LOCUS       NM_001039693            5123 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens tRNA-yW synthesizing protein 5 (TYW5), transcript
            variant 1, mRNA.
ACCESSION   NM_001039693
VERSION     NM_001039693.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5123)
  AUTHORS   Zhang,C., Li,X., Zhao,L., Liang,R., Deng,W., Guo,W., Wang,Q.,
            Hu,X., Du,X., Sham,P.C., Luo,X. and Li,T.
  TITLE     Comprehensive and integrative analyses identify TYW5 as a
            schizophrenia risk gene
  JOURNAL   BMC Med 20 (1), 169 (2022)
   PUBMED   35527273
  REMARK    GeneRIF: Comprehensive and integrative analyses identify TYW5 as a
            schizophrenia risk gene.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5123)
  AUTHORS   Li,S., Li,J., Liu,J., Wang,J., Li,X., Huo,Y., Li,Y., Liu,Y., Li,M.,
            Xiao,X. and Luo,X.J.
  TITLE     Regulatory variants at 2q33.1 confer schizophrenia risk by
            modulating distal gene TYW5 expression
  JOURNAL   Brain 145 (2), 770-786 (2022)
   PUBMED   34581804
  REMARK    GeneRIF: Regulatory variants at 2q33.1 confer schizophrenia risk by
            modulating distal gene TYW5 expression.
REFERENCE   3  (bases 1 to 5123)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5123)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 5123)
  AUTHORS   Ripke,S., O'Dushlaine,C., Chambert,K., Moran,J.L., Kahler,A.K.,
            Akterin,S., Bergen,S.E., Collins,A.L., Crowley,J.J., Fromer,M.,
            Kim,Y., Lee,S.H., Magnusson,P.K., Sanchez,N., Stahl,E.A.,
            Williams,S., Wray,N.R., Xia,K., Bettella,F., Borglum,A.D.,
            Bulik-Sullivan,B.K., Cormican,P., Craddock,N., de Leeuw,C.,
            Durmishi,N., Gill,M., Golimbet,V., Hamshere,M.L., Holmans,P.,
            Hougaard,D.M., Kendler,K.S., Lin,K., Morris,D.W., Mors,O.,
            Mortensen,P.B., Neale,B.M., O'Neill,F.A., Owen,M.J.,
            Milovancevic,M.P., Posthuma,D., Powell,J., Richards,A.L.,
            Riley,B.P., Ruderfer,D., Rujescu,D., Sigurdsson,E., Silagadze,T.,
            Smit,A.B., Stefansson,H., Steinberg,S., Suvisaari,J., Tosato,S.,
            Verhage,M., Walters,J.T., Levinson,D.F., Gejman,P.V., Kendler,K.S.,
            Laurent,C., Mowry,B.J., O'Donovan,M.C., Owen,M.J., Pulver,A.E.,
            Riley,B.P., Schwab,S.G., Wildenauer,D.B., Dudbridge,F., Holmans,P.,
            Shi,J., Albus,M., Alexander,M., Campion,D., Cohen,D., Dikeos,D.,
            Duan,J., Eichhammer,P., Godard,S., Hansen,M., Lerer,F.B.,
            Liang,K.Y., Maier,W., Mallet,J., Nertney,D.A., Nestadt,G.,
            Norton,N., O'Neill,F.A., Papadimitriou,G.N., Ribble,R.,
            Sanders,A.R., Silverman,J.M., Walsh,D., Williams,N.M., Wormley,B.,
            Arranz,M.J., Bakker,S., Bender,S., Bramon,E., Collier,D.,
            Crespo-Facorro,B., Hall,J., Iyegbe,C., Jablensky,A., Kahn,R.S.,
            Kalaydjieva,L., Lawrie,S., Lewis,C.M., Lin,K., Linszen,D.H.,
            Mata,I., McIntosh,A., Murray,R.M., Ophoff,R.A., Powell,J.,
            Rujescu,D., Van Os,J., Walshe,M., Weisbrod,M., Wiersma,D.,
            Donnelly,P., Barroso,I., Blackwell,J.M., Bramon,E., Brown,M.A.,
            Casas,J.P., Corvin,A.P., Deloukas,P., Duncanson,A., Jankowski,J.,
            Markus,H.S., Mathew,C.G., Palmer,C.N., Plomin,R., Rautanen,A.,
