LOCUS       NM_018961               2520 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens ubiquitin associated and SH3 domain containing A
            (UBASH3A), transcript variant 1, mRNA.
ACCESSION   NM_018961
VERSION     NM_018961.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2520)
  AUTHORS   Wang,J., Wang,C., Hu,A., Yu,K., Kuang,Y., Gajendran,B.,
            Zacksenhaus,E., Sample,K.M., Xiao,X., Liu,W. and Ben-David,Y.
  TITLE     FLI1 induces erythroleukemia through opposing effects on UBASH3A
            and UBASH3B expression
  JOURNAL   BMC Cancer 24 (1), 326 (2024)
   PUBMED   38461240
  REMARK    GeneRIF: FLI1 induces erythroleukemia through opposing effects on
            UBASH3A and UBASH3B expression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2520)
  AUTHORS   Howarth,S., Sneddon,G., Allinson,K.R., Razvi,S., Mitchell,A.L. and
            Pearce,S.H.S.
  TITLE     Replication of association at the LPP and UBASH3A loci in a UK
            autoimmune Addison's disease cohort
  JOURNAL   Eur J Endocrinol 188 (1) (2023)
   PUBMED   36651163
  REMARK    GeneRIF: Replication of association at the LPP and UBASH3A loci in
            a UK autoimmune Addison's disease cohort.
REFERENCE   3  (bases 1 to 2520)
  AUTHORS   Lozic,M., Minarik,L., Racetin,A., Filipovic,N., Saraga Babic,M. and
            Vukojevic,K.
  TITLE     CRKL, AIFM3, AIF, BCL2, and UBASH3A during Human Kidney Development
  JOURNAL   Int J Mol Sci 22 (17), 9183 (2021)
   PUBMED   34502088
  REMARK    GeneRIF: CRKL, AIFM3, AIF, BCL2, and UBASH3A during Human Kidney
            Development.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2520)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 2520)
  AUTHORS   Tsygankov,A.Y.
  TITLE     TULA-family proteins: an odd couple
  JOURNAL   Cell Mol Life Sci 66 (17), 2949-2952 (2009)
   PUBMED   19585081
  REMARK    Review article
REFERENCE   6  (bases 1 to 2520)
  AUTHORS   Bertelsen,V., Breen,K., Sandvig,K., Stang,E. and Madshus,I.H.
  TITLE     The Cbl-interacting protein TULA inhibits dynamin-dependent
            endocytosis
  JOURNAL   Exp Cell Res 313 (8), 1696-1709 (2007)
   PUBMED   17382318
  REMARK    GeneRIF: TULA inhibits both clathrin-dependent and
            clathrin-independent endocytic pathways by functionally
            sequestering dynamin via the SH3 domain of TULA binding
            proline-rich sequences in dynamin
REFERENCE   7  (bases 1 to 2520)
  AUTHORS   Hoeller,D., Crosetto,N., Blagoev,B., Raiborg,C., Tikkanen,R.,
            Wagner,S., Kowanetz,K., Breitling,R., Mann,M., Stenmark,H. and
            Dikic,I.
  TITLE     Regulation of ubiquitin-binding proteins by monoubiquitination
  JOURNAL   Nat Cell Biol 8 (2), 163-169 (2006)
   PUBMED   16429130
REFERENCE   8  (bases 1 to 2520)
  AUTHORS   Kowanetz,K., Crosetto,N., Haglund,K., Schmidt,M.H.H., Heldin,C.H.
            and Dikic,I.
  TITLE     Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to
            Cbl and inhibit endocytosis of receptor tyrosine kinases
  JOURNAL   J Biol Chem 279 (31), 32786-32795 (2004)
   PUBMED   15159412
  REMARK    GeneRIF: Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of
            receptor tyrosine kinases
REFERENCE   9  (bases 1 to 2520)
  AUTHORS   Feshchenko,E.A., Smirnova,E.V., Swaminathan,G., Teckchandani,A.M.,
            Agrawal,R., Band,H., Zhang,X., Annan,R.S., Carr,S.A. and
            Tsygankov,A.Y.
