LOCUS       NM_001033930            2848 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens ubiquitin A-52 residue ribosomal protein fusion
            product 1 (UBA52), transcript variant 1, mRNA.
ACCESSION   NM_001033930
VERSION     NM_001033930.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2848)
  AUTHORS   Park,J., Wu,J., Szkop,K.J., Jeong,J., Jovanovic,P., Husmann,D.,
            Flores,N.M., Francis,J.W., Chen,Y.C., Benitez,A.M., Zahn,E.,
            Song,S., Ajani,J.A., Wang,L., Singh,K., Larsson,O., Garcia,B.A.,
            Topisirovic,I., Gozani,O. and Mazur,P.K.
  TITLE     SMYD5 methylation of rpL40 links ribosomal output to gastric cancer
  JOURNAL   Nature 632 (8025), 656-663 (2024)
   PUBMED   39048817
  REMARK    GeneRIF: SMYD5 methylation of rpL40 links ribosomal output to
            gastric cancer.
REFERENCE   2  (bases 1 to 2848)
  AUTHORS   Tong,L., Zheng,X., Wang,T., Gu,W., Shen,T., Yuan,W., Wang,S.,
            Xing,S., Liu,X., Zhang,C. and Zhang,C.
  TITLE     Inhibition of UBA52 induces autophagy via EMC6 to suppress
            hepatocellular carcinoma tumorigenesis and progression
  JOURNAL   J Cell Mol Med 28 (6), e18164 (2024)
   PUBMED   38445807
  REMARK    GeneRIF: Inhibition of UBA52 induces autophagy via EMC6 to suppress
            hepatocellular carcinoma tumorigenesis and progression.
REFERENCE   3  (bases 1 to 2848)
  AUTHORS   Lee,S.O., Kelliher,J.L., Song,W., Tengler,K., Sarkar,A., Dray,E.
            and Leung,J.W.C.
  TITLE     UBA80 and UBA52 fine-tune RNF168-dependent histone ubiquitination
            and DNA repair
  JOURNAL   J Biol Chem 299 (8), 105043 (2023)
   PUBMED   37451480
  REMARK    GeneRIF: UBA80 and UBA52 fine-tune RNF168-dependent histone
            ubiquitination and DNA repair.
REFERENCE   4  (bases 1 to 2848)
  AUTHORS   Eastham,M.J., Pelava,A., Wells,G.R., Watkins,N.J. and Schneider,C.
  TITLE     RPS27a and RPL40, Which Are Produced as Ubiquitin Fusion Proteins,
            Are Not Essential for p53 Signalling
  JOURNAL   Biomolecules 13 (6), 898 (2023)
   PUBMED   37371478
  REMARK    GeneRIF: RPS27a and RPL40, Which Are Produced as Ubiquitin Fusion
            Proteins, Are Not Essential for p53 Signalling.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2848)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 2848)
  AUTHORS   Kato,S., Sekine,S., Oh,S.W., Kim,N.S., Umezawa,Y., Abe,N.,
            Yokoyama-Kobayashi,M. and Aoki,T.
  TITLE     Construction of a human full-length cDNA bank
  JOURNAL   Gene 150 (2), 243-250 (1994)
   PUBMED   7821789
REFERENCE   7  (bases 1 to 2848)
  AUTHORS   Baker,R.T. and Board,P.G.
  TITLE     The human ubiquitin/52-residue ribosomal protein fusion gene
            subfamily (UbA52) is composed primarily of processed pseudogenes
  JOURNAL   Genomics 14 (2), 520-522 (1992)
   PUBMED   1330885
REFERENCE   8  (bases 1 to 2848)
  AUTHORS   Baker,R.T. and Board,P.G.
  TITLE     The human ubiquitin-52 amino acid fusion protein gene shares
            several structural features with mammalian ribosomal protein genes
  JOURNAL   Nucleic Acids Res 19 (5), 1035-1040 (1991)
   PUBMED   1850507
REFERENCE   9  (bases 1 to 2848)
  AUTHORS   Monia,B.P., Ecker,D.J., Jonnalagadda,S., Marsh,J., Gotlib,L.,
            Butt,T.R. and Crooke,S.T.
  TITLE     Gene synthesis, expression, and processing of human ubiquitin
            carboxyl extension proteins
  JOURNAL   J Biol Chem 264 (7), 4093-4103 (1989)
   PUBMED   2537304
REFERENCE   10 (bases 1 to 2848)
  AUTHORS   Salvesen,G., Lloyd,C. and Farley,D.
  TITLE     cDNA encoding a human homolog of yeast ubiquitin 1
  JOURNAL   Nucleic Acids Res 15 (13), 5485 (1987)
   PUBMED   3037496
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from BQ428688.1, CB124676.1, BQ428515.1, AF545864.1,
            BU677484.1 and AC005253.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_001033930.2.
