LOCUS       NM_001080415            7424 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens U2 snRNP associated SURP domain containing (U2SURP),
            transcript variant 1, mRNA.
ACCESSION   NM_001080415 XM_031553
VERSION     NM_001080415.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7424)
  AUTHORS   Deng,L., Liao,L., Zhang,Y.L., Hu,S.Y., Yang,S.Y., Ma,X.Y.,
            Huang,M.Y., Zhang,F.L. and Li,D.Q.
  TITLE     MYC-driven U2SURP regulates alternative splicing of SAT1 to promote
            triple-negative breast cancer progression
  JOURNAL   Cancer Lett 560, 216124 (2023)
   PUBMED   36907504
  REMARK    GeneRIF: MYC-driven U2SURP regulates alternative splicing of SAT1
            to promote triple-negative breast cancer progression.
REFERENCE   2  (bases 1 to 7424)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 7424)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 7424)
  AUTHORS   Wang,Q., Wang,Y., Liu,Y., Zhang,C., Luo,Y., Guo,R., Zhan,Z.,
            Wei,N., Xie,Z., Shen,L., Wu,G., Wu,W. and Feng,Y.
  TITLE     U2-related proteins CHERP and SR140 contribute to colorectal
            tumorigenesis via alternative splicing regulation
  JOURNAL   Int J Cancer 145 (10), 2728-2739 (2019)
   PUBMED   30977118
  REMARK    GeneRIF: Study observed that CHERP and its binding partner SR140
            are significantly upregulated in human clinical colorectal cancer
            tissues (CRC) and clarified how CHERP/SR140 exert an oncogenic role
            in CRC development partially through regulating expression of UPF3A
            variants.
REFERENCE   5  (bases 1 to 7424)
  AUTHORS   Fasci,D., van Ingen,H., Scheltema,R.A. and Heck,A.J.R.
  TITLE     Histone Interaction Landscapes Visualized by Crosslinking Mass
            Spectrometry in Intact Cell Nuclei
  JOURNAL   Mol Cell Proteomics 17 (10), 2018-2033 (2018)
   PUBMED   30021884
REFERENCE   6  (bases 1 to 7424)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   7  (bases 1 to 7424)
  AUTHORS   Hegele,A., Kamburov,A., Grossmann,A., Sourlis,C., Wowro,S.,
            Weimann,M., Will,C.L., Pena,V., Luhrmann,R. and Stelzl,U.
  TITLE     Dynamic protein-protein interaction wiring of the human spliceosome
  JOURNAL   Mol Cell 45 (4), 567-580 (2012)
   PUBMED   22365833
REFERENCE   8  (bases 1 to 7424)
  AUTHORS   Gilmore-Hebert,M., Ramabhadran,R. and Stern,D.F.
  TITLE     Interactions of ErbB4 and Kap1 connect the growth factor and DNA
            damage response pathways
  JOURNAL   Mol Cancer Res 8 (10), 1388-1398 (2010)
   PUBMED   20858735
REFERENCE   9  (bases 1 to 7424)
  AUTHORS   Will,C.L., Urlaub,H., Achsel,T., Gentzel,M., Wilm,M. and
            Luhrmann,R.
  TITLE     Characterization of novel SF3b and 17S U2 snRNP proteins, including
            a human Prp5p homologue and an SF3b DEAD-box protein
  JOURNAL   EMBO J 21 (18), 4978-4988 (2002)
   PUBMED   12234937
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC026304.19 and AC018450.26.
