LOCUS       NM_207309               3349 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
            (UAP1L1), mRNA.
ACCESSION   NM_207309 XR_017862
VERSION     NM_207309.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3349)
  AUTHORS   Xiao,X., Jiang,L., Hu,H., Huang,Y., Yang,L., Jiao,Y. and Wei,G.
  TITLE     Silencing of UAP1L1 inhibits proliferation and induces apoptosis in
            esophageal squamous cell carcinoma
  JOURNAL   Mol Carcinog 60 (3), 179-187 (2021)
   PUBMED   33434300
  REMARK    GeneRIF: Silencing of UAP1L1 inhibits proliferation and induces
            apoptosis in esophageal squamous cell carcinoma.
REFERENCE   2  (bases 1 to 3349)
  AUTHORS   Qi,J., Liu,S., Liu,W., Cai,G. and Liao,G.
  TITLE     Identification of UAP1L1 as tumor promotor in gastric cancer
            through regulation of CDK6
  JOURNAL   Aging (Albany NY) 12 (8), 6904-6927 (2020)
   PUBMED   32310823
  REMARK    GeneRIF: Identification of UAP1L1 as tumor promotor in gastric
            cancer through regulation of CDK6.
REFERENCE   3  (bases 1 to 3349)
  AUTHORS   Lai,C.Y., Liu,H., Tin,K.X., Huang,Y., Yeh,K.H., Peng,H.W.,
            Chen,H.D., He,J.Y., Chiang,Y.J., Liu,C.S., Weng,S.Y., Tao,M.H.,
            Yen,J.J. and Yang-Yen,H.F.
  TITLE     Identification of UAP1L1 as a critical factor for protein
            O-GlcNAcylation and cell proliferation in human hepatoma cells
  JOURNAL   Oncogene 38 (3), 317-331 (2019)
   PUBMED   30097606
  REMARK    GeneRIF: UAP1L1 is upregulated in a distinct subset of HCC tissues.
            Patients with upregulated expression of UAP1L1 have a poor
            prognosis. UAP1L1 overexpression promoted, and UAP1L1 knockdown
            reduced the proliferation of human hepatoma cells both in vitro and
            in vivo. UAP1L1 directly interacts with OGT but is not a substrate
            and cannot activate it alone.UAP1L1 knockdown attenuated c-MYC
            O-GlcNAcylation and protein stability.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX333979.2, CR979381.1, BC106035.1 and AL807752.10.
            
            On Nov 23, 2018 this sequence version replaced NM_207309.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL832421.1, AK095393.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000409858.8/ ENSP00000386935.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               BX333979.2         17-142
            127-284             CR979381.1         17-174
            285-1553            BC106035.1         13-1281
            1554-1554           AL807752.10        152705-152705
            1555-3014           BC106035.1         1283-2742
            3015-3349           BC106035.1         2745-3079
FEATURES             Location/Qualifiers
     source          1..3349
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..3349
                     /gene="UAP1L1"
                     /note="UDP-N-acetylglucosamine pyrophosphorylase 1 like 1"
                     /db_xref="GeneID:91373"
                     /db_xref="HGNC:HGNC:28082"
     exon            1..305
                     /gene="UAP1L1"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..1540
                     /gene="UAP1L1"
