LOCUS       NM_003335               3304 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ubiquitin like modifier activating enzyme 7 (UBA7),
            mRNA.
ACCESSION   NM_003335
VERSION     NM_003335.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3304)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3304)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 3304)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3304)
  AUTHORS   Fan,J.B., Miyauchi,S., Xu,H.Z., Liu,D., Kim,L.J.Y., Burkart,C.,
            Cheng,H., Arimoto,K.I., Yan,M., Zhou,Y., Gyorffy,B.,
            Knobeloch,K.P., Rich,J.N., Cang,H., Fu,X.D. and Zhang,D.E.
  TITLE     Type I Interferon Regulates a Coordinated Gene Network to Enhance
            Cytotoxic T Cell-Mediated Tumor Killing
  JOURNAL   Cancer Discov 10 (3), 382-393 (2020)
   PUBMED   31974171
  REMARK    GeneRIF: Type I Interferon Regulates a Coordinated Gene Network to
            Enhance Cytotoxic T Cell-Mediated Tumor Killing.
REFERENCE   5  (bases 1 to 3304)
  AUTHORS   Lertsooksawat,W., Wongnoppavich,A. and Chairatvit,K.
  TITLE     Up-regulation of interferon-stimulated gene 15 and its conjugation
            machinery, UbE1L and UbcH8 expression by tumor necrosis
            factor-alpha through p38 MAPK and JNK signaling pathways in human
            lung carcinoma
  JOURNAL   Mol Cell Biochem 462 (1-2), 51-59 (2019)
   PUBMED   31428903
  REMARK    GeneRIF: TNF-alpha, similar to the response by IFN-beta, could
            directly induce expression of ISG15 and its conjugation machinery,
            UbE1L and UbcH8, in human lung carcinoma.
REFERENCE   6  (bases 1 to 3304)
  AUTHORS   Yuan,W. and Krug,R.M.
  TITLE     Influenza B virus NS1 protein inhibits conjugation of the
            interferon (IFN)-induced ubiquitin-like ISG15 protein
  JOURNAL   EMBO J 20 (3), 362-371 (2001)
   PUBMED   11157743
REFERENCE   7  (bases 1 to 3304)
  AUTHORS   McLaughlin,P.M., Helfrich,W., Kok,K., Mulder,M., Hu,S.W.,
            Brinker,M.G., Ruiters,M.H., de Leij,L.F. and Buys,C.H.
  TITLE     The ubiquitin-activating enzyme E1-like protein in lung cancer cell
            lines
  JOURNAL   Int J Cancer 85 (6), 871-876 (2000)
   PUBMED   10709110
REFERENCE   8  (bases 1 to 3304)
  AUTHORS   Kok,K., Van den Berg,A., Veldhuis,P.M., Franke,M., Terpstra,P. and
            Buys,C.H.
  TITLE     The genomic structure of the human UBE1L gene
  JOURNAL   Gene Expr 4 (3), 163-175 (1995)
   PUBMED   7734949
REFERENCE   9  (bases 1 to 3304)
  AUTHORS   Kok,K., Hofstra,R., Pilz,A., van den Berg,A., Terpstra,P.,
            Buys,C.H. and Carritt,B.
  TITLE     A gene in the chromosomal region 3p21 with greatly reduced
            expression in lung cancer is similar to the gene for
            ubiquitin-activating enzyme
  JOURNAL   Proc Natl Acad Sci U S A 90 (13), 6071-6075 (1993)
   PUBMED   8327486
REFERENCE   10 (bases 1 to 3304)
  AUTHORS   Carritt,B., Kok,K., van den Berg,A., Osinga,J., Pilz,A.,
            Hofstra,R.M., Davis,M.B., van der Veen,A.Y., Rabbitts,P.H.,
            Gulati,K. et al.
