaag ataagataca tgtttgaagt attcaatcat aggagcaaag aacttgcaaa
     3061 atatgaagtg acttggaatt aaccatgttg tagcctaacg tgctactgca tttctaaatc
     3121 atcaatattt gcttgtcttt gcccctagac tctagactat gttaactagt taaggatgtt
     3181 acattttgaa aggatgtatg ttagatatat tatttgcagc aagaagttca ttctgtgcaa
     3241 tatggacatg tttgcaaacc ataccaaggg tcaggttgtt gtacacttac agtacgtgtc
     3301 aaccataatg gaacatccac aaatgcatca attataccag ggatgtatag taagtcaggg
     3361 aactaatata aatgatgaca gtcatggctg cactgctact tgtgctgtcg ttttgtttgt
     3421 ttttctatga taatttaaaa tacataggta gggctactga ggaaatttgg agagccacat
     3481 tctgtggttt ctcattatac ttacttcctg catttagagg gagtttattt aaaagaaata
     3541 aatgacaatc aaaccaaatc atcagttatc aatgtctgtt taattgtgtg actatctgac
     3601 tgttgatggc cacagatgat ggtctcctat ggtatagttc actctgtaga agatgtatgc
     3661 aaagtgaaat gccagccctt taaagagaca ttagttagtg taaaatggat ctttacatgt
     3721 tgcagtaaca ttgactatgt ttcaaaactc agatgcataa aacgtaaggt atataaaaat
     3781 acatctatgc ttgcgtttga aactacaact tgataacccc tagaaagaag aggacatgaa
     3841 aggatgctgg ctatatatgt taatgagcaa aaggattata gttgttttgt tttgttttta
     3901 gagacagggt ctcactataa tgcttagact ggtcttgaac tcctgggctc aagcgatcct
     3961 cctgcccctg tctcccaaag tgctaggatt acaggtgtga gccaccacac ctggcccata
     4021 gttgtatttt ttttaggtca cttagaaaaa tatgtcatgt attttacatt ttgagaaaca
     4081 aatcaatcat ggtttcttct agcgttgcgc aaacactgac ccagcttctg ggtatggaaa
     4141 taaccctgtg atgatgtgtt aatataaaat gttgggaggg aatattccca ataaaggtct
     4201 taagagaaaa gtcacattac aagtaatgta atggctctac cattcattct tctggtattt
     4261 gtaatgaagt gaatccactg tttaatcaga tccataatct ttaacagatt caccacaaat
     4321 tttcatgggc gttgagtgct cagaataatg cttgaacacc tcaccttgaa actgtagcag
     4381 tgtgttctgg gcagtatctg taatgtatga aatagagtct ggaataggtt atccactcca
     4441 tcttctaggt tatcttagtt gtatgacgaa ctgataaatc tgtctgactg ggctacaatc
     4501 cattgttctt agtccaatat ggacactgcc ttaggcaatg gtctatataa gcaaaaggag
     4561 atagagatct gaaataattt tccgaataat tcaggtggaa aacaagaaag attgtatttc
     4621 tctgctttca tttcaatttc attatttcaa attgcttgtc aaaatggccc aaaagatctg
     4681 aattcacatt aagttcccct tgcacactta cctatttaaa aaactaaact tgcactgcaa
     4741 ctgagaaatt atttgtaaat catgtggcat ctatgtataa taaaagaaag agacaactat
     4801 attactcaat ttcatataca tccaaaaagt ataggctaat atatataacc tgaagttgca
     4861 gctggttctt tttgatctga agctgatgct tattaaaaca aatgatgtat ggggagagga
     4921 gaaggaaggg caaggaagga attgacagat aagaagcaaa tggtttcttg tacagaggaa
     4981 ttttgtttta atgtagaaag ttatttgaaa taaactaggt gaaatgaaat taactaaagg
     5041 ttttaatctg ggattgaaag cctgaaagca tttcctgctt ctacaagtgt gccacatcaa
     5101 tccggtaatg ccccagtgtt attcacagac agaactttgt ttcctgtgat tttaaaatac
     5161 cgcgtctgtt cctccatgga ccagagtaat tggcacattt taatgcataa gctgggggtt
     5221 tcattttccc aggctctctt caccatcact gcattggtag ctaggagctt attgcttcac
     5281 cccagtatgg agttcagatt acagtgtttt ccattacatt tagattcata gaatctgaat
     5341 ggctgattaa atggccatct gatggctgaa agaggggcgt atttttcact ctgtagtgaa
     5401 aggcttggag gagtttctac tttttatttt aattatactt taaccaaaga attattttaa
     5461 agtaacctta tatttaaaag atgattttgc aaaaaataaa aaataaaaaa tatgccttct
     5521 ggagtgatgt ctgtttggta aatcattgtt gataatttcc ttgttagtgg tatttggaat
     5581 gcatatagat tgtcttgtca ttgtgcttaa cattaccata agtgtgtctt ttccactcaa
     5641 ctagctgtat tcgtattaaa atgaagtctc ttatttcaat tacctagtgt tgttgggaac
     5701 taattgaaca gctacagtaa aagaagttcc tatctcattg cctttgtgga aaggcttccc
     5761 tatgtggtaa aagaaaggca ttcctccgta acctaggcac tctgcaagtc cagtgtttaa
     5821 tttcaaagca gtgatgaatt gctcttttga aattactcta agtaatccat gtgttagaat
     5881 acagatgaac ctccgtttga tttcacagcc ttcagcacag gcaactgtta ctgagtctgc
     5941 acgaacttag ataatgaggt gcagggttat ttgcatttaa attgcaatcc agcacacgtg
     6001 tgagaaagaa gaggcactag tctaaaaggc tgcattgcgg ggagagatga gacaggcaga
     6061 ggagggtggg gtaaagagcg atttaacatc tatttaggtt aatgttcact ttacaaaggt
     6121 gatgggggat attttgttag gtgatagcag aagcttttca tttttaaaca tagaattaaa
     6181 attggatttg cttctcttta atacttcaac atattgaatt tccctaggaa agtgactagc
     6241 tataatgaaa attcaagcga aaagggaaaa agattgtaaa tgcagatgaa ataacttcat
     6301 ttttaagtac aaataatagt aggattggtg tatgtaggtt taaaattata gtgatgacta
     6361 gtcgaactta atatacaatc agttcttgca aatactttac acttagctgc cattacacaa
     6421 caaattggaa ttttccagct gttcaactat catggactct gtacaggata gatgtgtata
     6481 atggaaaata tgtactgctt ctttctttga ttgccactca agatggaaac accatgccaa
     6541 ggcattttgg ttatacacag atcattctaa acctgttatt ttggagaggt gtattggttt
     6601 ctttctcatt tataaggcta ttgtattttt ttttgtatgt gattcaggtg tatttatttg
     6661 aagactattt gtagttatag gaaaaccaca cctacctgta ttgccaaatt ctttgtaaac
     6721 tctccgtggc acttgtgctt tcctggctga gagctctccc ctgttgatac agctatggca
     6781 ccattgtaat tacagatgca cctttcagga gcatctccat taaatggttc atagatgatt
     6841 taataaaaag aaacttctca gttga
//
