LOCUS       NM_138467               3437 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens tRNA-yW synthesizing protein 3 homolog (TYW3),
            transcript variant 1, mRNA.
ACCESSION   NM_138467 XM_059122
VERSION     NM_138467.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3437)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3437)
  AUTHORS   Perry,J.R., Day,F., Elks,C.E., Sulem,P., Thompson,D.J.,
            Ferreira,T., He,C., Chasman,D.I., Esko,T., Thorleifsson,G.,
            Albrecht,E., Ang,W.Q., Corre,T., Cousminer,D.L., Feenstra,B.,
            Franceschini,N., Ganna,A., Johnson,A.D., Kjellqvist,S.,
            Lunetta,K.L., McMahon,G., Nolte,I.M., Paternoster,L., Porcu,E.,
            Smith,A.V., Stolk,L., Teumer,A., Tsernikova,N., Tikkanen,E.,
            Ulivi,S., Wagner,E.K., Amin,N., Bierut,L.J., Byrne,E.M.,
            Hottenga,J.J., Koller,D.L., Mangino,M., Pers,T.H.,
            Yerges-Armstrong,L.M., Zhao,J.H., Andrulis,I.L., Anton-Culver,H.,
            Atsma,F., Bandinelli,S., Beckmann,M.W., Benitez,J., Blomqvist,C.,
            Bojesen,S.E., Bolla,M.K., Bonanni,B., Brauch,H., Brenner,H.,
            Buring,J.E., Chang-Claude,J., Chanock,S., Chen,J.,
            Chenevix-Trench,G., Collee,J.M., Couch,F.J., Couper,D.,
            Coveillo,A.D., Cox,A., Czene,K., D'adamo,A.P., Smith,G.D., De
            Vivo,I., Demerath,E.W., Dennis,J., Devilee,P., Dieffenbach,A.K.,
            Dunning,A.M., Eiriksdottir,G., Eriksson,J.G., Fasching,P.A.,
            Ferrucci,L., Flesch-Janys,D., Flyger,H., Foroud,T., Franke,L.,
            Garcia,M.E., Garcia-Closas,M., Geller,F., de Geus,E.E., Giles,G.G.,
            Gudbjartsson,D.F., Gudnason,V., Guenel,P., Guo,S., Hall,P.,
            Hamann,U., Haring,R., Hartman,C.A., Heath,A.C., Hofman,A.,
            Hooning,M.J., Hopper,J.L., Hu,F.B., Hunter,D.J., Karasik,D.,
            Kiel,D.P., Knight,J.A., Kosma,V.M., Kutalik,Z., Lai,S.,
            Lambrechts,D., Lindblom,A., Magi,R., Magnusson,P.K., Mannermaa,A.,
            Martin,N.G., Masson,G., McArdle,P.F., McArdle,W.L., Melbye,M.,
            Michailidou,K., Mihailov,E., Milani,L., Milne,R.L., Nevanlinna,H.,
            Neven,P., Nohr,E.A., Oldehinkel,A.J., Oostra,B.A., Palotie,A.,
            Peacock,M., Pedersen,N.L., Peterlongo,P., Peto,J., Pharoah,P.D.,
            Postma,D.S., Pouta,A., Pylkas,K., Radice,P., Ring,S.,
            Rivadeneira,F., Robino,A., Rose,L.M., Rudolph,A., Salomaa,V.,
            Sanna,S., Schlessinger,D., Schmidt,M.K., Southey,M.C., Sovio,U.,
            Stampfer,M.J., Stockl,D., Storniolo,A.M., Timpson,N.J., Tyrer,J.,
            Visser,J.A., Vollenweider,P., Volzke,H., Waeber,G.,
            Waldenberger,M., Wallaschofski,H., Wang,Q., Willemsen,G.,
            Winqvist,R., Wolffenbuttel,B.H., Wright,M.J., Boomsma,D.I.,
            Econs,M.J., Khaw,K.T., Loos,R.J., McCarthy,M.I., Montgomery,G.W.,
            Rice,J.P., Streeten,E.A., Thorsteinsdottir,U., van Duijn,C.M.,
            Alizadeh,B.Z., Bergmann,S., Boerwinkle,E., Boyd,H.A., Crisponi,L.,
            Gasparini,P., Gieger,C., Harris,T.B., Ingelsson,E., Jarvelin,M.R.,
            Kraft,P., Lawlor,D., Metspalu,A., Pennell,C.E., Ridker,P.M.,
            Snieder,H., Sorensen,T.I., Spector,T.D., Strachan,D.P.,
            Uitterlinden,A.G., Wareham,N.J., Widen,E., Zygmunt,M., Murray,A.,
            Easton,D.F., Stefansson,K., Murabito,J.M. and Ong,K.K.