  TITLE     TULA: an SH3- and UBA-containing protein that binds to c-Cbl and
            ubiquitin
  JOURNAL   Oncogene 23 (27), 4690-4706 (2004)
   PUBMED   15107835
  REMARK    Erratum:[Oncogene. 2004 Dec 16;23(58):9449]
REFERENCE   10 (bases 1 to 2520)
  AUTHORS   Wattenhofer,M., Shibuya,K., Kudoh,J., Lyle,R., Michaud,J.,
            Rossier,C., Kawasaki,K., Asakawa,S., Minoshima,S., Berry,A.,
            Bonne-Tamir,B., Shimizu,N., Antonarakis,S.E. and Scott,H.S.
  TITLE     Isolation and characterization of the UBASH3A gene on 21q22.3
            encoding a potential nuclear protein with a novel combination of
            domains
  JOURNAL   Hum Genet 108 (2), 140-147 (2001)
   PUBMED   11281453
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA926085.1, AJ277750.1,
            AA707211.1 and AP001624.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_018961.3.
            
            Summary: This gene encodes one of two family members belonging to
            the T-cell ubiquitin ligand (TULA) family. Both family members can
            negatively regulate T-cell signaling. This family member can
            facilitate growth factor withdrawal-induced apoptosis in T cells,
            which may occur via its interaction with AIF, an apoptosis-inducing
            factor. Alternative splicing of this gene results in multiple
            transcript variants. [provided by RefSeq, Aug 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1, also known as long
            form).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ277750.1, BC069483.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000319294.11/ ENSP00000317327.6
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                DA926085.1         41-53
            14-2500             AJ277750.1         1-2487
            2501-2516           AA707211.1         1-16                c
            2517-2520           AP001624.1         48506-48509
FEATURES             Location/Qualifiers
     source          1..2520
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.3"
     gene            1..2520
                     /gene="UBASH3A"
                     /gene_synonym="CLIP4; STS-2; TULA; TULA-1"
                     /note="ubiquitin associated and SH3 domain containing A"
                     /db_xref="GeneID:53347"
                     /db_xref="HGNC:HGNC:12462"
                     /db_xref="MIM:605736"
     exon            1..157
                     /gene="UBASH3A"
                     /gene_synonym="CLIP4; STS-2; TULA; TULA-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..2030
                     /gene="UBASH3A"
                     /gene_synonym="CLIP4; STS-2; TULA; TULA-1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     T-cell ubiquitin ligand protein; cbl-interacting protein
                     4; suppressor of T-cell receptor signaling 2; T-cell
                     ubiquitin ligand 1"
                     /codon_start=1
                     /product="ubiquitin-associated and SH3 domain-containing
                     protein A isoform 1"
                     /protein_id="NP_061834.1"
                     /db_xref="CCDS:CCDS13687.1"
                     /db_xref="GeneID:53347"
                     /db_xref="HGNC:HGNC:12462"
                     /db_xref="MIM:605736"
                     /translation="MAAGETQLYAKVSNKLKSRSSPSLLEPLLAMGFPVHTALKALAA
                     TGRKTAEEALAWLHDHCNDPSLDDPIPQEYALFLCPTGPLLEKLQEFWRESKRQCAKN
                     RAHEVFPHVTLCDFFTCEDQKVECLYEALKRAGDRLLGSFPTAVPLALHSSISYLGFF
                     VSGSPADVIREFAMTFATEASLLAGTSVSRFWIFSQVPGHGPNLRLSNLTRASFVSHY
