LOCUS       NM_014847               3877 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens ubiquitin associated protein 2 like (UBAP2L),
            transcript variant 1, mRNA.
ACCESSION   NM_014847
VERSION     NM_014847.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3877)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3877)
  AUTHORS   Liao,Y., Andronov,L., Liu,X., Lin,J., Guerber,L., Lu,L.,
            Agote-Aran,A., Pangou,E., Ran,L., Kleiss,C., Qu,M., Schmucker,S.,
            Cirillo,L., Zhang,Z., Riveline,D., Gotta,M., Klaholz,B.P. and
            Sumara,I.
  TITLE     UBAP2L ensures homeostasis of nuclear pore complexes at the intact
            nuclear envelope
  JOURNAL   J Cell Biol 223 (7) (2024)
   PUBMED   38652117
  REMARK    GeneRIF: UBAP2L ensures homeostasis of nuclear pore complexes at
            the intact nuclear envelope.
REFERENCE   3  (bases 1 to 3877)
  AUTHORS   Guerber,L., Vuidel,A., Liao,Y., Kleiss,C., Grandgirard,E.,
            Sumara,I. and Pangou,E.
  TITLE     UBAP2L-dependent coupling of PLK1 localization and stability during
            mitosis
  JOURNAL   EMBO Rep 24 (6), e56241 (2023)
   PUBMED   37039032
  REMARK    GeneRIF: UBAP2L-dependent coupling of PLK1 localization and
            stability during mitosis.
REFERENCE   4  (bases 1 to 3877)
  AUTHORS   Zhou,Y., Liu,Y., Gupta,S., Paramo,M.I., Hou,Y., Mao,C., Luo,Y.,
            Judd,J., Wierbowski,S., Bertolotti,M., Nerkar,M., Jehi,L.,
            Drayman,N., Nicolaescu,V., Gula,H., Tay,S., Randall,G., Wang,P.,
            Lis,J.T., Feschotte,C., Erzurum,S.C., Cheng,F. and Yu,H.
  TITLE     A comprehensive SARS-CoV-2-human protein-protein interactome
            reveals COVID-19 pathobiology and potential host therapeutic
            targets
  JOURNAL   Nat Biotechnol 41 (1), 128-139 (2023)
   PUBMED   36217030
REFERENCE   5  (bases 1 to 3877)
  AUTHORS   Herlihy,A.E., Boeing,S., Weems,J.C., Walker,J.,
            Dirac-Svejstrup,A.B., Lehner,M.H., Conaway,R.C., Conaway,J.W. and
            Svejstrup,J.Q.
  TITLE     UBAP2/UBAP2L regulate UV-induced ubiquitylation of RNA polymerase
            II and are the human orthologues of yeast Def1
  JOURNAL   DNA Repair (Amst) 115, 103343 (2022)
   PUBMED   35633597
  REMARK    GeneRIF: UBAP2/UBAP2L regulate UV-induced ubiquitylation of RNA
            polymerase II and are the human orthologues of yeast Def1.
REFERENCE   6  (bases 1 to 3877)
  AUTHORS   Rush,J., Moritz,A., Lee,K.A., Guo,A., Goss,V.L., Spek,E.J.,
            Zhang,H., Zha,X.M., Polakiewicz,R.D. and Comb,M.J.
  TITLE     Immunoaffinity profiling of tyrosine phosphorylation in cancer
            cells
  JOURNAL   Nat Biotechnol 23 (1), 94-101 (2005)
   PUBMED   15592455
REFERENCE   7  (bases 1 to 3877)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   8  (bases 1 to 3877)
  AUTHORS   Brill,L.M., Salomon,A.R., Ficarro,S.B., Mukherji,M.,
            Stettler-Gill,M. and Peters,E.C.
  TITLE     Robust phosphoproteomic profiling of tyrosine phosphorylation sites
            from human T cells using immobilized metal affinity chromatography
            and tandem mass spectrometry
  JOURNAL   Anal Chem 76 (10), 2763-2772 (2004)
   PUBMED   15144186
REFERENCE   9  (bases 1 to 3877)
  AUTHORS   Lehner,B., Semple,J.I., Brown,S.E., Counsell,D., Campbell,R.D. and
            Sanderson,C.M.