            
            On May 17, 2019 this sequence version replaced NM_001080415.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.61448.1,
                                           SRR1803615.71690.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000473835.7/ ENSP00000418563.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               AC026304.19        1717-1820           c
            105-149             AC018450.26        182003-182047       c
            150-281             AC018450.26        180509-180640       c
            282-380             AC018450.26        178453-178551       c
            381-495             AC018450.26        176491-176605       c
            496-629             AC018450.26        175887-176020       c
            630-697             AC018450.26        172826-172893       c
            698-792             AC018450.26        172169-172263       c
            793-828             AC018450.26        171477-171512       c
            829-911             AC018450.26        171307-171389       c
            912-1077            AC018450.26        170200-170365       c
            1078-1289           AC018450.26        169798-170009       c
            1290-1333           AC018450.26        168844-168887       c
            1334-1438           AC018450.26        165609-165713       c
            1439-1505           AC018450.26        164456-164522       c
            1506-1669           AC018450.26        164216-164379       c
            1670-1832           AC018450.26        159916-160078       c
            1833-1912           AC018450.26        159512-159591       c
            1913-2000           AC018450.26        157887-157974       c
            2001-2123           AC018450.26        156758-156880       c
            2124-2280           AC018450.26        155527-155683       c
            2281-2376           AC018450.26        154659-154754       c
            2377-2443           AC018450.26        153902-153968       c
            2444-2603           AC018450.26        149586-149745       c
            2604-2714           AC018450.26        141813-141923       c
            2715-2833           AC018450.26        139068-139186       c
            2834-3010           AC018450.26        137743-137919       c
            3011-7424           AC018450.26        132137-136550       c
FEATURES             Location/Qualifiers
     source          1..7424
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q23"
     gene            1..7424
                     /gene="U2SURP"
                     /gene_synonym="fSAPa; SR140"
                     /note="U2 snRNP associated SURP domain containing"
                     /db_xref="GeneID:23350"
                     /db_xref="HGNC:HGNC:30855"
                     /db_xref="MIM:617849"
     exon            1..104
                     /gene="U2SURP"
                     /gene_synonym="fSAPa; SR140"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..3149
                     /gene="U2SURP"
                     /gene_synonym="fSAPa; SR140"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Ser/Arg-rich domain protein, 140 kDa; functional
                     spliceosome-associated protein a; U2-associated protein
                     SR140; U2-associated SR140 protein; U2 snRNP-associated
                     SURP motif-containing protein; 140 kDa Ser/Arg-rich domain
