LOCUS       NM_016172               1860 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens UBA domain containing 1 (UBAC1), mRNA.
ACCESSION   NM_016172
VERSION     NM_016172.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1860)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1860)
  AUTHORS   Mazzone,P., Congestri,M., Scudiero,I., Polvere,I., Voccola,S.,
            Zerillo,L., Telesio,G., Vito,P., Stilo,R. and Zotti,T.
  TITLE     UBAC1/KPC2 Regulates TLR3 Signaling in Human Keratinocytes through
            Functional Interaction with the CARD14/CARMA2sh-TANK Complex
  JOURNAL   Int J Mol Sci 21 (24), 9365 (2020)
   PUBMED   33316896
  REMARK    GeneRIF: UBAC1/KPC2 Regulates TLR3 Signaling in Human Keratinocytes
            through Functional Interaction with the CARD14/CARMA2sh-TANK
            Complex.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1860)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 1860)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1860)
  AUTHORS   Deneyer,N., Bridoux,L., Bombled,C., Pringels,T., Bergiers,I., Pyr
            Dit Ruys,S., Vertommen,D., Twizere,J.C. and Rezsohazy,R.
  TITLE     HOXA2 activity regulation by cytoplasmic relocation, protein
            stabilization and post-translational modification
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1862 (9), 194404 (2019)
   PUBMED   31323436
  REMARK    GeneRIF: our experiments support that PPP1CB and KPC2 together
            inhibit the activity of HOXA2 by activating its nuclear export, but
            favored HOXA2 de-ubiquitination and stabilization thereby
            establishing a store of HOXA2 in the cytoplasm.
REFERENCE   6  (bases 1 to 1860)
  AUTHORS   Kotoshiba,S., Kamura,T., Hara,T., Ishida,N. and Nakayama,K.I.
  TITLE     Molecular dissection of the interaction between p27 and Kip1
            ubiquitylation-promoting complex, the ubiquitin ligase that
            regulates proteolysis of p27 in G1 phase
  JOURNAL   J Biol Chem 280 (18), 17694-17700 (2005)
   PUBMED   15746103
REFERENCE   7  (bases 1 to 1860)
  AUTHORS   Kamura,T., Hara,T., Matsumoto,M., Ishida,N., Okumura,F.,
            Hatakeyama,S., Yoshida,M., Nakayama,K. and Nakayama,K.I.
  TITLE     Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1)
            at G1 phase
  JOURNAL   Nat Cell Biol 6 (12), 1229-1235 (2004)
   PUBMED   15531880
REFERENCE   8  (bases 1 to 1860)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
REFERENCE   9  (bases 1 to 1860)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
REFERENCE   10 (bases 1 to 1860)
  AUTHORS   Li,C., Rodriguez,M., Adamson,J.W. and Banerjee,D.
  TITLE     Identification of a glialblastoma cell differentiation
            factor-related gene mRNA in human microvascular endothelial cells
  JOURNAL   Genomics 65 (3), 243-252 (2000)
   PUBMED   10857748
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL355574.27.
            
            On May 17, 2019 this sequence version replaced NM_016172.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HM005604.1, BC004967.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371756.4/ ENSP00000360821.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-349               AL355574.27        57849-58197         c
            350-470             AL355574.27        52119-52239         c
            471-544             AL355574.27        50504-50577         c
            545-652             AL355574.27        44622-44729         c
            653-755             AL355574.27        43093-43195         c
            756-864             AL355574.27        42713-42821         c
            865-1087            AL355574.27        41852-42074         c
            1088-1174           AL355574.27        36497-36583         c
            1175-1313           AL355574.27        35046-35184         c
            1314-1860           AL355574.27        29793-30339         c
FEATURES             Location/Qualifiers
     source          1..1860
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..1860
                     /gene="UBAC1"
                     /gene_synonym="GBDR1; KPC2; UBADC1"
                     /note="UBA domain containing 1"
                     /db_xref="GeneID:10422"
                     /db_xref="HGNC:HGNC:30221"
                     /db_xref="MIM:608129"
     exon            1..349
                     /gene="UBAC1"
                     /gene_synonym="GBDR1; KPC2; UBADC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             212..1429
                     /gene="UBAC1"
                     /gene_synonym="GBDR1; KPC2; UBADC1"
                     /note="putative glialblastoma cell differentiation-related
                     protein; ubiquitin associated domain containing 1; UBA
                     domain-containing protein 1; E3 ubiquitin-protein ligase
                     subunit KPC2; kip1 ubiquitination-promoting complex
                     protein 2; Kip1 ubiquitination-promoting complex subunit
                     2; glialblastoma cell differentiation-related protein 1;
                     testicular secretory protein Li 64"