  TITLE     Analysis of a high-throughput yeast two-hybrid system and its use
            to predict the function of intracellular proteins encoded within
            the human MHC class III region
  JOURNAL   Genomics 83 (1), 153-167 (2004)
   PUBMED   14667819
REFERENCE   10 (bases 1 to 3877)
  AUTHORS   Marenholz,I., Zirra,M., Fischer,D.F., Backendorf,C., Ziegler,A. and
            Mischke,D.
  TITLE     Identification of human epidermal differentiation complex
            (EDC)-encoded genes by subtractive hybridization of entire YACs to
            a gridded keratinocyte cDNA library
  JOURNAL   Genome Res 11 (3), 341-355 (2001)
   PUBMED   11230159
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC404293.1, BC003170.1 and D63478.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014847.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003170.1, SRR1660805.20549.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000428931.6/ ENSP00000389445.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               DC404293.1         107-266
            161-1506            BC003170.1         149-1494
            1507-2963           D63478.1           1552-3008
            2964-3816           BC003170.1         2952-3804
            3817-3877           BC003170.1         3806-3866
FEATURES             Location/Qualifiers
     source          1..3877
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..3877
                     /gene="UBAP2L"
                     /gene_synonym="NEDLBF; NICE-4; NICE4"
                     /note="ubiquitin associated protein 2 like"
                     /db_xref="GeneID:9898"
                     /db_xref="HGNC:HGNC:29877"
                     /db_xref="MIM:616472"
     exon            1..21
                     /gene="UBAP2L"
                     /gene_synonym="NEDLBF; NICE-4; NICE4"
                     /inference="alignment:Splign:2.1.0"
     exon            22..151
                     /gene="UBAP2L"
                     /gene_synonym="NEDLBF; NICE-4; NICE4"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..3325
                     /gene="UBAP2L"
                     /gene_synonym="NEDLBF; NICE-4; NICE4"
                     /note="isoform a is encoded by transcript variant 1;
                     protein NICE-4; RNA polymerase II degradation factor
                     UBAP2L"
                     /codon_start=1
                     /product="ubiquitin-associated protein 2-like isoform a"
                     /protein_id="NP_055662.3"
                     /db_xref="CCDS:CCDS1063.1"
                     /db_xref="GeneID:9898"
                     /db_xref="HGNC:HGNC:29877"
                     /db_xref="MIM:616472"
                     /translation="MMTSVGTNRARGNWEQPQNQNQTQHKQRPQATAEQIRLAQMISD
                     HNDADFEEKVKQLIDITGKNQDECVIALHDCNGDVNRAINVLLEGNPDTHSWEMVGKK
                     KGVSGQKDGGQTESNEEGKENRDRDRDYSRRRGGPPRRGRGASRGREFRGQENGLDGT
                     KSGGPSGRGTERGRRGRGRGRGGSGRRGGRFSAQGMGTFNPADYAEPANTDDNYGNSS
                     GNTWNNTGHFEPDDGTSAWRTATEEWGTEDWNEDLSETKIFTASNVSSVPLPAENVTI
                     TAGQRIDLAVLLGKTPSTMENDSSNLDPSQAPSLAQPLVFSNSKQTAISQPASGNTFS
                     HHSMVSMLGKGFGDVGEAKGGSTTGSQFLEQFKTAQALAQLAAQHSQSGSTTTSSWDM
                     GSTTQSPSLVQYDLKNPSDSAVHSPFTKRQAFTPSSTMMEVFLQEKSPAVATSTAAPP
                     PPSSPLPSKSTSAPQMSPGSSDNQSSSPQPAQQKLKQQKKKASLTSKIPALAVEMPGS
                     ADISGLNLQFGALQFGSEPVLSDYESTPTTSASSSQAPSSLYTSTASESSSTISSNQS