                     protein"
                     /codon_start=1
                     /product="U2 snRNP-associated SURP motif-containing
                     protein isoform 1"
                     /protein_id="NP_001073884.1"
                     /db_xref="CCDS:CCDS46928.1"
                     /db_xref="GeneID:23350"
                     /db_xref="HGNC:HGNC:30855"
                     /db_xref="MIM:617849"
                     /translation="MADKTPGGSQKASSKTRSSDVHSSGSSDAHMDASGPSDSDMPSR
                     TRPKSPRKHNYRNESARESLCDSPHQNLSRPLLENKLKAFSIGKMSTAKRTLSKKEQE
                     ELKKKEDEKAAAEIYEEFLAAFEGSDGNKVKTFVRGGVVNAAKEEHETDEKRGKIYKP
                     SSRFADQKNPPNQSSNERPPSLLVIETKKPPLKKGEKEKKKSNLELFKEELKQIQEER
                     DERHKTKGRLSRFEPPQSDSDGQRRSMDAPSRRNRSSGVLDDYAPGSHDVGDPSTTNL
                     YLGNINPQMNEEMLCQEFGRFGPLASVKIMWPRTDEERARERNCGFVAFMNRRDAERA
                     LKNLNGKMIMSFEMKLGWGKAVPIPPHPIYIPPSMMEHTLPPPPSGLPFNAQPRERLK
                     NPNAPMLPPPKNKEDFEKTLSQAIVKVVIPTERNLLALIHRMIEFVVREGPMFEAMIM
                     NREINNPMFRFLFENQTPAHVYYRWKLYSILQGDSPTKWRTEDFRMFKNGSFWRPPPL
                     NPYLHGMSEEQETEAFVEEPSKKGALKEEQRDKLEEILRGLTPRKNDIGDAMVFCLNN
                     AEAAEEIVDCITESLSILKTPLPKKIARLYLVSDVLYNSSAKVANASYYRKFFETKLC
                     QIFSDLNATYRTIQGHLQSENFKQRVMTCFRAWEDWAIYPEPFLIKLQNIFLGLVNII
                     EEKETEDVPDDLDGAPIEEELDGAPLEDVDGIPIDATPIDDLDGVPIKSLDDDLDGVP
                     LDATEDSKKNEPIFKVAPSKWEAVDESELEAQAVTTSKWELFDQHEESEEEENQNQEE
                     ESEDEEDTQSSKSEEHHLYSNPIKEEMTESKFSKYSEMSEEKRAKLREIELKVMKFQD
                     ELESGKRPKKPGQSFQEQVEHYRDKLLQREKEKELERERERDKKDKEKLESRSKDKKE
                     KDECTPTRKERKRRHSTSPSPSRSSSGRRVKSPSPKSERSERSERSHKESSRSRSSHK
                     DSPRDVSKKAKRSPSGSRTPKRSRRSRSRSPKKSGKKSRSQSRSPHRSHKKSKKNKH"
     exon            105..149
                     /gene="U2SURP"
                     /gene_synonym="fSAPa; SR140"
                     /inference="alignment:Splign:2.1.0"
     exon            150..281
                     /gene="U2SURP"
                     /gene_synonym="fSAPa; SR140"
                     /inference="alignment:Splign:2.1.0"
     exon            282..380
                     /gene="U2SURP"
                     /gene_synonym="fSAPa; SR140"
                     /inference="alignment:Splign:2.1.0"
     exon            381..495
                     /gene="U2SURP"
                     /gene_synonym="fSAPa; SR140"
                     /inference="alignment:Splign:2.1.0"
     exon            496..629
                     /gene="U2SURP"
                     /gene_synonym="fSAPa; SR140"
                     /inference="alignment:Splign:2.1.0"
     exon            630..697
                     /gene="U2SURP"
                     /gene_synonym="fSAPa; SR140"
                     /inference="alignment:Splign:2.1.0"
     exon            698..792
                     /gene="U2SURP"
                     /gene_synonym="fSAPa; SR140"
                     /inference="alignment:Splign:2.1.0"
     exon            793..828
                     /gene="U2SURP"
                     /gene_synonym="fSAPa; SR140"
                     /inference="alignment:Splign:2.1.0"
     exon            829..911
                     /gene="U2SURP"
                     /gene_synonym="fSAPa; SR140"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1077
