LOCUS       NM_018003               6904 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens uveal autoantigen with coiled-coil domains and ankyrin
            repeats (UACA), transcript variant 1, mRNA.
ACCESSION   NM_018003
VERSION     NM_018003.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6904)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 6904)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 6904)
  AUTHORS   Sugis,E., Dauvillier,J., Leontjeva,A., Adler,P., Hindie,V.,
            Moncion,T., Collura,V., Daudin,R., Loe-Mie,Y., Herault,Y.,
            Lambert,J.C., Hermjakob,H., Pupko,T., Rain,J.C., Xenarios,I.,
            Vilo,J., Simonneau,M. and Peterson,H.
  TITLE     HENA, heterogeneous network-based data set for Alzheimer's disease
  JOURNAL   Sci Data 6 (1), 151 (2019)
   PUBMED   31413325
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6904)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 6904)
  AUTHORS   Sun,B., Zhang,Z., Dong,C., Zhang,Y., Yan,C. and Li,S.
  CONSRTM   Medscape
  TITLE     99Tcm-octreotide scintigraphy and serum eye muscle antibodies in
            evaluation of active thyroid-associated ophthalmopathy
  JOURNAL   Eye (Lond) 31 (5), 668-676 (2017)
   PUBMED   28387769
REFERENCE   6  (bases 1 to 6904)
  AUTHORS   Cockman,M.E., Lancaster,D.E., Stolze,I.P., Hewitson,K.S.,
            McDonough,M.A., Coleman,M.L., Coles,C.H., Yu,X., Hay,R.T.,
            Ley,S.C., Pugh,C.W., Oldham,N.J., Masson,N., Schofield,C.J. and
            Ratcliffe,P.J.
  TITLE     Posttranslational hydroxylation of ankyrin repeats in IkappaB
            proteins by the hypoxia-inducible factor (HIF) asparaginyl
            hydroxylase, factor inhibiting HIF (FIH)
  JOURNAL   Proc Natl Acad Sci U S A 103 (40), 14767-14772 (2006)
   PUBMED   17003112
REFERENCE   7  (bases 1 to 6904)
  AUTHORS   Sakai,T., Liu,L., Teng,X., Mukai-Sakai,R., Shimada,H., Kaji,R.,
            Mitani,T., Matsumoto,M., Toida,K., Ishimura,K., Shishido,Y.,
            Mak,T.W. and Fukui,K.
  TITLE     Nucling recruits Apaf-1/pro-caspase-9 complex for the induction of
            stress-induced apoptosis
  JOURNAL   J Biol Chem 279 (39), 41131-41140 (2004)
   PUBMED   15271982
REFERENCE   8  (bases 1 to 6904)
  AUTHORS   Ohkura,T., Taniguchi,S., Yamada,K., Nishio,N., Okamura,T.,
            Yoshida,A., Kamijou,K., Fukata,S., Kuma,K., Inoue,Y., Hisatome,I.,
            Senju,S., Nishimura,Y. and Shigemasa,C.
  TITLE     Detection of the novel autoantibody (anti-UACA antibody) in
            patients with Graves' disease
  JOURNAL   Biochem Biophys Res Commun 321 (2), 432-440 (2004)
   PUBMED   15358194
  REMARK    GeneRIF: UACA is a novel candidate for eye muscle autoantigens in
            thyroid-associated ophthalmopathy
REFERENCE   9  (bases 1 to 6904)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   10 (bases 1 to 6904)
  AUTHORS   Yamada,K., Senju,S., Nakatsura,T., Murata,Y., Ishihara,M.,
            Nakamura,S., Ohno,S., Negi,A. and Nishimura,Y.
  TITLE     Identification of a novel autoantigen UACA in patients with
            panuveitis
  JOURNAL   Biochem Biophys Res Commun 280 (4), 1169-1176 (2001)
   PUBMED   11162650
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA517503.1, AF322916.1,
            AB046781.2, BM693348.1, AC087699.11 and BU736944.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_018003.3.
            
            Summary: This gene encodes a protein that contains ankyrin repeats
            and coiled coil domains and likely plays a role in apoptosis.
            Studies in rodents have implicated the encoded protein in the
            stimulation of apoptosis and the regulation of mammary gland
            involution, in which the mammary gland returns to its pre-pregnant
            state. This protein has also been proposed to negatively regulate
            apoptosis based on experiments in human cell lines in which the
            protein was shown to interact with PRKC apoptosis WT1 regulator
            protein, also known as PAR-4, and inhibit translocation of the
            PAR-4 receptor. Autoantibodies to this protein have been identified
            in human patients with panuveitis and Graves' disease. Differential
            expression of this gene has been observed in various human cancers.