  TITLE     A gene from human chromosome region 3p21 with reduced expression in
            small cell lung cancer
  JOURNAL   Cancer Res 52 (6), 1536-1541 (1992)
   PUBMED   1311632
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM152341.1 and BC006378.2.
            
            On Nov 23, 2018 this sequence version replaced NM_003335.2.
            
            Summary: The modification of proteins with ubiquitin is an
            important cellular mechanism for targeting abnormal or short-lived
            proteins for degradation. Ubiquitination involves at least three
            classes of enzymes: ubiquitin-activating enzymes, or E1s,
            ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein
            ligases, or E3s. This gene encodes a member of the E1
            ubiquitin-activating enzyme family. The encoded enzyme is a
            retinoid target that triggers promyelocytic leukemia (PML)/retinoic
            acid receptor alpha (RARalpha) degradation and apoptosis in acute
            promyelocytic leukemia, where it is involved in the conjugation of
            the ubiquitin-like interferon-stimulated gene 15 protein. [provided
            by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006378.2, L13852.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000333486.4/ ENSP00000333266.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                BM152341.1         8-77
            71-3304             BC006378.2         1-3234
FEATURES             Location/Qualifiers
     source          1..3304
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..3304
                     /gene="UBA7"
                     /gene_synonym="D8; UBA1B; UBE1L; UBE2; UBE7"
                     /note="ubiquitin like modifier activating enzyme 7"
                     /db_xref="GeneID:7318"
                     /db_xref="HGNC:HGNC:12471"
                     /db_xref="MIM:191325"
     exon            1..222
                     /gene="UBA7"
                     /gene_synonym="D8; UBA1B; UBE1L; UBE2; UBE7"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..3205
                     /gene="UBA7"
                     /gene_synonym="D8; UBA1B; UBE1L; UBE2; UBE7"
                     /note="UBA1, ubiquitin-activating enzyme E1 homolog B;
                     UBA7, ubiquitin-activating enzyme E1; ubiquitin-activating
                     enzyme E1-related protein; ubiquitin-activating enzyme-2;
                     ubiquitin-activating enzyme 7"
                     /codon_start=1
                     /product="ubiquitin-like modifier-activating enzyme 7"
                     /protein_id="NP_003326.2"
                     /db_xref="CCDS:CCDS2805.1"
                     /db_xref="GeneID:7318"
                     /db_xref="HGNC:HGNC:12471"
                     /db_xref="MIM:191325"
                     /translation="MDALDASKLLDEELYSRQLYVLGSPAMQRIQGARVLVSGLQGLG
                     AEVAKNLVLMGVGSLTLHDPHPTCWSDLAAQFLLSEQDLERSRAEASQELLAQLNRAV
                     QVVVHTGDITEDLLLDFQVVVLTAAKLEEQLKVGTLCHKHGVCFLAADTRGLVGQLFC
                     DFGEDFTVQDPTEAEPLTAAIQHISQGSPGILTLRKGANTHYFRDGDLVTFSGIEGMV
                     ELNDCDPRSIHVREDGSLEIGDTTTFSRYLRGGAITEVKRPKTVRHKSLDTALLQPHV