                     /note="UDP-N-acteylglucosamine pyrophosphorylase 1-like 1"
                     /codon_start=1
                     /product="UDP-N-acetylhexosamine pyrophosphorylase-like
                     protein 1"
                     /protein_id="NP_997192.2"
                     /db_xref="CCDS:CCDS7028.2"
                     /db_xref="GeneID:91373"
                     /db_xref="HGNC:HGNC:28082"
                     /translation="MASEQDVRARLQRAGQEHLLRFWAELAPEPRAALLAELALLEPE
                     ALREHCRRAAEACARPHGPPPDLAARLRPLPPERVGRASRSDPETRRRWEEEGFRQIS
                     LNKVAVLLLAGGQGTRLGVTYPKGMYRVGLPSRKTLYQLQAERIRRVEQLAGERHGTR
                     CTVPWYVMTSEFTLGPTAEFFREHNFFHLDPANVVMFEQRLLPAVTFDGKVILERKDK
                     VAMAPDGNGGLYCALEDHKILEDMERRGVEFVHVYCVDNILVRLADPVFIGFCVLQGA
                     DCGAKVVEKAYPEEPVGVVCQVDGVPQVVEYSEISPETAQLRASDGSLLYNAGNICNH
                     FFTRGFLKAVTREFEPLLKPHVAVKKVPYVDEEGNLVKPLKPNGIKMEKFVFDVFRFA
                     KNFAALEVLREEEFSPLKNAEPADRDSPRTARQALLTQHYRWALRAGARFLDAHGAWL
                     PELPSLPPNGDPPAICEISPLVSYSGEGLEVYLQGREFQSPLILDEDQAREPQLQES"
     exon            306..510
                     /gene="UAP1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            511..686
                     /gene="UAP1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            687..859
                     /gene="UAP1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            860..1053
                     /gene="UAP1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1194
                     /gene="UAP1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1380
                     /gene="UAP1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1447
                     /gene="UAP1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..3349
                     /gene="UAP1L1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3325..3330
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UAP1L1"
                     /note="hexamer: AATAAA"
     polyA_site      3349
                     /gene="UAP1L1"
                     /note="major polyA site"
ORIGIN      
        1 agacggcagc ggcgacatgg cttcggagca ggacgtgcgc gcccggctgc agcgcgctgg
       61 ccaggagcac ctcctgcgct tctgggccga gctggcgccg gagccacgag ccgcgctgct
      121 ggcggagctg gcgctgctgg agcccgaggc gctgcgcgag cactgccggc gggcggcgga
      181 ggcctgcgcg cgcccccacg gcccgccgcc cgacttggcc gcgcgcctgc ggcccctgcc
      241 cccagagcgc gtgggcaggg ccagccgcag cgaccccgag acacggcggc gctgggagga
      301 ggaaggtttc cgtcagattt ctctgaacaa ggtggccgtc ctgctgctgg ctggggggca
      361 gggcactcgc ctgggcgtga cctaccccaa gggtatgtac cgtgtggggc tgcccagccg
      421 gaagaccctg taccagctgc aggcggagcg gattcggcgg gtggagcagc tggccggtga
      481 gcgccacggg acccgctgca ccgtcccctg gtacgtcatg accagcgagt tcactctggg
      541 gcccacggcc gagttcttca gggagcacaa cttcttccac ctggaccccg ccaacgtggt
      601 catgtttgag cagcgcctgc tgcctgctgt gacctttgat ggcaaggtta tcctggagcg
      661 gaaagacaaa gttgccatgg ccccagacgg caacgggggc ctctactgcg cgctggagga
      721 ccacaagatc ctggaggaca tggagcgccg gggagtggag tttgtgcacg tgtactgtgt
      781 ggacaacatc ctggtgcggc tggcggaccc tgtcttcatc ggcttctgtg tgttgcaggg