  CONSRTM   Australian Ovarian Cancer Study; GENICA Network; kConFab; LifeLines
            Cohort Study; InterAct Consortium; Early Growth Genetics (EGG)
            Consortium
  TITLE     Parent-of-origin-specific allelic associations among 106 genomic
            loci for age at menarche
  JOURNAL   Nature 514 (7520), 92-97 (2014)
   PUBMED   25231870
REFERENCE   3  (bases 1 to 3437)
  AUTHORS   Qi,Q., Menzaghi,C., Smith,S., Liang,L., de Rekeneire,N.,
            Garcia,M.E., Lohman,K.K., Miljkovic,I., Strotmeyer,E.S.,
            Cummings,S.R., Kanaya,A.M., Tylavsky,F.A., Satterfield,S., Ding,J.,
            Rimm,E.B., Trischitta,V., Hu,F.B., Liu,Y. and Qi,L.
  TITLE     Genome-wide association analysis identifies TYW3/CRYZ and NDST4
            loci associated with circulating resistin levels
  JOURNAL   Hum Mol Genet 21 (21), 4774-4780 (2012)
   PUBMED   22843503
REFERENCE   4  (bases 1 to 3437)
  AUTHORS   Fox,C.S., Liu,Y., White,C.C., Feitosa,M., Smith,A.V.,
            Heard-Costa,N., Lohman,K., Johnson,A.D., Foster,M.C.,
            Greenawalt,D.M., Griffin,P., Ding,J., Newman,A.B., Tylavsky,F.,
            Miljkovic,I., Kritchevsky,S.B., Launer,L., Garcia,M.,
            Eiriksdottir,G., Carr,J.J., Gudnason,V., Harris,T.B., Cupples,L.A.
            and Borecki,I.B.
  CONSRTM   GIANT Consortium; MAGIC Consortium; GLGC Consortium
  TITLE     Genome-wide association for abdominal subcutaneous and visceral
            adipose reveals a novel locus for visceral fat in women
  JOURNAL   PLoS Genet 8 (5), e1002695 (2012)
   PUBMED   22589738
REFERENCE   5  (bases 1 to 3437)
  AUTHORS   Noma,A. and Suzuki,T.
  TITLE     Ribonucleome analysis identified enzyme genes responsible for
            wybutosine synthesis
  JOURNAL   Nucleic Acids Symp Ser (Oxf) (50), 65-66 (2006)
   PUBMED   17150819
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091611.5, BC071765.1, AK098237.1 and BM680331.1.
            
            On May 17, 2019 this sequence version replaced NM_138467.2.
            
            Summary: Wybutosine (yW) is a hypermodified guanosine at the
            3-prime position adjacent to the anticodon of phenylalanine tRNA
            that stabilizes codon-anticodon interactions during decoding on the
            ribosome. TYW3 is the human homolog of a yeast gene essential for
            yW synthesis (Noma and Suzuki, 2006).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.258411.1,
                                           SRR1660803.202963.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370867.8/ ENSP00000359904.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AC091611.5         14686-14689
            5-520               BC071765.1         1-516
            521-2384            AK098237.1         517-2380
            2385-3434           AC091611.5         47159-48208
            3435-3437           BM680331.1         16-18               c
FEATURES             Location/Qualifiers
     source          1..3437
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.1"
     gene            1..3437
                     /gene="TYW3"
                     /gene_synonym="C1orf171"
                     /note="tRNA-yW synthesizing protein 3 homolog"
                     /db_xref="GeneID:127253"
                     /db_xref="HGNC:HGNC:24757"
                     /db_xref="MIM:611245"
     exon            1..267
                     /gene="TYW3"
                     /gene_synonym="C1orf171"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..873