                     VAQSSQEVHHAHCLHQAFCALHKFQHLHGRPPQPWDPVDAETVVGLARDLEPLKRTEE
                     EPLEEPLDEALVRTVALSSAGVLSPMVAMLGAVAAQEVLKAISRKFMPLDQWLYFDAL
                     DCLPEDGELLPSPEDCALRGSRYDGQIAVFGAGFQEKLRRQHYLLVGAGAIGCELLKV
                     FALVGLGAGNSGGLTVVDMDHIERSNLSRQFLFRSQDVGRPKAEVAAAAARGLNPDLQ
                     VIPLTYPLDPTTEHIYGDNFFSRVDGVAAALDSFQARRYVAARCTHYLKPLLEAGTSG
                     TWGSATVFMPHVTEAYRAPASAAASEDAPYPVCTVRYFPSTAEHTLQWARHEFEELFR
                     LSAETINHHQQAHTSLADMDEPQTLTLLKPVLGVLRVRPQNWQDCVAWALGHWKLCFH
                     YGIKQLLRHFPPNKVLEDGTPFWSGPKQCPQPLEFDTNQDTHLLYVLAAANLYAQMHG
                     LPGSQDWTALRELLKLLPQPDPQQMAPIFASNLELASASAEFGPEQQKELNKALEVWS
                     VGPPLKPLMFEKDDDSNFHVDFVVAAASLRCQNYGIPPVNRAQSKRIVGQIIPAIATT
                     TAAVAGLLGLELYKVVSGPRPRSAFRHSYLHLAENYLIRYMPFAPAIQTFHHLKWTSW
                     DRLKVPAGQPERTLESLLAHLQEQHGLRVRILLHGSALLYAAGWSPEKQAQHLPLRVT
                     ELVQQLTGQAPAPGQRVLVLELSCEGDDEDTAFPPLHYEL"
     exon            223..391
                     /gene="UBA7"
                     /gene_synonym="D8; UBA1B; UBE1L; UBE2; UBE7"
                     /inference="alignment:Splign:2.1.0"
     exon            392..526
                     /gene="UBA7"
                     /gene_synonym="D8; UBA1B; UBE1L; UBE2; UBE7"
                     /inference="alignment:Splign:2.1.0"
     exon            527..633
                     /gene="UBA7"
                     /gene_synonym="D8; UBA1B; UBE1L; UBE2; UBE7"
                     /inference="alignment:Splign:2.1.0"
     exon            634..724
                     /gene="UBA7"
                     /gene_synonym="D8; UBA1B; UBE1L; UBE2; UBE7"
                     /inference="alignment:Splign:2.1.0"
     exon            725..860
                     /gene="UBA7"
                     /gene_synonym="D8; UBA1B; UBE1L; UBE2; UBE7"
                     /inference="alignment:Splign:2.1.0"
     exon            861..958
                     /gene="UBA7"
                     /gene_synonym="D8; UBA1B; UBE1L; UBE2; UBE7"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1105
                     /gene="UBA7"
                     /gene_synonym="D8; UBA1B; UBE1L; UBE2; UBE7"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1288
                     /gene="UBA7"
                     /gene_synonym="D8; UBA1B; UBE1L; UBE2; UBE7"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1396
                     /gene="UBA7"
                     /gene_synonym="D8; UBA1B; UBE1L; UBE2; UBE7"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1477
                     /gene="UBA7"
                     /gene_synonym="D8; UBA1B; UBE1L; UBE2; UBE7"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1633
                     /gene="UBA7"
                     /gene_synonym="D8; UBA1B; UBE1L; UBE2; UBE7"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1799
                     /gene="UBA7"
                     /gene_synonym="D8; UBA1B; UBE1L; UBE2; UBE7"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..2005
                     /gene="UBA7"
                     /gene_synonym="D8; UBA1B; UBE1L; UBE2; UBE7"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2070