                     ILQKYCSVKPCTKQLHLTLAHKFYPHHQRTLEQLARAIPLGHSCQWTAALYSRDMRFV
                     HYQTLRALFQYKPQNVDELTLSPGDYIFVDPTQQDEASEGWVIGISQRTGCRGFLPEN
                     YTDRASESDTWVKHRMYTFSLATDLNSRKDGEASSRCSGEFLPQTARSLSSLQALQAT
                     VARKSVLVVRHGERVDQIFGKAWLQQCSTPDGKYYRPDLNFPCSLPRRSRGIKDFEND
                     PPLSSCGIFQSRIAGDALLDSGIRISSVFASPALRCVQTAKLILEELKLEKKIKIRVE
                     PGIFEWTKWEAGKTTPTLMSLEELKEANFNIDTDYRPAFPLSALMPAESYQEYMDRCT
                     ASMVQIVNTCPQDTGVILIVSHGSTLDSCTRPLLGLPPRECGDFAQLVRKIPSLGMCF
                     CEENKEEGKWELVNPPVKTLTHGANAAFNWRNWISGN"
     exon            158..211
                     /gene="UBASH3A"
                     /gene_synonym="CLIP4; STS-2; TULA; TULA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            212..398
                     /gene="UBASH3A"
                     /gene_synonym="CLIP4; STS-2; TULA; TULA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            399..597
                     /gene="UBASH3A"
                     /gene_synonym="CLIP4; STS-2; TULA; TULA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            598..711
                     /gene="UBASH3A"
                     /gene_synonym="CLIP4; STS-2; TULA; TULA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            712..881
                     /gene="UBASH3A"
                     /gene_synonym="CLIP4; STS-2; TULA; TULA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1090
                     /gene="UBASH3A"
                     /gene_synonym="CLIP4; STS-2; TULA; TULA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1214
                     /gene="UBASH3A"
                     /gene_synonym="CLIP4; STS-2; TULA; TULA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1314
                     /gene="UBASH3A"
                     /gene_synonym="CLIP4; STS-2; TULA; TULA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1437
                     /gene="UBASH3A"
                     /gene_synonym="CLIP4; STS-2; TULA; TULA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1530
                     /gene="UBASH3A"
                     /gene_synonym="CLIP4; STS-2; TULA; TULA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1675
                     /gene="UBASH3A"
                     /gene_synonym="CLIP4; STS-2; TULA; TULA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1782
                     /gene="UBASH3A"
                     /gene_synonym="CLIP4; STS-2; TULA; TULA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1892
                     /gene="UBASH3A"
                     /gene_synonym="CLIP4; STS-2; TULA; TULA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..2520
                     /gene="UBASH3A"
                     /gene_synonym="CLIP4; STS-2; TULA; TULA-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2344..2349
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBASH3A"
                     /gene_synonym="CLIP4; STS-2; TULA; TULA-1"
                     /note="hexamer: ATTAAA"
     polyA_site      2377
                     /gene="UBASH3A"
                     /gene_synonym="CLIP4; STS-2; TULA; TULA-1"
                     /note="major polyA site"
     regulatory      2400..2405
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBASH3A"
                     /gene_synonym="CLIP4; STS-2; TULA; TULA-1"
                     /note="hexamer: ATTAAA"
     polyA_site      2417
                     /gene="UBASH3A"
                     /gene_synonym="CLIP4; STS-2; TULA; TULA-1"