            
            Summary: Ubiquitin is a highly conserved nuclear and cytoplasmic
            protein that has a major role in targeting cellular proteins for
            degradation by the 26S proteosome. It is also involved in the
            maintenance of chromatin structure, the regulation of gene
            expression, and the stress response. Ubiquitin is synthesized as a
            precursor protein consisting of either polyubiquitin chains or a
            single ubiquitin moiety fused to an unrelated protein. This gene
            encodes a fusion protein consisting of ubiquitin at the N terminus
            and ribosomal protein L40 at the C terminus, a C-terminal extension
            protein (CEP). Multiple processed pseudogenes derived from this
            gene are present in the genome. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.230820.1,
                                           SRR1660807.99101.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000442744.7/ ENSP00000388107.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 BQ428688.1         58-58
            2-532               CB124676.1         1-531
            533-740             BQ428515.1         495-702
            741-2757            AF545864.1         1-2017
            2758-2758           BU677484.1         18-18               c
            2759-2848           AC005253.1         31725-31814
FEATURES             Location/Qualifiers
     source          1..2848
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..2848
                     /gene="UBA52"
                     /gene_synonym="CEP52; HUBCEP52; L40; RPL40"
                     /note="ubiquitin A-52 residue ribosomal protein fusion
                     product 1"
                     /db_xref="GeneID:7311"
                     /db_xref="HGNC:HGNC:12458"
                     /db_xref="MIM:191321"
     exon            1..53
                     /gene="UBA52"
                     /gene_synonym="CEP52; HUBCEP52; L40; RPL40"
                     /inference="alignment:Splign:2.1.0"
     exon            54..164
                     /gene="UBA52"
                     /gene_synonym="CEP52; HUBCEP52; L40; RPL40"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..448
                     /gene="UBA52"
                     /gene_synonym="CEP52; HUBCEP52; L40; RPL40"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; ubiquitin-52 amino acid fusion protein;
                     ubiquitin carboxyl extension protein 52; ubiquitin-CEP52;
                     ubiquitin-60S ribosomal protein L40; ubiquitin-ribosomal
                     protein eL40 fusion protein"
                     /codon_start=1
                     /product="ubiquitin-ribosomal protein eL40 fusion protein
                     isoform 1 precursor"
                     /protein_id="NP_001029102.1"
                     /db_xref="CCDS:CCDS12382.1"
                     /db_xref="GeneID:7311"
                     /db_xref="HGNC:HGNC:12458"
                     /db_xref="MIM:191321"
                     /translation="MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLI
                     FAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGIIEPSLRQLAQKYNCDKMICRKCYAR
                     LHPRAVNCRKKKCGHTNNLRPKKKVK"
     exon            165..251
                     /gene="UBA52"
                     /gene_synonym="CEP52; HUBCEP52; L40; RPL40"
                     /inference="alignment:Splign:2.1.0"
     exon            252..354
                     /gene="UBA52"
                     /gene_synonym="CEP52; HUBCEP52; L40; RPL40"
                     /inference="alignment:Splign:2.1.0"
     exon            355..2848
                     /gene="UBA52"
                     /gene_synonym="CEP52; HUBCEP52; L40; RPL40"
                     /inference="alignment:Splign:2.1.0"
     regulatory      506..511
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBA52"
                     /gene_synonym="CEP52; HUBCEP52; L40; RPL40"
                     /note="hexamer: AATAAA"
     polyA_site      539
                     /gene="UBA52"
                     /gene_synonym="CEP52; HUBCEP52; L40; RPL40"
                     /note="major polyA site"
     regulatory      720..725
