LOCUS       NM_001145440            3117 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens tRNA-yW synthesizing protein 1 homolog B (TYW1B),
            transcript variant 1, coding, mRNA.
ACCESSION   NM_001145440 XR_015176 XR_015229 XR_041925
VERSION     NM_001145440.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3117)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3117)
  AUTHORS   Willer,C.J., Schmidt,E.M., Sengupta,S., Peloso,G.M., Gustafsson,S.,
            Kanoni,S., Ganna,A., Chen,J., Buchkovich,M.L., Mora,S.,
            Beckmann,J.S., Bragg-Gresham,J.L., Chang,H.Y., Demirkan,A., Den
            Hertog,H.M., Do,R., Donnelly,L.A., Ehret,G.B., Esko,T.,
            Feitosa,M.F., Ferreira,T., Fischer,K., Fontanillas,P., Fraser,R.M.,
            Freitag,D.F., Gurdasani,D., Heikkila,K., Hypponen,E., Isaacs,A.,
            Jackson,A.U., Johansson,A., Johnson,T., Kaakinen,M., Kettunen,J.,
            Kleber,M.E., Li,X., Luan,J., Lyytikainen,L.P., Magnusson,P.K.E.,
            Mangino,M., Mihailov,E., Montasser,M.E., Muller-Nurasyid,M.,
            Nolte,I.M., O'Connell,J.R., Palmer,C.D., Perola,M., Petersen,A.K.,
            Sanna,S., Saxena,R., Service,S.K., Shah,S., Shungin,D., Sidore,C.,
            Song,C., Strawbridge,R.J., Surakka,I., Tanaka,T., Teslovich,T.M.,
            Thorleifsson,G., Van den Herik,E.G., Voight,B.F., Volcik,K.A.,
            Waite,L.L., Wong,A., Wu,Y., Zhang,W., Absher,D., Asiki,G.,
            Barroso,I., Been,L.F., Bolton,J.L., Bonnycastle,L.L., Brambilla,P.,
            Burnett,M.S., Cesana,G., Dimitriou,M., Doney,A.S.F., Doring,A.,
            Elliott,P., Epstein,S.E., Ingi Eyjolfsson,G., Gigante,B.,
            Goodarzi,M.O., Grallert,H., Gravito,M.L., Groves,C.J., Hallmans,G.,
            Hartikainen,A.L., Hayward,C., Hernandez,D., Hicks,A.A., Holm,H.,
            Hung,Y.J., Illig,T., Jones,M.R., Kaleebu,P., Kastelein,J.J.P.,
            Khaw,K.T., Kim,E., Klopp,N., Komulainen,P., Kumari,M.,
            Langenberg,C., Lehtimaki,T., Lin,S.Y., Lindstrom,J., Loos,R.J.F.,
            Mach,F., McArdle,W.L., Meisinger,C., Mitchell,B.D., Muller,G.,
            Nagaraja,R., Narisu,N., Nieminen,T.V.M., Nsubuga,R.N., Olafsson,I.,
            Ong,K.K., Palotie,A., Papamarkou,T., Pomilla,C., Pouta,A.,
            Rader,D.J., Reilly,M.P., Ridker,P.M., Rivadeneira,F., Rudan,I.,
            Ruokonen,A., Samani,N., Scharnagl,H., Seeley,J., Silander,K.,
            Stancakova,A., Stirrups,K., Swift,A.J., Tiret,L.,
            Uitterlinden,A.G., van Pelt,L.J., Vedantam,S., Wainwright,N.,
            Wijmenga,C., Wild,S.H., Willemsen,G., Wilsgaard,T., Wilson,J.F.,
            Young,E.H., Zhao,J.H., Adair,L.S., Arveiler,D., Assimes,T.L.,
            Bandinelli,S., Bennett,F., Bochud,M., Boehm,B.O., Boomsma,D.I.,
            Borecki,I.B., Bornstein,S.R., Bovet,P., Burnier,M., Campbell,H.,
            Chakravarti,A., Chambers,J.C., Chen,Y.I., Collins,F.S.,