            [provided by RefSeq, May 2017].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript but encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.39834.1,
                                           SRR1803613.43279.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000322954.11/ ENSP00000314556.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               DA517503.1         36-137
            103-567             AF322916.1         1-465
            568-3105            AB046781.2         417-2954
            3106-3381           BM693348.1         212-487
            3382-4524           AB046781.2         3231-4373
            4525-6341           AC087699.11        115182-116998       c
            6342-6904           BU736944.1         17-579              c
FEATURES             Location/Qualifiers
     source          1..6904
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q23"
     gene            1..6904
                     /gene="UACA"
                     /gene_synonym="NUCLING"
                     /note="uveal autoantigen with coiled-coil domains and
                     ankyrin repeats"
                     /db_xref="GeneID:55075"
                     /db_xref="HGNC:HGNC:15947"
                     /db_xref="MIM:612516"
     exon            1..229
                     /gene="UACA"
                     /gene_synonym="NUCLING"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..4402
                     /gene="UACA"
                     /gene_synonym="NUCLING"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nuclear membrane binding protein"
                     /codon_start=1
                     /product="uveal autoantigen with coiled-coil domains and
                     ankyrin repeats isoform 1"
                     /protein_id="NP_060473.2"
                     /db_xref="CCDS:CCDS10235.1"
                     /db_xref="GeneID:55075"
                     /db_xref="HGNC:HGNC:15947"
                     /db_xref="MIM:612516"
                     /translation="MKSLKSRLRRQDVPGPASSGAAAASAHAADWNKYDDRLMKAAER
                     GDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGR
                     NALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASV
                     NAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEV
                     LIKNGADISLLDALGHDSSYYARIGDNLDILTLLKTASENTNKGRELWKKGPSLQQRN
                     LTHMQDEVNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEE
                     VMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRKE
                     DMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKELEAMR
                     TFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYE
                     SEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQ
                     IKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLA
                     LSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHV
                     KPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEM
                     KNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSR
                     LETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMS
                     NQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENT
                     QNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKK
                     ELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQEN
                     DKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEK
                     LVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQ
                     QTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKL
                     QSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVL
                     HAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNK
                     ITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQ
                     EVIAIYRTHLLSAAQGHMDEDVQEALLQIIQMRQGLVC"
     exon            230..363
                     /gene="UACA"
                     /gene_synonym="NUCLING"
                     /inference="alignment:Splign:2.1.0"
     exon            364..452