                     QESGYQSGPIQSTTYTSQNNAQGPLYEQRSTQTRRYPSSISSSPQKDLTQAKNGFSSV
                     QATQLQTTQSVEGATGSAVKSDSPSTSSIPPLNETVSAASLLTTTNQHSSSLGGLSHS
                     EEIPNTTTTQHSSTLSTQQNTLSSSTSSGRTSTSTLLHTSVESEANLHSSSSTFSTTS
                     STVSAPPPVVSVSSSLNSGSSLGLSLGSNSTVTASTRSSVATTSGKAPPNLPPGVPPL
                     LPNPYIMAPGLLHAYPPQVYGYDDLQMLQTRFPLDYYSIPFPTPTTPLTGRDGSLASN
                     PYSGDLTKFGRGDASSPAPATTLAQPQQNQTQTHHTTQQTFLNPALPPGYSYTSLPYY
                     TGVPGLPSTFQYGPAVFPVAPTSSKQHGVNVSVNASATPFQQPSGYGSHGYNTGVSVT
                     SSNTGVPDISGSVYSKTQQSFEKQGFHSGTPAASFNLPSALGSGGPINPATAAAYPPA
                     PFMHILTPHQQPHSQILHHHLQQDGQTGSGQRSQTSSIPQKPQTNKSAYNSYSWGAN"
     exon            152..229
                     /gene="UBAP2L"
                     /gene_synonym="NEDLBF; NICE-4; NICE4"
                     /inference="alignment:Splign:2.1.0"
     exon            230..340
                     /gene="UBAP2L"
                     /gene_synonym="NEDLBF; NICE-4; NICE4"
                     /inference="alignment:Splign:2.1.0"
     exon            341..509
                     /gene="UBAP2L"
                     /gene_synonym="NEDLBF; NICE-4; NICE4"
                     /inference="alignment:Splign:2.1.0"
     exon            510..605
                     /gene="UBAP2L"
                     /gene_synonym="NEDLBF; NICE-4; NICE4"
                     /inference="alignment:Splign:2.1.0"
     exon            606..651
                     /gene="UBAP2L"
                     /gene_synonym="NEDLBF; NICE-4; NICE4"
                     /inference="alignment:Splign:2.1.0"
     exon            652..764
                     /gene="UBAP2L"
                     /gene_synonym="NEDLBF; NICE-4; NICE4"
                     /inference="alignment:Splign:2.1.0"
     exon            765..817
                     /gene="UBAP2L"
                     /gene_synonym="NEDLBF; NICE-4; NICE4"
                     /inference="alignment:Splign:2.1.0"
     exon            818..903
                     /gene="UBAP2L"
                     /gene_synonym="NEDLBF; NICE-4; NICE4"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1075
                     /gene="UBAP2L"
                     /gene_synonym="NEDLBF; NICE-4; NICE4"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1274
                     /gene="UBAP2L"
                     /gene_synonym="NEDLBF; NICE-4; NICE4"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1552
                     /gene="UBAP2L"
                     /gene_synonym="NEDLBF; NICE-4; NICE4"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1725
                     /gene="UBAP2L"
                     /gene_synonym="NEDLBF; NICE-4; NICE4"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1915
                     /gene="UBAP2L"
                     /gene_synonym="NEDLBF; NICE-4; NICE4"
                     /inference="alignment:Splign:2.1.0"
     exon            1916..1970
                     /gene="UBAP2L"
                     /gene_synonym="NEDLBF; NICE-4; NICE4"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2145
                     /gene="UBAP2L"
                     /gene_synonym="NEDLBF; NICE-4; NICE4"
                     /inference="alignment:Splign:2.1.0"
     exon            2146..2218
                     /gene="UBAP2L"
                     /gene_synonym="NEDLBF; NICE-4; NICE4"
                     /inference="alignment:Splign:2.1.0"