            Cooper,R.S., Danesh,J., Dedoussis,G., de Faire,U., Feranil,A.B.,
            Ferrieres,J., Ferrucci,L., Freimer,N.B., Gieger,C., Groop,L.C.,
            Gudnason,V., Gyllensten,U., Hamsten,A., Harris,T.B., Hingorani,A.,
            Hirschhorn,J.N., Hofman,A., Hovingh,G.K., Hsiung,C.A.,
            Humphries,S.E., Hunt,S.C., Hveem,K., Iribarren,C., Jarvelin,M.R.,
            Jula,A., Kahonen,M., Kaprio,J., Kesaniemi,A., Kivimaki,M.,
            Kooner,J.S., Koudstaal,P.J., Krauss,R.M., Kuh,D., Kuusisto,J.,
            Kyvik,K.O., Laakso,M., Lakka,T.A., Lind,L., Lindgren,C.M.,
            Martin,N.G., Marz,W., McCarthy,M.I., McKenzie,C.A., Meneton,P.,
            Metspalu,A., Moilanen,L., Morris,A.D., Munroe,P.B., Njolstad,I.,
            Pedersen,N.L., Power,C., Pramstaller,P.P., Price,J.F., Psaty,B.M.,
            Quertermous,T., Rauramaa,R., Saleheen,D., Salomaa,V.,
            Sanghera,D.K., Saramies,J., Schwarz,P.E.H., Sheu,W.H.,
            Shuldiner,A.R., Siegbahn,A., Spector,T.D., Stefansson,K.,
            Strachan,D.P., Tayo,B.O., Tremoli,E., Tuomilehto,J., Uusitupa,M.,
            van Duijn,C.M., Vollenweider,P., Wallentin,L., Wareham,N.J.,
            Whitfield,J.B., Wolffenbuttel,B.H.R., Ordovas,J.M., Boerwinkle,E.,
            Palmer,C.N.A., Thorsteinsdottir,U., Chasman,D.I., Rotter,J.I.,
            Franks,P.W., Ripatti,S., Cupples,L.A., Sandhu,M.S., Rich,S.S.,
            Boehnke,M., Deloukas,P., Kathiresan,S., Mohlke,K.L., Ingelsson,E.
            and Abecasis,G.R.
  CONSRTM   Global Lipids Genetics Consortium
  TITLE     Discovery and refinement of loci associated with lipid levels
  JOURNAL   Nat Genet 45 (11), 1274-1283 (2013)
   PUBMED   24097068
REFERENCE   3  (bases 1 to 3117)
  AUTHORS   Teslovich,T.M., Musunuru,K., Smith,A.V., Edmondson,A.C.,
            Stylianou,I.M., Koseki,M., Pirruccello,J.P., Ripatti,S.,
            Chasman,D.I., Willer,C.J., Johansen,C.T., Fouchier,S.W., Isaacs,A.,
            Peloso,G.M., Barbalic,M., Ricketts,S.L., Bis,J.C., Aulchenko,Y.S.,
            Thorleifsson,G., Feitosa,M.F., Chambers,J., Orho-Melander,M.,
            Melander,O., Johnson,T., Li,X., Guo,X., Li,M., Shin Cho,Y., Jin
            Go,M., Jin Kim,Y., Lee,J.Y., Park,T., Kim,K., Sim,X., Twee-Hee
            Ong,R., Croteau-Chonka,D.C., Lange,L.A., Smith,J.D., Song,K., Hua
            Zhao,J., Yuan,X., Luan,J., Lamina,C., Ziegler,A., Zhang,W.,
            Zee,R.Y., Wright,A.F., Witteman,J.C., Wilson,J.F., Willemsen,G.,
            Wichmann,H.E., Whitfield,J.B., Waterworth,D.M., Wareham,N.J.,
            Waeber,G., Vollenweider,P., Voight,B.F., Vitart,V.,
            Uitterlinden,A.G., Uda,M., Tuomilehto,J., Thompson,J.R., Tanaka,T.,
            Surakka,I., Stringham,H.M., Spector,T.D., Soranzo,N., Smit,J.H.,
            Sinisalo,J., Silander,K., Sijbrands,E.J., Scuteri,A., Scott,J.,
            Schlessinger,D., Sanna,S., Salomaa,V., Saharinen,J., Sabatti,C.,
            Ruokonen,A., Rudan,I., Rose,L.M., Roberts,R., Rieder,M.,