                     /gene="UBA7"
                     /gene_synonym="D8; UBA1B; UBE1L; UBE2; UBE7"
                     /inference="alignment:Splign:2.1.0"
     exon            2071..2254
                     /gene="UBA7"
                     /gene_synonym="D8; UBA1B; UBE1L; UBE2; UBE7"
                     /inference="alignment:Splign:2.1.0"
     exon            2255..2329
                     /gene="UBA7"
                     /gene_synonym="D8; UBA1B; UBE1L; UBE2; UBE7"
                     /inference="alignment:Splign:2.1.0"
     exon            2330..2513
                     /gene="UBA7"
                     /gene_synonym="D8; UBA1B; UBE1L; UBE2; UBE7"
                     /inference="alignment:Splign:2.1.0"
     exon            2514..2596
                     /gene="UBA7"
                     /gene_synonym="D8; UBA1B; UBE1L; UBE2; UBE7"
                     /inference="alignment:Splign:2.1.0"
     exon            2597..2689
                     /gene="UBA7"
                     /gene_synonym="D8; UBA1B; UBE1L; UBE2; UBE7"
                     /inference="alignment:Splign:2.1.0"
     exon            2690..2881
                     /gene="UBA7"
                     /gene_synonym="D8; UBA1B; UBE1L; UBE2; UBE7"
                     /inference="alignment:Splign:2.1.0"
     exon            2882..2974
                     /gene="UBA7"
                     /gene_synonym="D8; UBA1B; UBE1L; UBE2; UBE7"
                     /inference="alignment:Splign:2.1.0"
     exon            2975..3075
                     /gene="UBA7"
                     /gene_synonym="D8; UBA1B; UBE1L; UBE2; UBE7"
                     /inference="alignment:Splign:2.1.0"
     exon            3076..3304
                     /gene="UBA7"
                     /gene_synonym="D8; UBA1B; UBE1L; UBE2; UBE7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3284..3289
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBA7"
                     /gene_synonym="D8; UBA1B; UBE1L; UBE2; UBE7"
                     /note="hexamer: AATAAA"
     polyA_site      3304
                     /gene="UBA7"
                     /gene_synonym="D8; UBA1B; UBE1L; UBE2; UBE7"
                     /note="major polyA site"
ORIGIN      
        1 cttttctcca ggaagagagc tgtgaccagc agcgtccctt attcgcttgg ccttggttcc
       61 tgtttgcact ggctacagca gggcactggc ccctactgtc accgccacct acacaaagac
      121 cctatctctg agcgctgcag cctactgttc agccccaggt ttgaggatgg atgccctgga
      181 cgcttcgaag ctactggatg aggagctgta ttcaagacag ctgtatgtgc tgggctcacc
      241 tgccatgcag aggattcagg gagccagggt cctggtgtca ggcctgcagg gcctgggggc
      301 cgaggtggcc aagaacttgg ttctgatggg tgtgggcagc ctcactctgc atgatcccca
      361 ccccacctgc tggtccgacc tggctgccca gtttctcctc tcagagcagg acttggaaag
      421 gagcagagcc gaggcctctc aagagctctt ggctcagctc aacagagctg tccaggtcgt
      481 cgtgcacacg ggtgacatca ctgaggacct gctgttggac ttccaggtgg tggtgctgac
      541 tgctgcaaag ctggaggagc agctgaaggt gggcaccttg tgtcataagc atggagtttg
      601 ctttctggcg gctgacaccc ggggcctcgt ggggcagttg ttctgtgact ttggtgagga
      661 cttcactgtg caggacccca cagaggcaga acccctgaca gctgccatcc agcacatctc
      721 ccagggctcc cctggcattc tcactctgag gaaaggggcc aatacccact acttccgtga