                     /gene="U2SURP"
                     /gene_synonym="fSAPa; SR140"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1289
                     /gene="U2SURP"
                     /gene_synonym="fSAPa; SR140"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1333
                     /gene="U2SURP"
                     /gene_synonym="fSAPa; SR140"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1438
                     /gene="U2SURP"
                     /gene_synonym="fSAPa; SR140"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1505
                     /gene="U2SURP"
                     /gene_synonym="fSAPa; SR140"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1669
                     /gene="U2SURP"
                     /gene_synonym="fSAPa; SR140"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1832
                     /gene="U2SURP"
                     /gene_synonym="fSAPa; SR140"
                     /inference="alignment:Splign:2.1.0"
     exon            1833..1912
                     /gene="U2SURP"
                     /gene_synonym="fSAPa; SR140"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..2000
                     /gene="U2SURP"
                     /gene_synonym="fSAPa; SR140"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..2123
                     /gene="U2SURP"
                     /gene_synonym="fSAPa; SR140"
                     /inference="alignment:Splign:2.1.0"
     exon            2124..2280
                     /gene="U2SURP"
                     /gene_synonym="fSAPa; SR140"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2376
                     /gene="U2SURP"
                     /gene_synonym="fSAPa; SR140"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..2443
                     /gene="U2SURP"
                     /gene_synonym="fSAPa; SR140"
                     /inference="alignment:Splign:2.1.0"
     exon            2444..2603
                     /gene="U2SURP"
                     /gene_synonym="fSAPa; SR140"
                     /inference="alignment:Splign:2.1.0"
     exon            2604..2714
                     /gene="U2SURP"
                     /gene_synonym="fSAPa; SR140"
                     /inference="alignment:Splign:2.1.0"
     exon            2715..2833
                     /gene="U2SURP"
                     /gene_synonym="fSAPa; SR140"
                     /inference="alignment:Splign:2.1.0"
     exon            2834..3010
                     /gene="U2SURP"
                     /gene_synonym="fSAPa; SR140"
                     /inference="alignment:Splign:2.1.0"
     exon            3011..7424
                     /gene="U2SURP"
                     /gene_synonym="fSAPa; SR140"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3520..3525
                     /regulatory_class="polyA_signal_sequence"
                     /gene="U2SURP"
                     /gene_synonym="fSAPa; SR140"
                     /note="hexamer: AATAAA"
     polyA_site      3542
                     /gene="U2SURP"
                     /gene_synonym="fSAPa; SR140"
                     /note="major polyA site"
     regulatory      4323..4328
                     /regulatory_class="polyA_signal_sequence"
                     /gene="U2SURP"
                     /gene_synonym="fSAPa; SR140"
                     /note="hexamer: AATAAA"