            Psaty,B.M., Pramstaller,P.P., Pichler,I., Perola,M., Penninx,B.W.,
            Pedersen,N.L., Pattaro,C., Parker,A.N., Pare,G., Oostra,B.A.,
            O'Donnell,C.J., Nieminen,M.S., Nickerson,D.A., Montgomery,G.W.,
            Meitinger,T., McPherson,R., McCarthy,M.I., McArdle,W., Masson,D.,
            Martin,N.G., Marroni,F., Mangino,M., Magnusson,P.K., Lucas,G.,
            Luben,R., Loos,R.J., Lokki,M.L., Lettre,G., Langenberg,C.,
            Launer,L.J., Lakatta,E.G., Laaksonen,R., Kyvik,K.O., Kronenberg,F.,
            Konig,I.R., Khaw,K.T., Kaprio,J., Kaplan,L.M., Johansson,A.,
            Jarvelin,M.R., Janssens,A.C., Ingelsson,E., Igl,W., Kees
            Hovingh,G., Hottenga,J.J., Hofman,A., Hicks,A.A., Hengstenberg,C.,
            Heid,I.M., Hayward,C., Havulinna,A.S., Hastie,N.D., Harris,T.B.,
            Haritunians,T., Hall,A.S., Gyllensten,U., Guiducci,C., Groop,L.C.,
            Gonzalez,E., Gieger,C., Freimer,N.B., Ferrucci,L., Erdmann,J.,
            Elliott,P., Ejebe,K.G., Doring,A., Dominiczak,A.F., Demissie,S.,
            Deloukas,P., de Geus,E.J., de Faire,U., Crawford,G., Collins,F.S.,
            Chen,Y.D., Caulfield,M.J., Campbell,H., Burtt,N.P.,
            Bonnycastle,L.L., Boomsma,D.I., Boekholdt,S.M., Bergman,R.N.,
            Barroso,I., Bandinelli,S., Ballantyne,C.M., Assimes,T.L.,
            Quertermous,T., Altshuler,D., Seielstad,M., Wong,T.Y., Tai,E.S.,
            Feranil,A.B., Kuzawa,C.W., Adair,L.S., Taylor,H.A. Jr.,
            Borecki,I.B., Gabriel,S.B., Wilson,J.G., Holm,H.,
            Thorsteinsdottir,U., Gudnason,V., Krauss,R.M., Mohlke,K.L.,
            Ordovas,J.M., Munroe,P.B., Kooner,J.S., Tall,A.R., Hegele,R.A.,
            Kastelein,J.J., Schadt,E.E., Rotter,J.I., Boerwinkle,E.,
            Strachan,D.P., Mooser,V., Stefansson,K., Reilly,M.P., Samani,N.J.,
            Schunkert,H., Cupples,L.A., Sandhu,M.S., Ridker,P.M., Rader,D.J.,
            van Duijn,C.M., Peltonen,L., Abecasis,G.R., Boehnke,M. and
            Kathiresan,S.
  TITLE     Biological, clinical and population relevance of 95 loci for blood
            lipids
  JOURNAL   Nature 466 (7307), 707-713 (2010)
   PUBMED   20686565
REFERENCE   4  (bases 1 to 3117)
  AUTHORS   Noma,A. and Suzuki,T.
  TITLE     Ribonucleome analysis identified enzyme genes responsible for
            wybutosine synthesis
  JOURNAL   Nucleic Acids Symp Ser (Oxf) (50), 65-66 (2006)
   PUBMED   17150819
REFERENCE   5  (bases 1 to 3117)
  AUTHORS   Waas,W.F., de Crecy-Lagard,V. and Schimmel,P.
  TITLE     Discovery of a gene family critical to wyosine base formation in a
            subset of phenylalanine-specific transfer RNAs
  JOURNAL   J Biol Chem 280 (45), 37616-37622 (2005)
   PUBMED   16162496
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA769764.1, BC068520.1,
            BC106019.1 and AI984113.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001145440.2.