            Sawcer,S.J., Trembath,R.C., Viswanathan,A.C., Wood,N.W.,
            Spencer,C.C., Band,G., Bellenguez,C., Freeman,C., Hellenthal,G.,
            Giannoulatou,E., Pirinen,M., Pearson,R.D., Strange,A., Su,Z.,
            Vukcevic,D., Donnelly,P., Langford,C., Hunt,S.E., Edkins,S.,
            Gwilliam,R., Blackburn,H., Bumpstead,S.J., Dronov,S., Gillman,M.,
            Gray,E., Hammond,N., Jayakumar,A., McCann,O.T., Liddle,J.,
            Potter,S.C., Ravindrarajah,R., Ricketts,M.,
            Tashakkori-Ghanbaria,A., Waller,M.J., Weston,P., Widaa,S.,
            Whittaker,P., Barroso,I., Deloukas,P., Mathew,C.G., Blackwell,J.M.,
            Brown,M.A., Corvin,A.P., McCarthy,M.I., Spencer,C.C., Bramon,E.,
            Corvin,A.P., O'Donovan,M.C., Stefansson,K., Scolnick,E.,
            Purcell,S., McCarroll,S.A., Sklar,P., Hultman,C.M. and
            Sullivan,P.F.
  CONSRTM   Multicenter Genetic Studies of Schizophrenia Consortium; Psychosis
            Endophenotypes International Consortium; Wellcome Trust Case
            Control Consortium 2
  TITLE     Genome-wide association analysis identifies 13 new risk loci for
            schizophrenia
  JOURNAL   Nat Genet 45 (10), 1150-1159 (2013)
   PUBMED   23974872
REFERENCE   6  (bases 1 to 5123)
  AUTHORS   Kato,M., Araiso,Y., Noma,A., Nagao,A., Suzuki,T., Ishitani,R. and
            Nureki,O.
  TITLE     Crystal structure of a novel JmjC-domain-containing protein, TYW5,
            involved in tRNA modification
  JOURNAL   Nucleic Acids Res 39 (4), 1576-1585 (2011)
   PUBMED   20972222
REFERENCE   7  (bases 1 to 5123)
  AUTHORS   Noma,A., Ishitani,R., Kato,M., Nagao,A., Nureki,O. and Suzuki,T.
  TITLE     Expanding role of the jumonji C domain as an RNA hydroxylase
  JOURNAL   J Biol Chem 285 (45), 34503-34507 (2010)
   PUBMED   20739293
REFERENCE   8  (bases 1 to 5123)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC132835.1, AC097717.3 and BM673915.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001039693.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and is the protein-coding transcript.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.256332.1,
                                           SRR18074967.1868253.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000354611.9/ ENSP00000346627.4
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1149              BC132835.1         10-1158
            1150-4831           AC097717.3         49916-53597         c
            4832-5123           BM673915.1         17-308              c
FEATURES             Location/Qualifiers
     source          1..5123
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q33.1"
     gene            1..5123
                     /gene="TYW5"
                     /gene_synonym="C2orf60; hTYW5"
                     /note="tRNA-yW synthesizing protein 5"
                     /db_xref="GeneID:129450"
                     /db_xref="HGNC:HGNC:26754"
                     /db_xref="MIM:619882"
     exon            1..99
                     /gene="TYW5"
                     /gene_synonym="C2orf60; hTYW5"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..969
                     /gene="TYW5"
                     /gene_synonym="C2orf60; hTYW5"
                     /EC_number="1.14.11.42"