                     /gene="UACA"
                     /gene_synonym="NUCLING"
                     /inference="alignment:Splign:2.1.0"
     exon            453..517
                     /gene="UACA"
                     /gene_synonym="NUCLING"
                     /inference="alignment:Splign:2.1.0"
     exon            518..575
                     /gene="UACA"
                     /gene_synonym="NUCLING"
                     /inference="alignment:Splign:2.1.0"
     exon            576..646
                     /gene="UACA"
                     /gene_synonym="NUCLING"
                     /inference="alignment:Splign:2.1.0"
     exon            647..753
                     /gene="UACA"
                     /gene_synonym="NUCLING"
                     /inference="alignment:Splign:2.1.0"
     exon            754..935
                     /gene="UACA"
                     /gene_synonym="NUCLING"
                     /inference="alignment:Splign:2.1.0"
     exon            936..973
                     /gene="UACA"
                     /gene_synonym="NUCLING"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1042
                     /gene="UACA"
                     /gene_synonym="NUCLING"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1150
                     /gene="UACA"
                     /gene_synonym="NUCLING"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1183
                     /gene="UACA"
                     /gene_synonym="NUCLING"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1282
                     /gene="UACA"
                     /gene_synonym="NUCLING"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1319
                     /gene="UACA"
                     /gene_synonym="NUCLING"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1372
                     /gene="UACA"
                     /gene_synonym="NUCLING"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..4111
                     /gene="UACA"
                     /gene_synonym="NUCLING"
                     /inference="alignment:Splign:2.1.0"
     exon            4112..4264
                     /gene="UACA"
                     /gene_synonym="NUCLING"
                     /inference="alignment:Splign:2.1.0"
     exon            4265..4330
                     /gene="UACA"
                     /gene_synonym="NUCLING"
                     /inference="alignment:Splign:2.1.0"
     exon            4331..6904
                     /gene="UACA"
                     /gene_synonym="NUCLING"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4505..4510
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UACA"
                     /gene_synonym="NUCLING"
                     /note="hexamer: AATAAA"
     polyA_site      4525
                     /gene="UACA"
                     /gene_synonym="NUCLING"
                     /note="major polyA site"
     regulatory      5061..5066
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UACA"
                     /gene_synonym="NUCLING"
                     /note="hexamer: AATAAA"
     polyA_site      5082
                     /gene="UACA"
                     /gene_synonym="NUCLING"
     regulatory      6334..6339
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UACA"
                     /gene_synonym="NUCLING"
                     /note="hexamer: AATAAA"
     polyA_site      6352
                     /gene="UACA"
                     /gene_synonym="NUCLING"
     regulatory      6878..6883
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UACA"
                     /gene_synonym="NUCLING"
                     /note="hexamer: AATAAA"
     polyA_site      6904
                     /gene="UACA"
                     /gene_synonym="NUCLING"
ORIGIN      
        1 gtcgacgtct gctgcccggg gcccgcaggt ggcaggcagg tggggctggt acagcccgcg
       61 ccgcctctgc tgcagccgct gccgtctact ccttgcgcgc tggcactccg cagcctttaa
      121 ggttcgcgcg ggggccaggc aagagttagc catgaagagc ctcaagtccc gcctgaggag
      181 gcaggacgtg cccggccccg cgtcgtctgg cgccgccgcc gccagcgcgc atgcagcaga
      241 ttggaataaa tatgatgacc gattgatgaa agcagcagaa aggggggatg tagaaaaagt