            
            Summary: Wybutosine is a hypermodified guanosine found in
            phenylalanine tRNA. Wybutosine functions to stabilize
            codon-anticodon interactions during ribosome decoding and therefore
            supports the maintenance of the reading frame. In yeast, the
            homolog of this gene is essential for the synthesis of wybutosine.
            The human genome contains two closely related genes that putatively
            function in wybutosine synthesis. The open reading frame of this
            locus is disrupted in some individuals. Thus, this locus appears to
            be an evolving pseudogene, but may still be functional in some
            members of the population. [provided by RefSeq, Apr 2014].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC068520.1, SRR1660803.235670.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000620995.5/ ENSP00000482502.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 DA769764.1         35-36
            3-1656              BC068520.1         1-1654
            1657-3115           BC106019.1         97-1555
            3116-3117           AI984113.1         21-22               c
FEATURES             Location/Qualifiers
     source          1..3117
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q11.22-q11.23"
     gene            1..3117
                     /gene="TYW1B"
                     /gene_synonym="LINC00069; NCRNA00069; RSAFD2"
                     /note="tRNA-yW synthesizing protein 1 homolog B"
                     /db_xref="GeneID:441250"
                     /db_xref="HGNC:HGNC:33908"
     exon            1..129
                     /gene="TYW1B"
                     /gene_synonym="LINC00069; NCRNA00069; RSAFD2"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..2132
                     /gene="TYW1B"
                     /gene_synonym="LINC00069; NCRNA00069; RSAFD2"
                     /EC_number="4.1.3.44"
                     /note="isoform 1 is encoded by transcript variant 1,
                     coding; radical S-adenosyl methionine and flavodoxin
                     domains 1; tRNA-yW synthesizing protein 1 homolog B
                     (non-protein coding); tRNA wybutosine-synthesizing protein
                     1 homolog B; radical S-adenosyl methionine and flavodoxin
                     domain-containing protein 2; long intergenic non-protein
                     coding RNA 69; S-adenosyl-L-methionine-dependent tRNA
                     4-demethylwyosine synthase TYW1B"
                     /codon_start=1
                     /product="S-adenosyl-L-methionine-dependent tRNA
                     4-demethylwyosine synthase TYW1B isoform 1"
                     /protein_id="NP_001138912.2"
                     /db_xref="CCDS:CCDS69309.1"
                     /db_xref="GeneID:441250"
                     /db_xref="HGNC:HGNC:33908"
                     /translation="MDPSADTWDLSSPLISLWINRFYIYLGFAVSISLWICVQIVIEM
                     QGFATVLAEAVTSLDLPVAIINLKEYDPDDHLIEEVTSKNVCVFLVATYTDGLPTESA
                     EWFCKWLEEASIDFRFGKTYLKGMRDAVFGLGNSAYASHFNKVGKNVDKWLWMLGVHR
                     VMSRGEGDCDVVKSKHGSIEANFRAWKTKFISQLQALQKGERKKSCGGHCKKGKCESH
                     QHGSEEREEGSQEQDELHHRDTKEEEPFESSSEEEFGGEDHQSLNSIVDVEDLGKIMD
                     HVKKEKREKEQQEEKSGLFRNMGRNEDGERRAMITPALREALTKQVDAPRERSLLQTH
                     ILWNESHRCMETTPSLACANKCVFCWWHHNNPVGTEWLWKMDQPEMILKEAIENHQNM