     exon            2219..2414
                     /gene="UBAP2L"
                     /gene_synonym="NEDLBF; NICE-4; NICE4"
                     /inference="alignment:Splign:2.1.0"
     exon            2415..2503
                     /gene="UBAP2L"
                     /gene_synonym="NEDLBF; NICE-4; NICE4"
                     /inference="alignment:Splign:2.1.0"
     exon            2504..2557
                     /gene="UBAP2L"
                     /gene_synonym="NEDLBF; NICE-4; NICE4"
                     /inference="alignment:Splign:2.1.0"
     exon            2558..2639
                     /gene="UBAP2L"
                     /gene_synonym="NEDLBF; NICE-4; NICE4"
                     /inference="alignment:Splign:2.1.0"
     exon            2640..2857
                     /gene="UBAP2L"
                     /gene_synonym="NEDLBF; NICE-4; NICE4"
                     /inference="alignment:Splign:2.1.0"
     exon            2858..2963
                     /gene="UBAP2L"
                     /gene_synonym="NEDLBF; NICE-4; NICE4"
                     /inference="alignment:Splign:2.1.0"
     exon            2964..3031
                     /gene="UBAP2L"
                     /gene_synonym="NEDLBF; NICE-4; NICE4"
                     /inference="alignment:Splign:2.1.0"
     exon            3032..3229
                     /gene="UBAP2L"
                     /gene_synonym="NEDLBF; NICE-4; NICE4"
                     /inference="alignment:Splign:2.1.0"
     exon            3230..3877
                     /gene="UBAP2L"
                     /gene_synonym="NEDLBF; NICE-4; NICE4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3859..3864
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBAP2L"
                     /gene_synonym="NEDLBF; NICE-4; NICE4"
                     /note="hexamer: TATAAA"
     polyA_site      3877
                     /gene="UBAP2L"
                     /gene_synonym="NEDLBF; NICE-4; NICE4"
                     /note="major polyA site"
ORIGIN      
        1 gtcagtgtgg aggagactga gtattctacc ttgtaaatac tgttatttgt atatactgta
       61 aatgatgaca tcggtgggca ctaaccgagc ccggggaaac tgggaacaac ctcaaaacca
      121 aaaccagaca cagcacaagc agcggccaca ggccactgca gaacaaatta gacttgcaca
      181 gatgatttcg gaccataatg atgctgactt tgaggagaag gtgaaacaat tgattgatat
      241 tacaggcaag aaccaggatg aatgtgtgat tgctttgcat gactgcaatg gagatgtcaa
      301 cagagctatc aatgttcttc tggaaggaaa cccagacacg cattcctggg agatggtcgg
      361 gaagaagaag ggagtctcag gccagaagga tggtggccag acggaatcca atgaggaagg
      421 caaagaaaat cgagaccggg acagagacta tagtcggcga cgtggtgggc caccaagacg
      481 ggggagaggt gccagccgtg gacgagagtt tcgaggtcag gaaaatggat tggatggcac
      541 caagagtgga gggccttctg gaagaggaac agaaagaggc agaaggggcc gtggccgagg
      601 cagaggtggc tctggtaggc gaggaggaag gttttctgct caaggaatgg gaacctttaa
      661 cccagctgat tatgcagagc cagccaatac tgatgataac tatggcaata gcagcggcaa
      721 tacgtggaac aacactggcc actttgaacc agatgatggg acgagtgcat ggaggactgc
      781 aacagaggag tgggggactg aagattggaa tgaagatctt tctgagacca agatcttcac
      841 tgcctctaat gtgtcttcag tgcctctgcc tgcggagaat gtgacaatca ctgctggtca
      901 gagaattgac cttgctgttc tgctggggaa gacaccatct acaatggaga atgattcatc
      961 taatctggat ccgtctcagg ctccttctct ggcccagcct ctggtgttca gtaattcgaa
     1021 gcagactgcc atatcacagc ctgcttcagg gaacacattt tctcatcaca gtatggtgag
     1081 catgttaggg aaaggatttg gtgatgtcgg tgaagctaaa ggcggcagta ctacaggctc