      841 cgcagactgt ggcgccaagg tggtggaaaa ggcatacccc gaggagcccg tgggcgtggt
      901 gtgccaggtg gacggtgtcc cccaggtggt ggagtacagc gagatcagtc ctgagaccgc
      961 acagctacgt gcctccgacg ggagcctgct gtacaatgca ggcaacatct gcaaccactt
     1021 cttcacccga ggcttcctta aggcggtcac cagggagttt gagcctttgc tgaagccaca
     1081 cgtggctgtg aagaaggtcc cgtatgtgga tgaggagggg aatctggtaa agccgctaaa
     1141 accgaacggg ataaagatgg agaagtttgt gtttgatgtg ttccggtttg ctaagaactt
     1201 tgctgccttg gaagtgctgc gggaggagga attttcccca ctgaagaacg cagagccagc
     1261 cgacagggac agtccccgca ccgctcgcca ggccctgctc acccagcact accggtgggc
     1321 tctgcgggcc ggggcccgct tcctggatgc ccatggggcc tggctcccag agctgcccag
     1381 cttgccccca aatggagacc ctccggccat ctgtgagata tcgcccttgg tgtcttactc
     1441 tggagagggt ttagaagtgt acctgcaagg ccgggagttc cagtccccgc tcatcctgga
     1501 tgaagaccag gccagggagc cgcagctgca ggagtcctga cccgcccaga ctgtccccag
     1561 actcccccga gacctgccag ccccggcatc ctggaagtcc cgactccccc cagacctgcc
     1621 agccccggcg tcctggagct gggggctaca gcccagcctg agctctgggt gggaaagcag
     1681 cctgccccat gcttccagcc tgcagaacac agaatgaaac atgctggtag actccacgag
     1741 ggcagggcct ctcctgtcgc ctctggacac aagtggcgac agcctgctgg gggctctgtg
     1801 gctccattcc tggctgtggg gtctagtcaa gaggcagagg gacttgggac ctgggagaat
     1861 ggggctgaga ggaggcttcg ggttggggcc caagggaggt gtggtgtcat ctggggagaa
     1921 caggagggca tgtccctttg ggagcccgcc ttgtggatcc accacacccc accgagcact
     1981 agaagctgca taagctacac aggatgtgct tctgcagcct acagatgcag aaccagaatg
     2041 agggggacaa ttccacccac tcgagggctg ccccctcttc cttagcagac gaaccagtaa
     2101 tgggggcaag gctggggcat cccagcccac acaccctgga tgcccagcaa ggccacagaa
     2161 agagcctgat gtccatgatc caggtggctc tgagaagctt ggcctggaca cctgagcctg
     2221 cggccggtac tcctgccttc tccccatcta tccccaaggc ctctgcctct cagcctcttc
     2281 catggtcggt ttaggctgct gagttttctg tgcttcccca agaaccagtg ggatcaatgc
     2341 cggcggcctc tgtgatggtt gctgactaat ccgggatttc atgagtcaga ggcaccaccc
     2401 ctcaccccag ctgcctgctg cttctgacgg atcttggtgc tcaggctgcc tggctctccg
     2461 agtgaggacg cagcctccat atttggtgca ctcaggcatg gctgggacaa gccagctgcc
     2521 ccagggttct tcccctggtg attctcgcct gctttctcat ctcaggggag gcagtggcac
     2581 ctccctctcc ctgctgacat gaagagagct atgatatgcc actgctgcca actcatcctc
     2641 tgcccccacc tcgaaaccca cagtccccag tggagggcca ctactcatcc ccattggttt
     2701 cccaggggag gggtgttgtc tggaagggca ggttcagatg cagccttcca gatttagagg
     2761 cactgggagg acagtggctg agtggaggcg cccagacctg ggcaggcagc aggctcaggc
     2821 ccacaccttg tgatttttga aaccaaagcc cagaagatga tgtttacttc tctctccctg
     2881 gctctgccct tcttactgca aaccatgctg tgccttaggg cccttctcat agctgttcct
     2941 catggccatg actggaacag ggatgcaacc tctttctaca caagcacagt tagttgggtg
     3001 aagtcttttt ttttgtttgt tttagacgga gtttcactct tgttgcccag gctggagtga
     3061 agtggcgtga ccttggctca ctgcaacctc caggccagcc tcagcctccc tagtagctgg
     3121 gactacaggc acccactacc acgcctggct aattctttgt atttttagta gagatggggt
     3181 ttgaccgtgt tagccaggat ggtctcgatc tcctgacctc gtgatccacc cacctcggcc
     3241 tcccaaagtg ctgggattat aggtgtgagc caccgcgccg ggccggttgc tggcatctta
     3301 atgttctgta ggtggaatat ttccaataaa cacaaggtgc cgtaattga
//