                     /gene="TYW3"
                     /gene_synonym="C1orf171"
                     /EC_number="2.1.1.282"
                     /note="isoform 1 is encoded by transcript variant 1; tRNA
                     wybutosine-synthesizing protein 3 homolog;
                     tRNA-yW-synthesizing protein 3; tRNA(Phe)
                     7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-
                     methyltransferase"
                     /codon_start=1
                     /product="tRNA wybutosine-synthesizing protein 3 homolog
                     isoform 1"
                     /protein_id="NP_612476.1"
                     /db_xref="CCDS:CCDS666.1"
                     /db_xref="GeneID:127253"
                     /db_xref="HGNC:HGNC:24757"
                     /db_xref="MIM:611245"
                     /translation="MDRSAEFRKWKAQCLSKADLSRKGSVDEDVVELVQFLNMRDQFF
                     TTSSCAGRILLLDRGINGFEVQKQNCCWLLVTHKLCVKDDVIVALKKANGDATLKFEP
                     FVLHVQCRQLQDAQILHSMAIDSGFRNSGITVGKRGKTMLAVRSTHGLEVPLSHKGKL
                     MVTEEYIDFLLNVANQKMEENKKRIERFYNCLQHALERETMTNLHPKIKEKNNSSYIH
                     KKKRNPEKTRAQCITKESDEELENDDDDDLGINVTIFPEDY"
     exon            268..348
                     /gene="TYW3"
                     /gene_synonym="C1orf171"
                     /inference="alignment:Splign:2.1.0"
     exon            349..447
                     /gene="TYW3"
                     /gene_synonym="C1orf171"
                     /inference="alignment:Splign:2.1.0"
     exon            448..519
                     /gene="TYW3"
                     /gene_synonym="C1orf171"
                     /inference="alignment:Splign:2.1.0"
     exon            520..653
                     /gene="TYW3"
                     /gene_synonym="C1orf171"
                     /inference="alignment:Splign:2.1.0"
     exon            654..3437
                     /gene="TYW3"
                     /gene_synonym="C1orf171"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1140..1145
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TYW3"
                     /gene_synonym="C1orf171"
                     /note="hexamer: AATAAA"
     polyA_site      1160
                     /gene="TYW3"
                     /gene_synonym="C1orf171"
                     /note="major polyA site"
     regulatory      3417..3422
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TYW3"
                     /gene_synonym="C1orf171"
                     /note="hexamer: AATAAA"
     polyA_site      3437
                     /gene="TYW3"
                     /gene_synonym="C1orf171"
                     /note="major polyA site"
ORIGIN      
        1 cttttcggcc accgctcgct tcaatatggc tgcccccagg gagagacgag gctaccatga
       61 aggagccgag cgcagaccct gagtccgtca cccatggatc gcagcgcgga gttcaggaaa
      121 tggaaggcgc aatgtttgag caaagcggac ctcagccgga agggcagtgt tgacgaggat
      181 gtggtagagc ttgtgcagtt tctgaacatg cgagatcagt ttttcaccac cagctcctgc
      241 gctggccgca tcctactcct tgaccggggt ataaatggtt ttgaggttca gaaacaaaac
      301 tgttgctggc tactggttac acacaaactt tgtgtaaaag atgatgtgat tgtagctctg
      361 aagaaagcaa atggtgatgc cactttgaaa tttgaaccat ttgttcttca tgtgcagtgt
      421 cgacaattgc aggatgcaca gattctgcat tccatggcaa tagattctgg tttcaggaac
      481 tctggcataa cggtgggaaa gagaggaaaa actatgttgg ctgtccggag tacacatggc
      541 ttagaagttc cattaagcca taagggaaaa ctgatggtga cagaggaata tattgacttc
      601 ctgttaaatg tggcaaatca aaaaatggag gaaaacaaga aaagaattga gaggttttac