                     /note="tRNA yW-synthesizing enzyme 5; jmjC
                     domain-containing protein C2orf60; tRNA(Phe)
                     (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase"
                     /codon_start=1
                     /product="tRNA wybutosine-synthesizing protein 5"
                     /protein_id="NP_001034782.1"
                     /db_xref="CCDS:CCDS42795.1"
                     /db_xref="GeneID:129450"
                     /db_xref="HGNC:HGNC:26754"
                     /db_xref="MIM:619882"
                     /translation="MAGQHLPVPRLEGVSREQFMQHLYPQRKPLVLEGIDLGPCTSKW
                     TVDYLSQVGGKKEVKIHVAAVAQMDFISKNFVYRTLPFDQLVQRAAEEKHKEFFVSED
                     EKYYLRSLGEDPRKDVADIRKQFPLLKGDIKFPEFFKEEQFFSSVFRISSPGLQLWTH
                     YDVMDNLLIQVTGKKRVVLFSPRDAQYLYLKGTKSEVLNIDNPDLAKYPLFSKARRYE
                     CSLEAGDVLFIPALWFHNVISEEFGVGVNIFWKHLPSECYDKTDTYGNKDPTAASRAA
                     QILDRALKTLAELPEEYRDFYARRMVLHIQDKAYSKNSE"
     exon            100..254
                     /gene="TYW5"
                     /gene_synonym="C2orf60; hTYW5"
                     /inference="alignment:Splign:2.1.0"
     exon            255..324
                     /gene="TYW5"
                     /gene_synonym="C2orf60; hTYW5"
                     /inference="alignment:Splign:2.1.0"
     exon            325..369
                     /gene="TYW5"
                     /gene_synonym="C2orf60; hTYW5"
                     /inference="alignment:Splign:2.1.0"
     exon            370..507
                     /gene="TYW5"
                     /gene_synonym="C2orf60; hTYW5"
                     /inference="alignment:Splign:2.1.0"
     exon            508..595
                     /gene="TYW5"
                     /gene_synonym="C2orf60; hTYW5"
                     /inference="alignment:Splign:2.1.0"
     exon            596..712
                     /gene="TYW5"
                     /gene_synonym="C2orf60; hTYW5"
                     /inference="alignment:Splign:2.1.0"
     exon            713..5123
                     /gene="TYW5"
                     /gene_synonym="C2orf60; hTYW5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1124..1129
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TYW5"
                     /gene_synonym="C2orf60; hTYW5"
                     /note="hexamer: ATTAAA"
     polyA_site      1145
                     /gene="TYW5"
                     /gene_synonym="C2orf60; hTYW5"
                     /note="major polyA site"
     regulatory      2686..2691
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TYW5"
                     /gene_synonym="C2orf60; hTYW5"
                     /note="hexamer: ATTACA"
     polyA_site      2705
                     /gene="TYW5"
                     /gene_synonym="C2orf60; hTYW5"
     regulatory      4874..4879
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TYW5"
                     /gene_synonym="C2orf60; hTYW5"
                     /note="hexamer: ATTAAA"
     polyA_site      4895
                     /gene="TYW5"
                     /gene_synonym="C2orf60; hTYW5"
     regulatory      5104..5109
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TYW5"
                     /gene_synonym="C2orf60; hTYW5"
                     /note="hexamer: ATTAAA"