                     /note="major polyA site"
     regulatory      2483..2488
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBASH3A"
                     /gene_synonym="CLIP4; STS-2; TULA; TULA-1"
                     /note="hexamer: AATAAA"
     polyA_site      2520
                     /gene="UBASH3A"
                     /gene_synonym="CLIP4; STS-2; TULA; TULA-1"
                     /note="major polyA site"
ORIGIN      
        1 atttctgtgt gcaggcgagc ttcttggcct aagggcagga agagatggca gcgggggaga
       61 cgcagctcta cgccaaggtc tccaacaagc tcaagagccg cagcagcccc tcgctcctgg
      121 agcccctcct ggccatgggc ttcccggtgc acaccgcgct gaaagcgttg gcagccacgg
      181 ggaggaagac ggcggaggag gccttggcct ggctgcatga tcattgcaat gacccttccc
      241 tagacgaccc catcccccag gagtatgccc ttttcctctg tccaacgggg cccctgctgg
      301 aaaaacttca agagttctgg agagagagca agcgccagtg tgcaaagaac agagctcatg
      361 aggtcttccc acacgtgaca ctctgtgact tcttcacgtg tgaagaccag aaggtggaat
      421 gcctgtacga ggcgctgaag agagctggag acaggctcct gggctccttc cccacggccg
      481 tgcctctggc tctccactcc tccatcagct acctcggctt cttcgtcagt ggcagccccg
      541 cagacgtcat ccgggaattc gccatgacct tcgccacgga agcatctctc ttagcaggca
      601 cttccgtttc ccgcttctgg attttcagcc aggtgcctgg acatggccct aacctgaggc
      661 tgagcaattt aactagagcc tccttcgtga gccactacat ccttcaaaaa tactgctccg
      721 tgaagccttg caccaaacag ctgcatctga ccttggccca caagttctac ccccaccacc
      781 agaggacgct ggagcagctg gccagagcca tccccctggg ccacagctgc cagtggaccg
      841 cagcactcta ctcccgagac atgcgctttg tgcactacca gaccctgaga gccctattcc
      901 agtacaaacc ccagaacgtg gatgagctga cgctaagtcc tggtgactac atctttgtgg
      961 accccacgca gcaggacgaa gccagcgagg gctgggtgat tgggatctca cagcggacgg
     1021 gctgccgggg cttcctgccg gaaaactaca cggatcgagc cagtgagtct gacacgtggg
     1081 tgaagcacag gatgtacacc ttcagtctag ccacagacct gaactccaga aaggatggtg
     1141 aagccagcag cagatgcagc ggggaatttc ttccacaaac ggcaaggagt cttagcagct
     1201 tacaggcctt gcaggctacc gttgcaagga agagcgtgct ggtggttcgc cacggggaga
     1261 gagtggatca gatcttcggg aaggcatggc tgcagcaatg ctccactcct gatgggaaat
     1321 actacaggcc agacctgaat ttcccctgca gtctgccaag acggagtcgt gggatcaaag
     1381 actttgaaaa cgatccccca ttatcatcgt gtggcatttt ccagtccaga attgcagggg
     1441 acgcgctact ggacagtggt atcagaatca gctctgtgtt tgcctcccca gccctccgct
     1501 gtgtgcagac ggccaaactc atcctggaag aactcaaact ggagaaaaaa atcaagatac
     1561 gagtggaacc tggaatcttt gaatggacaa aatgggaagc tggcaaaacc accccaaccc
     1621 tcatgagcct ggaagagctg aaagaggcaa atttcaacat tgacactgat tacaggcccg
     1681 cgtttcccct gtccgccctc atgccggccg agagctacca ggagtacatg gacaggtgca
     1741 cggcgagcat ggtgcaaatc gtcaacacct gtccacagga cacgggtgtc atcctaattg
     1801 tgagtcacgg ctccactctg gactcctgca cgcggccact gctcgggctg ccgccccggg
     1861 aatgtgggga ttttgcccaa ctcgtgagaa agatcccttc cctgggcatg tgcttctgtg
     1921 aagaaaataa agaggaagga aaatgggagt tggtgaaccc accggtgaag accctgaccc
     1981 acggggcgaa cgcagcattt aactggagga actggatctc aggcaactga gagccacggt
     2041 gatgttgtca taacctcaga gtggagaggc agaaaccatg tgcagaggct gggagatgct
     2101 gctgtttcca gaggcgtctt agtctcaccc aatgtgattt gtagaagcac gagacgcact
     2161 tttatatccc ggaatatttc cctccggctt tcgcctttgt aactcccatc tgtggaccca
     2221 tcgtccacca gcccagctgc ggggagcaca gggcaggtgg ctgggtgagg atgccgccct
     2281 gcagcatgta caccgagtgt ctgcagctgg ggacacaact gcccgggact ctaacttcca
     2341 ggaattaaag actcaccaca cacgaaggat ctaaccactt cattttccat ggtctaatca
     2401 ttaaattccc aatcgttttt tctttttctg ggtccatcac tctttagcca tatccacatg
     2461 ggctaaaaca ggtgtaatag tcaataaaat ggtcccagaa aaccatcgac caggtcaaaa
//