                     IKQFKGVPGVKAERFEEGMTVKHCALSLVGEPIMYPEINRFLKLLHQCKISSFLVTNA
                     QFPAEIRNLEPVTQLYVSVDASTKDSLKKIDRPLFKDFWQQFLDSLKALAVKQQRTVY
                     RLMLVKAWNVDELQAYAQLVSLGNPDFIEVKGVTYCRESSASSLTMAHVPWHEEVVQF
                     VRELVDLIPEYEIACEHEHSNCLLIAHRKFKIGGEWWTWIDYNRFQELIQEYEDSGGS
                     KTFSAKDYMARTPHWALFGANERSFDPKDTRHQRKNKSKAISGC"
     exon            130..260
                     /gene="TYW1B"
                     /gene_synonym="LINC00069; NCRNA00069; RSAFD2"
                     /inference="alignment:Splign:2.1.0"
     exon            261..362
                     /gene="TYW1B"
                     /gene_synonym="LINC00069; NCRNA00069; RSAFD2"
                     /inference="alignment:Splign:2.1.0"
     exon            363..557
                     /gene="TYW1B"
                     /gene_synonym="LINC00069; NCRNA00069; RSAFD2"
                     /inference="alignment:Splign:2.1.0"
     exon            558..848
                     /gene="TYW1B"
                     /gene_synonym="LINC00069; NCRNA00069; RSAFD2"
                     /inference="alignment:Splign:2.1.0"
     exon            849..971
                     /gene="TYW1B"
                     /gene_synonym="LINC00069; NCRNA00069; RSAFD2"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1089
                     /gene="TYW1B"
                     /gene_synonym="LINC00069; NCRNA00069; RSAFD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1207
                     /gene="TYW1B"
                     /gene_synonym="LINC00069; NCRNA00069; RSAFD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1317
                     /gene="TYW1B"
                     /gene_synonym="LINC00069; NCRNA00069; RSAFD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1495
                     /gene="TYW1B"
                     /gene_synonym="LINC00069; NCRNA00069; RSAFD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1631
                     /gene="TYW1B"
                     /gene_synonym="LINC00069; NCRNA00069; RSAFD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1742
                     /gene="TYW1B"
                     /gene_synonym="LINC00069; NCRNA00069; RSAFD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..1910
                     /gene="TYW1B"
                     /gene_synonym="LINC00069; NCRNA00069; RSAFD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..3117
                     /gene="TYW1B"
                     /gene_synonym="LINC00069; NCRNA00069; RSAFD2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3095..3100
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TYW1B"
                     /gene_synonym="LINC00069; NCRNA00069; RSAFD2"
                     /note="hexamer: AATAAA"
     polyA_site      3117
                     /gene="TYW1B"
                     /gene_synonym="LINC00069; NCRNA00069; RSAFD2"
                     /note="major polyA site"
ORIGIN      
        1 acagttctgc agccactcgg tacggcgcta acgccgcgag gtagctcggt gcgtctcgca
       61 gtaccagtgc gaacctttgg gctctccagg tccgagatcc tagtctcctg tcggctctga
      121 ggaggatgga tccttctgcg gatacatggg acctctcctc acctttaata tcattatgga
      181 taaacaggtt ttacatttat ctgggctttg ctgttagcat tagcctttgg atttgtgtcc
      241 agattgtcat cgagatgcag ggatttgcaa cagttcttgc tgaagcagtt acgtccctgg
      301 atctgcctgt ggccattatt aatctaaaag aatatgatcc agatgatcat ctgatagaag