     polyA_site      5123
                     /gene="TYW5"
                     /gene_synonym="C2orf60; hTYW5"
ORIGIN      
        1 agagggcagg cgtgagcaac catggccggg cagcacctcc cggtaccccg gctggagggc
       61 gtttctcggg agcagttcat gcagcacctc tacccacaga gaaaacctct tgtgttggaa
      121 gggattgatt tggggccatg tacaagcaaa tggacagtgg attacctaag ccaagttgga
      181 gggaagaaag aagtaaagat tcatgttgct gcagttgcac agatggactt cattagtaag
      241 aactttgtat atagaacttt accttttgac cagttggtcc agagggcagc tgaagagaaa
      301 cataaagaat tctttgtttc agaggatgag aaatactact tacggtcact tggagaagac
      361 cctagaaagg atgttgcaga tatcagaaag cagtttcctt tgttgaaagg agatattaag
      421 tttccagaat tcttcaaaga ggaacagttc ttttccagtg tttttcgaat tagttcacca
      481 ggattacaac tatggactca ttatgatgta atggataatt tgttaataca agtgacagga
      541 aaaaagcgtg ttgtactctt cagtcctcga gatgcccagt atttatattt aaaaggtact
      601 aaatcagaag tactgaatat agataaccca gacttggcta aatatccact tttttccaag
      661 gctagaagat atgaatgttc ccttgaagct ggtgatgtat tattcattcc tgctttatgg
      721 ttccataatg taatttctga agagtttgga gtgggagtga atatcttttg gaagcacctt
      781 ccatctgaat gctatgataa aacagatacc tatggaaaca aagatcctac agcagcatca
      841 agagctgcac aaattctgga cagagccttg aaaacactgg ccgagttacc agaggaatat
      901 agggacttct atgcacgacg aatggtccta cacattcaag acaaagccta cagcaagaac
      961 tctgagtaaa taatgaagtg aatgcaatgc acattaacac tttagtaagg tataacgata
     1021 taaattaaag attttgttaa aataggaaag atacatcaga tttacagatt atgtaagtac
     1081 gaaggggtgt ttgtgtggat tctacttgat acagattgtt ataattaaag aatgctgtgc
     1141 tgggaccact ctttaacatt cagatgctga ccactaaaag tccaacttaa aatgacttaa
     1201 aaacagtaag aaaatatatt gattcacaat acatgaaatc tattgacaga atgtgctgca
     1261 gtgtttctga tccaatgatt cagtaatgtc atcaagaacc ttgggaaccc gcctccacac
     1321 cccaccccct tttcaaccac aacattggca tcatcctaag gctggctacc ctcgtggtca
     1381 tgggatgatt gccagtagca gttggagcct tgtgcatctt catttacatg cagcggaaga
     1441 gtcaggctgg attctagggg ccctgtccta gtatgagaaa gctttcccag aattcacttt
     1501 ccatatcctt aggtctcatt gctctaaagt aacttagacc tgtccatccc tgagccagtc
     1561 actggcaaag ggtctagaat aacctttagg gcagtcaggt ccactggagc tgagagtaga
     1621 agtggaggcc acatgaggga tatatgggga cagaaaggat agttttttta aaatcatggt
     1681 tctgatagga aaaacatgag caacgcacaa tatctattac atttgcctag aagcagaatt
     1741 ttttgaggaa ctttaaaaaa tgtacagata cctaggtccc aactttgtag actgattcaa
     1801 gagtgtttgg gatttggtat aggaacttaa tagacctcac agggtgttct gatgcataat
     1861 cagagctgag atcaactgga gttgatgata gtgacttgga ttattagttt tgtgattagt
     1921 gcaaaacaaa tgtttaatct gatcttgact tttcttgcca cccagtatgt cagggtggtt
     1981 tttggttttt gaatgttaca aaataaataa tttataccta tgtctaaacc ttagcctagt
     2041 taaagatttc ccaactattt tttccaccta tccctttttt aaaagaaaaa ttacttaaag
     2101 aatgaataaa tgagatccta aaagtgttgt catcgaagac agtgagccat tgtgtgtgga
     2161 tctctgcttt tgttttgtac ctagtaatta tattgcagtg tcattgaaga ccacataatc
     2221 ttcactgaac ataaatgtgt tcatctaaag caatctctta gtacatcaat ttggtgcatt
     2281 ttaattagag aaaatcattt tctctattga agagaatcca tccactcatg tcctataaat
     2341 tatagtaaat aaggaaaagc atatataaca ttctgaattt cctaggtgtc tttggaaaca
     2401 ggtaagttac tcaggtgaat aaaggtgaaa aaagtcttgt cagaaaagga atgattatat
     2461 tagccaaatt taattaccag gttttgatct tcattaagca aagcaaagaa cttctttact