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBA52"
                     /gene_synonym="CEP52; HUBCEP52; L40; RPL40"
                     /note="hexamer: AGTAAA"
     polyA_site      741
                     /gene="UBA52"
                     /gene_synonym="CEP52; HUBCEP52; L40; RPL40"
     regulatory      2740..2745
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBA52"
                     /gene_synonym="CEP52; HUBCEP52; L40; RPL40"
                     /note="hexamer: AATAAA"
     polyA_site      2758
                     /gene="UBA52"
                     /gene_synonym="CEP52; HUBCEP52; L40; RPL40"
ORIGIN      
        1 cttctttttc ttcagcgagg cggccgagct ggttggtggc ggcggtcgtg cggacgcaaa
       61 catgcagatc tttgtgaaga ccctcactgg caaaaccatc acccttgagg tcgagcccag
      121 tgacaccatt gagaatgtca aagccaaaat tcaagacaag gagggtatcc cacctgacca
      181 gcagcgtctg atatttgccg gcaaacagct ggaggatggc cgcactctct cagactacaa
      241 catccagaaa gagtccaccc tgcacctggt gttgcgcctg cgaggtggca ttattgagcc
      301 ttctctccgc cagcttgccc agaaatacaa ctgcgacaag atgatctgcc gcaagtgcta
      361 tgctcgcctt caccctcgtg ctgtcaactg ccgcaagaag aagtgtggtc acaccaacaa
      421 cctgcgtccc aagaagaagg tcaaataagg tggttctttc cttgaagggc agcctcctgc
      481 ccaggccccg tggccctgga gcctcaataa agtgtccctt tcattgactg gagcagcaat
      541 tggtgtcctc atggctgatc tgtccaggga ggtggctgaa gagtgggcat ctcccttagg
      601 gactctactc agcactccat tctgtgccac ctgtggggtc ttctgtccta gattctgtca
      661 catcggcatt ggtccctgcc ctatgcccct gactctggat ttgtcatctg taaaactgga
      721 gtaaaaacct cagtcgtgta attggtggga ctgaggatca gttttgtcat tgctgggatc
      781 ctgtcaggca ctttgaggtg tccctcaggc cttggccctg aagtgtctag gtgtgtggag
      841 atgggtagaa aattaggtac acccaatggt gtagaacgtt gattctcaaa tttttttatt
      901 ttatacaaat ggggtctcac tatgttgtcc aggctggtct tgaactcctg ggctcaagcc
      961 atccgcccat ctcagcccct caaagtgttg ggattacaag caagaactgc catgcctgac
     1021 ccagttctca gttttttgtt tgtttgtttg tttgtttgtt ttgagacgga gtcttgctct
     1081 gtcgcccagg ctggagtgca gtggcgcagt ctcggcttac tacaacctct gcctccgggg
     1141 ttcacatcct tctcctgcct cagcctcccg agtagctggg actacaggtg cccgccacaa
     1201 ctcctggcta attttttgta tttttagtag agacggggtt tcactgggtt agccaggttg
     1261 gtctcgatct cctgaccttg tgatccattc gccttggcct cccagaatgc tggtattaca
     1321 ggcgtgagcc agcacgcctg gcccagttac tcagttttga atctgaggcc gtgacatcac
     1381 tcatggtctg cagtcagtgc tctgcccctg agctgtaccc tctcctatga taatcactct
     1441 taagaagggc aacccttggt gttttcccct taaggtcacc caggctggaa tgcagtggtg
     1501 tggtcatggc tccctgtacc ctggaactca ggcttgggtg atcctctctc ctttgcctcc
     1561 gaagtagcca ggactacagg tgtgcaccca ccaccacact cagataattg ctttggtgtt
     1621 tttaaagctt gtaatgatca gtaggctgag gtgggcaaat cataaggtca agagtttttt
     1681 agatggggtg agcacagacc aattcctgtt ttatttactg atttaaaatt ttgagacagt
     1741 ctcactgtca cccaggttgg ggtgcagtgg taggatcata gcttgctgca gccttgatct
     1801 cccaggatct tgcctcagcc tcccgagtag ctgggactgc atgcttgtgc caccacactc
     1861 ggttaatatt ttgtagagat ggggtcttgc tatgttgccc aggctggctt caaactcctg
     1921 aacttaaaag cctcctgttt agttttggtt ttttatcact tttttttttt ttttttgaga
     1981 tggagccttg ctcccatcgt gcaggctgga gtgcggtggc gcagtctcgg ctcactgcag
     2041 cttctgcctc tcgggttcaa gcgattctcc tttctcagcc tcttgagtag ctggaattac
     2101 cagtgtgcgc caccaccacc acgcctggct agtttttctg tttttagtag agacagggtt
     2161 ttgctatgtt ggccaggctg gtcttgaact actgacctct tgtgatctac ctgtcttggc
     2221 cttccaaagt gctaggatta caagcgtaag ccacagcgcc tggccttgct acattttttt
     2281 tttttttttt ttttttacag acatggtctc gctatgttgc ccagaatggt tttgcactgg
     2341 gtccaagcag ttctgccgca gcctcccaaa gtgctgggat tacaggggtg aggcaccttg
     2401 ctggcccctg ttttgattag ggtgcagtgc tggtgaagcc ggtgcacgag gccagtgatg
     2461 catcctaatg aggggtggag ttggcgggac ttcctgggcc agtttgggga ctttcacaaa
     2521 agacccccat gactcagggt tttgagttct taactgatcg aatgaaggat tcaaaattaa
     2581 ccactccaag gggggattga aggaagaacc actcttaatg gacaaaaaga aagaaagggg
     2641 agggagtaac agggatatga gctctagccg cccaagctag caatggcaac ccttctgggt
     2701 ccccttccag catgtggaag ctttcctttc gcttcattca ataaacagct gctgctcact
     2761 ctcctggtcc gtggactctt tttgaactgt taacactccc cgcaaaggtc cgcagcttca
     2821 ttcttcaaag ttagcgagac caggaacc
//