      361 aggtgactag taaaaatgtc tgtgtcttcc tggttgcgac atacactgac ggcctaccaa
      421 ccgaaagtgc agagtggttc tgcaaatggt tagaggaagc atccattgat tttcgatttg
      481 gcaaaactta cctgaagggt atgagagatg cggtatttgg cctgggaaat tctgcctatg
      541 ctagccactt caacaaggtt ggcaaaaatg ttgacaagtg gctctggatg cttggcgtgc
      601 atcgtgtgat gagtcgaggg gagggcgact gcgacgtggt taaaagcaag cacggcagca
      661 ttgaggccaa cttcagagca tggaagacca agttcatctc ccagctgcag gcacttcaga
      721 aaggggagag aaagaagtcc tgtggcggcc actgcaagaa aggcaaatgt gaatctcacc
      781 aacatggctc agaggagagg gaggaaggat ctcaagagca ggacgaattg catcacagag
      841 acaccaagga ggaagaaccc ttcgagagct ccagtgaaga agagtttggt ggtgaggacc
      901 atcagagcct aaattccatt gttgatgttg aagatttggg caaaattatg gatcacgtga
      961 agaaagaaaa gagagaaaag gaacagcagg aagagaagtc tggtttgttc aggaacatgg
     1021 ggaggaatga agatggtgaa agaagagcta tgataactcc tgctctccga gaagccctta
     1081 ctaaacaagt cgatgctccg agggagagga gcttgttaca aacacacatt ctatggaatg
     1141 agagccatcg ctgcatggaa accaccccga gcttggcgtg tgctaataaa tgtgtcttct
     1201 gttggtggca ccacaacaac cctgtgggca ctgaatggtt gtggaagatg gaccagcctg
     1261 aaatgatctt gaaggaagcc attgaaaacc atcagaacat gattaagcag tttaaaggag
     1321 taccgggcgt caaagcagaa cgctttgaag aaggaatgac ggtaaagcac tgtgcattgt
     1381 ccctcgtggg agaaccaata atgtacccag agatcaacag gtttttgaag ctactccacc
     1441 agtgtaaaat ctccagcttc ctggtcacaa atgcacaatt tcctgcggaa atcaggaacc
     1501 tcgagccagt tactcagctg tatgtcagtg tggatgccag taccaaagac agcctgaaga
     1561 aaatcgaccg cccactcttc aaggatttct ggcagcaatt ccttgacagt ttaaaagcct
     1621 tggcagtcaa gcaacaacga actgtctaca gactgatgct cgtgaaagca tggaacgtgg
     1681 acgagctcca ggcctacgcg cagctcgtgt ccctggggaa tcctgacttc atcgaagtga
     1741 agggcgttac ctactgcaga gaaagttcag caagcagtct taccatggcc catgtgccct
     1801 ggcatgagga agtggtacag tttgtccgcg agctggtgga tctgatcccc gaatatgaaa
     1861 ttgcatgtga acacgaacac tctaattgcc tcctgatagc acacagaaag tttaaaattg
     1921 gtggtgaatg gtggacatgg atcgattata accgcttcca ggagctcatc caggaatatg
     1981 aagatagtgg tggatcaaaa acgttcagcg caaaggatta tatggccaga actcctcact
     2041 gggcattatt tggtgccaat gaaagaagct ttgatcccaa ggacacaaga catcagagaa
     2101 agaacaaatc aaaggctatt tctggatgtt gagattatct gatttcaagg tactgaagga
     2161 caaaaacttg gatggcctca aaaggttctt gaacaccact ctgattctcc aaggacgaat
     2221 tacgtaaatt atactttcat acaaaggaga cgataaggca gtaaacatgg agacacgggg
     2281 gacagcgtcc acactcagag ggcctgggcc acagccccga tgtttctttt cagaactcag
     2341 cccctttcct gattttactt ctaagaggaa aattattttg gggaggaact acacagtcgt
     2401 gattagaatt taactgatgg ttttgtatta taacttctaa gacctgccag aatgctagtc
     2461 ctgagagtgt cagacaagga agaaatccct gggcctcttc ccctcacctg gcccttggat
     2521 ttcatggagc agccacttag cattgaattg cactaccctg agctaaacgt gtctgtgctt
     2581 tctaagataa gagcttgatc cctttcttct gtcttaagac agcacctcct gaaaagaatc
     2641 gaagttgtca caactctcaa ttatttttta aatactgcat agattgagtt ttggtttatt
     2701 actaaccctt cccaaaattg catcggatct aaaactacta gatctcatcc cattcccatg
     2761 taaattacca cagaccgcag taccggggct ggagcggagt gaagctgtct gctgtaagag
     2821 gagtggccat gtgagggcat ggagtcatta gtctcacaaa cacactttgg actgaagagg
     2881 atcatttctt tttgttcgtg aggtcactgt ccgggcctct catatcacga ccagacggcg
     2941 ggtctccatc ttctttgact cctgtggccc tcgctgcttt acacaatctg ttctataagg
     3001 ttcaggtgtt ttcaagttgg aaagatcata aatactcaaa attgttttca agttagcaaa
     3061 ttcttttaac agtcttttat gcaaaaattg aattaataaa ataatatttt gtaaaga
//