     1141 ccagttcttg gagcaattca agactgccca agccctggct cagttggcag ctcagcattc
     1201 tcagtctgga agcaccacca cctcctcttg ggacatgggc tcgacgacac aatccccatc
     1261 actggtgcag tatgatttga agaacccaag tgattcagca gtgcacagcc cctttacaaa
     1321 gcgccaggct tttaccccat cttcaaccat gatggaggtg ttccttcagg agaagtcacc
     1381 tgcagtggct acctccacag ctgcacctcc acctccgtct tctcctctgc caagcaaatc
     1441 cacatcggct ccacagatgt cgcctggatc ttcagacaac cagtcctcta gccctcagcc
     1501 ggctcagcag aaactgaaac agcagaagaa aaaagcctcc ttgacttcta agattcctgc
     1561 tctggctgtg gagatgcctg gctcagcaga tatctcaggg ctaaacctgc agtttggggc
     1621 attgcagttt gggtcagagc ctgtcctttc tgattatgag tccaccccca ccacgagcgc
     1681 ctcttcaagc caggctccaa gtagcctgta taccagcacg gccagtgaat catcctctac
     1741 aatttcatct aaccagagtc aggagtctgg ttatcagagc ggcccaattc agtcgacaac
     1801 ctatacctcc caaaataatg ctcagggccc tctttatgaa cagagatcca cacagactcg
     1861 gcggtacccc agctccatct cttcatcacc ccaaaaggac ctgactcagg caaagaatgg
     1921 cttcagttct gtgcaggcca cgcagttaca gaccacacaa tctgttgaag gtgctacagg
     1981 ctctgcagtg aaatctgatt caccttccac ttctagcatc ccccctctca atgaaacggt
     2041 atctgcagct tccttactga cgacaaccaa tcagcattca tcctccttgg gtggcttgag
     2101 ccacagtgag gagattccaa atactaccac cacacaacac agcagcacgt tatctacgca
     2161 gcagaatacc ctttcatcat caacatcttc tgggcgcact tcgacatcca ctcttttgca
     2221 cacaagtgtg gagagtgagg cgaatctcca ttcttcctcc agcacttttt ccaccacatc
     2281 cagcacagtc tctgcacctc ccccagtggt cagtgtctcc tccagtctca atagtggcag
     2341 tagcctgggc ctcagcctag gcagcaactc cactgtcaca gcctcgactc gaagctcagt
     2401 tgctacgact tcaggaaaag ctcctcccaa cctccctcct ggggtcccgc cgttgttgcc
     2461 taatccgtat attatggctc cagggctgtt acatgcctac ccgccacaag tatatggtta
     2521 tgatgacttg cagatgcttc agacaagatt tccattggat tactacagca tcccatttcc
     2581 cacacccact actccgctga ctgggaggga tggtagcctg gccagcaacc cttattctgg
     2641 tgacctcaca aagttcggcc gtggggatgc ctcctcccca gccccggcca caaccttggc
     2701 ccaaccccaa cagaaccaga cgcagactca ccataccacg cagcagacat tcctgaaccc
     2761 ggcgctgcct cctggctaca gttacaccag cctgccatac tatacagggg tcccgggcct
     2821 ccccagcacc ttccagtatg ggcctgctgt gttccctgtg gctcctacct cttccaagca
     2881 gcatggtgtg aatgtcagtg tgaatgcatc ggccacccct ttccaacagc cgagtggata
     2941 tgggtctcat ggatacaaca ctggtgtttc agtcacctcc agtaacacgg gcgtgccaga
     3001 tatctcgggt tctgtgtact ccaaaaccca gcagtccttt gagaaacaag gttttcattc
     3061 cggtactcct gctgcttcct tcaacttgcc ttcagcccta ggaagtgggg gccccatcaa
     3121 tccggccaca gctgctgcct acccacctgc cccctttatg cacattctga ccccccatca
     3181 gcagccgcat tctcagatcc ttcaccatca cctgcagcag gatggccaga cgggcagcgg
     3241 gcaacgtagc cagaccagct ccatcccgca gaagccccag accaacaagt ctgcctacaa
     3301 cagctacagc tggggggcca actgaggccc tgaccctctt ctcccggtcc catcttctga
     3361 gagggcttct cagcctggaa actatggaaa cagcatcaaa gagaaaggaa tgtggggggt
     3421 ttccgctgcc ccccaccccc agcggcccac cccatgcctc agcttcatgt ctgtcccatt
     3481 cctataccat ccccaccctg ttgtatgtat tataggattt gtattttctc cttttttttc
     3541 ccccttccat tccttctccc ctcttgcatt caagattatg aaactttgct atgggccctg
     3601 cacttccttt gcttcctcct gttcaccctg gtggtgtacg gatgaggcgg ggaggtggga
     3661 cccccaaaca tatatcagcc caacagccct aagtctcctt ctttattatt aggaaaacaa
     3721 caacaacaac aaacaaaaaa atggcgtcat gaatatgaac agcattgtca gatgaattag
     3781 ttgaagtggt tttttttttg tttttttttt ttttttgtac tgtgtcctca aatttaatgg
     3841 attaatgtgt cttgtatata taaaaagaaa acctcta
//