      301 gacctcaatc cttgctaaaa agggggtcaa tccaggcaaa ctagatgtgg aaggcagatc
      361 tgtcttccat gttgtgacct caaaggggaa tcttgagtgt ttgaatgcca tccttataca
      421 tggagttgat attacaacca gtgacactgc agggagaaat gctcttcacc tggctgctaa
      481 gtatggacat gcattgtgcc tacaaaaact tctacagtac aattgtccca ctgagcatgc
      541 agacctgcag ggaagaactg cacttcacga tgccgcaatg gcagattgtc cttctagcat
      601 acagctgctt tgtgaccatg gggcctctgt gaatgccaaa gatgtagacg ggcggacacc
      661 acttgttctg gctactcaga tgagtaggcc aacaatatgt caactgctga tagatagagg
      721 agcggatgtt aattccagag acaaacaaaa cagaactgcc ctcatgctag gttgcgaata
      781 tggttgcaga gatgcagtag aagtcttaat taaaaatggt gctgatataa gcttgctgga
      841 tgcgcttggc catgatagtt cttactatgc aagaattggt gacaatctgg acattctaac
      901 cttgttgaag actgcatcgg aaaataccaa caaagggaga gaactttgga agaaagggcc
      961 atctttgcaa cagcgaaatt tgacacacat gcaagatgaa gtaaatgtga agtcacatca
     1021 gagggagcat caaaatattc aggatttgga gattgaaaat gaagatttga aagagaggtt
     1081 gagaaaaatt cagcaagaac aaagaatact tttggataaa gtcaatggtt tacagttaca
     1141 gctgaatgag gaagttatgg ttgctgatga tctggaaagc gagagagaaa agctgaagtc
     1201 ccttttggca gctaaagaaa agcaacatga agaaagctta aggactattg aggctctgaa
     1261 aaatagattt aaatattttg agagtgatca tttaggatca ggaagtcatt tcagtaaccg
     1321 aaaagaagat atgcttctta aacaaggtca gatgtatatg gcagactcac agtgtacttc
     1381 cccaggtata ccagcccata tgcaaagcag atctatgtta agacctctgg aactatcttt
     1441 acccagtcaa acgtcatact ctgaaaatga aattttaaag aaagagttag aagcaatgcg
     1501 aactttctgt gagtcagcaa aacaagaccg actgaagctc caaaatgaac tggcacacaa
     1561 agtggcagaa tgcaaagctt tagcattaga atgtgaaagg gtcaaggagg attcagatga
     1621 acagataaag caattagaag atgcattaaa agatgtgcag aagaggatgt atgagtcaga
     1681 aggtaaagtt aaacaaatgc agacccattt tcttgccctt aaagaacact taacaagtga
     1741 agcagcctca gggaatcaca gactaaccga ggaactgaag gatcagttga aagacttgaa
     1801 agtaaaatat gaaggtgctt cagcagaagt ggggaaatta agaaaccaaa tcaaacaaaa
     1861 tgagatgata gtagaagagt ttaagaggga tgaaggcaag ctgatagaag aaaataagcg
     1921 attacagaag gaacttagta tgtgtgaaat ggagcgagag aagaaaggaa gaaaggtcac
     1981 agagatggaa ggccaggcaa aagaattgtc agcgaagttg gccctttcca ttccagctga
     2041 aaaatttgaa aacatgaaga gctcattatc aaatgaagtg aatgagaaag caaaaaaatt
     2101 agtagaaatg gaaagagaac atgaaaaatc acttagtgaa attagacagt taaagagaga
     2161 acttgagaat gttaaggcca agcttgctca gcacgtcaaa ccagaggaac atgaacaggt
     2221 taagagcaga ttagaacaga aatcaggaga acttgggaag aagatcactg agttaacatt
     2281 gaaaaatcag acactacaaa aggaaattga aaaagtttat ttggataata agctcctcaa
     2341 ggagcaagca cataacttaa caattgaaat gaaaaatcat tatgttcctt taaaagtaag
     2401 tgaagacatg aaaaagtcac atgatgcaat tattgatgat cttaatagaa agcttttaga
     2461 tgtaacacaa aaatatacag aaaagaagtt ggaaatggag aaattgctac tggaaaatga
     2521 cagcttaagt aaggatgtaa gccgcctaga aactgtgttt gtacctcctg agaaacatga
     2581 aaaagagata atagctctga aatccaatat tgttgaactt aagaaacagc tgtctgaact
     2641 taagaaaaaa tgtggtgaag accaggagaa aatacacgct ctcacatctg aaaacactaa
     2701 cttgaagaag atgatgagta atcagtatgt gccagttaaa acccatgaag aggttaaaat
     2761 gacactgaat gacacgttag ccaaaactaa cagagaatta ttagatgtga agaaaaaatt
     2821 tgaagatata aatcaggaat ttgtaaaaat aaaagataag aatgaaatat taaaaagaaa
     2881 cctggaaaac actcagaacc aaataaaagc tgagtacatc agcctggcag agcacgaggc
     2941 aaagatgagc tcgctaagtc agagcatgag aaaggtgcag gatagtaatg ctgaaatctt
     3001 ggccaactac agaaaaggcc aagaagagat tgtgacactg catgccgaaa ttaaagccca
     3061 gaagaaggag ctcgacacaa tacaagaatg cattaaggta aaatacgccc caattgtcag
     3121 ctttgaggag tgcgagagaa aatttaaagc aacagagaaa gaactaaaag accagttatc
     3181 agagcagaca caaaagtata gtgtcagtga agaagaagtc aagaaaaaca agcaagagaa
     3241 tgacaagtta aagaaggaga tttttaccct tcagaaagat ttgagagata agacagttct
     3301 cattgagaag tctcatgaaa tggaaagagc attaagcaga aaaacagacg agctaaacaa
     3361 acagttaaaa gacttgtcac agaaatacac ggaagtaaag aatgtgaaag agaagctagt
     3421 agaagaaaat gccaaacaga cttctgagat acttgcagtg caaaatcttt tgcaaaaaca
     3481 acatgttcca ttggaacagg ttgaggctct gaaaaaatct cttaatggca caattgaaaa
     3541 tctaaaggaa gaactgaaga gtatgcaaag gtgttacgag aaagagcagc agacagtgac