     polyA_site      4352
                     /gene="U2SURP"
                     /gene_synonym="fSAPa; SR140"
     regulatory      6862..6867
                     /regulatory_class="polyA_signal_sequence"
                     /gene="U2SURP"
                     /gene_synonym="fSAPa; SR140"
                     /note="hexamer: ATTAAA"
     polyA_site      6885
                     /gene="U2SURP"
                     /gene_synonym="fSAPa; SR140"
     regulatory      7218..7223
                     /regulatory_class="polyA_signal_sequence"
                     /gene="U2SURP"
                     /gene_synonym="fSAPa; SR140"
                     /note="hexamer: AATAAA"
     polyA_site      7245
                     /gene="U2SURP"
                     /gene_synonym="fSAPa; SR140"
ORIGIN      
        1 ctttcggtgc tcgactcgcc cgtgctgctg ccgccgccga aggaggggca aagctcaaga
       61 tggcggacaa aacgccaggc ggatctcaga aggccagttc aaagacgaga tcatcagatg
      121 ttcattcatc tggatcttca gatgcacata tggatgcatc tggaccctca gatagtgata
      181 tgccaagtcg gacacgacct aagagcccaa gaaaacataa ttataggaat gaaagtgccc
      241 gtgaaagcct ttgtgattct cctcatcaga atctctcaag acctcttctg gaaaacaaac
      301 ttaaagcatt cagtattgga aaaatgagta cagctaagcg aactttaagt aaaaaggaac
      361 aggaagaatt aaagaaaaag gaggatgaaa aggcagctgc tgagatttat gaggagtttc
      421 ttgctgcttt tgaaggaagt gatggtaata aagtgaaaac atttgtgcga gggggtgttg
      481 ttaatgcagc taaagaagaa catgaaacag atgaaaaaag aggtaaaatc tataagccat
      541 cttcaagatt tgcagatcaa aaaaatcctc caaatcagtc ttccaatgaa agaccaccat
      601 ctcttcttgt gatagaaacc aaaaaacctc cacttaaaaa aggagagaaa gaaaagaaaa
      661 aaagcaattt ggaactcttc aaagaagaat taaagcaaat tcaagaggaa cgtgatgaga
      721 gacataaaac aaaaggcaga ttaagtcgat ttgaacctcc tcagtcagat tctgatggtc
      781 agcgtcgttc tatggacgcg ccttcaagaa gaaatagatc atctggtgtt cttgatgatt
      841 acgcacctgg ctcacatgat gtaggagatc caagcactac taatttatac cttggaaaca
      901 ttaatccaca gatgaatgaa gaaatgctgt gccaagaatt tggaagattt ggaccgttag
      961 ccagtgtgaa aatcatgtgg cctagaactg atgaagaaag agccagagag agaaattgcg
     1021 gctttgtggc ctttatgaat agaagagatg ctgaaagagc tttaaaaaat ttgaatggaa
     1081 aaatgattat gtcttttgaa atgaagttag gttggggtaa agctgtacct attcctccac
     1141 atccaatata cattccgcct tctatgatgg aacatacgct tcccccacct ccatccggac
     1201 tgccttttaa tgcgcagcct agagagcggt taaaaaaccc taatgctcct atgttaccgc
     1261 cacctaaaaa caaagaggat tttgagaaga ctctgtcgca agccatagtc aaagtggtta
     1321 tcccaacaga aaggaatttg ctcgccctga tacatcgaat gatagagttt gttgtacgtg
     1381 aagggccaat gtttgaagct atgattatga acagagaaat caacaatcct atgttcaggt
     1441 tcttatttga aaaccagaca ccagcccatg tttactatag gtggaagctt tattctattc
     1501 tgcagggaga ttctccaact aaatggcgga cggaagattt tcgtatgttc aaaaatggat
     1561 ctttttggag gccaccacca ttaaatccgt acttgcatgg aatgtcagaa gagcaagaaa
     1621 cagaagcttt tgtagaggaa cctagtaaaa agggagcact taaggaagaa cagagggata
     1681 aattggaaga aatcttgcgg ggattaactc caaggaaaaa tgatattgga gatgcaatgg
     1741 ttttctgtct taataatgct gaagctgctg aagaaatagt ggattgcatt actgagtcgt
     1801 tgtccatctt aaagacaccc cttcctaaaa agattgccag attatatttg gtttctgatg
     1861 ttttgtacaa ctcttcagcc aaagttgcta atgcttcata ttatagaaaa ttttttgaaa
     1921 caaagttatg tcagatattt tcagacctca atgccaccta tcgtacaatt caaggccatt
     1981 tacaatctga aaactttaag caacgggtaa tgacttgctt cagagcatgg gaagattggg