     2521 gattccttgt ccttcagtaa ggaaaaagac aaaactctcc ttagtttaca cattatttat
     2581 ggtcagtttt taataaatct tgtttttttt cttaaccagc aagagaattg atacaaagta
     2641 taaatccaga gtcatgtaga aaacttggaa gtattaataa aacagattac agtttgtgca
     2701 ctgaatagtc atcttaattg attgtttaat ggagaagcaa actggatgac cttagacaaa
     2761 ataacattta tctatgaagc ttattttcct catctttaaa acagaactac aaaaatgcag
     2821 agagttcaag ggcaggcaca tagttgataa ctggtgctag ttcttctatt taattatatt
     2881 ccatctttgt tgagagattt gaggtagctc ctgttgcagt attaatttat aatattttaa
     2941 aagttagaga actttccttt gggatgtttt aaaattattt ccctggtcat aattaatatt
     3001 agggtctgtt tatttcaaat acaaaatatt ttaatctttt cttcctactg ggttaagacc
     3061 aaatgagatg tttgttttta atgtataaaa tcttatacag tgtatgttag ctgcaacttc
     3121 tcaggaattc tgaatcttag aactttttta ttgaaagaga tcttagaagc catctaacca
     3181 acccagattg cttaatgatt gtctgggttc acatagctat gggtgataga aaccgggatt
     3241 cgttgtgacc agtaattctc cattctccct aatgtgcagc acatctccag tacttctgaa
     3301 tagattacac agcttttctt tggctagttt gggggcttga cctgatgcaa aaaggaattt
     3361 ttttcctctg ccaacaaaat ttctcactgc actgcttgct acacagacaa gattcaaaat
     3421 aaaagtaatg gtgggtcagg tgccatggct catgcctgta atcccagcac tttgggaggc
     3481 cgaggtgggc agatcacgag gtcagatcaa gaccattctg gccaacatgg taaaaccccg
     3541 tctctactaa aaatagaaaa attaaatgtt acatgaaaaa catatttgaa actgtactgc
     3601 catttgtgta aaacaaggta tgtggtgtgt gaacatctta tttgcatatg catataatta
     3661 tctctaagga tgcacgagaa accagtgata attatgcctc caagaagagg ttcaactagg
     3721 tgggctgctt agaatctagt tttgtattat ttggactttt gttcacatta tcctttcaaa
     3781 atacatttta aaaatactat atgcaccgag gtgggtggat catctgaact caggagttcg
     3841 agaccagcct gggcaacatg gcgaaacctt gtctctacca aaaatacaga gaattagctg
     3901 gctgtggtgg tgtgcgcctg tagtcccagc tactcaggag gctaagatag gaggatcact
     3961 tgagcctggg aggtgcaggt tgcagtgagc tggaattgtg caactgcact ccagcctggg
     4021 tgacagagtg agaccctgtc tcaaaaaaaa aaaaaaaaaa aaaaatatta tatgcagagc
     4081 tggggagtgg tggtccacac ctgtagtccc agcatcttgg gaggctgagg caggaggagt
     4141 gcttgaagcc aggagttcaa gttcagtctg ggcaacatgg ggagacctgt ctcaaaaaaa
     4201 aaaactaaac agagtgtaat tattagcatt tcataacatt atttgtcttg gtatttgaat
     4261 acattagaat tctatttgtc ctgtaattaa tttctaactc actttgataa aataccaaaa
     4321 caaaggaaac aaagtcaaca aaacttaatt tgtatccttc atccttttga acagcagcta
     4381 tgtgaacatt tggaaagaac cttagtaagg cggcttttct atcacctata aaaagttgcc
     4441 aacagacatc aaaggagttg acaaaaaaaa aaaaaaaaaa atgcaggaag ctggaaggca
     4501 ggcctggatg gaattggaac tgtgctgctg tgactccttt ccccagtgct aaaaaataga
     4561 tgtagtcagg aggaactaac atagattggc agtcacccac acatctctgg tgttacctta
     4621 gtcttgtttc aagcatacaa gccacaagtt tttgggtgtc ttaaatatac ctaagttgta
     4681 gtctctattt atttttttat tatactttta agttctaggg tacatgtgca caacgtgcag
     4741 gtttgttaca tatgtataca tgtgccatgt tggtgtgctg cacccgttaa ctcgtcattt
     4801 acattaggta tatctcctaa tgctatccct tccccctccc ccaaccccac gatgtagtct
     4861 ctttctaagt tccattaaac agaatactaa aatgaccttt tttggtgact cttgcctgtc
     4921 tctaccacta actggcttaa aagctgctgg gtctcttcct ttgtaaagag caacatgagt
     4981 ttacagatga ggtctgtcta tatctcctct tatgtttttc tcttaagaac ttcaagtgaa
     5041 ataaaacaaa atagctcttt tatgaatact accttttgta ttttacctca taagatttaa
     5101 tgtattaaac atttctatac caa
//