      781 tggagacttg gtgactttct cgggaattga gggaatggtt gagctcaacg actgtgatcc
      841 ccggtctatc cacgtgcggg aggatgggtc cctggagatt ggagacacaa caactttctc
      901 tcggtacttg cgtggtgggg ctatcactga agtcaagaga cccaagactg tgagacataa
      961 gtccctggac acagccctgc tccagcccca tgtggtggcc cagagctccc aggaagttca
     1021 ccatgcccac tgcctgcatc aggccttctg tgcactgcac aagttccagc acctccatgg
     1081 ccggccaccc cagccctggg atcctgttga tgcagagact gtggtgggcc tggcccggga
     1141 cctggaacca ctgaagcgga cagaggaaga gccactggaa gagccactgg atgaggccct
     1201 agtgcggaca gtcgccctaa gcagtgcagg tgtcttgagc cctatggtgg ccatgctggg
     1261 tgcagtagct gcccaggaag tgctgaaggc aatctccagg aagttcatgc ctctggacca
     1321 gtggctttac tttgatgccc tcgattgtct tccggaagat ggggagctcc ttcccagtcc
     1381 tgaggactgt gccctgagag gcagccgcta tgatgggcaa attgcagtgt ttggggctgg
     1441 ttttcaggag aaactgagac gccagcacta cctcctggtg ggcgctggtg ccattggttg
     1501 tgagctgctc aaagtctttg ccctagtggg actgggggcc gggaacagcg ggggcttgac
     1561 tgttgttgac atggaccaca tagagcgctc caatctcagc cgtcagttcc tcttcaggtc
     1621 ccaggacgtt ggtagaccca aggcagaggt ggctgcagca gctgcccggg gcctgaaccc
     1681 agacttacag gtgatcccgc tcacctaccc actggatccc accacagagc acatctatgg
     1741 ggataacttt ttctcccgtg tggatggtgt ggctgctgcc ctggacagtt tccaggcccg
     1801 gcgctatgtg gctgctcgtt gcacccacta tctgaagcca ctgctggagg caggcacatc
     1861 gggcacctgg ggcagtgcta cagtattcat gccacatgtg actgaggcct acagagcccc
     1921 tgcctcagct gcagcttctg aggatgcccc ctaccctgtc tgtaccgtgc ggtacttccc
     1981 tagcacagcc gagcacaccc tgcagtgggc ccggcatgag tttgaagaac tcttccgact
     2041 gtctgcagag accatcaacc accaccaaca ggcacacact tccctggcag acatggatga
     2101 gccacagaca ctcaccttac tgaagccagt gcttggggtc ctgagagtgc gtccacagaa
     2161 ctggcaagac tgtgtggcgt gggctcttgg ccactggaaa ctctgctttc attatggcat
     2221 caaacagctg ctgaggcact tcccacctaa taaagtgctt gaggatggaa ctcccttctg
     2281 gtcaggtccc aaacagtgtc cccagccctt ggagtttgac accaaccaag acacacacct
     2341 cctctacgta ctggcagctg ccaacctgta tgcccagatg catgggctgc ctggctcaca
     2401 ggactggact gcactcaggg agctgctgaa gctgctgcca cagcctgacc cccaacagat
     2461 ggcccccatc tttgctagta atctagagct ggcttcggct tctgctgagt ttggccctga
     2521 gcagcagaag gaactgaaca aagccctgga agtctggagt gtgggccctc ccctgaagcc
     2581 tctgatgttt gagaaggatg atgacagcaa cttccatgtg gactttgtgg tagcggcagc
     2641 tagcctgaga tgtcagaact acgggattcc accggtcaac cgtgcccaga gcaagcgaat
     2701 tgtgggccag attatcccag ccattgccac cactacagca gctgtggcag gcctgttggg
     2761 cctggagctg tataaggtgg tgagtgggcc acggcctcgt agtgcctttc gccacagcta
     2821 cctacatctg gctgaaaact acctcatccg ctatatgcct tttgccccag ccatccagac
     2881 gttccatcac ctgaagtgga cctcttggga ccgtctgaag gtaccagctg ggcagcctga
     2941 gaggaccctg gagtcgctgc tggctcatct tcaggagcag cacgggttga gggtgaggat
     3001 cctgctgcac ggctcagccc tgctctatgc ggccggatgg tcacctgaaa agcaggccca
     3061 gcacctgccc ctcagggtga cagaactggt tcagcagctg acaggccagg cacctgctcc
     3121 tgggcagcgg gtgttggtgc tagagctgag ctgtgagggt gacgacgagg acactgcctt
     3181 cccacctctg cactatgagc tgtgacaagg cagccaccct gtcacctagc tcaatggagc
     3241 cccggatccc aagccctgca ttgtaagccc acagtaggca ctcaataaat gcttgttaaa
     3301 ggaa
//