     2041 caatttatcc agaaccattt ttgatcaaac tacaaaatat tttcttagga cttgtaaata
     2101 ttattgaaga aaaggaaaca gaggatgttc cagatgacct tgatggtgcc cccatcgagg
     2161 aagagcttga tggtgcacct ctggaagatg tagatggaat tcctattgat gctactccca
     2221 tcgatgatct tgatggagtc cctataaaaa gtcttgatga tgatcttgat ggagtgcctt
     2281 tggatgcaac tgaagactca aaaaagaatg agcctatatt taaagttgcc ccatcaaaat
     2341 gggaagctgt ggatgaatct gaattggaag cacaggctgt tacaacttct aaatgggaat
     2401 tatttgacca gcatgaagaa tcagaagaag aagaaaatca aaatcaagaa gaagaaagtg
     2461 aagatgaaga agatactcaa agttccaaat ctgaagaaca tcatttgtac tctaatccaa
     2521 tcaaagaaga aatgactgag tctaagttct ctaagtactc tgaaatgagt gaggaaaaac
     2581 gagccaaact tcgtgaaatt gagctcaaag ttatgaagtt tcaggatgaa ttggaatctg
     2641 ggaaaagacc taaaaaacca ggccagagtt ttcaggagca agtagaacac tacagagata
     2701 aacttcttca acgagagaaa gagaaagagt tagaaagaga acgagaaaga gacaagaaag
     2761 ataaagaaaa attggaatct cgctccaaag acaagaagga aaaagatgag tgtactccga
     2821 caaggaagga aaggaagagg cgacacagta catcccccag cccatctcgc agtagcagtg
     2881 gtagacgagt gaaatcccca tcaccaaaat cggagcgatc agagcgttca gaaagatctc
     2941 ataaagagag ctcacggtcc aggtcatctc acaaagattc tcctagagat gttagcaaaa
     3001 aagccaaaag atcaccatct ggttcaagga cacctaaaag gtctaggcga tcacggtcta
     3061 gatctcctaa aaaatcagga aagaagtcca gatcccagtc cagatctcca cacaggtctc
     3121 ataaaaagtc aaagaaaaac aaacactgac gtaaattttt aagatgctgt cacttattgg
     3181 aaatgcgatt tgttttgtgc ctgaacggtc tgttttttaa aaaaacaaaa aatcaaatga
     3241 aagagcattc ctggggtttt ttgtttgttt gtgtatgcat gtgtaaactc atgagcaact
     3301 gcatctgtag atctgtcatt gttttatatt gtgtaaatta ctttcattgt ggctatttct
     3361 caagatgaaa tttttattgt tctaatggat ttcatcagaa atgtgtataa tggatctgct
     3421 gacagtagta gtattttgtt ttaggatgtt gtgacttagc aaaaataata cagatgtctt
     3481 cccccctttt gtagctttga caatttgaat tagatttcaa ataaaatctg aacagaaaac
     3541 tataatgttg tttttttgcc ccaccggtga tattaagtcc cttaaagtcc tactgagttt
     3601 cacactactg ttgtgcttct tatacctgat gcactttata agccccagtg ttcaagtagc
     3661 ttaagtttta tatttactaa gatgactatc caaattaagg gacctgagac tcctatttgg
     3721 tggtttgcta accatttgct tttgataagt ttctcttggg taatactaat acccagatat
     3781 caaagactag gtagatatgg catggcgttt tgttagtgga atgcctggct aaaacatttt
     3841 tttcacagaa gcaatatgat ttccatacat ccaacccatg ttctgagcaa ctacttactt
     3901 ttagggggaa attaaatatc ttttcatttc ctcttctatt atgaaagaag tttatttgta
     3961 aaacaaattt tctaacaagg tttggccata gaattctctt gtatgatcgt tgacctttta
     4021 taatcttctg taggctatct ttcaaacact ggcatcagaa tattttttat aagtttgtgt
     4081 ttaaacagct tagttggtcc ccccccactc ccaagagact tgggtttagt tatagcttta
     4141 agtaaaattt aaaaataaaa tgtttttcag gaaacttcgt atctaatggt ttgtaaattc
     4201 aaggtgcaaa aagttgattt aaaccatttg cagagttgaa ctctattatg aaaataaatt
     4261 tgctacggta tgaggaagaa ataaaacttg tgtaatgttg gtcataatac tgctataaat
     4321 ataataaagg gttatgtaga attgaactga cactattatt tgtgaatctt gatttcagtt
     4381 ttttatgtag gcacttcata cactggtttg atgggttttt tttttcctcc ctaaaagaga
     4441 aagtagaaaa ctattctaac aatggattat tttgatttag cttgcttttt aaaaaaatct
     4501 tttcaacttg ttttacttaa tcttgcctag tcacaaaata agatgtgcac ccatggtttg
     4561 gagagttcct atattagctg agcagtgaga tacactattt ccaaacggtg cacacctaca
     4621 gtagctttgg aaatgagcca atcactgttt tacttaatgg ttcttatcag catgcaaata
     4681 ttgcttgaaa gttatttcct tattcactgt tttgttagtc cattttgtta ggaaacatta