      661 aactgcctac agcatgcttt ggaaagggaa acgatgacta acttacatcc caagatcaaa
      721 gagaaaaata actcatcata tattcataag aaaaaaagaa acccagaaaa aacacgtgcc
      781 cagtgtatta ctaaagaaag tgatgaagaa cttgaaaatg atgatgatga tgatctagga
      841 atcaatgtta ccatcttccc tgaagattac taagctttgg ttctgatgtg tcttggccgt
      901 aatgtttcta gtaggtttta taaagctgct cttcataaga gtattttagt ttgttgagtg
      961 tatcagccat tcataagcca gtaatgacaa gtgcagagct tcaaactata actttgttgc
     1021 ccagaggatg tgcagttgtc atctaagctc tcagcagtac ccggcttatc ctacgacttc
     1081 acctgaaatg ctatagttat ccctactttt ttaccagttt ctcccagaag cacctgctta
     1141 ataaatcaaa gatgtttgaa tggtgtctta ttctgaaata acctgaccta agacaggtat
     1201 ttagattatt ttggatacat tttgaaaagg gatagcataa atattttaag taaaaagacc
     1261 tttattttaa ataatagtgg atattttaat gctggaaatt agcattatag ttgatatgcc
     1321 agaaattata tctttggttg tgatttaaac ttatgctata aactaaatta atgatgtaaa
     1381 tacatagttt taaacattct tttagggaca tgtaactttt aagtatcact tcaataatac
     1441 gtattattat aggaacaaag atttgggaat aattgattac aggtgaggaa gtactggaat
     1501 tccagttcaa ggagatacca tttcatttag gactaaaagg acaagataca agttcacatg
     1561 atgggaaaaa tcagaaaacc tctcgcagac aaagggtata taatggatat gaggcatcaa
     1621 aaagcatggt atagtcagtg atggggaata gtccagaaag gctgaaacac agcatgtgat
     1681 gcgagtcaag gtagttgatg cccaactgtg aagggccgtt ctaatctagc atggaggtag
     1741 acagtgtttc cttaatatgg ctgcatatca gaattaccta ggtcaggacg aggcatggag
     1801 atgctacttt aataggccct gccgcagatc ttccaaacca gaatcttaat cctggagtct
     1861 aggaatcttt atttttcaca caactcatcc aagtggttct gataaaatca gtccagcact
     1921 tttagaaccc actgataaca gacttattcc tggagacagc atttgaggag gaattgaaga
     1981 tttttctaat gaaaagaaaa agggtcacat gaacagatgt tgcagtgtac ctgtgccagg
     2041 gatttcatgt gtacacttta taggagaata agcaagagct taggtaagtt atagtcctta
     2101 ccattgggtc taaggcagtt tccaggaaag catggcaact cgttcagcta tgtaagttga
     2161 actctgtacc acttgggagg gaacattccc ctagatgaca atgtcagtgg cactcgaagt
     2221 tgtgcagtgc acattcttat ctaccaacat atacagcagt ccttctggga aggaaatttg
     2281 ggcaggaaag ggaactcaca gtgtcggaat gcctggagca tttcttctag tctggtggac
     2341 agaatatgaa agtatctgcc tggcagtgca gtaaatgaaa agagaagata aatgaataaa
     2401 aaaaaaagtt ataaataaca gtaggaaaga gagagtgcag gtggaacgag cctatcctgt
     2461 ggtgaaatga caacacattc tgcagtttta aaatctaaga ggctcattga cttttcttca
     2521 ttcatttaaa ttgatctcca agaaaactat gtattttaaa gattccataa actgaatata
     2581 tgaatgagaa ttaagaagag aggggctgct tcctaatctg tttatataag gtatagtata
     2641 gtataatctg tttatataag gttagtagag aggagacacc aggtgctggc cataaaccta
     2701 agaagacatt gaatcccatt cactccttaa cattccttaa tatacattca tgagctacat
     2761 aacattttaa tcatcaatga tggaccatat accatatacg atatggtggc cccataagat
     2821 tataatggac ctgaaaaatt cctattgcta gtgatgtggt cattgtaaag ctgtagcaca
     2881 acacattacc cacgtttgtg gtgacagtca tataaaagta tggtacatat aattatgtac
     2941 agtgcataca taatacttga taatatgtta ctggtttgtg tctttgctat gctttttatc
     3001 attattttag ggtatactac ttaaaatgtt aactgtaaaa cagcttctga caggtccttc
     3061 aggaagtact ccagaagaag gcattgttat catagaaggt gacagcttca tgtgtgttat
     3121 tgcccctgaa gaccttccag tggtacaaga tgtggaggag gaagacagtg atactgagga
     3181 ttctgaccct gtgtaggctt aggctaatgt gtgtgtttat atcttagttt ttcacaaaaa
     3241 ggtttttcca atgttaaaaa aaatatataa aaaagcttat agaataagga tataaagaaa
     3301 tattttgtac agctgtacaa taagctaagc attattacca aagagtcaaa aagttttaag
     3361 aaattaaagt ttataaacca aatgttcatt gtgagccaag gttaatttat tgaagaaata
     3421 aaacattttt aatgaaa
//