                     /codon_start=1
                     /product="ubiquitin-associated domain-containing protein
                     1"
                     /protein_id="NP_057256.2"
                     /db_xref="CCDS:CCDS35177.1"
                     /db_xref="GeneID:10422"
                     /db_xref="HGNC:HGNC:30221"
                     /db_xref="MIM:608129"
                     /translation="MFVQEEKIFAGKVLRLHICASDGAEWLEEATEDTSVEKLKERCL
                     KHCAHGSLEDPKSITHHKLIHAASERVLSDARTILEENIQDQDVLLLIKKRAPSPLPK
                     MADVSAEEKKKQDQKAPDKEAILRATANLPSYNMDRAAVQTNMRDFQTELRKILVSLI
                     EVAQKLLALNPDAVELFKKANAMLDEDEDERVDEAALRQLTEMGFPENRATKALQLNH
                     MSVPQAMEWLIEHAEDPTIDTPLPGQAPPEAEGATAAASEAAAGASATDEEARDELTE
                     IFKKIRRKREFRADARAVISLMEMGFDEKEVIDALRVNNNQQNAACEWLLGDRKPSPE
                     ELDKGIDPDSPLFQAILDNPVVQLGLTNPKTLLAFEDMLENPLNSTQWMNDPETGPVM
                     LQISRIFQTLNRT"
     exon            350..470
                     /gene="UBAC1"
                     /gene_synonym="GBDR1; KPC2; UBADC1"
                     /inference="alignment:Splign:2.1.0"
     exon            471..544
                     /gene="UBAC1"
                     /gene_synonym="GBDR1; KPC2; UBADC1"
                     /inference="alignment:Splign:2.1.0"
     exon            545..652
                     /gene="UBAC1"
                     /gene_synonym="GBDR1; KPC2; UBADC1"
                     /inference="alignment:Splign:2.1.0"
     exon            653..755
                     /gene="UBAC1"
                     /gene_synonym="GBDR1; KPC2; UBADC1"
                     /inference="alignment:Splign:2.1.0"
     exon            756..864
                     /gene="UBAC1"
                     /gene_synonym="GBDR1; KPC2; UBADC1"
                     /inference="alignment:Splign:2.1.0"
     exon            865..1087
                     /gene="UBAC1"
                     /gene_synonym="GBDR1; KPC2; UBADC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1174
                     /gene="UBAC1"
                     /gene_synonym="GBDR1; KPC2; UBADC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1313
                     /gene="UBAC1"
                     /gene_synonym="GBDR1; KPC2; UBADC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1860
                     /gene="UBAC1"
                     /gene_synonym="GBDR1; KPC2; UBADC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1842..1847
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBAC1"
                     /gene_synonym="GBDR1; KPC2; UBADC1"
                     /note="hexamer: AATAAA"
     polyA_site      1860
                     /gene="UBAC1"
                     /gene_synonym="GBDR1; KPC2; UBADC1"
                     /note="major polyA site"
ORIGIN      
        1 ggcgcgcccc cggcggctgc tgcggcggcg ggagcgaggc gaccgctgag gccgcggaga
       61 gtgacggcgg cccggccgac gggagccggg gcggggcggc ggcccagcga aggagcgcgc
      121 gggcggtctg gccccgcccc ctccccgccc gccttcccgg tgaccttcag gggcccgggt
      181 ggcgggcgca ggcccctgcg gcggcggcgg gatgttcgtg caggaggaga agatcttcgc
      241 gggcaaggtg ctgcggctgc acatctgcgc gtccgacggc gccgagtggc tggaggaggc
      301 caccgaggac acctcggtgg agaagctcaa ggagcgctgc ctcaagcact gtgctcatgg
      361 gagcttagaa gatcccaaaa gtataaccca tcataaatta atccacgctg cctcagagag
      421 ggtgctgagt gatgccagga ccatcctgga agagaacatc caggaccaag atgtcctatt
      481 attgataaaa aagcgtgctc catcaccact tcccaagatg gctgatgtct cagcagaaga
      541 aaagaaaaaa caagaccaga aagctccaga taaagaggcc atactgcggg ccaccgccaa
      601 cctgccctcc tacaacatgg accgggccgc ggtccagacc aacatgagag acttccagac
      661 agaactccgg aagatactgg tgtctctcat cgaggtggcg cagaagctgt tagcgctgaa
      721 cccagatgca gtggaattgt ttaagaaggc gaatgcaatg ctggacgagg acgaggatga
      781 gcgtgtggac gaggctgccc tgcggcagct cacggagatg ggctttccgg agaacagagc
      841 caccaaggcc cttcagctga accacatgtc ggtgcctcag gccatggagt ggctaattga
      901 acacgcagaa gacccgacca tagacacgcc tcttcctggc caagctcccc cagaggccga
      961 gggggccaca gcagctgcct ccgaggctgc cgcgggagcc agcgccaccg atgaggaggc
     1021 cagagatgag ctgacggaaa tcttcaagaa gatccggagg aaaagggagt ttcgggctga
     1081 tgctcgggcc gtcatttccc tgatggagat ggggttcgac gagaaagagg tgatagatgc
     1141 cctcagagtg aacaacaacc agcagaatgc cgcgtgcgag tggctgctgg gggaccggaa
     1201 gccctctccg gaggagctgg acaagggcat cgaccccgac agtcctctct ttcaggccat
     1261 cctggataac ccggtggtgc agctgggcct gaccaacccg aaaacattgc tagcatttga
     1321 agacatgctg gagaacccac tgaacagcac ccagtggatg aatgatccag aaacggggcc
     1381 tgtcatgctg cagatctcta gaatcttcca gacactaaat cgcacgtagg tggcgttgtt
     1441 ccactcggct atcaggccac agcagccccc tggtgcggcc cgagaccggg cagagtggac
     1501 ctcacctgga aactcacctt cagcgcctca gccctggact gttagaggtg ctgcagctgc
     1561 tcctgctctc tgatcttatt gcttataaac tttggtgacg gtagtgtgta aggccgtatt
     1621 tttagcatct gacaggtgtt tacaaaaaag tggttgtcgc actgggaagt ggagtgatgg
     1681 cctcgtctcc agtgctcctc tgggctcttg agttgctgct tgaattgccg tgtagacatt
     1741 tgcttggaga gtccacttgt tatttgacgg aggtaggttt caacccagag ttaatgtcaa
     1801 gcatgctaat ttaactagtc actcacagat gacttttctt taataaagtc ccttttccta
//