     4741 attcctaaaa atttgttcag aataattaaa agtgaacatt tggtgctgat actcaaaaac
     4801 ctacaaatgt agccatttaa aaagtaacat gtttttctcc cctgctcatt gcctgggaga
     4861 atggaatttt atataactac ctttctttgc aaaaataacg gtcgtgtcga gttggtggtg
     4921 attttggcat tccatcttgc actggtttct agtataggct tagaaataat tggtcaggta
     4981 ataatctttc cagtcaagtt gcaagggatg cttatttctc ttcaaaaaaa gacatcctgc
     5041 gggattgagt agaaaatttt aggtcagttt tgggtgctta tttgtaatat ttttcctact
     5101 acattggagt ttagcagttc tttttttctg gatccagata caagtgtcat ggtttatctt
     5161 acagtgggtg aaactgactt tcttttggtt gggtgggtga ggatttctta ggcctgatag
     5221 aatatatatt ctgtgaagtt tgttaatgta catattagat tgtattggat ttttttttct
     5281 tgaattgcaa atggtattat tagataggtt atttccagtt ttacttcatg acaaattacc
     5341 tagagtaaac ctacttaata ctcccatgga ttctatgaaa gtttaatggg atcagaaatt
     5401 ggtgacttat aagggggaag atattctacc atatttttat aatagcttat tattcatgtt
     5461 tcttgtctga aggacactca agttacagag caaaatttct ataggttgac tagaatgttc
     5521 ataagcatgg tcttccagtt gcaggaaaga tcatgttcta tctgtggaca cttactgtcc
     5581 tctaccacag ctacgtgcca gagttgtttt ccacagttct tataaagggc atgacttagg
     5641 ctctttaccc tccaacttaa tgtttataca cagggattgt ttactaggtt aatgacattt
     5701 aactcccctc tcttctgtag gtgagagaaa ataagtaagt cttgatctgt ttcttaccaa
     5761 agagagacag acctatgatg gaaaatgatc acgtctctga attttttctt taacgttata
     5821 gttccttatt acagatagta agcatatggg aatttctgag ctataacatg ttgagaagtt
     5881 agaaattaaa actaacacaa caaaaggcgc tgaatcaaaa gatctttgct tttatttggc
     5941 tcagaatgtt tttggctttt ctgctaaaga tggcagaaat tactctacac agacctgatt
     6001 tttctttatt gcagaccatt cttgtgggct taccctgaga cttttatccc aattagtgaa
     6061 tcttggaggg aatacttgct tatttatgac ttaggtattt ccccccaaac tttaatattc
     6121 ttgagcactt gaaaatactt ttgagaaatt ttaactgtga ttaaatttag gtttattaga
     6181 aatattctgt acacatttgc ctccatggtg gcgtaagttc tgaaaaatta tatgaccgtg
     6241 acaatagttt atcatcatca ttattgttat tcaaaataag ggtaaataaa tctctgtatt
     6301 gccaaagtga cttaaactgt tctgatgacc acacagtgtg atttctttag cagagaaagt
     6361 tggttttaaa aataaatagt accacttttc taagactgta cagtttacaa ataaggtttt
     6421 tttctttgtt gttttcctct tctattaagt tttagtgaaa agcctaatta cagaaaattg
     6481 tgcagatact agtgaagata ctagtataag tttaaaggaa cacgtgactg taaaatctca
     6541 catttacaaa gtgcttgatc tcttcatatt tcacacgcat gttttagaat agattttagg
     6601 gagtgtttaa ttcattatcc ttttgactta aaatttttgt taccaacttc ctaggactta
     6661 gataatatat aaataagtac aaatcccagg ggaagtgttg tgatgctaga ctaaaaggtg
     6721 ggaatgtgct gctgttccgt gagccttgtt ccattgttga aaatttgatg cctcagtgtt
     6781 tattcagtac cacctcatgg agcttcaatg taaatggatt atatgtataa ttggtaattt
     6841 gtatagtttt gtagattgta gattaaatgc actcatcatg tcacatgtaa ttgtgcttgg
     6901 agtatttgtg ttttattctt ttacttcaac gggttcttgt ctgttacatc tctggtgatt
     6961 tgaaatatca ggaaagacag tttgtcagaa atgagaataa tatagttgaa atcagttggg
     7021 ctaaaatatt ctacagcaag acaatttctt ttgggtgaac tgattctata atttacttac
     7081 ttttaatgta aggattagat ttattgttga gctgctttcc agatcagact gtcactttat
     7141 agtttttcta cataaagatt atatagttgc aaacaaaggt tgtgaaattt cccttttgtt
     7201 gtttttgact tttaattaat aaaagtacat tgttttcata gcaaacttag actgtccatg
     7261 taattttctc catattgttt ttccgatgca agcccagtta ataattagtt ttttagcagc
     7321 tttctctcaa gtgaaataag tgatgtgaca tgtttatcag ttatggctaa aatgttacac
     7381 tttacatgtt taaactataa tcatatgttt tcatgctaga tggt
//