     3601 caaactgcat caattgttgg agaatcaaaa gaactcttct gtacccctgg cagagcattt
     3661 gcagattaaa gaagcatttg agaaagaagt tggaatcata aaagccagct tgagagaaaa
     3721 ggaagaagaa agccaaaaca aaatggaaga agtctccaaa cttcagtcgg aggttcagaa
     3781 tactaaacaa gcattaaaaa aattagagac tagagaggta gttgacttgt ctaaatataa
     3841 agcaacaaaa agtgatttgg agacacagat ttctagctta aatgaaaaat tggccaatct
     3901 gaatagaaag tatgaggaag tatgtgagga agttttgcat gccaaaaaga aggaaatatc
     3961 tgcaaaagat gagaaggaat tactgcattt cagcattgag caagaaatta aggatcagaa
     4021 ggaacgatgt gataagtcct taacaacaat cacagagtta caaagaagaa tacaagaatc
     4081 tgctaaacaa atagaagcaa aagataataa gataactgaa ctgcttaatg atgtggaaag
     4141 attaaaacag gcactcaatg gcctttccca actcacctac acaagtggga accccaccaa
     4201 gaggcagagc cagctgattg acactctgca gcaccaagtg aaatctctgg agcaacagct
     4261 ggccgatgct gacagacagc accaagaagt aattgcaatt tatcggacac accttcttag
     4321 tgctgcacag ggtcacatgg atgaagatgt tcaggaggct ctgctccaga tcatacaaat
     4381 gcggcagggg cttgtgtgct agccgttagc actgactgcc agtatctgtt ttatcttgct
     4441 ggtgctgaac attctttgtg caactccatg gtctttctgg gccttactgt gctggtataa
     4501 ttaaaataaa atatattttg ttctattggt aggttttttt ttaaaattag atgaatatgt
     4561 tagtcttttt caatatcagt ttgaatctta ttttctgtat gtgttaattt tacaaatagg
     4621 caaacaacat aactttgccc tggattgact acatattttt aaaccttcaa gtccctaata
     4681 aaacatgagc catctgagtg agtccatatg aagcgaggtt aggctgaaat aattgcttaa
     4741 agatgtcttt cagagaaatt aatttggttg gtggccactt ttaggtggat caaaagacct
     4801 ttcagatcct cagaaccttg agacataata cagttgtgag gaatgtgttg taacttggct
     4861 ggccaagtta catgttacag tatctttact gaggtaactt cattagtgtc tttggccttt
     4921 tttgtaggta tagatatttt ttctttttac actaataact tttatgcctt ttaaaataaa
     4981 tttattttca taaatggttt gcagtgctaa attacattta gattaagaac aggcaggggt
     5041 ggaatatatc aggaatttat aataaaattg ccttaatctc tacaacagta tcttaatttt
     5101 tacttgcggt gactattctt gccacaatat tggagaataa tgatagatga tatactagat
     5161 ttttcaaagt gtgaaaacct ttagactttt tttagcaatt agtttgacat tcgctactat
     5221 agtaaccaag cactcattat atatgcatcc tccaaatgtt tcatgcttat ttataggaaa
     5281 gttatattaa tgagattaat aatgtgaaat acagttttcc tgcaaaatta gcattagaga
     5341 attgatttta gataacagat ttttaaagtt ttagagaaaa gtacagtaat acagtaaact
     5401 gaaagagtat atagatagca ataaaataac ataagtggac atgtttatag taaatactct
     5461 gaagtaaaca accgttttta ttaactgcat ctcattaggg aaagtttata tgtcttgtta
     5521 ttttttatta acattttatt taccattcag agtgaaaatt actaatttga gtattaacaa
     5581 ataactgaat aaatggatca ttacagttag gttttctcaa attgcaaaat ttgccttagc
     5641 aattatcttt gaacatcccg aaccagattt ttaaatccca tttttgttta atagggtaaa
     5701 aataccatca aaatgacttc tcataccaaa gaataagcca tcatattttt tcggtgttga
     5761 aacaacattg aaagtcagaa ttggatttgt ttttaattct ttatacggtt tacataagca
     5821 atatctgtct ctttaattat tatgattaat gtcgtccttc agcatgagtt ctgtttcaca
     5881 agttttgggc cacctatttc aataaaaaat aaaatataaa ttaaaaaagt tgccgggggt
     5941 ggtggctcat gcctgtaatc ccagcacttt gggaggctga gggaggtaga tcacctgagg
     6001 tcagaagttc gagaccagcc ttaccaatat ggtgaagccc catctctact aaaaatacaa
     6061 aaattagccc tgcatggtgg caggtgcctg tagtcccagg tactcgggag gctgagacag
     6121 gagaatcgct tgaacctggg aggcggaggt tgcagtgagc caagatctcg ccactgcact
     6181 ccagcttggg caatagcaag actccatctc aaaataaaat aaaataaaac ttagagcaaa
     6241 gtttaaaact gagtattcat attaagtgtt ttattttcca tattagagat gggaagggaa
     6301 ccttatgtgt attttatttt gttttcaacc atcaataaag ttttctctag aatattgttt
     6361 tgaacatcct tgtaaaagat ttgcgagtta aactatttta tttactgtct gtgagagcat
     6421 tgggagtagg aaacgatgga ctccaaagta caagggagaa tacccatttt cattcagcta
     6481 tctggagtaa aatatcaagt acttccttca actaatcttg tctcattcac tcaccttttg
     6541 atatcgaagg cagaaattgc gtttacaaca ctgaagacca aagcttttta attagtaaac
     6601 aagcggaaca tagataatgg acaatgctgg ccactgccat tctgtgttca gaaagactat
     6661 gagacctgaa catatggcca agaggaaaga agagtgacgt tgtctaagat gtaatgagtg
     6721 ctctctgaga gaatcactca attcctattg gagtgcaatc cttacttgag aactttatta
     6781 ctcttgttct gtgtagtttt ttttttttgt cacttcccca tcagaaaagc atattctttt
     6841 tgatagaggg tcagtgttat aaataattgt cttttgaaat aaaatcaaat attcatgcat
     6901 tgaa
//
